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The map label for this gene is mdh [H]

Identifier: 99082621

GI number: 99082621

Start: 2939877

End: 2941073

Strand: Reverse

Name: mdh [H]

Synonym: TM1040_2781

Alternate gene names: 99082621

Gene position: 2941073-2939877 (Counterclockwise)

Preceding gene: 99082622

Following gene: 99082619

Centisome position: 91.88

GC content: 61.9

Gene sequence:

>1197_bases
ATGGCAAGCGGGGGCAGCGCCCCCACCCCGGCTCACCATAGGAACATGCTGATGTCTCTCATTGGAAACTGGTCTTATCC
GACCGCAATCAAATTCGGCGCAGGCCGGATCAAGGAACTGGCCGATGCTTGCGCGCAAGCCGGGATCAAAAAGCCGCTCT
TGGTCACCGACAAGGGGCTTGCAGATCTGCCCGTCACTCAATCGACGCTCGATATCATGGAGGCCGCAGGCCTTGGGCGC
GGGATGTTTTCTGAGGTCGACCCCAACCCGAACGAGAAAAACCTCGACGCGGGTGTTGCGGCCTACAAGGCAGGCGGCCA
TGACGGTGTGATCGCCTTTGGCGGCGGCTCCGGCCTCGATCTGGGCAAAATGGTTGCGTTCATGGCGGGCCAGACCCGCC
CGGTTTGGGATTTTGAGGACATCGGCGACTGGTGGACCCGCGCGGACGCGGATGCGATCGCCCCGATCATTGCCGTGCCG
ACCACCGCGGGCACCGGATCTGAGGTCGGGCGTGCCTCTGTCATCACCGATAGCGCCACCCACCAGAAAAAGATCATCTT
CCACCCCAAGGTTCTGCCCACCGTGGTGATTTGCGATCCGGAGCTTACCGTCGGGATGCCCAAATTCATCACTGCCGGCA
CCGGGCTTGATGCCTTTGCCCATTGCGTCGAGGCGTTTTCCTCGCCGCACTACCACCCGATGTCACAGGGTATGGCGCTC
GAGGGTATGCGCCTGGTCAAGGACTACCTTCCGCGCGCTTATGCGGACGGCACCGACATTGAGGCGCGCGCGCACATGAT
GTCTGCGGCTGCCATGGGCGCCACCGCGTTCCAAAAAGGTCTTGGCGCGATTCACGCCATGAGCCACCCGATTGGCGCGC
ATTTCAACACGCACCACGGCACCACCAACGCGGTCTGCATGCCTGCAGTGCTGGAATTCAACGCGTCCGAGATTTCCGAA
CGCTTTGACATGGCAGCGGCCTACCTCGGGATCGAGGGCGGCTTTGAGGGCTTCAAGGCCTTCGTGCAAGAGTTCAACGA
CAGCCTCGGCATCCCGCGCGGCCTGTCTGCGTTGGGCGTGACCGAAGAGTCGATCCCGGAGCTGGTCAAAGGCGCGATCA
TTGATCCCAGCTGCGGCGGCAATCCCGTCAAGCTGACTGAGGAAAACCTCACCCAGCTGTTCAAAGCCGCGCTTTGA

Upstream 100 bases:

>100_bases
CGGCTATCACAACCTGACCCGGCCGAAGTCCTACCACCTGAAAAAAGTCACCGCCTAAGGCCCTTCATCTTCTCAAAAAT
ATCCCGGGGGAGCTTGCCGG

Downstream 100 bases:

>100_bases
TAGAATAATCGGTCCCCGAAACACCGAGGAAGAGGCCGTGCCCAGGATCTGGGCGCGGTCTCTTTTTGTGCGGTACTGCG
CAAATCAAGGGATGCGGGCA

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MASGGSAPTPAHHRNMLMSLIGNWSYPTAIKFGAGRIKELADACAQAGIKKPLLVTDKGLADLPVTQSTLDIMEAAGLGR
GMFSEVDPNPNEKNLDAGVAAYKAGGHDGVIAFGGGSGLDLGKMVAFMAGQTRPVWDFEDIGDWWTRADADAIAPIIAVP
TTAGTGSEVGRASVITDSATHQKKIIFHPKVLPTVVICDPELTVGMPKFITAGTGLDAFAHCVEAFSSPHYHPMSQGMAL
EGMRLVKDYLPRAYADGTDIEARAHMMSAAAMGATAFQKGLGAIHAMSHPIGAHFNTHHGTTNAVCMPAVLEFNASEISE
RFDMAAAYLGIEGGFEGFKAFVQEFNDSLGIPRGLSALGVTEESIPELVKGAIIDPSCGGNPVKLTEENLTQLFKAAL

Sequences:

>Translated_398_residues
MASGGSAPTPAHHRNMLMSLIGNWSYPTAIKFGAGRIKELADACAQAGIKKPLLVTDKGLADLPVTQSTLDIMEAAGLGR
GMFSEVDPNPNEKNLDAGVAAYKAGGHDGVIAFGGGSGLDLGKMVAFMAGQTRPVWDFEDIGDWWTRADADAIAPIIAVP
TTAGTGSEVGRASVITDSATHQKKIIFHPKVLPTVVICDPELTVGMPKFITAGTGLDAFAHCVEAFSSPHYHPMSQGMAL
EGMRLVKDYLPRAYADGTDIEARAHMMSAAAMGATAFQKGLGAIHAMSHPIGAHFNTHHGTTNAVCMPAVLEFNASEISE
RFDMAAAYLGIEGGFEGFKAFVQEFNDSLGIPRGLSALGVTEESIPELVKGAIIDPSCGGNPVKLTEENLTQLFKAAL
>Mature_397_residues
ASGGSAPTPAHHRNMLMSLIGNWSYPTAIKFGAGRIKELADACAQAGIKKPLLVTDKGLADLPVTQSTLDIMEAAGLGRG
MFSEVDPNPNEKNLDAGVAAYKAGGHDGVIAFGGGSGLDLGKMVAFMAGQTRPVWDFEDIGDWWTRADADAIAPIIAVPT
TAGTGSEVGRASVITDSATHQKKIIFHPKVLPTVVICDPELTVGMPKFITAGTGLDAFAHCVEAFSSPHYHPMSQGMALE
GMRLVKDYLPRAYADGTDIEARAHMMSAAAMGATAFQKGLGAIHAMSHPIGAHFNTHHGTTNAVCMPAVLEFNASEISER
FDMAAAYLGIEGGFEGFKAFVQEFNDSLGIPRGLSALGVTEESIPELVKGAIIDPSCGGNPVKLTEENLTQLFKAAL

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=415, Percent_Identity=28.6746987951807, Blast_Score=132, Evalue=4e-31,
Organism=Escherichia coli, GI48994951, Length=381, Percent_Identity=33.0708661417323, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI1789163, Length=377, Percent_Identity=32.0954907161804, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI87082107, Length=380, Percent_Identity=31.0526315789474, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1787493, Length=404, Percent_Identity=30.4455445544554, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1789386, Length=389, Percent_Identity=26.9922879177378, Blast_Score=88, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17537053, Length=417, Percent_Identity=25.1798561151079, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6321181, Length=385, Percent_Identity=33.5064935064935, Blast_Score=208, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24657991, Length=449, Percent_Identity=27.8396436525612, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 41750; Mature: 41619

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASGGSAPTPAHHRNMLMSLIGNWSYPTAIKFGAGRIKELADACAQAGIKKPLLVTDKGL
CCCCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCEEEECCCC
ADLPVTQSTLDIMEAAGLGRGMFSEVDPNPNEKNLDAGVAAYKAGGHDGVIAFGGGSGLD
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCCC
LGKMVAFMAGQTRPVWDFEDIGDWWTRADADAIAPIIAVPTTAGTGSEVGRASVITDSAT
HHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHCCEEEECCCCCCCCCCCCEEEEECCCC
HQKKIIFHPKVLPTVVICDPELTVGMPKFITAGTGLDAFAHCVEAFSSPHYHPMSQGMAL
CCCEEEECCCCCCEEEEECCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCCCCHHCCCHH
EGMRLVKDYLPRAYADGTDIEARAHMMSAAAMGATAFQKGLGAIHAMSHPIGAHFNTHHG
HHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
TTNAVCMPAVLEFNASEISERFDMAAAYLGIEGGFEGFKAFVQEFNDSLGIPRGLSALGV
CCCCEEHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHCC
TEESIPELVKGAIIDPSCGGNPVKLTEENLTQLFKAAL
CHHHHHHHHHCCEECCCCCCCCEEECHHHHHHHHHHCC
>Mature Secondary Structure 
ASGGSAPTPAHHRNMLMSLIGNWSYPTAIKFGAGRIKELADACAQAGIKKPLLVTDKGL
CCCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCEEEECCCC
ADLPVTQSTLDIMEAAGLGRGMFSEVDPNPNEKNLDAGVAAYKAGGHDGVIAFGGGSGLD
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCCC
LGKMVAFMAGQTRPVWDFEDIGDWWTRADADAIAPIIAVPTTAGTGSEVGRASVITDSAT
HHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHCCEEEECCCCCCCCCCCCEEEEECCCC
HQKKIIFHPKVLPTVVICDPELTVGMPKFITAGTGLDAFAHCVEAFSSPHYHPMSQGMAL
CCCEEEECCCCCCEEEEECCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCCCCHHCCCHH
EGMRLVKDYLPRAYADGTDIEARAHMMSAAAMGATAFQKGLGAIHAMSHPIGAHFNTHHG
HHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
TTNAVCMPAVLEFNASEISERFDMAAAYLGIEGGFEGFKAFVQEFNDSLGIPRGLSALGV
CCCCEEHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHCC
TEESIPELVKGAIIDPSCGGNPVKLTEENLTQLFKAAL
CHHHHHHHHHCCEECCCCCCCCEEECHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]