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The map label for this gene is cobM [H]

Identifier: 99082058

GI number: 99082058

Start: 2329881

End: 2330675

Strand: Direct

Name: cobM [H]

Synonym: TM1040_2218

Alternate gene names: 99082058

Gene position: 2329881-2330675 (Clockwise)

Preceding gene: 99082057

Following gene: 99082059

Centisome position: 72.79

GC content: 65.66

Gene sequence:

>795_bases
ATGACCGTTCATTTTATCGGTGCCGGACCCGGCGCCGCCGACCTCATTACCCTGCGCGGGCGTGATCTGATCGCGGCCTG
CCCTGTGTGTCTTTATGCAGGCTCCCTGGTGCCTGAAGCTCTCCTGAGCCATTGCCCCGAGGGCGCCAAGATCATCAACA
CGGCCCCCTTGTCGCTGGATGAGATCATGGCAGAAATCGCAAGCGCCCATGCCCAAGGCCATGACATCGCCCGGCTTCAT
TCAGGTGATCTGTCGGTCTGGTCGGCGATGGGCGAGCAGCTGCGCCGGCTGCGCGATCTCGACATCCCCTATGACATCAC
CCCCGGTGTCCCAGCCTTTGCCGCAGGGGCTGCCGCACTTGGCACCGAGCTCACGCTGCCGGGCGTGGCGCAATCGCTTG
TGCTCACACGGACGTCCGGGCGTGCCTCTGCCATGCCCGAGGGCGAGACGCTGGAGAACTTTGCCGCCACCGGCGCCACC
CTCGCGATCCACCTCTCGGTGCATGTCCTTGATGATGTGGTGGCCCGGCTCACACCCGCCTATGGCGCGGACTGCCCCGT
GGCGATCGTCTGGCGCGCCAGCTGGCCGGATCAAAAGATCGTCAAAGCCACGCTCGGCACCGTCATCGAGGCGACGGACG
GCGCTCGCGGACGCACGTCGCTGATCCTCGTCGGGCGCGCCCTCGGCGCGGAGGACTTTGCGGAAAGCTGCCTCTATGGC
GCGGAATATGACCGCCGCTATCGTCCGCAAAGTGCCGACAGCCCCTGGTCGGAATGGAGCGAAGGCGATGATTGA

Upstream 100 bases:

>100_bases
GCGCCCTTGTGGCAGCGGGCAAACACGCGCGCCTAATCCAAAGACGATTTGTGACCACGGATGGGCTTGCCACCGTGGCG
CTTGCGGAGACAATAGCAAG

Downstream 100 bases:

>100_bases
TCGCATGATGTGGGCCACCAAGGACAGCGCCGGAGCCTGGGTGCGGGCGCTGACCGGCTCGACGACCGGGCAAGAGATCT
CAGGACATGAGGTAACGAAA

Product: precorrin-4 C11-methyltransferase

Products: NA

Alternate protein names: Precorrin-3 methylase [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MTVHFIGAGPGAADLITLRGRDLIAACPVCLYAGSLVPEALLSHCPEGAKIINTAPLSLDEIMAEIASAHAQGHDIARLH
SGDLSVWSAMGEQLRRLRDLDIPYDITPGVPAFAAGAAALGTELTLPGVAQSLVLTRTSGRASAMPEGETLENFAATGAT
LAIHLSVHVLDDVVARLTPAYGADCPVAIVWRASWPDQKIVKATLGTVIEATDGARGRTSLILVGRALGAEDFAESCLYG
AEYDRRYRPQSADSPWSEWSEGDD

Sequences:

>Translated_264_residues
MTVHFIGAGPGAADLITLRGRDLIAACPVCLYAGSLVPEALLSHCPEGAKIINTAPLSLDEIMAEIASAHAQGHDIARLH
SGDLSVWSAMGEQLRRLRDLDIPYDITPGVPAFAAGAAALGTELTLPGVAQSLVLTRTSGRASAMPEGETLENFAATGAT
LAIHLSVHVLDDVVARLTPAYGADCPVAIVWRASWPDQKIVKATLGTVIEATDGARGRTSLILVGRALGAEDFAESCLYG
AEYDRRYRPQSADSPWSEWSEGDD
>Mature_263_residues
TVHFIGAGPGAADLITLRGRDLIAACPVCLYAGSLVPEALLSHCPEGAKIINTAPLSLDEIMAEIASAHAQGHDIARLHS
GDLSVWSAMGEQLRRLRDLDIPYDITPGVPAFAAGAAALGTELTLPGVAQSLVLTRTSGRASAMPEGETLENFAATGATL
AIHLSVHVLDDVVARLTPAYGADCPVAIVWRASWPDQKIVKATLGTVIEATDGARGRTSLILVGRALGAEDFAESCLYGA
EYDRRYRPQSADSPWSEWSEGDD

Specific function: Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5 [H]

COG id: COG2875

COG function: function code H; Precorrin-4 methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=239, Percent_Identity=27.6150627615063, Blast_Score=72, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322922, Length=252, Percent_Identity=24.6031746031746, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006362
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.133 [H]

Molecular weight: Translated: 27769; Mature: 27637

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00839 SUMT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVHFIGAGPGAADLITLRGRDLIAACPVCLYAGSLVPEALLSHCPEGAKIINTAPLSLD
CEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHH
EIMAEIASAHAQGHDIARLHSGDLSVWSAMGEQLRRLRDLDIPYDITPGVPAFAAGAAAL
HHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
GTELTLPGVAQSLVLTRTSGRASAMPEGETLENFAATGATLAIHLSVHVLDDVVARLTPA
CCCCCCCHHHHHHEEEECCCCCCCCCCCCHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCC
YGADCPVAIVWRASWPDQKIVKATLGTVIEATDGARGRTSLILVGRALGAEDFAESCLYG
CCCCCCEEEEEECCCCCHHHHHHHHHHHEECCCCCCCCEEEEEEECCCCHHHHHHHHHCC
AEYDRRYRPQSADSPWSEWSEGDD
CCHHHCCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure 
TVHFIGAGPGAADLITLRGRDLIAACPVCLYAGSLVPEALLSHCPEGAKIINTAPLSLD
EEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHH
EIMAEIASAHAQGHDIARLHSGDLSVWSAMGEQLRRLRDLDIPYDITPGVPAFAAGAAAL
HHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
GTELTLPGVAQSLVLTRTSGRASAMPEGETLENFAATGATLAIHLSVHVLDDVVARLTPA
CCCCCCCHHHHHHEEEECCCCCCCCCCCCHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCC
YGADCPVAIVWRASWPDQKIVKATLGTVIEATDGARGRTSLILVGRALGAEDFAESCLYG
CCCCCCEEEEEECCCCCHHHHHHHHHHHEECCCCCCCCEEEEEEECCCCHHHHHHHHHCC
AEYDRRYRPQSADSPWSEWSEGDD
CCHHHCCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9256491 [H]