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The map label for this gene is lktA [H]

Identifier: 99081675

GI number: 99081675

Start: 1931935

End: 1934538

Strand: Direct

Name: lktA [H]

Synonym: TM1040_1834

Alternate gene names: 99081675

Gene position: 1931935-1934538 (Clockwise)

Preceding gene: 99081673

Following gene: 99081676

Centisome position: 60.36

GC content: 60.87

Gene sequence:

>2604_bases
ATGCCTACGATTTACGATTCTTTTGCCGACACCCCAGGCAGCGCCGTGCGCCTGGACGTAGGCAGCCCGTATGAAGTCAG
ACTGACCCAGGCCGAGCTTGATGCGGCGGCCACGTTCGGCAACCCCGAATACGACTACTTCGAGTTTTACGCGGACCCCT
TCACGACCTACACGGTCCAAGTGATCGCGGCAAATGACGCCATCGATCAATCCCTCTGGCTGCCCTCCCCGACTTGGCCG
GGCTATAATACCGAGTTCGGATTCTCCGCCCCCGACGGTACGATGGTGACGCTCGAGGACGGGTATTCGGTGCGCAACTG
GGATCCTGGCGACAGGCTCATCACCACTCTTTATGATGGCGGGCTGGTCCGCATGGCGGTGCGATTTGACGGCTGGTTGC
AGGAATATCGGACCGGCGAGGACCTGTCCGACCTGCCCGGCTCTGACCGCAGTTTCTTTATCCGCATCGTCGAAGGCGAT
GTCGCCGGAACGCAGCCGCAGATCGACACCGTCGGCACGGGACCAGACGCCCTGGAGGTTTCGCCAGAAGACGCCTCCGG
GATCATCACCGGAGAGCTGGAGGATCTCGAAGGTACGCCGGACGTCGACGAGTATCTGTTCACCCTGCGCGCAGGTTTCC
ATTACGATGTGGTGGTGCGTGGCGCCACCGGCGCACAATCCGGCGAAAGCCCGGGGGTGTTCAGGGTCACCGTCAGCGAG
GAAAATGGCGCAAGCTCCTGGACGCTTGAATCGGATGTCGACCGCATGTCGACCGGCGATGTGGAGCAGACGATCACCTC
TGTGCGCATCGGAGATGGGTTTGGCAGCCTTCTCCTCGAGCCGGGCGAAGAGATCGACGTGCGCGTTTCAATCCAAAGCA
TCTATGACCCCAATCGCGAAGTCAGCCCCTACCAAACCGGTGGATATTCCGTCGGCGGATATGAGATCGAGATCCTTCCG
ACCGATGACGATCACGGCAACAACCGTCTCACGCCAAGCACGATCTCCGTTGGGGGCTGGCAGTCGGGCACTCTGAACCC
CTATTACGAGATCAGCGCCGCCGAACCCTTTGGCGATCGCGACTGGATGGAAATCGTCGGCGGTGTCGAAGAGGGGCGCT
ACTATGTTGCCAGCTTCGACTACAGCGATGGCCGCCCCTTCTCGATGTTCGCTAGCTTTCATAACTCGGTGTCCACCGAG
ACCGTGCGGGCCCCCGATTATGCGATCTGGCAGCCGAACTACACCGGCGCAGCCTGGCTCGAAGTGGACTCGAACTTCAT
CGGGTCGGCGGACTGGCGGGTCAGTCTCGGTAGCTATGAAACCCTGGAACTCGGCAACCGCTCAGACGAGAGACTGACCG
GCACCGCAGGCGAAAACTTCCTTGATGGGCGCGGCGGCGCAGATCTCATTGTGGGACGGGGGGGCGCGGACCAGCTCATT
GGCAATGGTGGCAATGATACCATCAAAGGCGGCGGCGGGCATGACATCCTGAGCGGTGGCGCCGGCAAGGATGTGCTCAA
AGGCAATGGCGGCAACGACGCGCTGAACGGCGGCGGCGGGCGTGACAAGCTCATCGGCGGACGCGGAAATGATACCATGT
CCGGGGGCGATGTCAGAGACGTGCTCAAAGGCGGCGGCGGCAATGACGTCCTGGACGGTGGTGAAGGCCGCGACAAACTG
ATCGGCGGCAGTGGCAACGATACGATCACCACGGGCTTTGATGGCGATGTGGTCAGGGCCGGAAGCGGCATCGACACGAT
CATCATCGCAGGCCCCGAGGGTGACCGGGATCTGCGCATCCGCGGCACGATGGACGACGGGGATATCCTCGATCTCTCCG
CGCTGAATATCGACAGCTATTTCGTCGAGGACAGTTTTGCGGGCGGTGGCGCATCCTCCGTCCGCACGCGCGGGGATGGC
TTGGGCTATGACATCGACTTTGACGGGGACGGCATCGGCGATCGCTCGATCTTCTTTGACAGCAGCGAAGATGCGGATCT
CGTCGATCTCGAAGGTGTCGCAGTCCGGACCCCCGCAACCTACTACGAATACCTCGCCGAGACCCTGACGCCGCTGGAGT
GGACGCCGACACGGGAACGCTACGTTTTGGATTCCTACGGCACATTCCAGTACGATCTGATCTCTGGCACCTCCGGCGCC
GACCTCATCAGCAACGACGGACGTGCGGACAACTACTTGTACAGGGGACAGGTCCGCGCCGGTGCCGGTGATGACATCAT
CGACATGCAACTGCATTCCAGCCTCACCTACTACGGAGGGACCGGAGACGACTATTTCGTGTGGCAGCCTCCCGTCGACC
CGAATTATGCGCTCTGGATCCGGCTCAATGATTTCAGGCAATACGGCGAAGAGGATTATATCGTCGTGCGGTCGGACATC
TGGGGCGAAGGTGTGAGCATCGACAATATCACCTTTGACCGCATGCGCAGCGATGGCGACTACCTCGAGGCCCATATCGT
CGGGACCAACGGTCTGGAAGGCACGATCTCCGTGACACAGCCTTTTCGGTCTTCGGACCCGCTGCGCAACAATGATGCAA
CCTCCGCCGATTTCCTCAATGTGGACGCCTTCATCTTTGTCTGA

Upstream 100 bases:

>100_bases
AACTTTGGTGCACGAATTTTGTGCAGCGGCCCATTTCTGCGAGAAATTCAGAACAATTTGGTATATTCAGGATTCCGATT
TTACCGGTTGTGAGTGGCCC

Downstream 100 bases:

>100_bases
CCCGCGCCAACAGGCGCATCCCGTCTGGCGCATCAGACAAGGCGAAAACGCCCTCTGACAGCATCAAACGCAGACGGTTT
CAAATGCGGGTGTGGGGCAA

Product: RTX toxins and related Ca2+-binding proteins-like

Products: NA

Alternate protein names: Lkt [H]

Number of amino acids: Translated: 867; Mature: 866

Protein sequence:

>867_residues
MPTIYDSFADTPGSAVRLDVGSPYEVRLTQAELDAAATFGNPEYDYFEFYADPFTTYTVQVIAANDAIDQSLWLPSPTWP
GYNTEFGFSAPDGTMVTLEDGYSVRNWDPGDRLITTLYDGGLVRMAVRFDGWLQEYRTGEDLSDLPGSDRSFFIRIVEGD
VAGTQPQIDTVGTGPDALEVSPEDASGIITGELEDLEGTPDVDEYLFTLRAGFHYDVVVRGATGAQSGESPGVFRVTVSE
ENGASSWTLESDVDRMSTGDVEQTITSVRIGDGFGSLLLEPGEEIDVRVSIQSIYDPNREVSPYQTGGYSVGGYEIEILP
TDDDHGNNRLTPSTISVGGWQSGTLNPYYEISAAEPFGDRDWMEIVGGVEEGRYYVASFDYSDGRPFSMFASFHNSVSTE
TVRAPDYAIWQPNYTGAAWLEVDSNFIGSADWRVSLGSYETLELGNRSDERLTGTAGENFLDGRGGADLIVGRGGADQLI
GNGGNDTIKGGGGHDILSGGAGKDVLKGNGGNDALNGGGGRDKLIGGRGNDTMSGGDVRDVLKGGGGNDVLDGGEGRDKL
IGGSGNDTITTGFDGDVVRAGSGIDTIIIAGPEGDRDLRIRGTMDDGDILDLSALNIDSYFVEDSFAGGGASSVRTRGDG
LGYDIDFDGDGIGDRSIFFDSSEDADLVDLEGVAVRTPATYYEYLAETLTPLEWTPTRERYVLDSYGTFQYDLISGTSGA
DLISNDGRADNYLYRGQVRAGAGDDIIDMQLHSSLTYYGGTGDDYFVWQPPVDPNYALWIRLNDFRQYGEEDYIVVRSDI
WGEGVSIDNITFDRMRSDGDYLEAHIVGTNGLEGTISVTQPFRSSDPLRNNDATSADFLNVDAFIFV

Sequences:

>Translated_867_residues
MPTIYDSFADTPGSAVRLDVGSPYEVRLTQAELDAAATFGNPEYDYFEFYADPFTTYTVQVIAANDAIDQSLWLPSPTWP
GYNTEFGFSAPDGTMVTLEDGYSVRNWDPGDRLITTLYDGGLVRMAVRFDGWLQEYRTGEDLSDLPGSDRSFFIRIVEGD
VAGTQPQIDTVGTGPDALEVSPEDASGIITGELEDLEGTPDVDEYLFTLRAGFHYDVVVRGATGAQSGESPGVFRVTVSE
ENGASSWTLESDVDRMSTGDVEQTITSVRIGDGFGSLLLEPGEEIDVRVSIQSIYDPNREVSPYQTGGYSVGGYEIEILP
TDDDHGNNRLTPSTISVGGWQSGTLNPYYEISAAEPFGDRDWMEIVGGVEEGRYYVASFDYSDGRPFSMFASFHNSVSTE
TVRAPDYAIWQPNYTGAAWLEVDSNFIGSADWRVSLGSYETLELGNRSDERLTGTAGENFLDGRGGADLIVGRGGADQLI
GNGGNDTIKGGGGHDILSGGAGKDVLKGNGGNDALNGGGGRDKLIGGRGNDTMSGGDVRDVLKGGGGNDVLDGGEGRDKL
IGGSGNDTITTGFDGDVVRAGSGIDTIIIAGPEGDRDLRIRGTMDDGDILDLSALNIDSYFVEDSFAGGGASSVRTRGDG
LGYDIDFDGDGIGDRSIFFDSSEDADLVDLEGVAVRTPATYYEYLAETLTPLEWTPTRERYVLDSYGTFQYDLISGTSGA
DLISNDGRADNYLYRGQVRAGAGDDIIDMQLHSSLTYYGGTGDDYFVWQPPVDPNYALWIRLNDFRQYGEEDYIVVRSDI
WGEGVSIDNITFDRMRSDGDYLEAHIVGTNGLEGTISVTQPFRSSDPLRNNDATSADFLNVDAFIFV
>Mature_866_residues
PTIYDSFADTPGSAVRLDVGSPYEVRLTQAELDAAATFGNPEYDYFEFYADPFTTYTVQVIAANDAIDQSLWLPSPTWPG
YNTEFGFSAPDGTMVTLEDGYSVRNWDPGDRLITTLYDGGLVRMAVRFDGWLQEYRTGEDLSDLPGSDRSFFIRIVEGDV
AGTQPQIDTVGTGPDALEVSPEDASGIITGELEDLEGTPDVDEYLFTLRAGFHYDVVVRGATGAQSGESPGVFRVTVSEE
NGASSWTLESDVDRMSTGDVEQTITSVRIGDGFGSLLLEPGEEIDVRVSIQSIYDPNREVSPYQTGGYSVGGYEIEILPT
DDDHGNNRLTPSTISVGGWQSGTLNPYYEISAAEPFGDRDWMEIVGGVEEGRYYVASFDYSDGRPFSMFASFHNSVSTET
VRAPDYAIWQPNYTGAAWLEVDSNFIGSADWRVSLGSYETLELGNRSDERLTGTAGENFLDGRGGADLIVGRGGADQLIG
NGGNDTIKGGGGHDILSGGAGKDVLKGNGGNDALNGGGGRDKLIGGRGNDTMSGGDVRDVLKGGGGNDVLDGGEGRDKLI
GGSGNDTITTGFDGDVVRAGSGIDTIIIAGPEGDRDLRIRGTMDDGDILDLSALNIDSYFVEDSFAGGGASSVRTRGDGL
GYDIDFDGDGIGDRSIFFDSSEDADLVDLEGVAVRTPATYYEYLAETLTPLEWTPTRERYVLDSYGTFQYDLISGTSGAD
LISNDGRADNYLYRGQVRAGAGDDIIDMQLHSSLTYYGGTGDDYFVWQPPVDPNYALWIRLNDFRQYGEEDYIVVRSDIW
GEGVSIDNITFDRMRSDGDYLEAHIVGTNGLEGTISVTQPFRSSDPLRNNDATSADFLNVDAFIFV

Specific function: One of the virulence factors of A.actinomycetemcomitans might be a cytotoxin, possibly the membrane-bound hemolysin [H]

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein. Secreted (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: NA

Molecular weight: Translated: 93438; Mature: 93307

Theoretical pI: Translated: 3.81; Mature: 3.81

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTIYDSFADTPGSAVRLDVGSPYEVRLTQAELDAAATFGNPEYDYFEFYADPFTTYTVQ
CCCCCCHHCCCCCCEEEEECCCCEEEEEEHHHCCCCEECCCCCCCEEEEECCCCEEEEEE
VIAANDAIDQSLWLPSPTWPGYNTEFGFSAPDGTMVTLEDGYSVRNWDPGDRLITTLYDG
EEEECCCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEEECCCEECCCCCCHHEEEEEECC
GLVRMAVRFDGWLQEYRTGEDLSDLPGSDRSFFIRIVEGDVAGTQPQIDTVGTGPDALEV
CEEEEEEEHHHHHHHHCCCCCHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCEEEE
SPEDASGIITGELEDLEGTPDVDEYLFTLRAGFHYDVVVRGATGAQSGESPGVFRVTVSE
CCCCCCEEEEEEHHCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEEEEC
ENGASSWTLESDVDRMSTGDVEQTITSVRIGDGFGSLLLEPGEEIDVRVSIQSIYDPNRE
CCCCCCEEECCCHHHCCCCCHHHHEEEEEECCCCCCEEECCCCCEEEEEEEEECCCCCCC
VSPYQTGGYSVGGYEIEILPTDDDHGNNRLTPSTISVGGWQSGTLNPYYEISAAEPFGDR
CCCCCCCCEEECCEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCC
DWMEIVGGVEEGRYYVASFDYSDGRPFSMFASFHNSVSTETVRAPDYAIWQPNYTGAAWL
CHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCEEECCCEEEECCCCCCEEEE
EVDSNFIGSADWRVSLGSYETLELGNRSDERLTGTAGENFLDGRGGADLIVGRGGADQLI
EECCCCCCCCCEEEECCCEEEEECCCCCCCEEECCCCCCCCCCCCCCEEEEECCCHHHHC
GNGGNDTIKGGGGHDILSGGAGKDVLKGNGGNDALNGGGGRDKLIGGRGNDTMSGGDVRD
CCCCCCCCCCCCCCHHCCCCCCCHHEECCCCCCCCCCCCCCCCEECCCCCCCCCCCCHHH
VLKGGGGNDVLDGGEGRDKLIGGSGNDTITTGFDGDVVRAGSGIDTIIIAGPEGDRDLRI
HHHCCCCCCCCCCCCCCCEEECCCCCCEEEECCCCCEEECCCCCCEEEEECCCCCCEEEE
RGTMDDGDILDLSALNIDSYFVEDSFAGGGASSVRTRGDGLGYDIDFDGDGIGDRSIFFD
EECCCCCCEEEEEEECCCEEEEECCCCCCCCCCCEECCCCCCEEEECCCCCCCCCEEEEC
SSEDADLVDLEGVAVRTPATYYEYLAETLTPLEWTPTRERYVLDSYGTFQYDLISGTSGA
CCCCCCEEEECCEEEECCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEEECCCCCC
DLISNDGRADNYLYRGQVRAGAGDDIIDMQLHSSLTYYGGTGDDYFVWQPPVDPNYALWI
CHHCCCCCCCCEEEEEEEECCCCCCEEEEEEECCEEEECCCCCCEEEECCCCCCCEEEEE
RLNDFRQYGEEDYIVVRSDIWGEGVSIDNITFDRMRSDGDYLEAHIVGTNGLEGTISVTQ
EEHHHHHCCCCCEEEEEECCCCCCCEECCEEHHHHCCCCCEEEEEEEECCCCCEEEEEEC
PFRSSDPLRNNDATSADFLNVDAFIFV
CCCCCCCCCCCCCCCCEEEECEEEEEC
>Mature Secondary Structure 
PTIYDSFADTPGSAVRLDVGSPYEVRLTQAELDAAATFGNPEYDYFEFYADPFTTYTVQ
CCCCCHHCCCCCCEEEEECCCCEEEEEEHHHCCCCEECCCCCCCEEEEECCCCEEEEEE
VIAANDAIDQSLWLPSPTWPGYNTEFGFSAPDGTMVTLEDGYSVRNWDPGDRLITTLYDG
EEEECCCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEEECCCEECCCCCCHHEEEEEECC
GLVRMAVRFDGWLQEYRTGEDLSDLPGSDRSFFIRIVEGDVAGTQPQIDTVGTGPDALEV
CEEEEEEEHHHHHHHHCCCCCHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCEEEE
SPEDASGIITGELEDLEGTPDVDEYLFTLRAGFHYDVVVRGATGAQSGESPGVFRVTVSE
CCCCCCEEEEEEHHCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEEEEC
ENGASSWTLESDVDRMSTGDVEQTITSVRIGDGFGSLLLEPGEEIDVRVSIQSIYDPNRE
CCCCCCEEECCCHHHCCCCCHHHHEEEEEECCCCCCEEECCCCCEEEEEEEEECCCCCCC
VSPYQTGGYSVGGYEIEILPTDDDHGNNRLTPSTISVGGWQSGTLNPYYEISAAEPFGDR
CCCCCCCCEEECCEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCC
DWMEIVGGVEEGRYYVASFDYSDGRPFSMFASFHNSVSTETVRAPDYAIWQPNYTGAAWL
CHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCEEECCCEEEECCCCCCEEEE
EVDSNFIGSADWRVSLGSYETLELGNRSDERLTGTAGENFLDGRGGADLIVGRGGADQLI
EECCCCCCCCCEEEECCCEEEEECCCCCCCEEECCCCCCCCCCCCCCEEEEECCCHHHHC
GNGGNDTIKGGGGHDILSGGAGKDVLKGNGGNDALNGGGGRDKLIGGRGNDTMSGGDVRD
CCCCCCCCCCCCCCHHCCCCCCCHHEECCCCCCCCCCCCCCCCEECCCCCCCCCCCCHHH
VLKGGGGNDVLDGGEGRDKLIGGSGNDTITTGFDGDVVRAGSGIDTIIIAGPEGDRDLRI
HHHCCCCCCCCCCCCCCCEEECCCCCCEEEECCCCCEEECCCCCCEEEEECCCCCCEEEE
RGTMDDGDILDLSALNIDSYFVEDSFAGGGASSVRTRGDGLGYDIDFDGDGIGDRSIFFD
EECCCCCCEEEEEEECCCEEEEECCCCCCCCCCCEECCCCCCEEEECCCCCCCCCEEEEC
SSEDADLVDLEGVAVRTPATYYEYLAETLTPLEWTPTRERYVLDSYGTFQYDLISGTSGA
CCCCCCEEEECCEEEECCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEEECCCCCC
DLISNDGRADNYLYRGQVRAGAGDDIIDMQLHSSLTYYGGTGDDYFVWQPPVDPNYALWI
CHHCCCCCCCCEEEEEEEECCCCCCEEEEEEECCEEEECCCCCCEEEECCCCCCCEEEEE
RLNDFRQYGEEDYIVVRSDIWGEGVSIDNITFDRMRSDGDYLEAHIVGTNGLEGTISVTQ
EEHHHHHCCCCCEEEEEECCCCCCCEECCEEHHHHCCCCCEEEEEEEECCCCCEEEEEEC
PFRSSDPLRNNDATSADFLNVDAFIFV
CCCCCCCCCCCCCCCCEEEECEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2670940 [H]