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The map label for this gene is phoR [H]

Identifier: 99081104

GI number: 99081104

Start: 1361081

End: 1362121

Strand: Reverse

Name: phoR [H]

Synonym: TM1040_1263

Alternate gene names: 99081104

Gene position: 1362121-1361081 (Counterclockwise)

Preceding gene: 99081105

Following gene: 99081103

Centisome position: 42.55

GC content: 61.77

Gene sequence:

>1041_bases
ATGTCGCAAGAGCTGATCGACGGGCTTCTGGCCGCGTTTCCGATGCCGGCTGTTTTGATCGATCAGACAGAGCGGTTGAT
TGCGGCCAATGTGGAGGGGGCGACCCTGCTTGGCCCGCAAGTCATCGGGCGTCATTTTGCAACGATCTTGCGTCAGCCCA
ATGTGACCACTGCGATCGAGGCCTGTCTTCTGGACCGCAAACCGCGCACCGCGCGCCATCTTTCCAATGATGGCGCGCAG
GACACCACCTTTGAAGTGACCCTGCGATATGTGCCGGGAGTAGGAGCCGTGAATGGCGGCGCGGTGCTCTTGTGTTTTGA
CGACATCACCGACCGCGAGCAGGCCAGCCAGATGCGGCGTGATTTTGTCGCCAATGTCAGCCACGAGCTGCGCACGCCAC
TGACCGCATTGATGGGGTTCATCGAGACCCTGCGGGGTGCTGCGCGCAATGATGCGGCGGCGCGGGATCGTTTCCTGGAA
ATCATGGAAGGCGAGGCGAGCCGGATGAATCGCCTTGTGGGGGATCTGCTGTCGCTCAACCGTGTCGAGAGCGAGGAACG
CGTACGCCCGAAGGAACGTATCGACCTCTTGGCGCATCTTCAGTCCACGATCAAATCGCTGGCGCCCCTCGCCGAGAGCG
GCGGCACCCAGCTTACGCTTGATGCGCCCGCAGGCGCAGTGGAGATCCCTGCGGATCCGGATCAGCTCCAGCAGGTTTTC
ACCAACCTCATAGAGAATGCGCTGAAATATGGTGGGGACAATGTGACCGTCTCCCTGATGGCGCTGGAGCGGGATCCCGC
GCTCAGATGTCCGGCGGTGCGGGTGCAGGTGATCGATGATGGCCCTGGCATTGATCCGGTTCACCTGCCGCGCCTGACCG
AACGATTCTATCGCGCCGACAATCACCGCTCCCGCGAGTTGGGGGGCACGGGCCTTGGACTCGCGATTGTAAAACACATC
ATCAACCGCCACCGCGGACGCCTGCGCGTCGAGAGCGACCTTGGCAAAGGCGCGACCTTCACCGTGATCTTGCCCCAATA
G

Upstream 100 bases:

>100_bases
CGCTCTGCGCGATCTTCGAGAACGCCATCACCTCTGCCATGTCCTAGTTACAATTGAACCCTAAGAAGGCCGCCACGACG
CAATGACGAGGCATAAAATC

Downstream 100 bases:

>100_bases
GTCCCGCGTCCTTCTCTTCGTTGAGACGGCTTTCACGTGCAATCCTGCGCGCGAACCATTGGTACTGGCGCGTTTTGTGA
CACAGGATTCATACTTTCTG

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MSQELIDGLLAAFPMPAVLIDQTERLIAANVEGATLLGPQVIGRHFATILRQPNVTTAIEACLLDRKPRTARHLSNDGAQ
DTTFEVTLRYVPGVGAVNGGAVLLCFDDITDREQASQMRRDFVANVSHELRTPLTALMGFIETLRGAARNDAAARDRFLE
IMEGEASRMNRLVGDLLSLNRVESEERVRPKERIDLLAHLQSTIKSLAPLAESGGTQLTLDAPAGAVEIPADPDQLQQVF
TNLIENALKYGGDNVTVSLMALERDPALRCPAVRVQVIDDGPGIDPVHLPRLTERFYRADNHRSRELGGTGLGLAIVKHI
INRHRGRLRVESDLGKGATFTVILPQ

Sequences:

>Translated_346_residues
MSQELIDGLLAAFPMPAVLIDQTERLIAANVEGATLLGPQVIGRHFATILRQPNVTTAIEACLLDRKPRTARHLSNDGAQ
DTTFEVTLRYVPGVGAVNGGAVLLCFDDITDREQASQMRRDFVANVSHELRTPLTALMGFIETLRGAARNDAAARDRFLE
IMEGEASRMNRLVGDLLSLNRVESEERVRPKERIDLLAHLQSTIKSLAPLAESGGTQLTLDAPAGAVEIPADPDQLQQVF
TNLIENALKYGGDNVTVSLMALERDPALRCPAVRVQVIDDGPGIDPVHLPRLTERFYRADNHRSRELGGTGLGLAIVKHI
INRHRGRLRVESDLGKGATFTVILPQ
>Mature_345_residues
SQELIDGLLAAFPMPAVLIDQTERLIAANVEGATLLGPQVIGRHFATILRQPNVTTAIEACLLDRKPRTARHLSNDGAQD
TTFEVTLRYVPGVGAVNGGAVLLCFDDITDREQASQMRRDFVANVSHELRTPLTALMGFIETLRGAARNDAAARDRFLEI
MEGEASRMNRLVGDLLSLNRVESEERVRPKERIDLLAHLQSTIKSLAPLAESGGTQLTLDAPAGAVEIPADPDQLQQVFT
NLIENALKYGGDNVTVSLMALERDPALRCPAVRVQVIDDGPGIDPVHLPRLTERFYRADNHRSRELGGTGLGLAIVKHII
NRHRGRLRVESDLGKGATFTVILPQ

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=345, Percent_Identity=33.3333333333333, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1788393, Length=233, Percent_Identity=33.9055793991416, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1786783, Length=279, Percent_Identity=31.1827956989247, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1790346, Length=282, Percent_Identity=32.2695035460993, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI145693157, Length=236, Percent_Identity=31.3559322033898, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1788713, Length=237, Percent_Identity=28.6919831223629, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1789149, Length=230, Percent_Identity=30.4347826086957, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI1790436, Length=230, Percent_Identity=32.6086956521739, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1786912, Length=230, Percent_Identity=30, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788549, Length=256, Percent_Identity=28.125, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI48994928, Length=274, Percent_Identity=28.1021897810219, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1789808, Length=235, Percent_Identity=30.6382978723404, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1789403, Length=216, Percent_Identity=32.4074074074074, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI87081816, Length=243, Percent_Identity=29.6296296296296, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=25.4385964912281, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790300, Length=234, Percent_Identity=29.4871794871795, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1790551, Length=236, Percent_Identity=28.3898305084746, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1790861, Length=210, Percent_Identity=30.4761904761905, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788279, Length=239, Percent_Identity=27.1966527196653, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787894, Length=227, Percent_Identity=26.431718061674, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322044, Length=73, Percent_Identity=41.0958904109589, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 37804; Mature: 37673

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQELIDGLLAAFPMPAVLIDQTERLIAANVEGATLLGPQVIGRHFATILRQPNVTTAIE
CCHHHHHHHHHHCCCCHHHHHCHHHHHEECCCCCEECCHHHHHHHHHHHHCCCCHHHHHH
ACLLDRKPRTARHLSNDGAQDTTFEVTLRYVPGVGAVNGGAVLLCFDDITDREQASQMRR
HHHHCCCCCHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHH
DFVANVSHELRTPLTALMGFIETLRGAARNDAAARDRFLEIMEGEASRMNRLVGDLLSLN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RVESEERVRPKERIDLLAHLQSTIKSLAPLAESGGTQLTLDAPAGAVEIPADPDQLQQVF
HCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCHHHHHHHH
TNLIENALKYGGDNVTVSLMALERDPALRCPAVRVQVIDDGPGIDPVHLPRLTERFYRAD
HHHHHHHHHHCCCCEEEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHCC
NHRSRELGGTGLGLAIVKHIINRHRGRLRVESDLGKGATFTVILPQ
CCCCHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECC
>Mature Secondary Structure 
SQELIDGLLAAFPMPAVLIDQTERLIAANVEGATLLGPQVIGRHFATILRQPNVTTAIE
CHHHHHHHHHHCCCCHHHHHCHHHHHEECCCCCEECCHHHHHHHHHHHHCCCCHHHHHH
ACLLDRKPRTARHLSNDGAQDTTFEVTLRYVPGVGAVNGGAVLLCFDDITDREQASQMRR
HHHHCCCCCHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHH
DFVANVSHELRTPLTALMGFIETLRGAARNDAAARDRFLEIMEGEASRMNRLVGDLLSLN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RVESEERVRPKERIDLLAHLQSTIKSLAPLAESGGTQLTLDAPAGAVEIPADPDQLQQVF
HCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCHHHHHHHH
TNLIENALKYGGDNVTVSLMALERDPALRCPAVRVQVIDDGPGIDPVHLPRLTERFYRAD
HHHHHHHHHHCCCCEEEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHCC
NHRSRELGGTGLGLAIVKHIINRHRGRLRVESDLGKGATFTVILPQ
CCCCHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]