Click here to switch to the map view.

The map label for this gene is groEL [H]

Identifier: 103485945

GI number: 103485945

Start: 463029

End: 464672

Strand: Reverse

Name: groEL [H]

Synonym: Sala_0452

Alternate gene names: 103485945

Gene position: 464672-463029 (Counterclockwise)

Preceding gene: 103485946

Following gene: 103485944

Centisome position: 13.89

GC content: 63.99

Gene sequence:

>1644_bases
ATGGCTGCCAAGGACGTTAAATTTTCGCGCGACGCGCGCGAGCGCATCCTGAAGGGCGTCGACATCCTCGCCGACGCCGT
CAAGGTCACCCTCGGTCCCAAGGGCCGCAACGTCGTGATCGACAAGAGCTTCGGCGCGCCCCGCATCACCAAGGACGGCG
TCAGCGTCGCCAAGGAAATCGAACTCAAGGACAAGTTCGAGAATATGGGCGCGCAGATGCTGCGCGAAGTCGCCAGCAAG
GCGAACGACAAGGCCGGCGACGGCACCACCACCGCGACCGTGCTTGCCCAGGCGATCGTGCGCGAAGGCATGAAGTCGGT
TGCCGCCGGCATGAACCCGATGGACCTGAAGCGCGGCATCGACCTCGCGGTCACCAAGGTCGTCGAAGACCTCAAGGCCC
GTTCGACCCCGGTTTCGGGTTCGTCGGAAATCGCGCAGGTCGGCATCATTTCGGCCAACGGCGACGTCGAAGTCGGTGAA
AAGATCGCCGAAGCGATGGAAAAGGTCGGCAAGGAAGGCGTCATCACCGTCGAGGAAGCCAAGGGCCTCGAGTTCGAACT
CGACGTCGTCGAAGGCATGCAGTTCGACCGCGGCTATCTGTCGCCTTACTTCATCACCAATCCGGAAAAGATGATCGTCG
AACTGACCGATCCCTATATCCTGATCTTCGAAAAGAAGCTGTCGAACCTCCAGTCGATGCTGCCCATCCTCGAAGCCGTG
GTGCAGTCGGGCCGTCCGCTGCTCATCATCGCCGAGGACATCGAAGGCGAAGCGCTCGCGACCCTCGTCGTCAACCGCCT
GCGCGGCGGTCTGAAGGTTGCTGCGGTCAAGGCGCCGGGCTTCGGCGATCGCCGCAAGGCGATGCTGCAGGACATCGCGA
TCCTGACCAAGGGCGAAATGATCAGCGAAGACCTGGGCATCAAGCTTGAAAACGTCACGCTCAACATGCTGGGCCAGGCG
AAGCGCGTCACGATCGACAAGGACAACACCACCATCGTCGACGGTGCGGGTGACGCCGAAGCGATCAAGGGCCGCGTCGA
ACAGATCCGCGCGCAGATCGAAACCACGACCAGCGACTATGACCGCGAAAAGCTGCAGGAACGTCTGGCGAAGCTCGCCG
GCGGCGTTGCCGTGATCAAGGTCGGCGGCGCAACCGAGGTCGAGGTGAAGGAGCGCAAGGACCGCGTCGACGACGCGCTG
CACGCGACCCGCGCCGCGGTCGAGGAAGGTATCGTTCCCGGTGGCGGCACCGCGCTCCTCTACGCGACCAAGGCCCTCGA
AGGGCTGAAGGGCGCCAATGACGACCAAACCCGCGGTATCGACATCATCCGCAAGGCGATCGAAACGCCGCTGCGCCAGA
TCGCGGCCAACGCCGGTCATGACGGCGCGGTCGTCGCGGGCAACCTGCTGCGCGTCGGCGACGTCGAACAGGGCTTTAAC
GCCGCGACCGACGTTTATGAAAATCTGAAGGCCGCCGGCGTGATCGACCCGACCAAGGTCGTACGCACCGCGCTTCAGGA
CGCCGCGTCGGTGGCGGGCCTGCTCATCACCACCGAAGCGGCGGTGAGCGAGCTGCCCGAAGACAAGCCGGCGATGCCGA
TGGGCAGCGGCGGCATGGGCGGCATGGGCGGCATGGACTTCTAA

Upstream 100 bases:

>100_bases
GCGTCATCGCCTGAGGACGGCCCGTCGTCGCCGCCCCGCCGGGACGGTGATTTCAAAGTAAAGTCACGCAGTTTTCTGCC
ATTTTCAAAGGAGCATCCAC

Downstream 100 bases:

>100_bases
AAGTCCAGGCCGGTCGGCGCTCAGCCAACAGAAACGGGGCCGGGGGAGCAATCCCTCGGCCCTTTTTTGCTTCCTTCTCG
CCAATCGTCACCCCGGACGC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MAAKDVKFSRDARERILKGVDILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELKDKFENMGAQMLREVASK
ANDKAGDGTTTATVLAQAIVREGMKSVAAGMNPMDLKRGIDLAVTKVVEDLKARSTPVSGSSEIAQVGIISANGDVEVGE
KIAEAMEKVGKEGVITVEEAKGLEFELDVVEGMQFDRGYLSPYFITNPEKMIVELTDPYILIFEKKLSNLQSMLPILEAV
VQSGRPLLIIAEDIEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMLQDIAILTKGEMISEDLGIKLENVTLNMLGQA
KRVTIDKDNTTIVDGAGDAEAIKGRVEQIRAQIETTTSDYDREKLQERLAKLAGGVAVIKVGGATEVEVKERKDRVDDAL
HATRAAVEEGIVPGGGTALLYATKALEGLKGANDDQTRGIDIIRKAIETPLRQIAANAGHDGAVVAGNLLRVGDVEQGFN
AATDVYENLKAAGVIDPTKVVRTALQDAASVAGLLITTEAAVSELPEDKPAMPMGSGGMGGMGGMDF

Sequences:

>Translated_547_residues
MAAKDVKFSRDARERILKGVDILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELKDKFENMGAQMLREVASK
ANDKAGDGTTTATVLAQAIVREGMKSVAAGMNPMDLKRGIDLAVTKVVEDLKARSTPVSGSSEIAQVGIISANGDVEVGE
KIAEAMEKVGKEGVITVEEAKGLEFELDVVEGMQFDRGYLSPYFITNPEKMIVELTDPYILIFEKKLSNLQSMLPILEAV
VQSGRPLLIIAEDIEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMLQDIAILTKGEMISEDLGIKLENVTLNMLGQA
KRVTIDKDNTTIVDGAGDAEAIKGRVEQIRAQIETTTSDYDREKLQERLAKLAGGVAVIKVGGATEVEVKERKDRVDDAL
HATRAAVEEGIVPGGGTALLYATKALEGLKGANDDQTRGIDIIRKAIETPLRQIAANAGHDGAVVAGNLLRVGDVEQGFN
AATDVYENLKAAGVIDPTKVVRTALQDAASVAGLLITTEAAVSELPEDKPAMPMGSGGMGGMGGMDF
>Mature_546_residues
AAKDVKFSRDARERILKGVDILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELKDKFENMGAQMLREVASKA
NDKAGDGTTTATVLAQAIVREGMKSVAAGMNPMDLKRGIDLAVTKVVEDLKARSTPVSGSSEIAQVGIISANGDVEVGEK
IAEAMEKVGKEGVITVEEAKGLEFELDVVEGMQFDRGYLSPYFITNPEKMIVELTDPYILIFEKKLSNLQSMLPILEAVV
QSGRPLLIIAEDIEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMLQDIAILTKGEMISEDLGIKLENVTLNMLGQAK
RVTIDKDNTTIVDGAGDAEAIKGRVEQIRAQIETTTSDYDREKLQERLAKLAGGVAVIKVGGATEVEVKERKDRVDDALH
ATRAAVEEGIVPGGGTALLYATKALEGLKGANDDQTRGIDIIRKAIETPLRQIAANAGHDGAVVAGNLLRVGDVEQGFNA
ATDVYENLKAAGVIDPTKVVRTALQDAASVAGLLITTEAAVSELPEDKPAMPMGSGGMGGMGGMDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=53.219696969697, Blast_Score=551, Evalue=1e-157,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=53.219696969697, Blast_Score=551, Evalue=1e-157,
Organism=Escherichia coli, GI1790586, Length=531, Percent_Identity=70.4331450094162, Blast_Score=727, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=53.5984848484849, Blast_Score=546, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI193210679, Length=210, Percent_Identity=52.3809523809524, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17564182, Length=558, Percent_Identity=22.0430107526882, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=58.206106870229, Blast_Score=590, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=56.25, Blast_Score=572, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=56.25, Blast_Score=572, Evalue=1e-163,
Organism=Drosophila melanogaster, GI45550936, Length=525, Percent_Identity=53.3333333333333, Blast_Score=546, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45550132, Length=525, Percent_Identity=53.3333333333333, Blast_Score=546, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45550935, Length=525, Percent_Identity=53.3333333333333, Blast_Score=546, Evalue=1e-155,
Organism=Drosophila melanogaster, GI17864606, Length=548, Percent_Identity=45.2554744525547, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24584129, Length=534, Percent_Identity=36.5168539325843, Blast_Score=322, Evalue=4e-88,
Organism=Drosophila melanogaster, GI19921262, Length=534, Percent_Identity=36.5168539325843, Blast_Score=322, Evalue=4e-88,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57953; Mature: 57822

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFSRDARERILKGVDILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCHHHHHHHHHH
ELKDKFENMGAQMLREVASKANDKAGDGTTTATVLAQAIVREGMKSVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCC
DLAVTKVVEDLKARSTPVSGSSEIAQVGIISANGDVEVGEKIAEAMEKVGKEGVITVEEA
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEECC
KGLEFELDVVEGMQFDRGYLSPYFITNPEKMIVELTDPYILIFEKKLSNLQSMLPILEAV
CCCEEEEEHHHCCCCCCCCCCCEEEECCHHEEEEECCCEEEEEHHHHHHHHHHHHHHHHH
VQSGRPLLIIAEDIEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMLQDIAILTKGEM
HHCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCH
ISEDLGIKLENVTLNMLGQAKRVTIDKDNTTIVDGAGDAEAIKGRVEQIRAQIETTTSDY
HHHHHCCEEEEEEEEECCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
DREKLQERLAKLAGGVAVIKVGGATEVEVKERKDRVDDALHATRAAVEEGIVPGGGTALL
HHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
YATKALEGLKGANDDQTRGIDIIRKAIETPLRQIAANAGHDGAVVAGNLLRVGDVEQGFN
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCEEEECCCHHCCC
AATDVYENLKAAGVIDPTKVVRTALQDAASVAGLLITTEAAVSELPEDKPAMPMGSGGMG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEECHHHHHHCCCCCCCCCCCCCCCC
GMGGMDF
CCCCCCC
>Mature Secondary Structure 
AAKDVKFSRDARERILKGVDILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEI
CCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCHHHHHHHHHH
ELKDKFENMGAQMLREVASKANDKAGDGTTTATVLAQAIVREGMKSVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCC
DLAVTKVVEDLKARSTPVSGSSEIAQVGIISANGDVEVGEKIAEAMEKVGKEGVITVEEA
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEECC
KGLEFELDVVEGMQFDRGYLSPYFITNPEKMIVELTDPYILIFEKKLSNLQSMLPILEAV
CCCEEEEEHHHCCCCCCCCCCCEEEECCHHEEEEECCCEEEEEHHHHHHHHHHHHHHHHH
VQSGRPLLIIAEDIEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMLQDIAILTKGEM
HHCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCH
ISEDLGIKLENVTLNMLGQAKRVTIDKDNTTIVDGAGDAEAIKGRVEQIRAQIETTTSDY
HHHHHCCEEEEEEEEECCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
DREKLQERLAKLAGGVAVIKVGGATEVEVKERKDRVDDALHATRAAVEEGIVPGGGTALL
HHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
YATKALEGLKGANDDQTRGIDIIRKAIETPLRQIAANAGHDGAVVAGNLLRVGDVEQGFN
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCEEEECCCHHCCC
AATDVYENLKAAGVIDPTKVVRTALQDAASVAGLLITTEAAVSELPEDKPAMPMGSGGMG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEECHHHHHHCCCCCCCCCCCCCCCC
GMGGMDF
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA