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The map label for this gene is pdxH

Identifier: 103486147

GI number: 103486147

Start: 665445

End: 666095

Strand: Reverse

Name: pdxH

Synonym: Sala_0654

Alternate gene names: 103486147

Gene position: 666095-665445 (Counterclockwise)

Preceding gene: 103486155

Following gene: 103486146

Centisome position: 19.91

GC content: 68.36

Gene sequence:

>651_bases
ATGCGTGCGGCGGCGGTCAAGTTCCGCACATGTCGCTCGACCACGCGCGTCCCGCGCATTATGACGGCGCGCATGAGCGA
CGACCCCCTGGCCCTGTTCGACAGCTGGTTCGCCGAAGCGCGTGCCAGCGAGCCCAATGATTCCAACGCGATGGCACTCG
CGACCGCGACGCCCGACGGGCGCCCGTCGCTGCGCATGGTTCTGCTCAAGGGGCATGGGCCGGACGGCTTCGTCTTCTAC
ACCAACCTCGACAGCCGCAAGGGCGGCGAACTTGCCGCGAACCCGCATGTCGCGCTGCTCTTCCACTGGAAATCGCTGCG
TCGCCAGATCCGGATCGAAGGAAGCGTCGCGCCGGTCGACAACGCCACCGCCGACGCCTATTTCGCGACGCGCAGCCGCG
ACAGCCAGATCGGCGCGTGGGCCAGCGACCAGTCGCGCCCGCTGGACAGCCGCGCGACCTTCGAGGCACGCTTCGCCGAA
ATGCAGGCGCGCTTTGCGGGACAGGACGTGCCGCGCCCGCCGCGCTGGTCGGGCTGGCGCGTGACACCCGAGCGAATCGA
GTTCTGGCAGGACCGCGCCCACCGGCTCCACGAACGAACGCTGTTCGAGCGCACCGCGATCGGCTGGACGAAAGGATATC
TCTATCCATGA

Upstream 100 bases:

>100_bases
GCGGTCTTCGCAACGCCCAGGGTGGAATAGGGATCGGCCATCTTGCTCCTGTGCCCGATTAGTGACTGGCCGTGAAGGCC
CATTGCGCGCGCATGTGGGA

Downstream 100 bases:

>100_bases
GCGCATCGCGCCGCCTGCCGATCAGCCGCGTTGACGCCTTTGCCGACCGGCCCTTCACCGGCAATCCCGCTGCGGTGATG
CCGCTCGAAGAATGGCTCGA

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MRAAAVKFRTCRSTTRVPRIMTARMSDDPLALFDSWFAEARASEPNDSNAMALATATPDGRPSLRMVLLKGHGPDGFVFY
TNLDSRKGGELAANPHVALLFHWKSLRRQIRIEGSVAPVDNATADAYFATRSRDSQIGAWASDQSRPLDSRATFEARFAE
MQARFAGQDVPRPPRWSGWRVTPERIEFWQDRAHRLHERTLFERTAIGWTKGYLYP

Sequences:

>Translated_216_residues
MRAAAVKFRTCRSTTRVPRIMTARMSDDPLALFDSWFAEARASEPNDSNAMALATATPDGRPSLRMVLLKGHGPDGFVFY
TNLDSRKGGELAANPHVALLFHWKSLRRQIRIEGSVAPVDNATADAYFATRSRDSQIGAWASDQSRPLDSRATFEARFAE
MQARFAGQDVPRPPRWSGWRVTPERIEFWQDRAHRLHERTLFERTAIGWTKGYLYP
>Mature_216_residues
MRAAAVKFRTCRSTTRVPRIMTARMSDDPLALFDSWFAEARASEPNDSNAMALATATPDGRPSLRMVLLKGHGPDGFVFY
TNLDSRKGGELAANPHVALLFHWKSLRRQIRIEGSVAPVDNATADAYFATRSRDSQIGAWASDQSRPLDSRATFEARFAE
MQARFAGQDVPRPPRWSGWRVTPERIEFWQDRAHRLHERTLFERTAIGWTKGYLYP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=207, Percent_Identity=42.512077294686, Blast_Score=172, Evalue=2e-43,
Organism=Escherichia coli, GI1787926, Length=189, Percent_Identity=43.3862433862434, Blast_Score=170, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17553712, Length=207, Percent_Identity=39.6135265700483, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6319509, Length=186, Percent_Identity=40.8602150537634, Blast_Score=141, Evalue=1e-34,
Organism=Drosophila melanogaster, GI45551845, Length=179, Percent_Identity=41.8994413407821, Blast_Score=130, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24644901, Length=179, Percent_Identity=41.8994413407821, Blast_Score=130, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24644903, Length=171, Percent_Identity=29.8245614035088, Blast_Score=84, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_SPHAL (Q1GVE7)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_615708.1
- ProteinModelPortal:   Q1GVE7
- SMR:   Q1GVE7
- GeneID:   4082744
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_0654
- NMPDR:   fig|317655.9.peg.607
- HOGENOM:   HBG327559
- OMA:   FTFFTNY
- ProtClustDB:   CLSK846710
- BioCyc:   SALA317655:SALA_0654-MONOMER
- BRENDA:   1.4.3.5
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 24512; Mature: 24512

Theoretical pI: Translated: 10.73; Mature: 10.73

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 65-65 BINDING 68-68 BINDING 70-70 BINDING 87-87 BINDING 127-127 BINDING 131-131 BINDING 135-135

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAAAVKFRTCRSTTRVPRIMTARMSDDPLALFDSWFAEARASEPNDSNAMALATATPDG
CCCCCEEHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCC
RPSLRMVLLKGHGPDGFVFYTNLDSRKGGELAANPHVALLFHWKSLRRQIRIEGSVAPVD
CCCEEEEEEECCCCCCEEEEEECCCCCCCCEECCCCEEEEEEEHHHHHEEEECCCCCCCC
NATADAYFATRSRDSQIGAWASDQSRPLDSRATFEARFAEMQARFAGQDVPRPPRWSGWR
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
VTPERIEFWQDRAHRLHERTLFERTAIGWTKGYLYP
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRAAAVKFRTCRSTTRVPRIMTARMSDDPLALFDSWFAEARASEPNDSNAMALATATPDG
CCCCCEEHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCC
RPSLRMVLLKGHGPDGFVFYTNLDSRKGGELAANPHVALLFHWKSLRRQIRIEGSVAPVD
CCCEEEEEEECCCCCCEEEEEECCCCCCCCEECCCCEEEEEEEHHHHHEEEECCCCCCCC
NATADAYFATRSRDSQIGAWASDQSRPLDSRATFEARFAEMQARFAGQDVPRPPRWSGWR
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
VTPERIEFWQDRAHRLHERTLFERTAIGWTKGYLYP
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA