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The map label for this gene is hyi [H]

Identifier: 99082605

GI number: 99082605

Start: 2913628

End: 2914395

Strand: Reverse

Name: hyi [H]

Synonym: TM1040_2765

Alternate gene names: 99082605

Gene position: 2914395-2913628 (Counterclockwise)

Preceding gene: 99082606

Following gene: 99082603

Centisome position: 91.05

GC content: 59.24

Gene sequence:

>768_bases
ATGCCTAAGTTCGCGGCCAATCTATCCATGCTCTTTGCGGAGCTTCCTTACCTTGACCGATTCTCGGCTGCCGCGGCTGC
TGGGTTCGAGGCGGTGGAAGTTCTCTTTCCTTATGAGTTTGCCGCCAAAGAAACGCAGCGTGCGCTTCTTGCCAATGGGC
TGGAGCTTTTGTTGATCAATGCCCCGCCGCCCAATTACACCGGTGGCGATCCGGGCTATGCTGCCGTTCCCGAACAGGCG
GAGCGCTTTCAGCGCGATATTCGTCGGGTACTGCGCTATGCCGACATGTTGAAAGCGGGACGTATCCACATCATGGCGGG
GCCAGCCAAAGGGGAGGCCGCGCGGCGGACCTTTGTGCAGAACCTGCAGGCAGCGGCGGAGTCTGCGCCGCAGCAGCAAT
TCACGATCGAACCGCTTAACAGCGGAGATTTCCCGGGCTATTTCCTCGACGATTACAACCTTGCGATCGACATTCTCGAT
GAGGTTGGGCGCGACAATGTCACCCTGCAGTTCGACGCTTATCACGCCCAACTTATCCACGGAGATGCGCTCAAGGTCTG
GGAGACTTTTGGGAGCCGCGCGAGCCATGTGCAATTTGCAGCAGCTCCGTCACGCTGCGAGCCGGGGCGCGGACCGGTGG
ATTTTGATGCGTTGTTTCAGGCGATCGATGACAGCGGCTATAGTGGTTGGGTCAGCGCGGAATACACCCCGAGCACCCCA
AGAACCGAAGACAGCCTGCGCTGGATGAAGGCCCTGCAGACCGCTTGA

Upstream 100 bases:

>100_bases
GGTACGTGCAGTTCAAGTTTAAAACAAAACCCGCACACGCGCGCCCGGGGACTGTGCTATAGTGGCGTGGCGAGGGCTGC
ACATCTAGCAGGAGGTGAGA

Downstream 100 bases:

>100_bases
CGGCGCTCTATTTGACGTCGTCCCTGCAATTTGGGGGGCGAATGCCGGCTCTGGGGATCATCCAAAGACAATCATCGAGA
GATGAGTTTCTAGCGTCGAT

Product: hydroxypyruvate isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MPKFAANLSMLFAELPYLDRFSAAAAAGFEAVEVLFPYEFAAKETQRALLANGLELLLINAPPPNYTGGDPGYAAVPEQA
ERFQRDIRRVLRYADMLKAGRIHIMAGPAKGEAARRTFVQNLQAAAESAPQQQFTIEPLNSGDFPGYFLDDYNLAIDILD
EVGRDNVTLQFDAYHAQLIHGDALKVWETFGSRASHVQFAAAPSRCEPGRGPVDFDALFQAIDDSGYSGWVSAEYTPSTP
RTEDSLRWMKALQTA

Sequences:

>Translated_255_residues
MPKFAANLSMLFAELPYLDRFSAAAAAGFEAVEVLFPYEFAAKETQRALLANGLELLLINAPPPNYTGGDPGYAAVPEQA
ERFQRDIRRVLRYADMLKAGRIHIMAGPAKGEAARRTFVQNLQAAAESAPQQQFTIEPLNSGDFPGYFLDDYNLAIDILD
EVGRDNVTLQFDAYHAQLIHGDALKVWETFGSRASHVQFAAAPSRCEPGRGPVDFDALFQAIDDSGYSGWVSAEYTPSTP
RTEDSLRWMKALQTA
>Mature_254_residues
PKFAANLSMLFAELPYLDRFSAAAAAGFEAVEVLFPYEFAAKETQRALLANGLELLLINAPPPNYTGGDPGYAAVPEQAE
RFQRDIRRVLRYADMLKAGRIHIMAGPAKGEAARRTFVQNLQAAAESAPQQQFTIEPLNSGDFPGYFLDDYNLAIDILDE
VGRDNVTLQFDAYHAQLIHGDALKVWETFGSRASHVQFAAAPSRCEPGRGPVDFDALFQAIDDSGYSGWVSAEYTPSTPR
TEDSLRWMKALQTA

Specific function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) [H]

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=262, Percent_Identity=38.9312977099237, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI300068964, Length=243, Percent_Identity=39.5061728395062, Blast_Score=142, Evalue=3e-34,
Organism=Escherichia coli, GI1786718, Length=255, Percent_Identity=37.6470588235294, Blast_Score=187, Evalue=5e-49,
Organism=Escherichia coli, GI1789095, Length=258, Percent_Identity=39.922480620155, Blast_Score=184, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17552022, Length=258, Percent_Identity=34.1085271317829, Blast_Score=151, Evalue=3e-37,
Organism=Drosophila melanogaster, GI17530883, Length=262, Percent_Identity=33.587786259542, Blast_Score=135, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017643
- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: =5.3.1.22 [H]

Molecular weight: Translated: 28085; Mature: 27954

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKFAANLSMLFAELPYLDRFSAAAAAGFEAVEVLFPYEFAAKETQRALLANGLELLLIN
CCCHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHEECCHHHHHHHHHHHHHHCCCEEEEEE
APPPNYTGGDPGYAAVPEQAERFQRDIRRVLRYADMLKAGRIHIMAGPAKGEAARRTFVQ
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHH
NLQAAAESAPQQQFTIEPLNSGDFPGYFLDDYNLAIDILDEVGRDNVTLQFDAYHAQLIH
HHHHHHHCCCCCCEEEECCCCCCCCCEEECCCCHHHHHHHHCCCCCEEEEEECEEEEEHC
GDALKVWETFGSRASHVQFAAAPSRCEPGRGPVDFDALFQAIDDSGYSGWVSAEYTPSTP
CCHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEECCCCCCCC
RTEDSLRWMKALQTA
CCHHHHHHHHHHHCC
>Mature Secondary Structure 
PKFAANLSMLFAELPYLDRFSAAAAAGFEAVEVLFPYEFAAKETQRALLANGLELLLIN
CCHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHEECCHHHHHHHHHHHHHHCCCEEEEEE
APPPNYTGGDPGYAAVPEQAERFQRDIRRVLRYADMLKAGRIHIMAGPAKGEAARRTFVQ
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHH
NLQAAAESAPQQQFTIEPLNSGDFPGYFLDDYNLAIDILDEVGRDNVTLQFDAYHAQLIH
HHHHHHHCCCCCCEEEECCCCCCCCCEEECCCCHHHHHHHHCCCCCEEEEEECEEEEEHC
GDALKVWETFGSRASHVQFAAAPSRCEPGRGPVDFDALFQAIDDSGYSGWVSAEYTPSTP
CCHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEECCCCCCCC
RTEDSLRWMKALQTA
CCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8440684; 10561547; 9278503 [H]