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The map label for this gene is hutU [H]

Identifier: 99082847

GI number: 99082847

Start: 3175510

End: 3177198

Strand: Direct

Name: hutU [H]

Synonym: TM1040_3007

Alternate gene names: 99082847

Gene position: 3175510-3177198 (Clockwise)

Preceding gene: 99082846

Following gene: 99082852

Centisome position: 99.21

GC content: 60.21

Gene sequence:

>1689_bases
ATGAGCGATCCCCGCAAGAATACCCGTGACATTTTCCCTGCCACTGGCACCGAGATCACTGCGAAGTCCTGGTTGACGGA
GGCTCCGATGCGGATGCTGATGAACAACCTGCACCCCGATGTGGCTGAAAACCCGCATGAGCTCGTGGTTTATGGCGGGA
TTGGCCGGGCGGCACGCACGTGGCAGGATTTCGACCTCATCGTCGAGACCCTCAAGACTCTTGAAGAAGATCAGACCCTG
ATGGTGCAGTCCGGCAAACCCGTCGGCGTCTTTCAGACCCACAAGGACGCGCCGCGCGTGTTGATCGCCAACTCCAACCT
CGTGCCGCATTGGGCCAATTGGGATCACTTCAACGAGCTCGATAAGAAGGGTCTGATGATGTACGGCCAGATGACCGCTG
GTTCGTGGATTTACATCGGCACCCAGGGCATCGTGCAGGGCACCTATGAGACCTTTGCCGAGGCGGGCCGTCAGCACTAT
GGCGGGGACCTGACGGGAAAATGGATCCTCACCGGCGGTCTTGGGGGGATGGGGGGGGCGCAGCCTTTGGCTGCGGTTTT
TGCTGGTGCTTGCTGCCTTGCGGTGGAGTGCAACCCCGACTCGATCGATTTCCGCCTGCGCACCAAATACCTTGATGAGA
AGGCTGAAACGCTGGACGAAGCGCTGGAGATGATTGAGCGTTGGACCAAGGCGGGCGAGGCCAAATCCGTTGGCCTTTTG
GGCAATGCGGCGGATGTGTTTGCAGAGCTTGTGGAGCGTGCGAAGGCGGGTGGCATGCGCCCCGACATCGTGACGGATCA
GACCTCAGCGCATGACCCGGTCAACGGTTATCTGCCGCAAGGCTGGACGATGGCCGAATGGAGAGAGAAGCGCGAAACGG
ACAAAAAGGCGGTTGAGAAAGCCTCTCGGGCGTCGATGAAGGCTCATGTGAAGGCCATGGTGGATTTCCACGAGATGGGG
ATTCCCACCGTCGATTATGGCAACAACATCCGTCAAGTCGCGCTGGAAGAGGGGCTGGAGACGGCGTTCTCATTCCCCGG
ATTTGTGCCAGCCTACATTCGCCCGCTGTTCTGCAAGGGGATCGGTCCCTTCCGTTGGTGTGCGCTCTCGGGGGATCCCG
AGGATATCCGCAAGACCGATGCCAAGATGAAAGAGCTGTTCCCGGAGAACGAGAGCCTGCACCGCTGGCTCGACATGGCG
CAGGACCGCATCGCCTTTCAGGGGCTACCGGCGCGGATCTGCTGGATCGGCCTTGGAGATCGCCACAAGGCGGGGCTTGC
CTTCAACGAAATGGTGCGCAACGGCGAATTGTCGGCGCCGGTCGTGATTGGCCGAGATCATCTTGACTCGGGTTCCGTGG
CATCGCCCAACCGTGAAACCGAAGCGATGATGGATGGATCGGATGCGGTCTCTGACTGGCCATTGCTCAATGCGCTTTTG
AACACGGCCTCGGGCGCGACATGGGTTTCGCTGCATCATGGCGGCGGTGTTGGCATGGGGTTTTCGCAGCACTCTGGCGT
GGTGATCTGCTGTGACGGCACAGAGGATGCAGATCGCCGGATCGGGCGCGTTCTGTGGAACGACCCGGCGACCGGCGTAA
TGCGTCACGCAGACGCAGGCTATGAGATCGCGAAGGACTGCGCCAAAGAGCACGGATTGAACCTGCCCGGTATCCTGCGC
TCGGAATGA

Upstream 100 bases:

>100_bases
GCGACGAGCAGCCGCCCTGGCGGTATGACCCCGTCCGCGCCGACCGGTTGCGCGGACATCTCACCCAAATCCTCACCGAT
CTGACCGAATGGAGGCCCGC

Downstream 100 bases:

>100_bases
CCGGATGGGCGGGGCGCATGTCCCGCCTCCCTTGGGGGACCCAAGGCTTCTGCGGTTACAGATCTGTCTGAGTGGCCAAC
CACCAGGTTGTGCCGCTCGG

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 562; Mature: 561

Protein sequence:

>562_residues
MSDPRKNTRDIFPATGTEITAKSWLTEAPMRMLMNNLHPDVAENPHELVVYGGIGRAARTWQDFDLIVETLKTLEEDQTL
MVQSGKPVGVFQTHKDAPRVLIANSNLVPHWANWDHFNELDKKGLMMYGQMTAGSWIYIGTQGIVQGTYETFAEAGRQHY
GGDLTGKWILTGGLGGMGGAQPLAAVFAGACCLAVECNPDSIDFRLRTKYLDEKAETLDEALEMIERWTKAGEAKSVGLL
GNAADVFAELVERAKAGGMRPDIVTDQTSAHDPVNGYLPQGWTMAEWREKRETDKKAVEKASRASMKAHVKAMVDFHEMG
IPTVDYGNNIRQVALEEGLETAFSFPGFVPAYIRPLFCKGIGPFRWCALSGDPEDIRKTDAKMKELFPENESLHRWLDMA
QDRIAFQGLPARICWIGLGDRHKAGLAFNEMVRNGELSAPVVIGRDHLDSGSVASPNRETEAMMDGSDAVSDWPLLNALL
NTASGATWVSLHHGGGVGMGFSQHSGVVICCDGTEDADRRIGRVLWNDPATGVMRHADAGYEIAKDCAKEHGLNLPGILR
SE

Sequences:

>Translated_562_residues
MSDPRKNTRDIFPATGTEITAKSWLTEAPMRMLMNNLHPDVAENPHELVVYGGIGRAARTWQDFDLIVETLKTLEEDQTL
MVQSGKPVGVFQTHKDAPRVLIANSNLVPHWANWDHFNELDKKGLMMYGQMTAGSWIYIGTQGIVQGTYETFAEAGRQHY
GGDLTGKWILTGGLGGMGGAQPLAAVFAGACCLAVECNPDSIDFRLRTKYLDEKAETLDEALEMIERWTKAGEAKSVGLL
GNAADVFAELVERAKAGGMRPDIVTDQTSAHDPVNGYLPQGWTMAEWREKRETDKKAVEKASRASMKAHVKAMVDFHEMG
IPTVDYGNNIRQVALEEGLETAFSFPGFVPAYIRPLFCKGIGPFRWCALSGDPEDIRKTDAKMKELFPENESLHRWLDMA
QDRIAFQGLPARICWIGLGDRHKAGLAFNEMVRNGELSAPVVIGRDHLDSGSVASPNRETEAMMDGSDAVSDWPLLNALL
NTASGATWVSLHHGGGVGMGFSQHSGVVICCDGTEDADRRIGRVLWNDPATGVMRHADAGYEIAKDCAKEHGLNLPGILR
SE
>Mature_561_residues
SDPRKNTRDIFPATGTEITAKSWLTEAPMRMLMNNLHPDVAENPHELVVYGGIGRAARTWQDFDLIVETLKTLEEDQTLM
VQSGKPVGVFQTHKDAPRVLIANSNLVPHWANWDHFNELDKKGLMMYGQMTAGSWIYIGTQGIVQGTYETFAEAGRQHYG
GDLTGKWILTGGLGGMGGAQPLAAVFAGACCLAVECNPDSIDFRLRTKYLDEKAETLDEALEMIERWTKAGEAKSVGLLG
NAADVFAELVERAKAGGMRPDIVTDQTSAHDPVNGYLPQGWTMAEWREKRETDKKAVEKASRASMKAHVKAMVDFHEMGI
PTVDYGNNIRQVALEEGLETAFSFPGFVPAYIRPLFCKGIGPFRWCALSGDPEDIRKTDAKMKELFPENESLHRWLDMAQ
DRIAFQGLPARICWIGLGDRHKAGLAFNEMVRNGELSAPVVIGRDHLDSGSVASPNRETEAMMDGSDAVSDWPLLNALLN
TASGATWVSLHHGGGVGMGFSQHSGVVICCDGTEDADRRIGRVLWNDPATGVMRHADAGYEIAKDCAKEHGLNLPGILRS
E

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=559, Percent_Identity=34.7048300536673, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI260306182, Length=225, Percent_Identity=39.5555555555556, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71997891, Length=575, Percent_Identity=33.5652173913043, Blast_Score=311, Evalue=4e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 61655; Mature: 61523

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPRKNTRDIFPATGTEITAKSWLTEAPMRMLMNNLHPDVAENPHELVVYGGIGRAART
CCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHH
WQDFDLIVETLKTLEEDQTLMVQSGKPVGVFQTHKDAPRVLIANSNLVPHWANWDHFNEL
HHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCEEEEECCCCCCCCCCCCHHHHH
DKKGLMMYGQMTAGSWIYIGTQGIVQGTYETFAEAGRQHYGGDLTGKWILTGGLGGMGGA
HHCCEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCC
QPLAAVFAGACCLAVECNPDSIDFRLRTKYLDEKAETLDEALEMIERWTKAGEAKSVGLL
HHHHHHHHCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEC
GNAADVFAELVERAKAGGMRPDIVTDQTSAHDPVNGYLPQGWTMAEWREKRETDKKAVEK
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ASRASMKAHVKAMVDFHEMGIPTVDYGNNIRQVALEEGLETAFSFPGFVPAYIRPLFCKG
HHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
IGPFRWCALSGDPEDIRKTDAKMKELFPENESLHRWLDMAQDRIAFQGLPARICWIGLGD
CCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
RHKAGLAFNEMVRNGELSAPVVIGRDHLDSGSVASPNRETEAMMDGSDAVSDWPLLNALL
CCCCCCHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHH
NTASGATWVSLHHGGGVGMGFSQHSGVVICCDGTEDADRRIGRVLWNDPATGVMRHADAG
HHCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHCCCC
YEIAKDCAKEHGLNLPGILRSE
HHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SDPRKNTRDIFPATGTEITAKSWLTEAPMRMLMNNLHPDVAENPHELVVYGGIGRAART
CCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHH
WQDFDLIVETLKTLEEDQTLMVQSGKPVGVFQTHKDAPRVLIANSNLVPHWANWDHFNEL
HHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCEEEEECCCCCCCCCCCCHHHHH
DKKGLMMYGQMTAGSWIYIGTQGIVQGTYETFAEAGRQHYGGDLTGKWILTGGLGGMGGA
HHCCEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCC
QPLAAVFAGACCLAVECNPDSIDFRLRTKYLDEKAETLDEALEMIERWTKAGEAKSVGLL
HHHHHHHHCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEC
GNAADVFAELVERAKAGGMRPDIVTDQTSAHDPVNGYLPQGWTMAEWREKRETDKKAVEK
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ASRASMKAHVKAMVDFHEMGIPTVDYGNNIRQVALEEGLETAFSFPGFVPAYIRPLFCKG
HHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
IGPFRWCALSGDPEDIRKTDAKMKELFPENESLHRWLDMAQDRIAFQGLPARICWIGLGD
CCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
RHKAGLAFNEMVRNGELSAPVVIGRDHLDSGSVASPNRETEAMMDGSDAVSDWPLLNALL
CCCCCCHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHH
NTASGATWVSLHHGGGVGMGFSQHSGVVICCDGTEDADRRIGRVLWNDPATGVMRHADAG
HHCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHCCCC
YEIAKDCAKEHGLNLPGILRSE
HHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA