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The map label for this gene is lktA [H]

Identifier: 99081440

GI number: 99081440

Start: 1710889

End: 1711800

Strand: Reverse

Name: lktA [H]

Synonym: TM1040_1599

Alternate gene names: 99081440

Gene position: 1711800-1710889 (Counterclockwise)

Preceding gene: 99081442

Following gene: 99081439

Centisome position: 53.48

GC content: 58.22

Gene sequence:

>912_bases
ATGGCCAATGCGTACCTTCAAAGCCTCCACACCAGCGCGTCTCTTCGGCAGCTCTTGCAGTTGCGTCCCTTTGAGGCGCC
CGTGTCATCTGAAATGGGCGATAGCCGGATCGAGTTGGAGGCCGAGAACGGAACGCGCCTTGTTCTTGACGGGTCGTTCT
CTTCCGAGGACGAAGGGAGCTGGGTCATTTATGCTCTGGCGCTCTATGACGGGGCCGACACGCTGGTGTCGATCTCGGAC
ATGGCGCTCTCCTACGAGGATTTTTTTGCAGCCAATGGCAGAGAGCGCCTGAACATGGTGTTCGAAGGCGCCGATGAGAT
CACGTCTAATCTCGGCTCTGGTCTTCGTATGAATTTTCAAGCCGGCGATGACGTTATCACCCTTGGCTTCGGTGATGACG
TGATCAACGGCGGTCGTGGCAACGACACGGTGTCTGCCGGGGCAGGGAATGACACGATCAACGGCAACGCGGGCAGAGAC
CAGATCAATGGCCATGACGGAGACGACGTCCTGACGGGCGGCGGCGGTCGCGACAAGCTAAACGGTGGTGTTGGAAACGA
CGTTCTGTCCGGGAACGCGGGACGCGACAAGCTGGTCGGTGGCACTGGCAATGACACGCTCTCTGGCGGTGCGGATGATG
ATGTCCTGCGCGGTGGAACCGGCGATGACGTTCTGACCGGCGGCGCGGGCGCAGATGTGTTCAAGTTTCGGGCCAATGAC
CACACCAATGTGATTACAGACTTCGAAGTTGGCGTCGATCACATCGAGGTCCTCAAAGGCGCGCGCGGTATGCGTGGCGT
TGATTTTGAGCAAATCGGCGACGATGTGGCGGTCTATTTCGGCAACGTAACCGTGATTGTCCAAGACACCACGGTCGAGT
TGATGGACGACAGCGACAACTTCTTGTTCTGA

Upstream 100 bases:

>100_bases
CCCTGAATATCTAAAAAGCAAGTCAATCATTTGCTCAGGTTTGCGCAAAAAAGTATGGAGTTTAATAAATTCCCTGCTTT
CCGGCAAAGGACTCCAACAC

Downstream 100 bases:

>100_bases
ACGTAACTTCGTTGCGAACGTGACGCCGGAGCACTGGCGCCTTTCCTGGTGGGAATGGGCTCAGGGCGTCCGTTCCGTGT
TTAGATGGCGTAGGTCTCAA

Product: hemolysin-type calcium-binding region

Products: NA

Alternate protein names: Lkt [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MANAYLQSLHTSASLRQLLQLRPFEAPVSSEMGDSRIELEAENGTRLVLDGSFSSEDEGSWVIYALALYDGADTLVSISD
MALSYEDFFAANGRERLNMVFEGADEITSNLGSGLRMNFQAGDDVITLGFGDDVINGGRGNDTVSAGAGNDTINGNAGRD
QINGHDGDDVLTGGGGRDKLNGGVGNDVLSGNAGRDKLVGGTGNDTLSGGADDDVLRGGTGDDVLTGGAGADVFKFRAND
HTNVITDFEVGVDHIEVLKGARGMRGVDFEQIGDDVAVYFGNVTVIVQDTTVELMDDSDNFLF

Sequences:

>Translated_303_residues
MANAYLQSLHTSASLRQLLQLRPFEAPVSSEMGDSRIELEAENGTRLVLDGSFSSEDEGSWVIYALALYDGADTLVSISD
MALSYEDFFAANGRERLNMVFEGADEITSNLGSGLRMNFQAGDDVITLGFGDDVINGGRGNDTVSAGAGNDTINGNAGRD
QINGHDGDDVLTGGGGRDKLNGGVGNDVLSGNAGRDKLVGGTGNDTLSGGADDDVLRGGTGDDVLTGGAGADVFKFRAND
HTNVITDFEVGVDHIEVLKGARGMRGVDFEQIGDDVAVYFGNVTVIVQDTTVELMDDSDNFLF
>Mature_302_residues
ANAYLQSLHTSASLRQLLQLRPFEAPVSSEMGDSRIELEAENGTRLVLDGSFSSEDEGSWVIYALALYDGADTLVSISDM
ALSYEDFFAANGRERLNMVFEGADEITSNLGSGLRMNFQAGDDVITLGFGDDVINGGRGNDTVSAGAGNDTINGNAGRDQ
INGHDGDDVLTGGGGRDKLNGGVGNDVLSGNAGRDKLVGGTGNDTLSGGADDDVLRGGTGDDVLTGGAGADVFKFRANDH
TNVITDFEVGVDHIEVLKGARGMRGVDFEQIGDDVAVYFGNVTVIVQDTTVELMDDSDNFLF

Specific function: One of the virulence factors of A.actinomycetemcomitans might be a cytotoxin, possibly the membrane-bound hemolysin [H]

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein. Secreted (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: NA

Molecular weight: Translated: 31767; Mature: 31636

Theoretical pI: Translated: 3.85; Mature: 3.85

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANAYLQSLHTSASLRQLLQLRPFEAPVSSEMGDSRIELEAENGTRLVLDGSFSSEDEGS
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCC
WVIYALALYDGADTLVSISDMALSYEDFFAANGRERLNMVFEGADEITSNLGSGLRMNFQ
EEEEEEEEECCCCCEEEHHHHHCCHHHHHHCCCHHHHHEEECCHHHHHHHCCCCEEEEEE
AGDDVITLGFGDDVINGGRGNDTVSAGAGNDTINGNAGRDQINGHDGDDVLTGGGGRDKL
CCCCEEEEECCHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCC
NGGVGNDVLSGNAGRDKLVGGTGNDTLSGGADDDVLRGGTGDDVLTGGAGADVFKFRAND
CCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEECCC
HTNVITDFEVGVDHIEVLKGARGMRGVDFEQIGDDVAVYFGNVTVIVQDTTVELMDDSDN
CCCEEEEHHCCHHHHHHHHCCCCCCCCCHHHHCCCEEEEECCEEEEEECCEEEEEECCCC
FLF
CCC
>Mature Secondary Structure 
ANAYLQSLHTSASLRQLLQLRPFEAPVSSEMGDSRIELEAENGTRLVLDGSFSSEDEGS
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCC
WVIYALALYDGADTLVSISDMALSYEDFFAANGRERLNMVFEGADEITSNLGSGLRMNFQ
EEEEEEEEECCCCCEEEHHHHHCCHHHHHHCCCHHHHHEEECCHHHHHHHCCCCEEEEEE
AGDDVITLGFGDDVINGGRGNDTVSAGAGNDTINGNAGRDQINGHDGDDVLTGGGGRDKL
CCCCEEEEECCHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCC
NGGVGNDVLSGNAGRDKLVGGTGNDTLSGGADDDVLRGGTGDDVLTGGAGADVFKFRAND
CCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEECCC
HTNVITDFEVGVDHIEVLKGARGMRGVDFEQIGDDVAVYFGNVTVIVQDTTVELMDDSDN
CCCEEEEHHCCHHHHHHHHCCCCCCCCCHHHHCCCEEEEECCEEEEEECCEEEEEECCCC
FLF
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2670940 [H]