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The map label for this gene is proA

Identifier: 103486074

GI number: 103486074

Start: 590451

End: 591740

Strand: Reverse

Name: proA

Synonym: Sala_0581

Alternate gene names: 103486074

Gene position: 591740-590451 (Counterclockwise)

Preceding gene: 103486076

Following gene: 103486073

Centisome position: 17.69

GC content: 70.39

Gene sequence:

>1290_bases
ATGATCACCGAAACGCTCACCGCTTCTTCCGCGCGGCCCGGCGAGGCCGCGGCGCTGATCGCCGAGATGGGCGCGCGCGC
GCGCACCGCCGCGAAACGGCTTGCACAGACACCGACCGCCGAAAAGGCGGCAGCGCTGAAAGCCGCGGCAGGCGCGATCC
GCGCGCGATCGGCGGCGATACTGGCGGCCAATGCCGAGGATATGGCGGCGGGGCAAACCAACGGCCTGTCGGGCGCGATG
CTCGACCGGCTGCGGCTCGACGAGGGGCGCCTTGCGGCGATCGCCGACGCGATCGAGGCGGTCGCGGCGCTGCCCGATCC
GGTCGGCCGCGAGATCGACCGCTTCACGCGGCCCAACGGACTGGAATTGAGCCGCGTGCGCGTCCCGCTCGGCGTGATCG
GCATTATCTATGAAAGCCGCCCCAATGTCACCGCCGACGCCGCGGCGCTCGGGCTGATGGCGGGCAATGCCGTGATCCTG
CGCGGCGGCAGCGAAGCGGTGCATTCGAACCGCGCGCTTCACGCCGCCTTCGCGGCGGGACTCGTCGAGGCGGGCCTGCC
CGCCGATGCCGTGCAGCTGGTCCCGACGCAGGACCGCGCCGCGGTCGGGGCGATGCTGCGCGCACAGGGGCTGATCGACA
TCATCATTCCGCGCGGCGGCAAGGGGCTGGTCGCGCGCGTGCAGGATGAGGCACGCGTGCCCGTTCTCGCGCACCTCGAC
GGCATCAACCATCTCTACATCGACGGAGCCGCCAACCCCGCGAAGGCGGTCGAGCTGGCGGTGAATGCCAAGATGCGCCG
CACCGGCATCTGCGGCGCGACCGAGACGATCCTGATCGACCGCGCCTACCCTGCCCCGCTGGGCATTGTCGACGCGCTAA
TCGCCGCGGGCTGCGAAGTGCGCGGTGACAGGGATGTCGCGGCGCTCAGCCCGCATGTCGAGTCCGCGAGCGCCGGCGAC
TGGGATACCGAATATCTCGATGCGATCGTCTCGATCGCCATGGTCGACGGCCTCGACGGCGCGCTCGCGCACATCGACGC
GCATTCGAGCCGCCACACCGACGCGATCGTCACCGAGGATGCCGCGACCGCCGAGCGTTTCCTGACGGGCGTCGACAGCG
CGATCGTCATGCACAACGCCTCGACGCAATTTGCGGATGGAGGAGAGTTCGGGCTGGGTGCCGAAATTGGCATCGCAACC
GGACGCCTCCACGCGCGCGGGCCGGTCGCGCTGGAAGGGCTGACGACGTACAAGTGGCTGGTGCGCGGGAGCGGACAGTT
GCGGCCTTGA

Upstream 100 bases:

>100_bases
CCCTTCGATGTCCCCGTTCATGCGCCCCTGACTAGTGGCCCGAAGGGTACCACGCAACGGGGCTTTCGGCAGGTCGGCGA
AACATGATAGAGGCGGTTCG

Downstream 100 bases:

>100_bases
GTCGTTTGTATACAAATGATATGTGCACAGCATGGATGCTACGACGCCGATCACGACGCGGCTTGACGCCGTAACCCTGG
AAACGCTCGACAGATTGGCG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MITETLTASSARPGEAAALIAEMGARARTAAKRLAQTPTAEKAAALKAAAGAIRARSAAILAANAEDMAAGQTNGLSGAM
LDRLRLDEGRLAAIADAIEAVAALPDPVGREIDRFTRPNGLELSRVRVPLGVIGIIYESRPNVTADAAALGLMAGNAVIL
RGGSEAVHSNRALHAAFAAGLVEAGLPADAVQLVPTQDRAAVGAMLRAQGLIDIIIPRGGKGLVARVQDEARVPVLAHLD
GINHLYIDGAANPAKAVELAVNAKMRRTGICGATETILIDRAYPAPLGIVDALIAAGCEVRGDRDVAALSPHVESASAGD
WDTEYLDAIVSIAMVDGLDGALAHIDAHSSRHTDAIVTEDAATAERFLTGVDSAIVMHNASTQFADGGEFGLGAEIGIAT
GRLHARGPVALEGLTTYKWLVRGSGQLRP

Sequences:

>Translated_429_residues
MITETLTASSARPGEAAALIAEMGARARTAAKRLAQTPTAEKAAALKAAAGAIRARSAAILAANAEDMAAGQTNGLSGAM
LDRLRLDEGRLAAIADAIEAVAALPDPVGREIDRFTRPNGLELSRVRVPLGVIGIIYESRPNVTADAAALGLMAGNAVIL
RGGSEAVHSNRALHAAFAAGLVEAGLPADAVQLVPTQDRAAVGAMLRAQGLIDIIIPRGGKGLVARVQDEARVPVLAHLD
GINHLYIDGAANPAKAVELAVNAKMRRTGICGATETILIDRAYPAPLGIVDALIAAGCEVRGDRDVAALSPHVESASAGD
WDTEYLDAIVSIAMVDGLDGALAHIDAHSSRHTDAIVTEDAATAERFLTGVDSAIVMHNASTQFADGGEFGLGAEIGIAT
GRLHARGPVALEGLTTYKWLVRGSGQLRP
>Mature_429_residues
MITETLTASSARPGEAAALIAEMGARARTAAKRLAQTPTAEKAAALKAAAGAIRARSAAILAANAEDMAAGQTNGLSGAM
LDRLRLDEGRLAAIADAIEAVAALPDPVGREIDRFTRPNGLELSRVRVPLGVIGIIYESRPNVTADAAALGLMAGNAVIL
RGGSEAVHSNRALHAAFAAGLVEAGLPADAVQLVPTQDRAAVGAMLRAQGLIDIIIPRGGKGLVARVQDEARVPVLAHLD
GINHLYIDGAANPAKAVELAVNAKMRRTGICGATETILIDRAYPAPLGIVDALIAAGCEVRGDRDVAALSPHVESASAGD
WDTEYLDAIVSIAMVDGLDGALAHIDAHSSRHTDAIVTEDAATAERFLTGVDSAIVMHNASTQFADGGEFGLGAEIGIAT
GRLHARGPVALEGLTTYKWLVRGSGQLRP

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=424, Percent_Identity=39.622641509434, Blast_Score=268, Evalue=8e-72,
Organism=Homo sapiens, GI21361368, Length=424, Percent_Identity=39.622641509434, Blast_Score=268, Evalue=1e-71,
Organism=Escherichia coli, GI1786438, Length=422, Percent_Identity=43.6018957345972, Blast_Score=332, Evalue=3e-92,
Organism=Caenorhabditis elegans, GI17569969, Length=424, Percent_Identity=39.1509433962264, Blast_Score=274, Evalue=7e-74,
Organism=Caenorhabditis elegans, GI17569967, Length=424, Percent_Identity=39.1509433962264, Blast_Score=274, Evalue=8e-74,
Organism=Saccharomyces cerevisiae, GI6324899, Length=433, Percent_Identity=36.7205542725173, Blast_Score=278, Evalue=2e-75,
Organism=Drosophila melanogaster, GI21357643, Length=430, Percent_Identity=38.8372093023256, Blast_Score=259, Evalue=2e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_SPHAL (Q1GVM0)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_615635.1
- ProteinModelPortal:   Q1GVM0
- SMR:   Q1GVM0
- GeneID:   4082012
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_0581
- NMPDR:   fig|317655.9.peg.539
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- ProtClustDB:   PRK00197
- BioCyc:   SALA317655:SALA_0581-MONOMER
- BRENDA:   1.2.1.41
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 44040; Mature: 44040

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITETLTASSARPGEAAALIAEMGARARTAAKRLAQTPTAEKAAALKAAAGAIRARSAAI
CCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEE
LAANAEDMAAGQTNGLSGAMLDRLRLDEGRLAAIADAIEAVAALPDPVGREIDRFTRPNG
EEECCHHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
LELSRVRVPLGVIGIIYESRPNVTADAAALGLMAGNAVILRGGSEAVHSNRALHAAFAAG
CEEEEEECCEEEEEEEEECCCCCCHHHHHHHHEECCEEEEECCCHHHHCCCHHHHHHHHH
LVEAGLPADAVQLVPTQDRAAVGAMLRAQGLIDIIIPRGGKGLVARVQDEARVPVLAHLD
HHHCCCCCCCEEEECCCCHHHHHHHHHHCCCEEEEECCCCCCEEEEECCCCCCCEEEEEC
GINHLYIDGAANPAKAVELAVNAKMRRTGICGATETILIDRAYPAPLGIVDALIAAGCEV
CCCEEEEECCCCHHHHEEEEECCHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCC
RGDRDVAALSPHVESASAGDWDTEYLDAIVSIAMVDGLDGALAHIDAHSSRHTDAIVTED
CCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHEEEECCCCCCCCEEEECC
AATAERFLTGVDSAIVMHNASTQFADGGEFGLGAEIGIATGRLHARGPVALEGLTTYKWL
HHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECEEECCCCEEECCCHHEEEE
VRGSGQLRP
EECCCCCCC
>Mature Secondary Structure
MITETLTASSARPGEAAALIAEMGARARTAAKRLAQTPTAEKAAALKAAAGAIRARSAAI
CCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEE
LAANAEDMAAGQTNGLSGAMLDRLRLDEGRLAAIADAIEAVAALPDPVGREIDRFTRPNG
EEECCHHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
LELSRVRVPLGVIGIIYESRPNVTADAAALGLMAGNAVILRGGSEAVHSNRALHAAFAAG
CEEEEEECCEEEEEEEEECCCCCCHHHHHHHHEECCEEEEECCCHHHHCCCHHHHHHHHH
LVEAGLPADAVQLVPTQDRAAVGAMLRAQGLIDIIIPRGGKGLVARVQDEARVPVLAHLD
HHHCCCCCCCEEEECCCCHHHHHHHHHHCCCEEEEECCCCCCEEEEECCCCCCCEEEEEC
GINHLYIDGAANPAKAVELAVNAKMRRTGICGATETILIDRAYPAPLGIVDALIAAGCEV
CCCEEEEECCCCHHHHEEEEECCHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCC
RGDRDVAALSPHVESASAGDWDTEYLDAIVSIAMVDGLDGALAHIDAHSSRHTDAIVTED
CCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHEEEECCCCCCCCEEEECC
AATAERFLTGVDSAIVMHNASTQFADGGEFGLGAEIGIATGRLHARGPVALEGLTTYKWL
HHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECEEECCCCEEECCCHHEEEE
VRGSGQLRP
EECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA