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The map label for this gene is fhs

Identifier: 99082198

GI number: 99082198

Start: 2478640

End: 2480316

Strand: Reverse

Name: fhs

Synonym: TM1040_2358

Alternate gene names: 99082198

Gene position: 2480316-2478640 (Counterclockwise)

Preceding gene: 99082199

Following gene: 99082197

Centisome position: 77.49

GC content: 61.06

Gene sequence:

>1677_bases
ATGAGCTATAAGAGTGACATTGAGATCGCCCGCGCGGCGAACAAGCTCCCGATCCAGGAGATCGGCGCCAAACTGGGCAT
GAAAAACGACGACCTGCTGCCCTATGGCCACGACAAGGCGAAGGTGAGCCAAGAGTTCATCAACTCCGTGCAGGGCAATG
AAGACGGCAAGCTGGTGCTGGTGACCGCGATCAACCCGACCCCGGCGGGTGAGGGCAAGACCACCACCACCGTTGGTCTG
GGCGATGGTCTGAACCGTATCGGCAAAAATGCGATGATCTGTATCCGCGAAGCGTCCCTCGGGCCGAACTTCGGCATGAA
GGGTGGCGCCGCCGGTGGCGGCATGGCGCAGGTTGTGCCGATGGAGGAAATGAACCTCCACTTCACAGGCGACTTCCATG
CGATCACCTCGGCGCACTCGTTGCTGTCGGCCATGATCGACAACCACATCTACTGGGGCAACGAGCAGGAAATCGACATC
CGCCGCGTTGCATGGCGTCGTGTGGTCGACATGAACGACCGCGCCCTGCGCCAGATCACGGCGTCGCTGGGTGGGGTGTC
CAACGGCTTCCCGCGCGAAACCGGTTTTGACATCACCGTGGCTTCCGAGGTCATGGCGATCCTCTGCCTTGCCAACGACC
TGAAGGACCTGGAAAAGCGTCTCGGCGACATCATCGTGGCCTATCGCCGCGACAAGACCCCGGTTTACTGCCGCGACATC
AAGGCCGAAGGCGCGATGACCGTTCTCCTGAAGGACGCCATGCAGCCCAACCTCGTTCAGACCCTGGAAAACAACCCGGC
GTTTGTACACGGTGGCCCGTTTGCGAACATCGCACATGGCTGTAACTCCGTGATCGCAACCAAGACCGCGCTCAAAGTGG
CGGATTACGTTGTCACAGAAGCAGGCTTTGGGGCCGACCTCGGCGCCGAGAAGTTCATGAACATCAAATGCCGCAAGGCC
GGCATCGCCCCCTCTGCGGTGGTGGTCGTTGCGACCGTGCGCGCCATGAAGATGAACGGTGGCGTGGCCAAGGCGGATCT
GGGCGCGGAAAACGTCGAGGCGGTCAAGAACGGCTGTGCAAACCTCGGTCGTCACATCGAGAACGTCAAATCCTTTGGCG
TGCCTGCGGTCGTGGCGATCAACCACTTCGTCACCGACACCGATGCGGAGATCAATGCGGTCAAGGAATATGTCGCCTCT
CACGGCGTCGAGGCGATCCTGTCGCGCCACTGGGAGCTGGGCTCCGAGGGCTCCGCGCCGTTGGCTGAGAAGGTGGTCGA
GCTTGTTGAGGGTGGCGGTGCAAACTTCGGTCCGCTCTATCCCGATGAGATGCCGCTGTTTGAGAAGATCGAAACCATCG
CCAAGCGCATCTATCGCGCTGACGAGGTTCTGGCCGATGCCAAGATCCGCAACCAGCTGAAAGAGTGGGAAGAAGCGGGC
TATGGCCATCTGCCGGTCTGCATGGCGAAGACCCAGTATTCGTTCTCGACCGATCCGAACCTGCGCGGTGCGCCCACCGG
CCACTCGGTTCCGGTTCGCGAAGTGCGCCTCTCGGCGGGTGCGGGCTTTATCGTGGTGGTTTGCGGTGAGATCATGACCA
TGCCGGGTCTGCCACGCACCCCGGCGGCGGAAAGCATCTGCCTCAATGAAGAGGGCCTGATCGAAGGCTTGTTCTAA

Upstream 100 bases:

>100_bases
CGGAAACCAATGGCGCGGTTTGTTTCAGACTCGCTAATCGTAGAGGCATACTCGGTGTCCGCCACCGGGCTCTGCAACGC
GACATTTAGGAATACCGGCT

Downstream 100 bases:

>100_bases
GGCACGAAATCGGCAATCTGCGGCCCGGGGCATATGCCTCGGGCCGTAGGAGTTTTGATAGAGAGATGACCCACCGCAAA
CCGCCGCAAGACTGTGTAGA

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 558; Mature: 557

Protein sequence:

>558_residues
MSYKSDIEIARAANKLPIQEIGAKLGMKNDDLLPYGHDKAKVSQEFINSVQGNEDGKLVLVTAINPTPAGEGKTTTTVGL
GDGLNRIGKNAMICIREASLGPNFGMKGGAAGGGMAQVVPMEEMNLHFTGDFHAITSAHSLLSAMIDNHIYWGNEQEIDI
RRVAWRRVVDMNDRALRQITASLGGVSNGFPRETGFDITVASEVMAILCLANDLKDLEKRLGDIIVAYRRDKTPVYCRDI
KAEGAMTVLLKDAMQPNLVQTLENNPAFVHGGPFANIAHGCNSVIATKTALKVADYVVTEAGFGADLGAEKFMNIKCRKA
GIAPSAVVVVATVRAMKMNGGVAKADLGAENVEAVKNGCANLGRHIENVKSFGVPAVVAINHFVTDTDAEINAVKEYVAS
HGVEAILSRHWELGSEGSAPLAEKVVELVEGGGANFGPLYPDEMPLFEKIETIAKRIYRADEVLADAKIRNQLKEWEEAG
YGHLPVCMAKTQYSFSTDPNLRGAPTGHSVPVREVRLSAGAGFIVVVCGEIMTMPGLPRTPAAESICLNEEGLIEGLF

Sequences:

>Translated_558_residues
MSYKSDIEIARAANKLPIQEIGAKLGMKNDDLLPYGHDKAKVSQEFINSVQGNEDGKLVLVTAINPTPAGEGKTTTTVGL
GDGLNRIGKNAMICIREASLGPNFGMKGGAAGGGMAQVVPMEEMNLHFTGDFHAITSAHSLLSAMIDNHIYWGNEQEIDI
RRVAWRRVVDMNDRALRQITASLGGVSNGFPRETGFDITVASEVMAILCLANDLKDLEKRLGDIIVAYRRDKTPVYCRDI
KAEGAMTVLLKDAMQPNLVQTLENNPAFVHGGPFANIAHGCNSVIATKTALKVADYVVTEAGFGADLGAEKFMNIKCRKA
GIAPSAVVVVATVRAMKMNGGVAKADLGAENVEAVKNGCANLGRHIENVKSFGVPAVVAINHFVTDTDAEINAVKEYVAS
HGVEAILSRHWELGSEGSAPLAEKVVELVEGGGANFGPLYPDEMPLFEKIETIAKRIYRADEVLADAKIRNQLKEWEEAG
YGHLPVCMAKTQYSFSTDPNLRGAPTGHSVPVREVRLSAGAGFIVVVCGEIMTMPGLPRTPAAESICLNEEGLIEGLF
>Mature_557_residues
SYKSDIEIARAANKLPIQEIGAKLGMKNDDLLPYGHDKAKVSQEFINSVQGNEDGKLVLVTAINPTPAGEGKTTTTVGLG
DGLNRIGKNAMICIREASLGPNFGMKGGAAGGGMAQVVPMEEMNLHFTGDFHAITSAHSLLSAMIDNHIYWGNEQEIDIR
RVAWRRVVDMNDRALRQITASLGGVSNGFPRETGFDITVASEVMAILCLANDLKDLEKRLGDIIVAYRRDKTPVYCRDIK
AEGAMTVLLKDAMQPNLVQTLENNPAFVHGGPFANIAHGCNSVIATKTALKVADYVVTEAGFGADLGAEKFMNIKCRKAG
IAPSAVVVVATVRAMKMNGGVAKADLGAENVEAVKNGCANLGRHIENVKSFGVPAVVAINHFVTDTDAEINAVKEYVASH
GVEAILSRHWELGSEGSAPLAEKVVELVEGGGANFGPLYPDEMPLFEKIETIAKRIYRADEVLADAKIRNQLKEWEEAGY
GHLPVCMAKTQYSFSTDPNLRGAPTGHSVPVREVRLSAGAGFIVVVCGEIMTMPGLPRTPAAESICLNEEGLIEGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=619, Percent_Identity=42.0032310177706, Blast_Score=458, Evalue=1e-129,
Organism=Homo sapiens, GI36796743, Length=619, Percent_Identity=42.81098546042, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI310124614, Length=86, Percent_Identity=37.2093023255814, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17568737, Length=622, Percent_Identity=43.5691318327974, Blast_Score=469, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17568739, Length=622, Percent_Identity=43.5691318327974, Blast_Score=469, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6321643, Length=628, Percent_Identity=42.1974522292994, Blast_Score=453, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6319558, Length=631, Percent_Identity=41.0459587955626, Blast_Score=446, Evalue=1e-126,
Organism=Drosophila melanogaster, GI62472483, Length=619, Percent_Identity=43.4571890145396, Blast_Score=463, Evalue=1e-130,
Organism=Drosophila melanogaster, GI45551871, Length=619, Percent_Identity=43.4571890145396, Blast_Score=463, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24645718, Length=619, Percent_Identity=43.4571890145396, Blast_Score=463, Evalue=1e-130,
Organism=Drosophila melanogaster, GI17137370, Length=619, Percent_Identity=43.4571890145396, Blast_Score=463, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_SILST (Q1GE26)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_614352.1
- ProteinModelPortal:   Q1GE26
- SMR:   Q1GE26
- STRING:   Q1GE26
- GeneID:   4076477
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_2358
- NMPDR:   fig|292414.1.peg.918
- eggNOG:   COG2759
- HOGENOM:   HBG677721
- OMA:   EIMAVLC
- PhylomeDB:   Q1GE26
- ProtClustDB:   PRK13505
- BioCyc:   SSP292414:TM1040_2358-MONOMER
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 59752; Mature: 59621

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYKSDIEIARAANKLPIQEIGAKLGMKNDDLLPYGHDKAKVSQEFINSVQGNEDGKLVL
CCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEE
VTAINPTPAGEGKTTTTVGLGDGLNRIGKNAMICIREASLGPNFGMKGGAAGGGMAQVVP
EEEECCCCCCCCCCEEEEECCCCHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEE
MEEMNLHFTGDFHAITSAHSLLSAMIDNHIYWGNEQEIDIRRVAWRRVVDMNDRALRQIT
HHHCCEEECCCHHHHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHHCCCHHHHHHHH
ASLGGVSNGFPRETGFDITVASEVMAILCLANDLKDLEKRLGDIIVAYRRDKTPVYCRDI
HHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEC
KAEGAMTVLLKDAMQPNLVQTLENNPAFVHGGPFANIAHGCNSVIATKTALKVADYVVTE
CCCCCEEHEEHHHCCCHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
AGFGADLGAEKFMNIKCRKAGIAPSAVVVVATVRAMKMNGGVAKADLGAENVEAVKNGCA
CCCCCCCCHHHHCCCEECCCCCCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHH
NLGRHIENVKSFGVPAVVAINHFVTDTDAEINAVKEYVASHGVEAILSRHWELGSEGSAP
HHHHHHHHHHHCCCCEEEEEHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCH
LAEKVVELVEGGGANFGPLYPDEMPLFEKIETIAKRIYRADEVLADAKIRNQLKEWEEAG
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YGHLPVCMAKTQYSFSTDPNLRGAPTGHSVPVREVRLSAGAGFIVVVCGEIMTMPGLPRT
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCEEEEEEHHHHHCCCCCCC
PAAESICLNEEGLIEGLF
CCCCCEECCCCCCCCCCC
>Mature Secondary Structure 
SYKSDIEIARAANKLPIQEIGAKLGMKNDDLLPYGHDKAKVSQEFINSVQGNEDGKLVL
CCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEE
VTAINPTPAGEGKTTTTVGLGDGLNRIGKNAMICIREASLGPNFGMKGGAAGGGMAQVVP
EEEECCCCCCCCCCEEEEECCCCHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEE
MEEMNLHFTGDFHAITSAHSLLSAMIDNHIYWGNEQEIDIRRVAWRRVVDMNDRALRQIT
HHHCCEEECCCHHHHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHHCCCHHHHHHHH
ASLGGVSNGFPRETGFDITVASEVMAILCLANDLKDLEKRLGDIIVAYRRDKTPVYCRDI
HHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEC
KAEGAMTVLLKDAMQPNLVQTLENNPAFVHGGPFANIAHGCNSVIATKTALKVADYVVTE
CCCCCEEHEEHHHCCCHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
AGFGADLGAEKFMNIKCRKAGIAPSAVVVVATVRAMKMNGGVAKADLGAENVEAVKNGCA
CCCCCCCCHHHHCCCEECCCCCCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHH
NLGRHIENVKSFGVPAVVAINHFVTDTDAEINAVKEYVASHGVEAILSRHWELGSEGSAP
HHHHHHHHHHHCCCCEEEEEHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCH
LAEKVVELVEGGGANFGPLYPDEMPLFEKIETIAKRIYRADEVLADAKIRNQLKEWEEAG
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YGHLPVCMAKTQYSFSTDPNLRGAPTGHSVPVREVRLSAGAGFIVVVCGEIMTMPGLPRT
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCEEEEEEHHHHHCCCCCCC
PAAESICLNEEGLIEGLF
CCCCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA