Click here to switch to the map view.

The map label for this gene is ldh [H]

Identifier: 99082619

GI number: 99082619

Start: 2938135

End: 2939205

Strand: Reverse

Name: ldh [H]

Synonym: TM1040_2779

Alternate gene names: 99082619

Gene position: 2939205-2938135 (Counterclockwise)

Preceding gene: 99082621

Following gene: 99082618

Centisome position: 91.82

GC content: 59.85

Gene sequence:

>1071_bases
ATGACACTGAACCTGACCGAGGAAACGGCACCCGAAGGCTATGAACGCCTCGTCTTTGCACAAGACCCCGAAAGCGGGCT
GCAGGCCTTTATATGTGTGCACTCCACAGTTCTTGGCCCTGCGGCGGGGGGGTGTCGGATGTGGAATTACGCCACCGTGG
ATGAGGCGCGCATGGATGTGCTGCGTCTGGCGGAGGGGATGACCTCAAAGAACGCCATGGCAGATCTGGCGCTTGGTGGC
GGCAAATCCGTGATCGTCGGCAATCCGCAAAGCGACAAGTCCCCCGCATTGCTCCGTGCATTTGGGCGCGCCGTCCAGAG
CCTCGATGGCAGCTATTACACCGCCGAAGATGTGGGAATTTCGCCGGACGACATGAAGATCGTCGCCGAGGAAACCCCAT
ATGCCGTTGGGCTTGAAGATGGGGCGCATGGGACCGGAGATCCCTCTCCCTTTACCGCGCAGGGGGTGTTCCAGTGTCTT
CTGGTCGGGGCAGAAGTGGTCTTTGGCACCAGCGATCTCTCCGGGCGTCGGGTGCTGGTTCAAGGTCTGGGCCACGTTGG
AATGTCTCTGGCCGAAAAGCTCTACGGTGCCGGGGCGGAGCTGATTGTGGCCGACATCAATGAGGCTGCGCTTCAGCATG
CAAAAACTGCATTTGGTGCAACGATTTGCGACCCTGCAGAGATTTTTGAGACCGAGATGGACATCTTTGCACCCTGCGCA
CTTGGGGGCGTGCTGACAGAGGCAACAGCGCAAAAACTGTCTGCAAAACTCGTTTGTGGTGCTGCGAACAACCAGCTTGA
GACGCCCGAGGTCGCAGATGCGCTGCGCGCAAGGGGTATTCGCTACCTGCCAGACTATGTGGTCAATGCTGGCGGCATCA
TCAGTGTCGCAGGCGAGATCCATAAAGCGGGCACAAGCTACCGCACCGAGCGGCTGGATGGCGTTGCCGCACGCATCCGC
ACCTTGGTTGACCTCAGCGACAAGACCGGGCGCACCACCACCGCCGTGGCAGACGACATGGTTGCAGATATTCTCGCCAA
GGCCTCGAACACCGCGCGAGGTGCAGCATGA

Upstream 100 bases:

>100_bases
AAGCACTAATGTTTGCGTGTTATTATGGGGGATATGGAATTTTTCCACCAGTGTTTCGCGATAAAATCTCCAAATCAGAT
TTCTGCGCGGTGGAGAGACC

Downstream 100 bases:

>100_bases
GCGACAACGAAACCTATGCACCGCTCGCACTGAATGTCCCGGAGCCGGGCTGCCGTCCGGGCGATACGCCTGATTTTTCG
TATTTCGAGGTGCCCCGCGC

Product: Glu/Leu/Phe/Val dehydrogenase, dimerisation region

Products: NA

Alternate protein names: LeuDH [H]

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MTLNLTEETAPEGYERLVFAQDPESGLQAFICVHSTVLGPAAGGCRMWNYATVDEARMDVLRLAEGMTSKNAMADLALGG
GKSVIVGNPQSDKSPALLRAFGRAVQSLDGSYYTAEDVGISPDDMKIVAEETPYAVGLEDGAHGTGDPSPFTAQGVFQCL
LVGAEVVFGTSDLSGRRVLVQGLGHVGMSLAEKLYGAGAELIVADINEAALQHAKTAFGATICDPAEIFETEMDIFAPCA
LGGVLTEATAQKLSAKLVCGAANNQLETPEVADALRARGIRYLPDYVVNAGGIISVAGEIHKAGTSYRTERLDGVAARIR
TLVDLSDKTGRTTTAVADDMVADILAKASNTARGAA

Sequences:

>Translated_356_residues
MTLNLTEETAPEGYERLVFAQDPESGLQAFICVHSTVLGPAAGGCRMWNYATVDEARMDVLRLAEGMTSKNAMADLALGG
GKSVIVGNPQSDKSPALLRAFGRAVQSLDGSYYTAEDVGISPDDMKIVAEETPYAVGLEDGAHGTGDPSPFTAQGVFQCL
LVGAEVVFGTSDLSGRRVLVQGLGHVGMSLAEKLYGAGAELIVADINEAALQHAKTAFGATICDPAEIFETEMDIFAPCA
LGGVLTEATAQKLSAKLVCGAANNQLETPEVADALRARGIRYLPDYVVNAGGIISVAGEIHKAGTSYRTERLDGVAARIR
TLVDLSDKTGRTTTAVADDMVADILAKASNTARGAA
>Mature_355_residues
TLNLTEETAPEGYERLVFAQDPESGLQAFICVHSTVLGPAAGGCRMWNYATVDEARMDVLRLAEGMTSKNAMADLALGGG
KSVIVGNPQSDKSPALLRAFGRAVQSLDGSYYTAEDVGISPDDMKIVAEETPYAVGLEDGAHGTGDPSPFTAQGVFQCLL
VGAEVVFGTSDLSGRRVLVQGLGHVGMSLAEKLYGAGAELIVADINEAALQHAKTAFGATICDPAEIFETEMDIFAPCAL
GGVLTEATAQKLSAKLVCGAANNQLETPEVADALRARGIRYLPDYVVNAGGIISVAGEIHKAGTSYRTERLDGVAARIRT
LVDLSDKTGRTTTAVADDMVADILAKASNTARGAA

Specific function: Functions catabolically in the bacterial metabolism of branched-chain L-amino acids, and plays an important role in spore germination in cooperation with alanine dehydrogenase [H]

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=310, Percent_Identity=25.1612903225806, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4885281, Length=310, Percent_Identity=24.8387096774194, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI45549226, Length=304, Percent_Identity=29.2763157894737, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45553475, Length=304, Percent_Identity=28.6184210526316, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR016211
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.9 [H]

Molecular weight: Translated: 37072; Mature: 36941

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLNLTEETAPEGYERLVFAQDPESGLQAFICVHSTVLGPAAGGCRMWNYATVDEARMDV
CEECCCCCCCCCCHHEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
LRLAEGMTSKNAMADLALGGGKSVIVGNPQSDKSPALLRAFGRAVQSLDGSYYTAEDVGI
HHHHHCCCCCHHHHHEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCC
SPDDMKIVAEETPYAVGLEDGAHGTGDPSPFTAQGVFQCLLVGAEVVFGTSDLSGRRVLV
CCCCCEEEECCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCCCCHHH
QGLGHVGMSLAEKLYGAGAELIVADINEAALQHAKTAFGATICDPAEIFETEMDIFAPCA
HHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LGGVLTEATAQKLSAKLVCGAANNQLETPEVADALRARGIRYLPDYVVNAGGIISVAGEI
HHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHCCCCEEEEHHHH
HKAGTSYRTERLDGVAARIRTLVDLSDKTGRTTTAVADDMVADILAKASNTARGAA
HHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TLNLTEETAPEGYERLVFAQDPESGLQAFICVHSTVLGPAAGGCRMWNYATVDEARMDV
EECCCCCCCCCCHHEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
LRLAEGMTSKNAMADLALGGGKSVIVGNPQSDKSPALLRAFGRAVQSLDGSYYTAEDVGI
HHHHHCCCCCHHHHHEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCC
SPDDMKIVAEETPYAVGLEDGAHGTGDPSPFTAQGVFQCLLVGAEVVFGTSDLSGRRVLV
CCCCCEEEECCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCCCCHHH
QGLGHVGMSLAEKLYGAGAELIVADINEAALQHAKTAFGATICDPAEIFETEMDIFAPCA
HHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LGGVLTEATAQKLSAKLVCGAANNQLETPEVADALRARGIRYLPDYVVNAGGIISVAGEI
HHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHCCCCEEEEHHHH
HKAGTSYRTERLDGVAARIRTLVDLSDKTGRTTTAVADDMVADILAKASNTARGAA
HHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9188201 [H]