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The map label for this gene is rnc [H]

Identifier: 99082399

GI number: 99082399

Start: 2702681

End: 2703409

Strand: Reverse

Name: rnc [H]

Synonym: TM1040_2559

Alternate gene names: 99082399

Gene position: 2703409-2702681 (Counterclockwise)

Preceding gene: 99082400

Following gene: 99082398

Centisome position: 84.46

GC content: 61.73

Gene sequence:

>729_bases
GTGCCCTCAAATTGTGCCCTCAAGCTGTTCAAAGGACCACACGTGAAGCTATCTCGGGATATCCTCGCCTTTCAGGCAAG
GCTGGGGCATGAATTTTCCAGCCCGGAGCTGTTGATCCGCGCGCTGACGCATCCGTCGGTGTCGTCTCCCAATCGGCAGG
ATAATCAGCGGCTGGAGTTTCTCGGGGATCGTGTGTTGGGTCTTGTCATGGCGACGGCGCTTTTGGAACACGACAAGGAT
GCCACCGAAGGCCAGCTGGCTCCGCGTTTCAATGCGCTGGTGCGCAAGGAAACCTGCGCCGATGTAGCCCGGCAAATCGA
TCTGGGTGCGGTGCTGAAACTGGGGCGTTCGGAAATGCTCTCTGGCGGGCGGCGCAAGCAGGCTCTGTTGGGCGACGCGA
TGGAGGCGGTGATCGCCGCAGTTTACCGCGATGCAGGCTTCGAGGCCGCTCAAAGCGTGATCCTTCGCCTCTGGGGGAAA
CGTGTGGGCACCGTCGAAGAAGACGCCCGCGACCCCAAAACCGCCCTTCAGGAATTTGTGCAGGCGCGACGTCAACCGCC
GCCTGCCTATGTATTGGTTGCCCGCAAGGGGCCAGATCACGAACCTATCTTTACCATCGCCGCCCGCCTTGAGGACGGCA
CCGAGGAGCAGGCCACCGCAGGCTCCAAACGCCTCGCCGAACAGGCGGCCGCCAAGGCCCTCCTGGCCAAACTGGAGCAA
CAGACATGA

Upstream 100 bases:

>100_bases
CGCAATATCAAGAGTTGCGATTGGCGCAAGGCCGATGGTCGCGCAGAGTGCTTTCCTCTGGCGCCGTGCTGGGATATGGA
ACGAAGCCACCGGGGCGATT

Downstream 100 bases:

>100_bases
CCACACGCGCAGGCTTTATCGCCCTCATAGGCGAGCCAAACGCCGGGAAATCCACGCTGCTCAACCGGATGGTCGGCGCC
AAAGTCTCGATCGTGACCCA

Product: RNAse III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MPSNCALKLFKGPHVKLSRDILAFQARLGHEFSSPELLIRALTHPSVSSPNRQDNQRLEFLGDRVLGLVMATALLEHDKD
ATEGQLAPRFNALVRKETCADVARQIDLGAVLKLGRSEMLSGGRRKQALLGDAMEAVIAAVYRDAGFEAAQSVILRLWGK
RVGTVEEDARDPKTALQEFVQARRQPPPAYVLVARKGPDHEPIFTIAARLEDGTEEQATAGSKRLAEQAAAKALLAKLEQ
QT

Sequences:

>Translated_242_residues
MPSNCALKLFKGPHVKLSRDILAFQARLGHEFSSPELLIRALTHPSVSSPNRQDNQRLEFLGDRVLGLVMATALLEHDKD
ATEGQLAPRFNALVRKETCADVARQIDLGAVLKLGRSEMLSGGRRKQALLGDAMEAVIAAVYRDAGFEAAQSVILRLWGK
RVGTVEEDARDPKTALQEFVQARRQPPPAYVLVARKGPDHEPIFTIAARLEDGTEEQATAGSKRLAEQAAAKALLAKLEQ
QT
>Mature_241_residues
PSNCALKLFKGPHVKLSRDILAFQARLGHEFSSPELLIRALTHPSVSSPNRQDNQRLEFLGDRVLGLVMATALLEHDKDA
TEGQLAPRFNALVRKETCADVARQIDLGAVLKLGRSEMLSGGRRKQALLGDAMEAVIAAVYRDAGFEAAQSVILRLWGKR
VGTVEEDARDPKTALQEFVQARRQPPPAYVLVARKGPDHEPIFTIAARLEDGTEEQATAGSKRLAEQAAAKALLAKLEQQ
T

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=226, Percent_Identity=27.4336283185841, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI155030234, Length=226, Percent_Identity=27.4336283185841, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1788920, Length=203, Percent_Identity=38.423645320197, Blast_Score=141, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17506883, Length=235, Percent_Identity=28.936170212766, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI193202651, Length=235, Percent_Identity=28.936170212766, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17137682, Length=234, Percent_Identity=28.2051282051282, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 26464; Mature: 26332

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSNCALKLFKGPHVKLSRDILAFQARLGHEFSSPELLIRALTHPSVSSPNRQDNQRLEF
CCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHH
LGDRVLGLVMATALLEHDKDATEGQLAPRFNALVRKETCADVARQIDLGAVLKLGRSEML
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
SGGRRKQALLGDAMEAVIAAVYRDAGFEAAQSVILRLWGKRVGTVEEDARDPKTALQEFV
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHH
QARRQPPPAYVLVARKGPDHEPIFTIAARLEDGTEEQATAGSKRLAEQAAAKALLAKLEQ
HHHCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
QT
CC
>Mature Secondary Structure 
PSNCALKLFKGPHVKLSRDILAFQARLGHEFSSPELLIRALTHPSVSSPNRQDNQRLEF
CCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHH
LGDRVLGLVMATALLEHDKDATEGQLAPRFNALVRKETCADVARQIDLGAVLKLGRSEML
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
SGGRRKQALLGDAMEAVIAAVYRDAGFEAAQSVILRLWGKRVGTVEEDARDPKTALQEFV
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHH
QARRQPPPAYVLVARKGPDHEPIFTIAARLEDGTEEQATAGSKRLAEQAAAKALLAKLEQ
HHHCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
QT
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA