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The map label for this gene is lrp [H]

Identifier: 99082533

GI number: 99082533

Start: 2835087

End: 2835566

Strand: Reverse

Name: lrp [H]

Synonym: TM1040_2693

Alternate gene names: 99082533

Gene position: 2835566-2835087 (Counterclockwise)

Preceding gene: 99082534

Following gene: 99082532

Centisome position: 88.59

GC content: 59.79

Gene sequence:

>480_bases
ATGCATCTCGATCAGCGCGACCTTGATATCCTTCGCATCCTGTCCCGCGATGGCCGCATCACCAAGGCGGCCCTTGCAGA
TCAGGTGGGTCTGTCGCCGACACCCTGTTGGGAGCGGCTGAAGAAACTGGAAAAGGCCGGGCTGATCGAAGGCTATAACG
CCCAGATCAACCTCAAGAAAATCGCACCGCACGTGACCGTCTTTGTGGCTGCCGAATTGGCGGATCACACGGCGGCAAGT
TTCCAGTCGTTCGAGGCAGCAATGCAGCGCTATGACGAGGTAGTGGCCTGCTGGGCGCTGGGCGGGGGCTTTGATTATCT
GTTGCAGATCGTGACCTGCGACATCGACGCCTACCAGCGTCTGATCGATGCGATGCTGGATGCCCGCATCGGCCTCAGCC
GCTACTTCACCTATATCGTGACCAAGCCCGTCAAAGGCGCGGGCGTGCCTCCTCTCGAAATCCTGCTCCGGGGCAGTTGA

Upstream 100 bases:

>100_bases
TACCGCGCCCGCCGCAGCGGCGTGCTCATCAGCCGCCATTTCCCCGGTATGATCAAATCCGGTGACTGCGCCGCGGTGAT
CGGCGTGGTCGAGGGCTGAC

Downstream 100 bases:

>100_bases
ATCCTCTGCCGAGTCGGCAAACTTTGGTCACTTCTTCTGATCGCGCCATGCAGACTGCCCCCAAGTCTAAAGGAGGAGCA
GACATGTCGTTATCGGCCCT

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MHLDQRDLDILRILSRDGRITKAALADQVGLSPTPCWERLKKLEKAGLIEGYNAQINLKKIAPHVTVFVAAELADHTAAS
FQSFEAAMQRYDEVVACWALGGGFDYLLQIVTCDIDAYQRLIDAMLDARIGLSRYFTYIVTKPVKGAGVPPLEILLRGS

Sequences:

>Translated_159_residues
MHLDQRDLDILRILSRDGRITKAALADQVGLSPTPCWERLKKLEKAGLIEGYNAQINLKKIAPHVTVFVAAELADHTAAS
FQSFEAAMQRYDEVVACWALGGGFDYLLQIVTCDIDAYQRLIDAMLDARIGLSRYFTYIVTKPVKGAGVPPLEILLRGS
>Mature_159_residues
MHLDQRDLDILRILSRDGRITKAALADQVGLSPTPCWERLKKLEKAGLIEGYNAQINLKKIAPHVTVFVAAELADHTAAS
FQSFEAAMQRYDEVVACWALGGGFDYLLQIVTCDIDAYQRLIDAMLDARIGLSRYFTYIVTKPVKGAGVPPLEILLRGS

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=146, Percent_Identity=38.3561643835616, Blast_Score=111, Evalue=2e-26,
Organism=Escherichia coli, GI87081742, Length=151, Percent_Identity=29.8013245033113, Blast_Score=86, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17621; Mature: 17621

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLDQRDLDILRILSRDGRITKAALADQVGLSPTPCWERLKKLEKAGLIEGYNAQINLKK
CCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEEHHH
IAPHVTVFVAAELADHTAASFQSFEAAMQRYDEVVACWALGGGFDYLLQIVTCDIDAYQR
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHH
LIDAMLDARIGLSRYFTYIVTKPVKGAGVPPLEILLRGS
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEECC
>Mature Secondary Structure
MHLDQRDLDILRILSRDGRITKAALADQVGLSPTPCWERLKKLEKAGLIEGYNAQINLKK
CCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEEHHH
IAPHVTVFVAAELADHTAASFQSFEAAMQRYDEVVACWALGGGFDYLLQIVTCDIDAYQR
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHH
LIDAMLDARIGLSRYFTYIVTKPVKGAGVPPLEILLRGS
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]