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The map label for this gene is yngJ [H]

Identifier: 99082284

GI number: 99082284

Start: 2584992

End: 2586695

Strand: Reverse

Name: yngJ [H]

Synonym: TM1040_2444

Alternate gene names: 99082284

Gene position: 2586695-2584992 (Counterclockwise)

Preceding gene: 99082287

Following gene: 99082283

Centisome position: 80.81

GC content: 60.56

Gene sequence:

>1704_bases
ATGCGCATGCCCCATGACGGACAATTGGACGGACAGGATATGAAACCCAACACCCCTCTGCTGCCGGAGCTTCTGGCATT
GACCAAGGAGGCGCTGCCGCCTCTGGACGAGCTGCTGGAGCGCGCGACCGCACGGGTGCGTGACAACGTCAGCAACAACG
GCAGGGTTTCCGGGGCGCTGGTAGAGCAGCACCAATATGCCGCCCATGGGCTCGCATGGCTAGCCACCTACGTCTATTCC
CTGCGCCAGATGCATCGCTGGGCAGAGGCGCTTGAGCGGGACGCAAAGTTTGGCGAGATGGAGCAGTTGATCCACCAGAT
CGCCTTTGGAGAATATCTCTGGCAGATCTATGGCGGGATCCAGATGAACCAGGGCGAAGTGCTGCGCCTTCAGGATCTGG
GGCTGTCGCAAGACGATCAGCGCGCGCTGATGGCACCCGCCGTCATGATGCTTACGCAGTCGGGAAACACGCAGGCCGCG
CGGGTCCGTCTTGTGGAATTGATGGAGCAGCAGGCGGGGAGCACGATGTTCGGGGCCTCCGGGCTCGACGAAGAGCTGGA
GATGATCCGTGATCAATTCCGCCGCTACGCGCAGGAAAAGGTCGAACCCTTTGCGCACGACTGGCACCTGAAGGACGAGT
TGATCCCTCTCGACGTGATTGAAGAGCTGGCGGAAATGGGGGTCTTTGGTCTGACTATCCCAGAGGAGTTTGGCGGCTTC
GGGCTCTCCAAAGCGTCGATGTGTGTGGTCTCTGAGGAGCTGTCGCGCGGTTACATCGGTGTCGGCTCTCTAGGCACCCG
CTCCGAAATTGCCGCCGAGCTGATCCTTGCCGGGGGCACCGACGCGCAGAAACAGCAATGGCTGCCCAAGATCGCGAGCG
CCGAGATTCTTCCCACGGCAGTCTTTACCGAGCCCAATACCGGATCTGATCTCGGCAGCCTGCGCACCCGCGCGGTGAAG
GACGCGGCGGGTGACTATCAGATCACCGGCAACAAGACCTGGATCACCCATGCTGCCCGTACCCATGTGATGACGCTTCT
CGCGCGCACGGACCCCGAGACTACGGACCATCGCGGTCTCAGCATGTTCCTTGCGGAAAAAACGCCGGGGACGGATGAAA
CCCCCTTCCCGACCGAAGGGATGACGGGGGGCGAAATCGAGGTCCTCGGCTATCGCGGTATGAAAGAATACGAACTTGGG
TTCGATGGCTTTCATGTGAAGGGCGAGAATCTCCTCGGTGGCGAAGAGGGCAAAGGTTTCAAGCAGTTGATGGAAACCTT
TGAATCGGCCCGGATCCAGACCGCGGCCCGGGCGATTGGCGTAGCACAATCGGCGCTCGATATTGCGATGCAATATGCAC
AGGATCGCAAACAGTTCGGCAAGGCGTTGATCAATTTCCCGCGCGTGTCTTCCAAGCTTGCGATGATGGCGGTCGAGGTC
ATGGTGGCGCGGCAGCTGACGTATTTCTCGGCTTGGGAGAAAGACAACGGCCACCGCTGCGATCTTGAGGCAGGAATGGC
CAAGCTCCTCGGCGCGCGTGTGGCCTGGGCGGCGGCGGACAACGGCTTGCAGATCCATGGCGGCAACGGGTTCGCGCTGG
AGTATAAGATCTCTCGCGTTCTCTGCGATGCGCGGATCCTCAATATTTTTGAGGGCGCAGCTGAGATCCAGGCACAGGTG
ATCGCGCGGCGTCTTCTGGCGTAA

Upstream 100 bases:

>100_bases
ACCTCTGGGTAATTATCGAATGAAAATTTGCCCATATGAGATTTAATATTGCGCTGCAGGTGCAAAATGACCTATCAGGG
GGCAAGCCCTGAGGAGGACC

Downstream 100 bases:

>100_bases
GGTGGCGCAATGGGCGGACAGCGTTTCCATCCCGGGGTGCGCTGTCCGACGAGAGGTTTAACTTCCTGTACGCCTCTTTT
GTGCTAGACCTCGTTTATGA

Product: isovaleryl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 567; Mature: 567

Protein sequence:

>567_residues
MRMPHDGQLDGQDMKPNTPLLPELLALTKEALPPLDELLERATARVRDNVSNNGRVSGALVEQHQYAAHGLAWLATYVYS
LRQMHRWAEALERDAKFGEMEQLIHQIAFGEYLWQIYGGIQMNQGEVLRLQDLGLSQDDQRALMAPAVMMLTQSGNTQAA
RVRLVELMEQQAGSTMFGASGLDEELEMIRDQFRRYAQEKVEPFAHDWHLKDELIPLDVIEELAEMGVFGLTIPEEFGGF
GLSKASMCVVSEELSRGYIGVGSLGTRSEIAAELILAGGTDAQKQQWLPKIASAEILPTAVFTEPNTGSDLGSLRTRAVK
DAAGDYQITGNKTWITHAARTHVMTLLARTDPETTDHRGLSMFLAEKTPGTDETPFPTEGMTGGEIEVLGYRGMKEYELG
FDGFHVKGENLLGGEEGKGFKQLMETFESARIQTAARAIGVAQSALDIAMQYAQDRKQFGKALINFPRVSSKLAMMAVEV
MVARQLTYFSAWEKDNGHRCDLEAGMAKLLGARVAWAAADNGLQIHGGNGFALEYKISRVLCDARILNIFEGAAEIQAQV
IARRLLA

Sequences:

>Translated_567_residues
MRMPHDGQLDGQDMKPNTPLLPELLALTKEALPPLDELLERATARVRDNVSNNGRVSGALVEQHQYAAHGLAWLATYVYS
LRQMHRWAEALERDAKFGEMEQLIHQIAFGEYLWQIYGGIQMNQGEVLRLQDLGLSQDDQRALMAPAVMMLTQSGNTQAA
RVRLVELMEQQAGSTMFGASGLDEELEMIRDQFRRYAQEKVEPFAHDWHLKDELIPLDVIEELAEMGVFGLTIPEEFGGF
GLSKASMCVVSEELSRGYIGVGSLGTRSEIAAELILAGGTDAQKQQWLPKIASAEILPTAVFTEPNTGSDLGSLRTRAVK
DAAGDYQITGNKTWITHAARTHVMTLLARTDPETTDHRGLSMFLAEKTPGTDETPFPTEGMTGGEIEVLGYRGMKEYELG
FDGFHVKGENLLGGEEGKGFKQLMETFESARIQTAARAIGVAQSALDIAMQYAQDRKQFGKALINFPRVSSKLAMMAVEV
MVARQLTYFSAWEKDNGHRCDLEAGMAKLLGARVAWAAADNGLQIHGGNGFALEYKISRVLCDARILNIFEGAAEIQAQV
IARRLLA
>Mature_567_residues
MRMPHDGQLDGQDMKPNTPLLPELLALTKEALPPLDELLERATARVRDNVSNNGRVSGALVEQHQYAAHGLAWLATYVYS
LRQMHRWAEALERDAKFGEMEQLIHQIAFGEYLWQIYGGIQMNQGEVLRLQDLGLSQDDQRALMAPAVMMLTQSGNTQAA
RVRLVELMEQQAGSTMFGASGLDEELEMIRDQFRRYAQEKVEPFAHDWHLKDELIPLDVIEELAEMGVFGLTIPEEFGGF
GLSKASMCVVSEELSRGYIGVGSLGTRSEIAAELILAGGTDAQKQQWLPKIASAEILPTAVFTEPNTGSDLGSLRTRAVK
DAAGDYQITGNKTWITHAARTHVMTLLARTDPETTDHRGLSMFLAEKTPGTDETPFPTEGMTGGEIEVLGYRGMKEYELG
FDGFHVKGENLLGGEEGKGFKQLMETFESARIQTAARAIGVAQSALDIAMQYAQDRKQFGKALINFPRVSSKLAMMAVEV
MVARQLTYFSAWEKDNGHRCDLEAGMAKLLGARVAWAAADNGLQIHGGNGFALEYKISRVLCDARILNIFEGAAEIQAQV
IARRLLA

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557231, Length=373, Percent_Identity=35.1206434316354, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI187960098, Length=373, Percent_Identity=35.1206434316354, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI4557233, Length=395, Percent_Identity=35.1898734177215, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI21361497, Length=356, Percent_Identity=34.8314606741573, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI4557235, Length=390, Percent_Identity=34.6153846153846, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI76496475, Length=390, Percent_Identity=34.6153846153846, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI226958412, Length=388, Percent_Identity=32.2164948453608, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI226958414, Length=346, Percent_Identity=32.9479768786127, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI4501859, Length=386, Percent_Identity=31.0880829015544, Blast_Score=172, Evalue=1e-42,
Organism=Homo sapiens, GI4501857, Length=385, Percent_Identity=28.051948051948, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI7656849, Length=410, Percent_Identity=28.0487804878049, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4503943, Length=392, Percent_Identity=29.5918367346939, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI7669494, Length=380, Percent_Identity=29.4736842105263, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI48976061, Length=368, Percent_Identity=25.8152173913043, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI211971008, Length=368, Percent_Identity=25.8152173913043, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI38505218, Length=360, Percent_Identity=25.8333333333333, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1786223, Length=362, Percent_Identity=29.2817679558011, Blast_Score=148, Evalue=8e-37,
Organism=Escherichia coli, GI87081958, Length=354, Percent_Identity=29.3785310734463, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87081702, Length=303, Percent_Identity=25.7425742574257, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17570075, Length=397, Percent_Identity=34.0050377833753, Blast_Score=208, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17569725, Length=390, Percent_Identity=34.1025641025641, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI17534899, Length=388, Percent_Identity=32.9896907216495, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17538396, Length=400, Percent_Identity=32.25, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI71985184, Length=357, Percent_Identity=35.0140056022409, Blast_Score=191, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17508101, Length=384, Percent_Identity=33.0729166666667, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17506239, Length=385, Percent_Identity=31.6883116883117, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17533517, Length=392, Percent_Identity=30.1020408163265, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71990804, Length=302, Percent_Identity=33.4437086092715, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71985192, Length=337, Percent_Identity=31.7507418397626, Blast_Score=146, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17505929, Length=386, Percent_Identity=27.2020725388601, Blast_Score=144, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17551932, Length=386, Percent_Identity=26.4248704663212, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17534353, Length=375, Percent_Identity=28, Blast_Score=128, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI32563615, Length=240, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI71982178, Length=329, Percent_Identity=26.7477203647416, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17562446, Length=520, Percent_Identity=23.0769230769231, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21356377, Length=389, Percent_Identity=33.9331619537275, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24660351, Length=426, Percent_Identity=31.924882629108, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24646207, Length=388, Percent_Identity=32.9896907216495, Blast_Score=191, Evalue=8e-49,
Organism=Drosophila melanogaster, GI281363737, Length=380, Percent_Identity=31.8421052631579, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24666513, Length=413, Percent_Identity=31.4769975786925, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI21355753, Length=428, Percent_Identity=30.3738317757009, Blast_Score=175, Evalue=1e-43,
Organism=Drosophila melanogaster, GI19920834, Length=395, Percent_Identity=29.620253164557, Blast_Score=126, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 62523; Mature: 62523

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMPHDGQLDGQDMKPNTPLLPELLALTKEALPPLDELLERATARVRDNVSNNGRVSGAL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEHHH
VEQHQYAAHGLAWLATYVYSLRQMHRWAEALERDAKFGEMEQLIHQIAFGEYLWQIYGGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
QMNQGEVLRLQDLGLSQDDQRALMAPAVMMLTQSGNTQAARVRLVELMEQQAGSTMFGAS
EECCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEECCC
GLDEELEMIRDQFRRYAQEKVEPFAHDWHLKDELIPLDVIEELAEMGVFGLTIPEEFGGF
CCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHCCEEEEECCHHHCCC
GLSKASMCVVSEELSRGYIGVGSLGTRSEIAAELILAGGTDAQKQQWLPKIASAEILPTA
CCCHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHEECCCCHHHHHHHHHHHCCCCCCEE
VFTEPNTGSDLGSLRTRAVKDAAGDYQITGNKTWITHAARTHVMTLLARTDPETTDHRGL
EEECCCCCCHHHHHHHHHHHHCCCCEEECCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCE
SMFLAEKTPGTDETPFPTEGMTGGEIEVLGYRGMKEYELGFDGFHVKGENLLGGEEGKGF
EEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHCCCCCCEEEECCCCCCCCCCCHH
KQLMETFESARIQTAARAIGVAQSALDIAMQYAQDRKQFGKALINFPRVSSKLAMMAVEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
MVARQLTYFSAWEKDNGHRCDLEAGMAKLLGARVAWAAADNGLQIHGGNGFALEYKISRV
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEECCCCEEEECCCCEEEEEEHHHH
LCDARILNIFEGAAEIQAQVIARRLLA
HHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRMPHDGQLDGQDMKPNTPLLPELLALTKEALPPLDELLERATARVRDNVSNNGRVSGAL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEHHH
VEQHQYAAHGLAWLATYVYSLRQMHRWAEALERDAKFGEMEQLIHQIAFGEYLWQIYGGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
QMNQGEVLRLQDLGLSQDDQRALMAPAVMMLTQSGNTQAARVRLVELMEQQAGSTMFGAS
EECCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEECCC
GLDEELEMIRDQFRRYAQEKVEPFAHDWHLKDELIPLDVIEELAEMGVFGLTIPEEFGGF
CCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHCCEEEEECCHHHCCC
GLSKASMCVVSEELSRGYIGVGSLGTRSEIAAELILAGGTDAQKQQWLPKIASAEILPTA
CCCHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHEECCCCHHHHHHHHHHHCCCCCCEE
VFTEPNTGSDLGSLRTRAVKDAAGDYQITGNKTWITHAARTHVMTLLARTDPETTDHRGL
EEECCCCCCHHHHHHHHHHHHCCCCEEECCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCE
SMFLAEKTPGTDETPFPTEGMTGGEIEVLGYRGMKEYELGFDGFHVKGENLLGGEEGKGF
EEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHCCCCCCEEEECCCCCCCCCCCHH
KQLMETFESARIQTAARAIGVAQSALDIAMQYAQDRKQFGKALINFPRVSSKLAMMAVEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
MVARQLTYFSAWEKDNGHRCDLEAGMAKLLGARVAWAAADNGLQIHGGNGFALEYKISRV
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEECCCCEEEECCCCEEEEEEHHHH
LCDARILNIFEGAAEIQAQVIARRLLA
HHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]