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The map label for this gene is cobF [H]

Identifier: 99082064

GI number: 99082064

Start: 2335093

End: 2335857

Strand: Direct

Name: cobF [H]

Synonym: TM1040_2224

Alternate gene names: 99082064

Gene position: 2335093-2335857 (Clockwise)

Preceding gene: 99082063

Following gene: 99082067

Centisome position: 72.95

GC content: 64.71

Gene sequence:

>765_bases
ATGCTCCAGCTCAGTCTGATCGGGATCGGCACCGGCAACCCCAAGCACCTGACCCGCGAGGCGATGGAGGCAATCTGCGC
GCAGGATTTGATCCTGATACCCAACAAGGGCGCAGGCAAGGACGACCTTGCCGGGCTGCGGCAAGCGATCTGCGCCGATG
TCCTGGCGGGCGCGGCATCGGCGCCCAAGATCGTCGAATTCGACCTTCCCGTGCGTGATCCGGCCACTCCGGATTACCGC
CAGCGGGTCGAGGACTGGCACGACGCCATCGCAGAGGTTTGGCAGGCCACACTCGCTGCACATCTCCCCAAAGGCGGGCA
AGCCGGGTTTCTGGTTTGGGGCGACCCCTCACTCTATGACAGCACCATGCGCATTGCCGAGCGTCTTGGTCAGCGCATGG
AAATGCAGATGCGGGTGATCCCCGGCATCACCTCGGTGCAAGCGCTGACGGCGGCGCATGGGGTGCCCCTCAACCGGATC
GGCGCGCCCGTGCAGATCACCACCGGACGCCAGCTCCGCGATGCGGGCTGGCCCGCGGGCTGTGACACGTTGGTCATCAT
GCTGGATGGGGAGTGCTCGTTCCAGAGCGTCGACCGTCCCGAACAGGTCATGATCCACTGGTCCGCCTATGCGGGGATGG
AAAACGAGATCAATATCGCCGGGCGTCTCTCCGACGTGCAGGACCAGATCCTGTCAGTGCGCGCCCGCGCACGGCGCGAT
CATGGCTGGATCATGGACATCTACATGCTGGAACGCCTGCGCTGA

Upstream 100 bases:

>100_bases
GGCGCGCGTTGTCGTGAGTGCCCCCTGATGGGGCACTCTTGACCTCTTTGCGCGGGCGTCCCATTGCGGGGCGACGGATT
TAACGGATGGAGAGCCTTCT

Downstream 100 bases:

>100_bases
CCCCAGCCATTTTTCGTGACGCTCGGCGGTTCATTCCAGATCCGCGTCTCTGTCAGTCGCGGCGGCGTCCGATGTGGAGA
TCCAGCGCTGCAGCCTGTCC

Product: precorrin 6A synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MLQLSLIGIGTGNPKHLTREAMEAICAQDLILIPNKGAGKDDLAGLRQAICADVLAGAASAPKIVEFDLPVRDPATPDYR
QRVEDWHDAIAEVWQATLAAHLPKGGQAGFLVWGDPSLYDSTMRIAERLGQRMEMQMRVIPGITSVQALTAAHGVPLNRI
GAPVQITTGRQLRDAGWPAGCDTLVIMLDGECSFQSVDRPEQVMIHWSAYAGMENEINIAGRLSDVQDQILSVRARARRD
HGWIMDIYMLERLR

Sequences:

>Translated_254_residues
MLQLSLIGIGTGNPKHLTREAMEAICAQDLILIPNKGAGKDDLAGLRQAICADVLAGAASAPKIVEFDLPVRDPATPDYR
QRVEDWHDAIAEVWQATLAAHLPKGGQAGFLVWGDPSLYDSTMRIAERLGQRMEMQMRVIPGITSVQALTAAHGVPLNRI
GAPVQITTGRQLRDAGWPAGCDTLVIMLDGECSFQSVDRPEQVMIHWSAYAGMENEINIAGRLSDVQDQILSVRARARRD
HGWIMDIYMLERLR
>Mature_254_residues
MLQLSLIGIGTGNPKHLTREAMEAICAQDLILIPNKGAGKDDLAGLRQAICADVLAGAASAPKIVEFDLPVRDPATPDYR
QRVEDWHDAIAEVWQATLAAHLPKGGQAGFLVWGDPSLYDSTMRIAERLGQRMEMQMRVIPGITSVQALTAAHGVPLNRI
GAPVQITTGRQLRDAGWPAGCDTLVIMLDGECSFQSVDRPEQVMIHWSAYAGMENEINIAGRLSDVQDQILSVRARARRD
HGWIMDIYMLERLR

Specific function: Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A [H]

COG id: COG2243

COG function: function code H; Precorrin-2 methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR012797 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.152 [H]

Molecular weight: Translated: 27899; Mature: 27899

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQLSLIGIGTGNPKHLTREAMEAICAQDLILIPNKGAGKDDLAGLRQAICADVLAGAAS
CEEEEEEEECCCCHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
APKIVEFDLPVRDPATPDYRQRVEDWHDAIAEVWQATLAAHLPKGGQAGFLVWGDPSLYD
CCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHH
STMRIAERLGQRMEMQMRVIPGITSVQALTAAHGVPLNRIGAPVQITTGRQLRDAGWPAG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHCCCCEEEECCCCHHCCCCCCC
CDTLVIMLDGECSFQSVDRPEQVMIHWSAYAGMENEINIAGRLSDVQDQILSVRARARRD
CCEEEEEECCCCCCCCCCCCHHEEEEEHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHCC
HGWIMDIYMLERLR
CCCCHHHHHHHHCC
>Mature Secondary Structure
MLQLSLIGIGTGNPKHLTREAMEAICAQDLILIPNKGAGKDDLAGLRQAICADVLAGAAS
CEEEEEEEECCCCHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
APKIVEFDLPVRDPATPDYRQRVEDWHDAIAEVWQATLAAHLPKGGQAGFLVWGDPSLYD
CCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHH
STMRIAERLGQRMEMQMRVIPGITSVQALTAAHGVPLNRIGAPVQITTGRQLRDAGWPAG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHCCCCEEEECCCCHHCCCCCCC
CDTLVIMLDGECSFQSVDRPEQVMIHWSAYAGMENEINIAGRLSDVQDQILSVRARARRD
CCEEEEEECCCCCCCCCCCCHHEEEEEHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHCC
HGWIMDIYMLERLR
CCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211521 [H]