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The map label for this gene is hutI

Identifier: 99082844

GI number: 99082844

Start: 3172003

End: 3173220

Strand: Direct

Name: hutI

Synonym: TM1040_3004

Alternate gene names: 99082844

Gene position: 3172003-3173220 (Clockwise)

Preceding gene: 99082842

Following gene: 99082845

Centisome position: 99.1

GC content: 62.89

Gene sequence:

>1218_bases
ATGCGCGATACATACGTGTTGAGCGGTGCTCGGTTGGCGACCATGGAGGCCGAGGGGTCTTATGGGCTTGTGGAAGACGG
GGCGATCGCCATTCAGGGGGATGAAATTCTCTGGTGCGGCGCGCGGGGCGCGCTACCGGACACCTACGCAGCTTGCCCCA
GCACCGACCTCAATGGACGTCTGGTCACGCCGGCCTTCATTGATTGTCACACGCACATCGTTTTTGGCGGAGACCGTGCG
GGCGAGTTCGAGATGCGCCTCGAGGGGGCAACCTATGAAGAGGTGGCCAAGGCTGGCGGCGGGATTGTGTCGACCGTCAC
GGCCACGCGTGCCGCAAGCCTGGATGCGCTTGTGACCGGGGCCTTGCCGCGGCTGGATGCACTGATTGCGGAAGGGGTGA
GCACGGTAGAAGTCAAATCCGGCTACGGGCTCGACCGCGAGACCGAGCTCAATATGCTGCGCGCGGCGCGTCGTCTGGCT
GAGCACAGAGATGTTACGGTCAAAACCACCTTTCTGGGCGCGCATGCAGTCCCTGCAGAGTATGCGGGTCGGGCAGATGC
CTATCTTGATGAGGTCTGCCTGCCGACGCTGCGCGCAGCGCATGCCGAGGGGTTGGTCGATGCGGTAGATGGCTTTTGTG
AAGGGATCGCTTTTTCGGCGGCGCAGATCGCAAAGGTTTTTGACGTGGCAGCAGAGTTGGGTTTGCCGGTGAAGCTCCAT
GCCGAACAGCTGTCGCATCAGGGCGGCACCAAATTGGCGGCAGAGCGCGGCGCACTGTCTGTGGATCATGTGGAATACGC
CACAGAAGCGGACGCACGGGCAATGGCGGCTTCGGGGTCCGTTGCGGTCCTGTTGCCCGGCGCGTTCTACACAATCCGCG
AAACGCAAGTCCCGCCCGTGGCAGAGTTTCGCATGCATGGCGTGCCGATGGCACTGGCGACAGACTGCAACCCCGGATCA
TCGCCGCTCACGTCGCTTCTGCTGACGCTCAATATGGGCTGCACATTGTTTCGCCTGACCCCGGAAGAGGCGCTTGCGGG
TGTGACCCGTAATGCCGCCCGCGCGCTGGGCATGCAGGATCGTGGGCGCATCGCCCCCGGGCTTCGTGCGGATCTGGCGG
TCTGGGATGTCTCTCGCCCGGCAGAGCTGGCTTATCGCATTGGTTTCAACCCGCTCTACGCGCGTGTCATGGGCGGCAAA
ATGGAGGTTCGTACATGA

Upstream 100 bases:

>100_bases
CGGTGGCGGCAAAAATTGTCTGCATCTGGCCCTCTTATGTATAGACATAACAACAATAAGCGCATACCGTTAATGGGGCA
AGAGGATTCTGGGGGACGAA

Downstream 100 bases:

>100_bases
TCGAGATGATCCCGGGCGCCGTGACGCTCGACACTTTGGAACGGATCTGGCGTCACGGCACGCCTGCACGTCTGGCCGAT
AGCGCGCGTGCAGGTGTCGA

Product: imidazolonepropionase

Products: NA

Alternate protein names: Imidazolone-5-propionate hydrolase

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MRDTYVLSGARLATMEAEGSYGLVEDGAIAIQGDEILWCGARGALPDTYAACPSTDLNGRLVTPAFIDCHTHIVFGGDRA
GEFEMRLEGATYEEVAKAGGGIVSTVTATRAASLDALVTGALPRLDALIAEGVSTVEVKSGYGLDRETELNMLRAARRLA
EHRDVTVKTTFLGAHAVPAEYAGRADAYLDEVCLPTLRAAHAEGLVDAVDGFCEGIAFSAAQIAKVFDVAAELGLPVKLH
AEQLSHQGGTKLAAERGALSVDHVEYATEADARAMAASGSVAVLLPGAFYTIRETQVPPVAEFRMHGVPMALATDCNPGS
SPLTSLLLTLNMGCTLFRLTPEEALAGVTRNAARALGMQDRGRIAPGLRADLAVWDVSRPAELAYRIGFNPLYARVMGGK
MEVRT

Sequences:

>Translated_405_residues
MRDTYVLSGARLATMEAEGSYGLVEDGAIAIQGDEILWCGARGALPDTYAACPSTDLNGRLVTPAFIDCHTHIVFGGDRA
GEFEMRLEGATYEEVAKAGGGIVSTVTATRAASLDALVTGALPRLDALIAEGVSTVEVKSGYGLDRETELNMLRAARRLA
EHRDVTVKTTFLGAHAVPAEYAGRADAYLDEVCLPTLRAAHAEGLVDAVDGFCEGIAFSAAQIAKVFDVAAELGLPVKLH
AEQLSHQGGTKLAAERGALSVDHVEYATEADARAMAASGSVAVLLPGAFYTIRETQVPPVAEFRMHGVPMALATDCNPGS
SPLTSLLLTLNMGCTLFRLTPEEALAGVTRNAARALGMQDRGRIAPGLRADLAVWDVSRPAELAYRIGFNPLYARVMGGK
MEVRT
>Mature_405_residues
MRDTYVLSGARLATMEAEGSYGLVEDGAIAIQGDEILWCGARGALPDTYAACPSTDLNGRLVTPAFIDCHTHIVFGGDRA
GEFEMRLEGATYEEVAKAGGGIVSTVTATRAASLDALVTGALPRLDALIAEGVSTVEVKSGYGLDRETELNMLRAARRLA
EHRDVTVKTTFLGAHAVPAEYAGRADAYLDEVCLPTLRAAHAEGLVDAVDGFCEGIAFSAAQIAKVFDVAAELGLPVKLH
AEQLSHQGGTKLAAERGALSVDHVEYATEADARAMAASGSVAVLLPGAFYTIRETQVPPVAEFRMHGVPMALATDCNPGS
SPLTSLLLTLNMGCTLFRLTPEEALAGVTRNAARALGMQDRGRIAPGLRADLAVWDVSRPAELAYRIGFNPLYARVMGGK
MEVRT

Specific function: Unknown

COG id: COG1228

COG function: function code Q; Imidazolonepropionase and related amidohydrolases

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hutI family

Homologues:

Organism=Homo sapiens, GI223972677, Length=337, Percent_Identity=36.2017804154303, Blast_Score=184, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17555004, Length=352, Percent_Identity=34.9431818181818, Blast_Score=188, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTI_SILST (Q1GC80)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_614998.1
- ProteinModelPortal:   Q1GC80
- SMR:   Q1GC80
- STRING:   Q1GC80
- GeneID:   4078034
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_3004
- NMPDR:   fig|292414.1.peg.1027
- eggNOG:   COG1228
- HOGENOM:   HBG686142
- OMA:   MNMACTL
- ProtClustDB:   PRK09356
- BioCyc:   SSP292414:TM1040_3004-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00372
- InterPro:   IPR006680
- InterPro:   IPR005920
- InterPro:   IPR011059
- TIGRFAMs:   TIGR01224

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.7

Molecular weight: Translated: 42718; Mature: 42718

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: BINDING 79-79 BINDING 92-92 BINDING 142-142 BINDING 175-175 BINDING 243-243

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDTYVLSGARLATMEAEGSYGLVEDGAIAIQGDEILWCGARGALPDTYAACPSTDLNGR
CCCCEEECCCEEEEEECCCCCCEEECCEEEEECCEEEEECCCCCCCCCHHCCCCCCCCCE
LVTPAFIDCHTHIVFGGDRAGEFEMRLEGATYEEVAKAGGGIVSTVTATRAASLDALVTG
ECCCEEEEEEEEEEECCCCCCCEEEEECCCCHHHHHHCCCCEEEEHHHHHHHHHHHHHHC
ALPRLDALIAEGVSTVEVKSGYGLDRETELNMLRAARRLAEHRDVTVKTTFLGAHAVPAE
CHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCHH
YAGRADAYLDEVCLPTLRAAHAEGLVDAVDGFCEGIAFSAAQIAKVFDVAAELGLPVKLH
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
AEQLSHQGGTKLAAERGALSVDHVEYATEADARAMAASGSVAVLLPGAFYTIRETQVPPV
HHHHCCCCCCEEHHHCCCCEEHHHHHHHCCCHHHHCCCCCEEEEECCCEEEEECCCCCCH
AEFRMHGVPMALATDCNPGSSPLTSLLLTLNMGCTLFRLTPEEALAGVTRNAARALGMQD
HHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCCCCC
RGRIAPGLRADLAVWDVSRPAELAYRIGFNPLYARVMGGKMEVRT
CCCCCCCCCCCEEEEECCCHHHHHEECCCCHHHHHHCCCEEEECC
>Mature Secondary Structure
MRDTYVLSGARLATMEAEGSYGLVEDGAIAIQGDEILWCGARGALPDTYAACPSTDLNGR
CCCCEEECCCEEEEEECCCCCCEEECCEEEEECCEEEEECCCCCCCCCHHCCCCCCCCCE
LVTPAFIDCHTHIVFGGDRAGEFEMRLEGATYEEVAKAGGGIVSTVTATRAASLDALVTG
ECCCEEEEEEEEEEECCCCCCCEEEEECCCCHHHHHHCCCCEEEEHHHHHHHHHHHHHHC
ALPRLDALIAEGVSTVEVKSGYGLDRETELNMLRAARRLAEHRDVTVKTTFLGAHAVPAE
CHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCHH
YAGRADAYLDEVCLPTLRAAHAEGLVDAVDGFCEGIAFSAAQIAKVFDVAAELGLPVKLH
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
AEQLSHQGGTKLAAERGALSVDHVEYATEADARAMAASGSVAVLLPGAFYTIRETQVPPV
HHHHCCCCCCEEHHHCCCCEEHHHHHHHCCCHHHHCCCCCEEEEECCCEEEEECCCCCCH
AEFRMHGVPMALATDCNPGSSPLTSLLLTLNMGCTLFRLTPEEALAGVTRNAARALGMQD
HHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCCCCC
RGRIAPGLRADLAVWDVSRPAELAYRIGFNPLYARVMGGKMEVRT
CCCCCCCCCCCEEEEECCCHHHHHEECCCCHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA