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The map label for this gene is clpA [C]

Identifier: 103485664

GI number: 103485664

Start: 169208

End: 171547

Strand: Direct

Name: clpA [C]

Synonym: Sala_0168

Alternate gene names: 103485664

Gene position: 169208-171547 (Clockwise)

Preceding gene: 103485663

Following gene: 103485666

Centisome position: 5.06

GC content: 63.16

Gene sequence:

>2340_bases
ATGCCGTCCTTTTCGGAAAGCCTCGAAAAGACCCTGCACAACGCGCTGAAGGCCGCGTCGGAACGTCACCATGAATATGC
GACACTCGAACATCTGCTCTTCGCGCTGATCGACGACGATCATGCCGCCGAAGTGATGCGCGCGTGCGGCGTCGCCCTGG
GCGATCTGCAATCGGCGGTCGTTCACTATCTCGATACCGAACTCGACAGCCTGAAGGTCGAGGGGCACAGTGATCCCAGC
CCCACCAGCGGATTCCAGCGCGTCGTGCAGCGCGCGATTCTGCATGTCCAGTCGTCGGGCAAGGATGAAGTGACGGGCGC
CAACGTCCTCGTCGCGCTGTTTTCAGAACGCGAAAGCTATGCGGTCTATTTCCTCCAGCAGCAGGATCTGACGCGGCTCG
ACGCGGTCTCCTATTTGAGCCACGGCGTCGGCAAGGGCGGCAAACCCGCCGCGCAGGCCGAGCCCGAGGAGAAGGAAGAA
GCCAAGGACAAGGACAGCAGCGGCAAGAACAAGAAGGAAACCGCGCTCGACCAGTTCACCGTCAACCTCAACGAAAAGGC
GAAGACCGGCAAGGTCGATCCGCTGATCGGTCGCAGTGCCGAGGTCGATCGCACGATCCAGATCCTTTGCCGCCGGTCGA
AGAACAATCCGCTCTATGTCGGCGATCCCGGCGTCGGCAAGACCGCCATCGCCGAAGGGCTCGCGCGCAAGATCATCGAG
GGCGACGTGCCCGAGGTGCTGCTGCCCGCGGTCATCTATTCGCTCGACATGGGCGCGCTGCTCGCGGGGACGCGCTACCG
CGGCGACTTCGAGGAGCGGCTGAAACAGGTCGTCACCGAACTCGAAGGGCTGCCGCACGCGATCCTGTTCATCGACGAAA
TCCATACCGTGATCGGCGCGGGTGCGACGAGCGGCGGCGCGATGGACGCGTCGAACCTCTTGAAACCCGCGCTGTCGGGC
GGTGTGATCCGATGCATCGGCTCGACGACCTACAAGGAGTTCCGCAACCATTTCGAAAAGGACCGCGCGTTGCTGCGCCG
CTTCCAGAAGATCGACGTGGTCGAACCGACGCTGGAGGACACCAAGAAAATCCTCGCCGGGCTGCGCAGCGCGTTCGAGG
CGCACCATCAGGTCCGCTACACCCCCGATGCGATCAACGCCGCGGTCGACCTGTCGGCGCGCTACATCAACGACCGCAAA
TTGCCCGACAAGGCGATCGACGTGATCGACGAGGTCGGCGCGATGCAGATGCTGGTTGCCCCGTCAAAGCGCAAGAAGAC
GATCACCGCCAGGGAAATCGAAGCGGTGATCGCGACTATGGCGCGCATCCCGCCCAAATCGGTGTCCACCGACGACAAGG
CGGTGCTTGCAAGCCTGGAGACGGACCTCAAGCGTGTCGTGTTCGGCCAGAACACCGCGATCGAAGTGCTGTCGTCGGCG
ATCAAGCTGTCCCGCGCGGGGCTGCGCGATCCCGAAAAGCCGATCGGCAACTATCTGTTCAGCGGCCCCACCGGCGTCGG
CAAGACCGAGGTTGCGAAGCAGCTCGCGTCGATCATGGGCATCCCGCTCCAGCGGTTCGACATGAGCGAATATATGGAAC
GGCACAGCGTCTCGCGCCTGATCGGCGCGCCACCGGGCTATGTCGGTTATGACCAGGGCGGCCTGCTCACCGATGCGATC
GACCAGAACCCGCATTGCGTGCTGCTGCTCGACGAGATCGAGAAGGCGCATCCCGACCTGTTCAACATCTTGCTTCAGGT
GATGGACAACGGCCGCCTGACCGACCACCACGGCAAGACGGTCGACTTTCGCAACGTCATCCTGATCATGACGACCAACG
CGGGCGCCAGCGACATGGCGCGCGAATCGATCGGCTTCGGCCAGCAGACGCGCGAGGATGCGCAGGAAGAAGCGGTGAAA
CGCATGTTCACCCCCGAGTTCCGCAACCGCCTCGATGCGATCGTGCCCTTCGGCTATCTGCCGCCCGAGGTGGTCGCGCG
TGTCGTTGACAAGTTCATCCTTGAACTCGAGCTCCAGCTCGCCGACCGCAACGTGCATATTCAGCTCGACGACGCGGCGC
GCGAATGGCTGACGGCGAAAGGCTATGACAAGCTTTATGGCGCGCGGCCGATGGGCCGCCTGATCCAGGAAAAGATCAAG
CAGCCGCTCGCGGAGGAGCTGCTGTTCGGCAAGCTCGTCCATGGCGGCGAGGTCAAGGTGAAGATGAAGACCGGCGAGGA
CGCCCATATCGGCAACCCGCTCGCTTTTGAAATCACCCCGGCGGCGCCCAAGGGCGCCAAGGCCAAGGCGAAAGCCAAGC
CGGCGAAGGCGGCCGAATAG

Upstream 100 bases:

>100_bases
GCGCTGCCGCTTTTCCCTTGCGGTGCGGCGACGGCATCGCCACGTTGCATTCTTAAGGGGGCCGCTCTCCCCGGCCTGGT
CCCCGCAAGGAGATAGACCC

Downstream 100 bases:

>100_bases
CGCGCGCGTTTCCGGTAGGATCGACGAAAAATCGTGTATCCCCGCCTTCGCGGGAGCCCGGTGTTTTCTGAACCCGGCGG
CGTTCCGCGCTGTCGCTATC

Product: ATPase AAA-2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 779; Mature: 778

Protein sequence:

>779_residues
MPSFSESLEKTLHNALKAASERHHEYATLEHLLFALIDDDHAAEVMRACGVALGDLQSAVVHYLDTELDSLKVEGHSDPS
PTSGFQRVVQRAILHVQSSGKDEVTGANVLVALFSERESYAVYFLQQQDLTRLDAVSYLSHGVGKGGKPAAQAEPEEKEE
AKDKDSSGKNKKETALDQFTVNLNEKAKTGKVDPLIGRSAEVDRTIQILCRRSKNNPLYVGDPGVGKTAIAEGLARKIIE
GDVPEVLLPAVIYSLDMGALLAGTRYRGDFEERLKQVVTELEGLPHAILFIDEIHTVIGAGATSGGAMDASNLLKPALSG
GVIRCIGSTTYKEFRNHFEKDRALLRRFQKIDVVEPTLEDTKKILAGLRSAFEAHHQVRYTPDAINAAVDLSARYINDRK
LPDKAIDVIDEVGAMQMLVAPSKRKKTITAREIEAVIATMARIPPKSVSTDDKAVLASLETDLKRVVFGQNTAIEVLSSA
IKLSRAGLRDPEKPIGNYLFSGPTGVGKTEVAKQLASIMGIPLQRFDMSEYMERHSVSRLIGAPPGYVGYDQGGLLTDAI
DQNPHCVLLLDEIEKAHPDLFNILLQVMDNGRLTDHHGKTVDFRNVILIMTTNAGASDMARESIGFGQQTREDAQEEAVK
RMFTPEFRNRLDAIVPFGYLPPEVVARVVDKFILELELQLADRNVHIQLDDAAREWLTAKGYDKLYGARPMGRLIQEKIK
QPLAEELLFGKLVHGGEVKVKMKTGEDAHIGNPLAFEITPAAPKGAKAKAKAKPAKAAE

Sequences:

>Translated_779_residues
MPSFSESLEKTLHNALKAASERHHEYATLEHLLFALIDDDHAAEVMRACGVALGDLQSAVVHYLDTELDSLKVEGHSDPS
PTSGFQRVVQRAILHVQSSGKDEVTGANVLVALFSERESYAVYFLQQQDLTRLDAVSYLSHGVGKGGKPAAQAEPEEKEE
AKDKDSSGKNKKETALDQFTVNLNEKAKTGKVDPLIGRSAEVDRTIQILCRRSKNNPLYVGDPGVGKTAIAEGLARKIIE
GDVPEVLLPAVIYSLDMGALLAGTRYRGDFEERLKQVVTELEGLPHAILFIDEIHTVIGAGATSGGAMDASNLLKPALSG
GVIRCIGSTTYKEFRNHFEKDRALLRRFQKIDVVEPTLEDTKKILAGLRSAFEAHHQVRYTPDAINAAVDLSARYINDRK
LPDKAIDVIDEVGAMQMLVAPSKRKKTITAREIEAVIATMARIPPKSVSTDDKAVLASLETDLKRVVFGQNTAIEVLSSA
IKLSRAGLRDPEKPIGNYLFSGPTGVGKTEVAKQLASIMGIPLQRFDMSEYMERHSVSRLIGAPPGYVGYDQGGLLTDAI
DQNPHCVLLLDEIEKAHPDLFNILLQVMDNGRLTDHHGKTVDFRNVILIMTTNAGASDMARESIGFGQQTREDAQEEAVK
RMFTPEFRNRLDAIVPFGYLPPEVVARVVDKFILELELQLADRNVHIQLDDAAREWLTAKGYDKLYGARPMGRLIQEKIK
QPLAEELLFGKLVHGGEVKVKMKTGEDAHIGNPLAFEITPAAPKGAKAKAKAKPAKAAE
>Mature_778_residues
PSFSESLEKTLHNALKAASERHHEYATLEHLLFALIDDDHAAEVMRACGVALGDLQSAVVHYLDTELDSLKVEGHSDPSP
TSGFQRVVQRAILHVQSSGKDEVTGANVLVALFSERESYAVYFLQQQDLTRLDAVSYLSHGVGKGGKPAAQAEPEEKEEA
KDKDSSGKNKKETALDQFTVNLNEKAKTGKVDPLIGRSAEVDRTIQILCRRSKNNPLYVGDPGVGKTAIAEGLARKIIEG
DVPEVLLPAVIYSLDMGALLAGTRYRGDFEERLKQVVTELEGLPHAILFIDEIHTVIGAGATSGGAMDASNLLKPALSGG
VIRCIGSTTYKEFRNHFEKDRALLRRFQKIDVVEPTLEDTKKILAGLRSAFEAHHQVRYTPDAINAAVDLSARYINDRKL
PDKAIDVIDEVGAMQMLVAPSKRKKTITAREIEAVIATMARIPPKSVSTDDKAVLASLETDLKRVVFGQNTAIEVLSSAI
KLSRAGLRDPEKPIGNYLFSGPTGVGKTEVAKQLASIMGIPLQRFDMSEYMERHSVSRLIGAPPGYVGYDQGGLLTDAID
QNPHCVLLLDEIEKAHPDLFNILLQVMDNGRLTDHHGKTVDFRNVILIMTTNAGASDMARESIGFGQQTREDAQEEAVKR
MFTPEFRNRLDAIVPFGYLPPEVVARVVDKFILELELQLADRNVHIQLDDAAREWLTAKGYDKLYGARPMGRLIQEKIKQ
PLAEELLFGKLVHGGEVKVKMKTGEDAHIGNPLAFEITPAAPKGAKAKAKAKPAKAAE

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=299, Percent_Identity=33.4448160535117, Blast_Score=166, Evalue=6e-41,
Organism=Escherichia coli, GI1787109, Length=740, Percent_Identity=57.1621621621622, Blast_Score=870, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=324, Percent_Identity=46.9135802469136, Blast_Score=294, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6320464, Length=325, Percent_Identity=45.5384615384615, Blast_Score=282, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6323002, Length=288, Percent_Identity=43.75, Blast_Score=236, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: 3.4.21.92

Molecular weight: Translated: 85296; Mature: 85164

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSFSESLEKTLHNALKAASERHHEYATLEHLLFALIDDDHAAEVMRACGVALGDLQSAV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VHYLDTELDSLKVEGHSDPSPTSGFQRVVQRAILHVQSSGKDEVTGANVLVALFSERESY
HHHHHCCHHHEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCE
AVYFLQQQDLTRLDAVSYLSHGVGKGGKPAAQAEPEEKEEAKDKDSSGKNKKETALDQFT
EEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHE
VNLNEKAKTGKVDPLIGRSAEVDRTIQILCRRSKNNPLYVGDPGVGKTAIAEGLARKIIE
ECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHC
GDVPEVLLPAVIYSLDMGALLAGTRYRGDFEERLKQVVTELEGLPHAILFIDEIHTVIGA
CCCHHHHHHHHHHHHCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
GATSGGAMDASNLLKPALSGGVIRCIGSTTYKEFRNHFEKDRALLRRFQKIDVVEPTLED
CCCCCCCCCHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
TKKILAGLRSAFEAHHQVRYTPDAINAAVDLSARYINDRKLPDKAIDVIDEVGAMQMLVA
HHHHHHHHHHHHHHHHCEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
PSKRKKTITAREIEAVIATMARIPPKSVSTDDKAVLASLETDLKRVVFGQNTAIEVLSSA
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
IKLSRAGLRDPEKPIGNYLFSGPTGVGKTEVAKQLASIMGIPLQRFDMSEYMERHSVSRL
HHHHHCCCCCCCHHHHCCEECCCCCCCHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHH
IGAPPGYVGYDQGGLLTDAIDQNPHCVLLLDEIEKAHPDLFNILLQVMDNGRLTDHHGKT
HCCCCCCCCCCCCCCEEHHCCCCCCEEEEEHHHHHHCHHHHHHHHHHHCCCCEECCCCCE
VDFRNVILIMTTNAGASDMARESIGFGQQTREDAQEEAVKRMFTPEFRNRLDAIVPFGYL
EEECCEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCC
PPEVVARVVDKFILELELQLADRNVHIQLDDAAREWLTAKGYDKLYGARPMGRLIQEKIK
CHHHHHHHHHHHHHHHHHEEECCEEEEEECHHHHHHHHHCCHHHHHCCCHHHHHHHHHHH
QPLAEELLFGKLVHGGEVKVKMKTGEDAHIGNPLAFEITPAAPKGAKAKAKAKPAKAAE
HHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PSFSESLEKTLHNALKAASERHHEYATLEHLLFALIDDDHAAEVMRACGVALGDLQSAV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VHYLDTELDSLKVEGHSDPSPTSGFQRVVQRAILHVQSSGKDEVTGANVLVALFSERESY
HHHHHCCHHHEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCE
AVYFLQQQDLTRLDAVSYLSHGVGKGGKPAAQAEPEEKEEAKDKDSSGKNKKETALDQFT
EEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHE
VNLNEKAKTGKVDPLIGRSAEVDRTIQILCRRSKNNPLYVGDPGVGKTAIAEGLARKIIE
ECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHC
GDVPEVLLPAVIYSLDMGALLAGTRYRGDFEERLKQVVTELEGLPHAILFIDEIHTVIGA
CCCHHHHHHHHHHHHCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
GATSGGAMDASNLLKPALSGGVIRCIGSTTYKEFRNHFEKDRALLRRFQKIDVVEPTLED
CCCCCCCCCHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
TKKILAGLRSAFEAHHQVRYTPDAINAAVDLSARYINDRKLPDKAIDVIDEVGAMQMLVA
HHHHHHHHHHHHHHHHCEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
PSKRKKTITAREIEAVIATMARIPPKSVSTDDKAVLASLETDLKRVVFGQNTAIEVLSSA
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
IKLSRAGLRDPEKPIGNYLFSGPTGVGKTEVAKQLASIMGIPLQRFDMSEYMERHSVSRL
HHHHHCCCCCCCHHHHCCEECCCCCCCHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHH
IGAPPGYVGYDQGGLLTDAIDQNPHCVLLLDEIEKAHPDLFNILLQVMDNGRLTDHHGKT
HCCCCCCCCCCCCCCEEHHCCCCCCEEEEEHHHHHHCHHHHHHHHHHHCCCCEECCCCCE
VDFRNVILIMTTNAGASDMARESIGFGQQTREDAQEEAVKRMFTPEFRNRLDAIVPFGYL
EEECCEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCC
PPEVVARVVDKFILELELQLADRNVHIQLDDAAREWLTAKGYDKLYGARPMGRLIQEKIK
CHHHHHHHHHHHHHHHHHEEECCEEEEEECHHHHHHHHHCCHHHHHCCCHHHHHHHHHHH
QPLAEELLFGKLVHGGEVKVKMKTGEDAHIGNPLAFEITPAAPKGAKAKAKAKPAKAAE
HHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]