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The map label for this gene is hutH [H]

Identifier: 99082845

GI number: 99082845

Start: 3173217

End: 3174740

Strand: Direct

Name: hutH [H]

Synonym: TM1040_3005

Alternate gene names: 99082845

Gene position: 3173217-3174740 (Clockwise)

Preceding gene: 99082844

Following gene: 99082846

Centisome position: 99.13

GC content: 64.24

Gene sequence:

>1524_bases
ATGATCGAGATGATCCCGGGCGCCGTGACGCTCGACACTTTGGAACGGATCTGGCGTCACGGCACGCCTGCACGTCTGGC
CGATAGCGCGCGTGCAGGTGTCGAGGCCGCTGCCGCGATGGTGGCAGAGGCCGCAGCGGGTGAAGTGCCCGTTTATGGCA
TCAACACTGGTTTTGGCAAACTTGCGTCGACCAAGATCGCGCCGGAGGATACTGCGACCCTGCAGCGCAACCTGATCCTG
AGCCATTCTTGCGGTGTGGGCGAGCCGCTGGCCGAAGACAAAACCCGGTTGATGATGGTGCTGAAGCTGTTGTCGCTGGG
TCGGGGCGCCTCCGGGGTGCGCTGGGCTGTCATTGAGCAGATCCAAGAGATGCTGGCACGCGGGGTGACACCTGTTGTGC
CGTCGCAAGGGTCCGTTGGCGCCTCTGGTGATCTTGCCCCGCTTGCCCACATGACTGCGGCCATGATCGGCGAAGGCGAG
GCAACAATCGACGGCGTGCGCCTGCCTGGTGCCGAAGCCTTGAGGCGTGCCGGGTTGGAGCCGATTGTGCTGGGCCCGAA
AGAAGGGCTTGGCCTGATAAATGGCACGCAGTTTTCCACCGCTTGCGCGCTCACCGGGTTGTTTGAGGCCCTGGAGATGG
CGCGGGCCTCCATGGCGATCGCGTCTTTGACAACCGACGCTATCATGGGCTCTACCGCGCCTTTGGTGGCGGATATTCAC
AGCTTGCGCGGCCATGCTGGGCAGATGGAGGTCGCGGCAACGATGCGCGACATCATGGCGGGCTCGGAAATTCGCGAGAG
CCACCGTGAGGGCGACACCCGCGTGCAGGATCCCTATTGCATCCGCTGCCAGCCTCAGGTGGTGGGCGCCGCGCTTGATG
TGCTGCGCATGGCGGCGCGCACGCTTGAAATCGAGGCGAACGCGGTCACCGACAATCCGTTGGTACTGGTGGAGGCGGGG
CAGATCGTCTCCGGGGGCAACTTCCATGCCGAATATGTGGGCTTTGCGGCAGATCAGATCGCGCTCGCCGTGGCTGAGAT
CGGCGCGATTGCGCAGCGCCGGGTTGCGCTGATGGTGGATCCTACCCTGAGCCACGACCTACCACCGTTCCTGACGCCGA
ACCCCGGCCTCAACTCGGGATTCATGATTGCCGAAGTCACGACTGCGGCGCTCATGAGCGAAAACAAACATCTGGCCAAC
CCCTGCGTTACGGATTCCACACCGACCTCCGCCAACCAAGAGGACCACGTCTCTATGGCGGCGCACGGTGCGCTGCGGCT
GGCGAAAATGAACGCAAACCTGTCGGTGATCCTTGGGGTCGAGATGCTTTGCGCGGCGCAGGGGGTCGAGGCGCGCGCGC
CGCTCAAGACCTCTAGCCGCTTGCAGAACCTGCTCGACATGCTGCGCGGCGAGATCCCGAGCCTTGGCGAGGACCGCTAT
CTTGCGCCGGAAATCGAAACCGCCAGCGCGATGGTGCGGGCAGGCCGCGTGGCGCAGGCCGCAGGCGTGGAGGTCAGCAC
ATGA

Upstream 100 bases:

>100_bases
TGGCGGTCTGGGATGTCTCTCGCCCGGCAGAGCTGGCTTATCGCATTGGTTTCAACCCGCTCTACGCGCGTGTCATGGGC
GGCAAAATGGAGGTTCGTAC

Downstream 100 bases:

>100_bases
TCGAAGTCACGCAGGGGTCTTCTCCGCTGGTTCTGGGGCTGCCCCATACGGGCACCGATGTTCCGGCCGAGGTGGCACAA
CATTTGAATGACCGCGGCCA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MIEMIPGAVTLDTLERIWRHGTPARLADSARAGVEAAAAMVAEAAAGEVPVYGINTGFGKLASTKIAPEDTATLQRNLIL
SHSCGVGEPLAEDKTRLMMVLKLLSLGRGASGVRWAVIEQIQEMLARGVTPVVPSQGSVGASGDLAPLAHMTAAMIGEGE
ATIDGVRLPGAEALRRAGLEPIVLGPKEGLGLINGTQFSTACALTGLFEALEMARASMAIASLTTDAIMGSTAPLVADIH
SLRGHAGQMEVAATMRDIMAGSEIRESHREGDTRVQDPYCIRCQPQVVGAALDVLRMAARTLEIEANAVTDNPLVLVEAG
QIVSGGNFHAEYVGFAADQIALAVAEIGAIAQRRVALMVDPTLSHDLPPFLTPNPGLNSGFMIAEVTTAALMSENKHLAN
PCVTDSTPTSANQEDHVSMAAHGALRLAKMNANLSVILGVEMLCAAQGVEARAPLKTSSRLQNLLDMLRGEIPSLGEDRY
LAPEIETASAMVRAGRVAQAAGVEVST

Sequences:

>Translated_507_residues
MIEMIPGAVTLDTLERIWRHGTPARLADSARAGVEAAAAMVAEAAAGEVPVYGINTGFGKLASTKIAPEDTATLQRNLIL
SHSCGVGEPLAEDKTRLMMVLKLLSLGRGASGVRWAVIEQIQEMLARGVTPVVPSQGSVGASGDLAPLAHMTAAMIGEGE
ATIDGVRLPGAEALRRAGLEPIVLGPKEGLGLINGTQFSTACALTGLFEALEMARASMAIASLTTDAIMGSTAPLVADIH
SLRGHAGQMEVAATMRDIMAGSEIRESHREGDTRVQDPYCIRCQPQVVGAALDVLRMAARTLEIEANAVTDNPLVLVEAG
QIVSGGNFHAEYVGFAADQIALAVAEIGAIAQRRVALMVDPTLSHDLPPFLTPNPGLNSGFMIAEVTTAALMSENKHLAN
PCVTDSTPTSANQEDHVSMAAHGALRLAKMNANLSVILGVEMLCAAQGVEARAPLKTSSRLQNLLDMLRGEIPSLGEDRY
LAPEIETASAMVRAGRVAQAAGVEVST
>Mature_507_residues
MIEMIPGAVTLDTLERIWRHGTPARLADSARAGVEAAAAMVAEAAAGEVPVYGINTGFGKLASTKIAPEDTATLQRNLIL
SHSCGVGEPLAEDKTRLMMVLKLLSLGRGASGVRWAVIEQIQEMLARGVTPVVPSQGSVGASGDLAPLAHMTAAMIGEGE
ATIDGVRLPGAEALRRAGLEPIVLGPKEGLGLINGTQFSTACALTGLFEALEMARASMAIASLTTDAIMGSTAPLVADIH
SLRGHAGQMEVAATMRDIMAGSEIRESHREGDTRVQDPYCIRCQPQVVGAALDVLRMAARTLEIEANAVTDNPLVLVEAG
QIVSGGNFHAEYVGFAADQIALAVAEIGAIAQRRVALMVDPTLSHDLPPFLTPNPGLNSGFMIAEVTTAALMSENKHLAN
PCVTDSTPTSANQEDHVSMAAHGALRLAKMNANLSVILGVEMLCAAQGVEARAPLKTSSRLQNLLDMLRGEIPSLGEDRY
LAPEIETASAMVRAGRVAQAAGVEVST

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=506, Percent_Identity=39.9209486166008, Blast_Score=367, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17567831, Length=476, Percent_Identity=41.5966386554622, Blast_Score=342, Evalue=4e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 52844; Mature: 52844

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00488 PAL_HISTIDASE ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEMIPGAVTLDTLERIWRHGTPARLADSARAGVEAAAAMVAEAAAGEVPVYGINTGFGK
CCEECCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCH
LASTKIAPEDTATLQRNLILSHSCGVGEPLAEDKTRLMMVLKLLSLGRGASGVRWAVIEQ
HHCCCCCCCHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
IQEMLARGVTPVVPSQGSVGASGDLAPLAHMTAAMIGEGEATIDGVRLPGAEALRRAGLE
HHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHCCCC
PIVLGPKEGLGLINGTQFSTACALTGLFEALEMARASMAIASLTTDAIMGSTAPLVADIH
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
SLRGHAGQMEVAATMRDIMAGSEIRESHREGDTRVQDPYCIRCQPQVVGAALDVLRMAAR
HHCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHH
TLEIEANAVTDNPLVLVEAGQIVSGGNFHAEYVGFAADQIALAVAEIGAIAQRRVALMVD
HEEEEEEEECCCCEEEEECCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
PTLSHDLPPFLTPNPGLNSGFMIAEVTTAALMSENKHLANPCVTDSTPTSANQEDHVSMA
CCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
AHGALRLAKMNANLSVILGVEMLCAAQGVEARAPLKTSSRLQNLLDMLRGEIPSLGEDRY
HHHHEEEEEECCCEEEEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
LAPEIETASAMVRAGRVAQAAGVEVST
CCCCHHHHHHHHHHCCHHHHCCCEECC
>Mature Secondary Structure
MIEMIPGAVTLDTLERIWRHGTPARLADSARAGVEAAAAMVAEAAAGEVPVYGINTGFGK
CCEECCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCH
LASTKIAPEDTATLQRNLILSHSCGVGEPLAEDKTRLMMVLKLLSLGRGASGVRWAVIEQ
HHCCCCCCCHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
IQEMLARGVTPVVPSQGSVGASGDLAPLAHMTAAMIGEGEATIDGVRLPGAEALRRAGLE
HHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHCCCC
PIVLGPKEGLGLINGTQFSTACALTGLFEALEMARASMAIASLTTDAIMGSTAPLVADIH
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
SLRGHAGQMEVAATMRDIMAGSEIRESHREGDTRVQDPYCIRCQPQVVGAALDVLRMAAR
HHCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHH
TLEIEANAVTDNPLVLVEAGQIVSGGNFHAEYVGFAADQIALAVAEIGAIAQRRVALMVD
HEEEEEEEECCCCEEEEECCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
PTLSHDLPPFLTPNPGLNSGFMIAEVTTAALMSENKHLANPCVTDSTPTSANQEDHVSMA
CCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
AHGALRLAKMNANLSVILGVEMLCAAQGVEARAPLKTSSRLQNLLDMLRGEIPSLGEDRY
HHHHEEEEEECCCEEEEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
LAPEIETASAMVRAGRVAQAAGVEVST
CCCCHHHHHHHHHHCCHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA