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The map label for this gene is folP [H]

Identifier: 103486456

GI number: 103486456

Start: 992319

End: 993449

Strand: Direct

Name: folP [H]

Synonym: Sala_0966

Alternate gene names: 103486456

Gene position: 992319-993449 (Clockwise)

Preceding gene: 103486455

Following gene: 103486460

Centisome position: 29.66

GC content: 69.32

Gene sequence:

>1131_bases
ATGTTCCACCCGCTGACCAGGGCCGACCTCGGCAAGACATGGGAGGATGCCCGCATCTACCTCCGCCCGACGTGCTTCGT
CGATCGCCCGCACGAACTGGACGACGCCTGCCTGCGGATCGCCGACACGATGGTCTGGTTCGCAGCCTGGCACGTCAGCC
TGCGCGATAATGGCGCCGTCCTTTCGGCGATCGTGCCGGTCGCCGAACTCGACGACTGGATCGCGGCGATGCCGGGCCGG
CTGGGCGAAGCGGCGAAAGCGCAGCGCGCGGGAGTCGCGCGGCCGCGCGGCAACCTCCAGCTTGGCGAACGCACGATCCG
GTTGAGTGAGCCGCAGCTGATGGGCATTGTGAACGTGACGCCCGACAGTTTTTCGGACGGCGGCAAGCATGTCGATGCCG
GTGCGGCGATCGACGCGGGTTTCGCGATGGGCGCGGCGGGCGCGGCGATCATCGACGTCGGCGGCGAATCGACGCGGCCC
GGCGCGCCGCTCATCTGGGAAGGCGACGAGATCCGGCGCATCGAAGGGGTGGTTTCGGCGCTGGCGAAGGGCGGTGTCGC
GGTGTCGATCGACACGCGCAAGGCCGCCGTGATGGAAGCCGCGCTCGCGGCAGGCGCCGGCATCGTCAACGATATTTCGG
CGCTGCGTTACGACGAGCGCGCGATGGACGTGGTGGTGCAGGCGGGCTGCCCGGTCGTGCTGATGCACGCGCCGTCGGCC
AAGAGCGACCCGCATGAGGGCGGAACTTACGCCCATGTCCTGTTCGACGTGTACGACATGCTCGCCGAGCGCGTTGCGGC
GTGCGTGGCCGCGGGGGTCGACCGCGCGAAGATCATCGTCGATCCGGGAATCGGCTTCGGCAAGGGGGTGGGCGACAATC
TGGCGCTCGTGAACGGCCTGGCACTGTTCCACACGCTCGGCTGTCCGGTGCTGTTCGGCGCGAGCCGCAAGCGGATGATC
GGCGCGCTCGACAATGAGGCCGCGGCGGATCAGCGGCTCGGCGGCACGGTCGCGCTGAACTATCAGGCGGCGGCGCAAGG
CGCGCAGCTGCTGCGCGTCCATGACCTGGCGGAAAACCGTCAGGCCCTGCGCGTGTGGCGGGGGTTGCGCGATGCGGCGC
TGACCAGTTAA

Upstream 100 bases:

>100_bases
GCGAGGAGCGGAGCGACGAAGCAATCTCCACCTATCGGCGCGCGTCCCCGGTGGCTGGAGATTGCTTCGCTTCGCTCGCA
ATGACGGATAGAGGATAAGC

Downstream 100 bases:

>100_bases
TCCTGTTCCCGCCGTTCTTTCTTGCCGCGCGCAATCTCGGTCGCAAGCGCTTCGAAGCGCGGCTCCCACGTGCGGCGGAA
GCGTTGCACCCATGCGTCGA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MFHPLTRADLGKTWEDARIYLRPTCFVDRPHELDDACLRIADTMVWFAAWHVSLRDNGAVLSAIVPVAELDDWIAAMPGR
LGEAAKAQRAGVARPRGNLQLGERTIRLSEPQLMGIVNVTPDSFSDGGKHVDAGAAIDAGFAMGAAGAAIIDVGGESTRP
GAPLIWEGDEIRRIEGVVSALAKGGVAVSIDTRKAAVMEAALAAGAGIVNDISALRYDERAMDVVVQAGCPVVLMHAPSA
KSDPHEGGTYAHVLFDVYDMLAERVAACVAAGVDRAKIIVDPGIGFGKGVGDNLALVNGLALFHTLGCPVLFGASRKRMI
GALDNEAAADQRLGGTVALNYQAAAQGAQLLRVHDLAENRQALRVWRGLRDAALTS

Sequences:

>Translated_376_residues
MFHPLTRADLGKTWEDARIYLRPTCFVDRPHELDDACLRIADTMVWFAAWHVSLRDNGAVLSAIVPVAELDDWIAAMPGR
LGEAAKAQRAGVARPRGNLQLGERTIRLSEPQLMGIVNVTPDSFSDGGKHVDAGAAIDAGFAMGAAGAAIIDVGGESTRP
GAPLIWEGDEIRRIEGVVSALAKGGVAVSIDTRKAAVMEAALAAGAGIVNDISALRYDERAMDVVVQAGCPVVLMHAPSA
KSDPHEGGTYAHVLFDVYDMLAERVAACVAAGVDRAKIIVDPGIGFGKGVGDNLALVNGLALFHTLGCPVLFGASRKRMI
GALDNEAAADQRLGGTVALNYQAAAQGAQLLRVHDLAENRQALRVWRGLRDAALTS
>Mature_376_residues
MFHPLTRADLGKTWEDARIYLRPTCFVDRPHELDDACLRIADTMVWFAAWHVSLRDNGAVLSAIVPVAELDDWIAAMPGR
LGEAAKAQRAGVARPRGNLQLGERTIRLSEPQLMGIVNVTPDSFSDGGKHVDAGAAIDAGFAMGAAGAAIIDVGGESTRP
GAPLIWEGDEIRRIEGVVSALAKGGVAVSIDTRKAAVMEAALAAGAGIVNDISALRYDERAMDVVVQAGCPVVLMHAPSA
KSDPHEGGTYAHVLFDVYDMLAERVAACVAAGVDRAKIIVDPGIGFGKGVGDNLALVNGLALFHTLGCPVLFGASRKRMI
GALDNEAAADQRLGGTVALNYQAAAQGAQLLRVHDLAENRQALRVWRGLRDAALTS

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=262, Percent_Identity=43.1297709923664, Blast_Score=199, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6324073, Length=360, Percent_Identity=26.6666666666667, Blast_Score=113, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 39563; Mature: 39563

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFHPLTRADLGKTWEDARIYLRPTCFVDRPHELDDACLRIADTMVWFAAWHVSLRDNGAV
CCCCCCHHHCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCE
LSAIVPVAELDDWIAAMPGRLGEAAKAQRAGVARPRGNLQLGERTIRLSEPQLMGIVNVT
EHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEECCEEEEECCCCEEEEEEEC
PDSFSDGGKHVDAGAAIDAGFAMGAAGAAIIDVGGESTRPGAPLIWEGDEIRRIEGVVSA
CCCCCCCCCEECCCCCHHCCHHHCCCCEEEEECCCCCCCCCCCEEECCHHHHHHHHHHHH
LAKGGVAVSIDTRKAAVMEAALAAGAGIVNDISALRYDERAMDVVVQAGCPVVLMHAPSA
HHHCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
KSDPHEGGTYAHVLFDVYDMLAERVAACVAAGVDRAKIIVDPGIGFGKGVGDNLALVNGL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHH
ALFHTLGCPVLFGASRKRMIGALDNEAAADQRLGGTVALNYQAAAQGAQLLRVHDLAENR
HHHHHHCCCEEECCCHHHHHCCCCCHHHHHHHCCCEEEEEEHHHHCCHHHHHHHHHHHHH
QALRVWRGLRDAALTS
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFHPLTRADLGKTWEDARIYLRPTCFVDRPHELDDACLRIADTMVWFAAWHVSLRDNGAV
CCCCCCHHHCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCE
LSAIVPVAELDDWIAAMPGRLGEAAKAQRAGVARPRGNLQLGERTIRLSEPQLMGIVNVT
EHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEECCEEEEECCCCEEEEEEEC
PDSFSDGGKHVDAGAAIDAGFAMGAAGAAIIDVGGESTRPGAPLIWEGDEIRRIEGVVSA
CCCCCCCCCEECCCCCHHCCHHHCCCCEEEEECCCCCCCCCCCEEECCHHHHHHHHHHHH
LAKGGVAVSIDTRKAAVMEAALAAGAGIVNDISALRYDERAMDVVVQAGCPVVLMHAPSA
HHHCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
KSDPHEGGTYAHVLFDVYDMLAERVAACVAAGVDRAKIIVDPGIGFGKGVGDNLALVNGL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHH
ALFHTLGCPVLFGASRKRMIGALDNEAAADQRLGGTVALNYQAAAQGAQLLRVHDLAENR
HHHHHHCCCEEECCCHHHHHCCCCCHHHHHHHCCCEEEEEEHHHHCCHHHHHHHHHHHHH
QALRVWRGLRDAALTS
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]