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The map label for this gene is era [H]

Identifier: 99082398

GI number: 99082398

Start: 2701779

End: 2702684

Strand: Reverse

Name: era [H]

Synonym: TM1040_2558

Alternate gene names: 99082398

Gene position: 2702684-2701779 (Counterclockwise)

Preceding gene: 99082399

Following gene: 99082397

Centisome position: 84.43

GC content: 61.15

Gene sequence:

>906_bases
ATGACCACACGCGCAGGCTTTATCGCCCTCATAGGCGAGCCAAACGCCGGGAAATCCACGCTGCTCAACCGGATGGTCGG
CGCCAAAGTCTCGATCGTGACCCACAAGGTTCAAACCACCCGGGCGCGCATTCGCGGTGTTGCCATGGAAGGCGACAGCC
AGCTTGTTTTTGTCGACACGCCGGGCCTGTTTCAGCCGCGCCGCCGGCTCGACCGTGCGATGGTGGCAGCAGCCTGGGGC
GGGGCTGCGGATGCAGATGTGATCGTGATGCTCATCGAAGCCCACCGCGGCGTGACCGAGGGCGTCGAGCGCATCCTGGA
AAACCTTGGAGAGGTAGCCGAGGGACGGCGCGTGGCGCTGGCGATCAACAAGATCGACAAGGTGCAATCCGATGTGCTGC
TCGGTCTGACCAAGGATCTCAACGACCGCTTCCCCTTCGCAGAGACCTTCATGATCTCGGCCGAAAAAGGCTATGGGACC
GAGGATCTGCGGCAGTGGCTTGCTGCCGAAGTGCCGGAAGGCCCGTGGCTCTATCCCGAAGACCAGATCGCCGATCTGCC
GCTGCGCATGATCGCTGCCGAAATGACCCGCGAAAAGCTCACCCTGCGTCTCCACCAGGAACTGCCCTACCAGCTCACGG
TGGAGACCGAGAAATGGGAAGAGCGCAAGGATGGCTCCGCACGCATTGACCAGGTGGTCTATGTGGTGCGCGATGGCCAC
AAGGGCATCGTGCTCGGCAAACGTGGCGAGACCATCAAGGCTGTTGGTCAGGCGGCACGCGCCGAGCTTGAGGAATTCCT
GGATCGCAAGATCCATCTTTTCCTGCAGGTTAAGGTGCGCCCCAACTGGCTTGAAGAATCCGAGCGGTACTCGGAAATGG
GCCTTGAGTTCAAAGACGGCAACTAA

Upstream 100 bases:

>100_bases
GCCTTGAGGACGGCACCGAGGAGCAGGCCACCGCAGGCTCCAAACGCCTCGCCGAACAGGCGGCCGCCAAGGCCCTCCTG
GCCAAACTGGAGCAACAGAC

Downstream 100 bases:

>100_bases
CCCGTCGAGCCGCTCTCTTTCCCTTCTTGTAAATACCCCCGCTGGAGGCACCCGCCCGTGCCTCTGGAGCAAAGGTTTGC
TTTTCTTGCACGCGCGCTGC

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MTTRAGFIALIGEPNAGKSTLLNRMVGAKVSIVTHKVQTTRARIRGVAMEGDSQLVFVDTPGLFQPRRRLDRAMVAAAWG
GAADADVIVMLIEAHRGVTEGVERILENLGEVAEGRRVALAINKIDKVQSDVLLGLTKDLNDRFPFAETFMISAEKGYGT
EDLRQWLAAEVPEGPWLYPEDQIADLPLRMIAAEMTREKLTLRLHQELPYQLTVETEKWEERKDGSARIDQVVYVVRDGH
KGIVLGKRGETIKAVGQAARAELEEFLDRKIHLFLQVKVRPNWLEESERYSEMGLEFKDGN

Sequences:

>Translated_301_residues
MTTRAGFIALIGEPNAGKSTLLNRMVGAKVSIVTHKVQTTRARIRGVAMEGDSQLVFVDTPGLFQPRRRLDRAMVAAAWG
GAADADVIVMLIEAHRGVTEGVERILENLGEVAEGRRVALAINKIDKVQSDVLLGLTKDLNDRFPFAETFMISAEKGYGT
EDLRQWLAAEVPEGPWLYPEDQIADLPLRMIAAEMTREKLTLRLHQELPYQLTVETEKWEERKDGSARIDQVVYVVRDGH
KGIVLGKRGETIKAVGQAARAELEEFLDRKIHLFLQVKVRPNWLEESERYSEMGLEFKDGN
>Mature_300_residues
TTRAGFIALIGEPNAGKSTLLNRMVGAKVSIVTHKVQTTRARIRGVAMEGDSQLVFVDTPGLFQPRRRLDRAMVAAAWGG
AADADVIVMLIEAHRGVTEGVERILENLGEVAEGRRVALAINKIDKVQSDVLLGLTKDLNDRFPFAETFMISAEKGYGTE
DLRQWLAAEVPEGPWLYPEDQIADLPLRMIAAEMTREKLTLRLHQELPYQLTVETEKWEERKDGSARIDQVVYVVRDGHK
GIVLGKRGETIKAVGQAARAELEEFLDRKIHLFLQVKVRPNWLEESERYSEMGLEFKDGN

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=327, Percent_Identity=29.3577981651376, Blast_Score=117, Evalue=9e-27,
Organism=Escherichia coli, GI1788919, Length=295, Percent_Identity=37.6271186440678, Blast_Score=192, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24646434, Length=256, Percent_Identity=30.46875, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 33775; Mature: 33644

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRAGFIALIGEPNAGKSTLLNRMVGAKVSIVTHKVQTTRARIRGVAMEGDSQLVFVDT
CCCCCEEEEEEECCCCCHHHHHHHHHCCEEEEEEEHHHHHHHHHEEEEEECCCEEEEEEC
PGLFQPRRRLDRAMVAAAWGGAADADVIVMLIEAHRGVTEGVERILENLGEVAEGRRVAL
CCCCCHHHHHHHHHHHHHCCCCCCHHHEEEEHHHHCCHHHHHHHHHHHHHHHHCCCEEEE
AINKIDKVQSDVLLGLTKDLNDRFPFAETFMISAEKGYGTEDLRQWLAAEVPEGPWLYPE
EEHHHHHHHHHHHHHHHHCCCCCCCCHHEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCC
DQIADLPLRMIAAEMTREKLTLRLHQELPYQLTVETEKWEERKDGSARIDQVVYVVRDGH
CHHHHCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCCHHHHHEEEEEECCC
KGIVLGKRGETIKAVGQAARAELEEFLDRKIHLFLQVKVRPNWLEESERYSEMGLEFKDG
CEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCHHHHHHHHHHCCCEEECC
N
C
>Mature Secondary Structure 
TTRAGFIALIGEPNAGKSTLLNRMVGAKVSIVTHKVQTTRARIRGVAMEGDSQLVFVDT
CCCCEEEEEEECCCCCHHHHHHHHHCCEEEEEEEHHHHHHHHHEEEEEECCCEEEEEEC
PGLFQPRRRLDRAMVAAAWGGAADADVIVMLIEAHRGVTEGVERILENLGEVAEGRRVAL
CCCCCHHHHHHHHHHHHHCCCCCCHHHEEEEHHHHCCHHHHHHHHHHHHHHHHCCCEEEE
AINKIDKVQSDVLLGLTKDLNDRFPFAETFMISAEKGYGTEDLRQWLAAEVPEGPWLYPE
EEHHHHHHHHHHHHHHHHCCCCCCCCHHEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCC
DQIADLPLRMIAAEMTREKLTLRLHQELPYQLTVETEKWEERKDGSARIDQVVYVVRDGH
CHHHHCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCCHHHHHEEEEEECCC
KGIVLGKRGETIKAVGQAARAELEEFLDRKIHLFLQVKVRPNWLEESERYSEMGLEFKDG
CEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCHHHHHHHHHHCCCEEECC
N
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA