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The map label for this gene is bioF [C]

Identifier: 103486958

GI number: 103486958

Start: 1532537

End: 1533676

Strand: Direct

Name: bioF [C]

Synonym: Sala_1473

Alternate gene names: 103486958

Gene position: 1532537-1533676 (Clockwise)

Preceding gene: 103486957

Following gene: 103486959

Centisome position: 45.81

GC content: 69.3

Gene sequence:

>1140_bases
ATGCCGCCGAACTCTCCCTTCAACACCCACCGCAAGGATCTCGCCGCCCTGGCGACGCAGAGCCGTCGCCGCGCTCTCGC
CCCGCGCGCCGGGCGCGATTTCGCGTCGAACGATTATCTCGGCCTTGCCGATTCCGATGTCCTGCGCGCCGCGCTGACCG
CGGGCATCGAACGCGGCCTCCCCGCGGGCTCGGGCGGCTCGCGGCTGCTGCGCGGCAACCACGCCGAACATGAAGCGCTC
GAGGTCCACGCCGCACGCCATTATGGCAGCGAGGCCGCACTGTTTTTCTCGACCGGGTTCGCCGCCAACGCCGCGCTGTT
CGCGACGCTGCCGCAGCGCGGGGATCTGGTCGTCCATGACGAACTCATCCACGCGAGCGCGCATGACGGAATGAGGCTCG
GCCGCGCGGGACATGTCGCCGCCGCGCACAACGACGCGCAGGCGTTCGAAGACATCATTGTCCGCTGGCGCGCCGGCGGC
GGCGCGGGAACGCCATGGATCGCGGTCGAAAGCCTTTACTCGATGGACGGCGATCGCGCCCCGCTCGCCCAGCTTGCCGA
AGTCGCCGACCGCCACGACGCCATATTCATCGTCGATGAAGCCCATGCGACCGGGGTGTTCGGTCCCGGCGGTGCGGGCC
TCTCGCACGGTCTGACGCGCCGCGACAATCTCGTCACCCTGCACACCTGCGGCAAGGCATTGGGCGCCGAAGGGGCGCTG
CTCTGCGCGCCCGCGATCGTTCGCGACTTCCTTGTCAACCGCGCGCGCCCCTTCATCTTTTCGACGGCGCCATCGCCGCT
GATGGCGTGGCTCGTCCGGCAGGCGATCGAAATCGTCGCTAACGAGCCGGAACGCCAGGCGCGCCTCCACGCGCTCGTCC
GTCACGCCGCCGAACGTCTCGTTCCGCTCGGCATCCCGGCGAGCGGAACGCAGATCCTTCCCGTGATCATCGGCGACAAT
GACCGTGCGATGCGCATCGCGCGGCGCTTGCAGGCGGCGGGTTTCGACATTCGCGGTATCCGCCCGCCGACGGTGGCCGA
GGGAACGGCGCGCCTTCGCATCGCGATCACGCTCAATATCGACGAGAGCGACATCGACGATATGGCCGACGCGCTCGCCG
ACGCGATGGCCGCGGCATGA

Upstream 100 bases:

>100_bases
TCTTGACTTTCGCCATCCCGGCGAAGGCCGGAATCGTGCCGTGGCGCTTTACGCGATGGTGAGATCCCGGCCTTCGCCCG
ATGACGCGTTTGAGGATAGA

Downstream 100 bases:

>100_bases
CGCGCTTCGTCGTCACCGGGACAGACACCGGCATCGGAAAAACCATTTTCTCCGCGAGCCTGGCGCGGGCGACGGGCACA
CCCTACTGGAAACCCGTCCA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MPPNSPFNTHRKDLAALATQSRRRALAPRAGRDFASNDYLGLADSDVLRAALTAGIERGLPAGSGGSRLLRGNHAEHEAL
EVHAARHYGSEAALFFSTGFAANAALFATLPQRGDLVVHDELIHASAHDGMRLGRAGHVAAAHNDAQAFEDIIVRWRAGG
GAGTPWIAVESLYSMDGDRAPLAQLAEVADRHDAIFIVDEAHATGVFGPGGAGLSHGLTRRDNLVTLHTCGKALGAEGAL
LCAPAIVRDFLVNRARPFIFSTAPSPLMAWLVRQAIEIVANEPERQARLHALVRHAAERLVPLGIPASGTQILPVIIGDN
DRAMRIARRLQAAGFDIRGIRPPTVAEGTARLRIAITLNIDESDIDDMADALADAMAAA

Sequences:

>Translated_379_residues
MPPNSPFNTHRKDLAALATQSRRRALAPRAGRDFASNDYLGLADSDVLRAALTAGIERGLPAGSGGSRLLRGNHAEHEAL
EVHAARHYGSEAALFFSTGFAANAALFATLPQRGDLVVHDELIHASAHDGMRLGRAGHVAAAHNDAQAFEDIIVRWRAGG
GAGTPWIAVESLYSMDGDRAPLAQLAEVADRHDAIFIVDEAHATGVFGPGGAGLSHGLTRRDNLVTLHTCGKALGAEGAL
LCAPAIVRDFLVNRARPFIFSTAPSPLMAWLVRQAIEIVANEPERQARLHALVRHAAERLVPLGIPASGTQILPVIIGDN
DRAMRIARRLQAAGFDIRGIRPPTVAEGTARLRIAITLNIDESDIDDMADALADAMAAA
>Mature_378_residues
PPNSPFNTHRKDLAALATQSRRRALAPRAGRDFASNDYLGLADSDVLRAALTAGIERGLPAGSGGSRLLRGNHAEHEALE
VHAARHYGSEAALFFSTGFAANAALFATLPQRGDLVVHDELIHASAHDGMRLGRAGHVAAAHNDAQAFEDIIVRWRAGGG
AGTPWIAVESLYSMDGDRAPLAQLAEVADRHDAIFIVDEAHATGVFGPGGAGLSHGLTRRDNLVTLHTCGKALGAEGALL
CAPAIVRDFLVNRARPFIFSTAPSPLMAWLVRQAIEIVANEPERQARLHALVRHAAERLVPLGIPASGTQILPVIIGDND
RAMRIARRLQAAGFDIRGIRPPTVAEGTARLRIAITLNIDESDIDDMADALADAMAAA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=347, Percent_Identity=32.5648414985591, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI284448556, Length=347, Percent_Identity=32.5648414985591, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI83977442, Length=357, Percent_Identity=28.8515406162465, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI83977444, Length=357, Percent_Identity=28.8515406162465, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI83977440, Length=357, Percent_Identity=28.8515406162465, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI4502025, Length=334, Percent_Identity=30.2395209580838, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI40316939, Length=334, Percent_Identity=30.2395209580838, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI4758668, Length=298, Percent_Identity=29.1946308724832, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI119220554, Length=367, Percent_Identity=25.3405994550409, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI5454084, Length=261, Percent_Identity=26.4367816091954, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1786993, Length=348, Percent_Identity=35.632183908046, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1790046, Length=332, Percent_Identity=35.8433734939759, Blast_Score=164, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71994529, Length=377, Percent_Identity=29.4429708222812, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI32566772, Length=358, Percent_Identity=25.9776536312849, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17560914, Length=359, Percent_Identity=25.3481894150418, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17560912, Length=359, Percent_Identity=25.3481894150418, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71982625, Length=252, Percent_Identity=24.6031746031746, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71982617, Length=252, Percent_Identity=24.6031746031746, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6320438, Length=380, Percent_Identity=29.7368421052632, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320267, Length=354, Percent_Identity=27.4011299435028, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6323954, Length=218, Percent_Identity=24.3119266055046, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24662918, Length=350, Percent_Identity=30.5714285714286, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI17137420, Length=333, Percent_Identity=32.1321321321321, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI17136286, Length=299, Percent_Identity=26.7558528428094, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24653280, Length=294, Percent_Identity=22.7891156462585, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24653276, Length=294, Percent_Identity=22.7891156462585, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24653278, Length=294, Percent_Identity=22.7891156462585, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 40173; Mature: 40042

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPNSPFNTHRKDLAALATQSRRRALAPRAGRDFASNDYLGLADSDVLRAALTAGIERGL
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
PAGSGGSRLLRGNHAEHEALEVHAARHYGSEAALFFSTGFAANAALFATLPQRGDLVVHD
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCCCEEEEH
ELIHASAHDGMRLGRAGHVAAAHNDAQAFEDIIVRWRAGGGAGTPWIAVESLYSMDGDRA
HHHHCCCCCCCCCCCCCCEEECCCHHHHHHHHHEEEECCCCCCCCHHHHHHHHHCCCCCC
PLAQLAEVADRHDAIFIVDEAHATGVFGPGGAGLSHGLTRRDNLVTLHTCGKALGAEGAL
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHCCCCCCCCEEEEECCCHHHCCCCCE
LCAPAIVRDFLVNRARPFIFSTAPSPLMAWLVRQAIEIVANEPERQARLHALVRHAAERL
EHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
VPLGIPASGTQILPVIIGDNDRAMRIARRLQAAGFDIRGIRPPTVAEGTARLRIAITLNI
EECCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEEEC
DESDIDDMADALADAMAAA
CCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PPNSPFNTHRKDLAALATQSRRRALAPRAGRDFASNDYLGLADSDVLRAALTAGIERGL
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
PAGSGGSRLLRGNHAEHEALEVHAARHYGSEAALFFSTGFAANAALFATLPQRGDLVVHD
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCCCEEEEH
ELIHASAHDGMRLGRAGHVAAAHNDAQAFEDIIVRWRAGGGAGTPWIAVESLYSMDGDRA
HHHHCCCCCCCCCCCCCCEEECCCHHHHHHHHHEEEECCCCCCCCHHHHHHHHHCCCCCC
PLAQLAEVADRHDAIFIVDEAHATGVFGPGGAGLSHGLTRRDNLVTLHTCGKALGAEGAL
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHCCCCCCCCEEEEECCCHHHCCCCCE
LCAPAIVRDFLVNRARPFIFSTAPSPLMAWLVRQAIEIVANEPERQARLHALVRHAAERL
EHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
VPLGIPASGTQILPVIIGDNDRAMRIARRLQAAGFDIRGIRPPTVAEGTARLRIAITLNI
EECCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEEEC
DESDIDDMADALADAMAAA
CCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA