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The map label for this gene is ilvC

Identifier: 103486957

GI number: 103486957

Start: 1531388

End: 1532428

Strand: Direct

Name: ilvC

Synonym: Sala_1472

Alternate gene names: 103486957

Gene position: 1531388-1532428 (Clockwise)

Preceding gene: 103486956

Following gene: 103486958

Centisome position: 45.78

GC content: 63.02

Gene sequence:

>1041_bases
ATGCAGGTTTATTACGATCGTGACGCCGACCAGGATCTGATCAAGGGCAAGAAGGTCGCCGTCGTCGGCTATGGCAGCCA
GGGCCATGCGCATGCGCAGAATATGCGCGACAGCGGCGTCAAGGAAGTCGCGATCGCGCTCCGTCCCGGCTCGCCGACCG
CGAAAAAGGCCGAAGCCGCGGGCTTCAAGGTGATGTCGAACAAGGAAGCCGCCGCGTGGGCCGATGTCATCATGATCGCC
GCCCCCGACGAGCATCAGGCGAAAATCTATGCCGAAGACATCGGCCCGAACATGAAGCCCGGCGCCGCCCTCGCCTTCGC
CCACGGCCTCAACATCCATTTCGGCCTCATCGAAGCGCGCCCGGACATCGACGTCTTCATGGTCGCGCCCAAAGGGCCCG
GCCATACGGTGCGCAGCGAATATCAGAAGGGCGGCGGCGTCCCCTGCCTGATCGCGGTCGCACAGGAAGCGCAAGGGTCG
GCCGCGGCGGGCAACGGCTATGCCAAGGCGCTCGCCCTGTCCTACGCGTCCGCAGTTGGGGGCGGGCGCAGCGGCATCAT
CGAAACGACCTTCAAGGAAGAGTGCGAGACCGACCTGTTCGGCGAACAGGCGGTGCTGTGCGGCGGCATCACCCACCTCA
TTCAGGCGGGTTTCGAAACGCTCGTCGAGGCGGGCTACGCCCCCGAAATGGCCTATTTCGAATGCCTCCACGAAACCAAG
CTGATCGTCGACCTCCTCTATGAAGGCGGCATCGCCAACATGCGCTATTCGATCTCGAACACCGCCGAATATGGCGACAT
CAAGACCGGGCCGCGCATCATCACCGAGGAAACGAAGAAGGAAATGAAGCGCGTCCTAGCCGACATCCAGTCGGGGCGTT
TCGTCAAGGATTTCGTGCTCGACAATCAGGCCGGCCAGCCTGAACTCAAGGCCAGCCGCAAGGCCGCCGCAGCGCACCCG
ATCGAGCAGACGGGCGAAAAGCTCCGCGCGATGATGCCGTGGATCGCCAAGAACAAGCTGGTCGACAAGGCGAAGAATTG
A

Upstream 100 bases:

>100_bases
CAGGAATGACGGTTCAACCTTCGTCACCCCGGACTTGATCCGGGGTCCATGGATGCCGGATCACGTCCGGCATGACGAAT
GAAAACAAGGGAAGAATGAC

Downstream 100 bases:

>100_bases
TGGCCGAATCTTGACTTTCGCCATCCCGGCGAAGGCCGGAATCGTGCCGTGGCGCTTTACGCGATGGTGAGATCCCGGCC
TTCGCCCGATGACGCGTTTG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MQVYYDRDADQDLIKGKKVAVVGYGSQGHAHAQNMRDSGVKEVAIALRPGSPTAKKAEAAGFKVMSNKEAAAWADVIMIA
APDEHQAKIYAEDIGPNMKPGAALAFAHGLNIHFGLIEARPDIDVFMVAPKGPGHTVRSEYQKGGGVPCLIAVAQEAQGS
AAAGNGYAKALALSYASAVGGGRSGIIETTFKEECETDLFGEQAVLCGGITHLIQAGFETLVEAGYAPEMAYFECLHETK
LIVDLLYEGGIANMRYSISNTAEYGDIKTGPRIITEETKKEMKRVLADIQSGRFVKDFVLDNQAGQPELKASRKAAAAHP
IEQTGEKLRAMMPWIAKNKLVDKAKN

Sequences:

>Translated_346_residues
MQVYYDRDADQDLIKGKKVAVVGYGSQGHAHAQNMRDSGVKEVAIALRPGSPTAKKAEAAGFKVMSNKEAAAWADVIMIA
APDEHQAKIYAEDIGPNMKPGAALAFAHGLNIHFGLIEARPDIDVFMVAPKGPGHTVRSEYQKGGGVPCLIAVAQEAQGS
AAAGNGYAKALALSYASAVGGGRSGIIETTFKEECETDLFGEQAVLCGGITHLIQAGFETLVEAGYAPEMAYFECLHETK
LIVDLLYEGGIANMRYSISNTAEYGDIKTGPRIITEETKKEMKRVLADIQSGRFVKDFVLDNQAGQPELKASRKAAAAHP
IEQTGEKLRAMMPWIAKNKLVDKAKN
>Mature_346_residues
MQVYYDRDADQDLIKGKKVAVVGYGSQGHAHAQNMRDSGVKEVAIALRPGSPTAKKAEAAGFKVMSNKEAAAWADVIMIA
APDEHQAKIYAEDIGPNMKPGAALAFAHGLNIHFGLIEARPDIDVFMVAPKGPGHTVRSEYQKGGGVPCLIAVAQEAQGS
AAAGNGYAKALALSYASAVGGGRSGIIETTFKEECETDLFGEQAVLCGGITHLIQAGFETLVEAGYAPEMAYFECLHETK
LIVDLLYEGGIANMRYSISNTAEYGDIKTGPRIITEETKKEMKRVLADIQSGRFVKDFVLDNQAGQPELKASRKAAAAHP
IEQTGEKLRAMMPWIAKNKLVDKAKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=303, Percent_Identity=38.6138613861386, Blast_Score=152, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6323387, Length=293, Percent_Identity=32.0819112627986, Blast_Score=105, Evalue=8e-24,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_SPHAL (Q1GT37)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616518.1
- ProteinModelPortal:   Q1GT37
- SMR:   Q1GT37
- GeneID:   4081244
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1472
- NMPDR:   fig|317655.9.peg.1405
- HOGENOM:   HBG286525
- OMA:   AMKQCLK
- ProtClustDB:   PRK05479
- BioCyc:   SALA317655:SALA_1472-MONOMER
- BRENDA:   1.1.1.86
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 37054; Mature: 37054

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVYYDRDADQDLIKGKKVAVVGYGSQGHAHAQNMRDSGVKEVAIALRPGSPTAKKAEAA
CEEEECCCCCHHHHCCCEEEEEEECCCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHC
GFKVMSNKEAAAWADVIMIAAPDEHQAKIYAEDIGPNMKPGAALAFAHGLNIHFGLIEAR
CEEEECCCCHHHEEEEEEEECCCCCCCEEEEHHCCCCCCCCCEEEEECCCEEEEEEEEEC
PDIDVFMVAPKGPGHTVRSEYQKGGGVPCLIAVAQEAQGSAAAGNGYAKALALSYASAVG
CCCEEEEECCCCCCCHHHHHHHHCCCCEEEEEEEHHCCCCCCCCCCHHHHHHHHHHHHCC
GGRSGIIETTFKEECETDLFGEQAVLCGGITHLIQAGFETLVEAGYAPEMAYFECLHETK
CCCCCCEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LIVDLLYEGGIANMRYSISNTAEYGDIKTGPRIITEETKKEMKRVLADIQSGRFVKDFVL
HHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCEEEHHHH
DNQAGQPELKASRKAAAAHPIEQTGEKLRAMMPWIAKNKLVDKAKN
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQVYYDRDADQDLIKGKKVAVVGYGSQGHAHAQNMRDSGVKEVAIALRPGSPTAKKAEAA
CEEEECCCCCHHHHCCCEEEEEEECCCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHC
GFKVMSNKEAAAWADVIMIAAPDEHQAKIYAEDIGPNMKPGAALAFAHGLNIHFGLIEAR
CEEEECCCCHHHEEEEEEEECCCCCCCEEEEHHCCCCCCCCCEEEEECCCEEEEEEEEEC
PDIDVFMVAPKGPGHTVRSEYQKGGGVPCLIAVAQEAQGSAAAGNGYAKALALSYASAVG
CCCEEEEECCCCCCCHHHHHHHHCCCCEEEEEEEHHCCCCCCCCCCHHHHHHHHHHHHCC
GGRSGIIETTFKEECETDLFGEQAVLCGGITHLIQAGFETLVEAGYAPEMAYFECLHETK
CCCCCCEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LIVDLLYEGGIANMRYSISNTAEYGDIKTGPRIITEETKKEMKRVLADIQSGRFVKDFVL
HHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCEEEHHHH
DNQAGQPELKASRKAAAAHPIEQTGEKLRAMMPWIAKNKLVDKAKN
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA