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The map label for this gene is metC [H]

Identifier: 99081105

GI number: 99081105

Start: 1362175

End: 1363356

Strand: Reverse

Name: metC [H]

Synonym: TM1040_1264

Alternate gene names: 99081105

Gene position: 1363356-1362175 (Counterclockwise)

Preceding gene: 99081106

Following gene: 99081104

Centisome position: 42.59

GC content: 63.28

Gene sequence:

>1182_bases
GTGAAGAATTCTCGCCCCTCCGTAATGCGTCCCCATGGCCTGCCGGACAGCGCCAGCCACCCGGTTGTCACTCCGCTGAG
CCCCTCGGTCGTTTACGCGTCTGAAACCCCGGATGCGCTGGATGATCAATATGAGGGCCGCGTCCATGGCTATACCTACT
CGCGCGAGGGACACCCAAACGCGGATGTGATCGCGCGGCGGCTCGACGACATGGAAGGGGCGTCGGGCGGCGTTGTCTGT
GGCTCCGGCATGGCGGCGGTCTCAGCGGTGCTGCTGGGGCTGTTGCAAACCGGTGATCATGTCATCGGCGGCGATCAGCT
CTACGGGCGCTCGCTGCGCCTGATGAAAGAAGACCTGCCACGGCTGGGGATCGCAACAACCCTCGCCAACCCCGGTGACG
TTGCGGCGATCCGCGCGGCAATCCGCCCCGAGACCAAGCTCATTCTGGTCGAAGCCGTTTCCAATCCGACACTGGCGGTG
GCCGACATCGATGGCCTTGCAGCGCTCTGCCGCGAGCACGGTATTTTGCTGGCCGTCGACAATACCTTCACCACGCCGCG
CGCGTTCAAACCCTTTGAGCATGGTGCGGACATCGTGATCCATTCGGTGACAAAGCTGCTCGCGGGCCACTCTGATGTGA
TGCTTGGGTATGTGGTCGCCAAAGATCCGGCGCTCAATGACCGGATGCGCGTGTTCTCCGTGACCACCGGCATGACGCCA
AGCCCCTTTGACTGCTGGTTGGCGGAGCGGGGGCTGTTGTCCTTTGATCTGCGCTTTGACCGCGCCGAGGCGACGGCTGC
ACGGCTTGCGGATCACATCGCAACCCTGCCGGGCATCAAACGCGTGATCTACCCCACGCGCAAGGATCATCCCGATCATG
CGCGCGCAGAGGCGCTCCTGAAGGGGCGGGGCTGCAATATGGTGAGCTTTGAGCTTGATGGCGGACGAGAAGCGGCCAAT
GCCTTTACCCGCGCAGCAGAAGGCCTGTCCTTTGCGCCGACCTTGGGCGATGTGGGCACGACGCTCTCGCATCCGGCATC
CTCATCGCATCGGGCGCTTACGGCTGAAAACCGGGCAGAACTCGGCCTGCACGAGGGTTTCTTTCGCGTGTCCGTAGGGC
TGGAGGATCCAGAGGCGCTCTGCGCGATCTTCGAGAACGCCATCACCTCTGCCATGTCCTAG

Upstream 100 bases:

>100_bases
GCGAGGTGGACGATGCGCTTGTCGCCAAGCTCACCGCAAGCGCCATTCACTACCAGGACAACATGCGCCGTTTTAAGAAA
GACCTGAAGGAAATTTGACC

Downstream 100 bases:

>100_bases
TTACAATTGAACCCTAAGAAGGCCGCCACGACGCAATGACGAGGCATAAAATCATGTCGCAAGAGCTGATCGACGGGCTT
CTGGCCGCGTTTCCGATGCC

Product: cystathionine gamma-synthase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MKNSRPSVMRPHGLPDSASHPVVTPLSPSVVYASETPDALDDQYEGRVHGYTYSREGHPNADVIARRLDDMEGASGGVVC
GSGMAAVSAVLLGLLQTGDHVIGGDQLYGRSLRLMKEDLPRLGIATTLANPGDVAAIRAAIRPETKLILVEAVSNPTLAV
ADIDGLAALCREHGILLAVDNTFTTPRAFKPFEHGADIVIHSVTKLLAGHSDVMLGYVVAKDPALNDRMRVFSVTTGMTP
SPFDCWLAERGLLSFDLRFDRAEATAARLADHIATLPGIKRVIYPTRKDHPDHARAEALLKGRGCNMVSFELDGGREAAN
AFTRAAEGLSFAPTLGDVGTTLSHPASSSHRALTAENRAELGLHEGFFRVSVGLEDPEALCAIFENAITSAMS

Sequences:

>Translated_393_residues
MKNSRPSVMRPHGLPDSASHPVVTPLSPSVVYASETPDALDDQYEGRVHGYTYSREGHPNADVIARRLDDMEGASGGVVC
GSGMAAVSAVLLGLLQTGDHVIGGDQLYGRSLRLMKEDLPRLGIATTLANPGDVAAIRAAIRPETKLILVEAVSNPTLAV
ADIDGLAALCREHGILLAVDNTFTTPRAFKPFEHGADIVIHSVTKLLAGHSDVMLGYVVAKDPALNDRMRVFSVTTGMTP
SPFDCWLAERGLLSFDLRFDRAEATAARLADHIATLPGIKRVIYPTRKDHPDHARAEALLKGRGCNMVSFELDGGREAAN
AFTRAAEGLSFAPTLGDVGTTLSHPASSSHRALTAENRAELGLHEGFFRVSVGLEDPEALCAIFENAITSAMS
>Mature_393_residues
MKNSRPSVMRPHGLPDSASHPVVTPLSPSVVYASETPDALDDQYEGRVHGYTYSREGHPNADVIARRLDDMEGASGGVVC
GSGMAAVSAVLLGLLQTGDHVIGGDQLYGRSLRLMKEDLPRLGIATTLANPGDVAAIRAAIRPETKLILVEAVSNPTLAV
ADIDGLAALCREHGILLAVDNTFTTPRAFKPFEHGADIVIHSVTKLLAGHSDVMLGYVVAKDPALNDRMRVFSVTTGMTP
SPFDCWLAERGLLSFDLRFDRAEATAARLADHIATLPGIKRVIYPTRKDHPDHARAEALLKGRGCNMVSFELDGGREAAN
AFTRAAEGLSFAPTLGDVGTTLSHPASSSHRALTAENRAELGLHEGFFRVSVGLEDPEALCAIFENAITSAMS

Specific function: Catalyzes the transformation of cystathionine into homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=357, Percent_Identity=32.4929971988796, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI299473759, Length=357, Percent_Identity=29.4117647058824, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI25453487, Length=356, Percent_Identity=26.9662921348315, Blast_Score=149, Evalue=5e-36,
Organism=Escherichia coli, GI1790375, Length=391, Percent_Identity=35.2941176470588, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI1789383, Length=335, Percent_Identity=25.0746268656716, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17538055, Length=357, Percent_Identity=34.1736694677871, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71980708, Length=381, Percent_Identity=32.2834645669291, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17560056, Length=357, Percent_Identity=33.3333333333333, Blast_Score=205, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6319307, Length=383, Percent_Identity=32.6370757180157, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6321170, Length=313, Percent_Identity=30.3514376996805, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323333, Length=422, Percent_Identity=25.5924170616114, Blast_Score=126, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6321254, Length=356, Percent_Identity=27.247191011236, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6321904, Length=238, Percent_Identity=26.4705882352941, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19922554, Length=383, Percent_Identity=35.509138381201, Blast_Score=240, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 41846; Mature: 41846

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNSRPSVMRPHGLPDSASHPVVTPLSPSVVYASETPDALDDQYEGRVHGYTYSREGHPN
CCCCCCCCCCCCCCCCCCCCCEECCCCCCEEEECCCCCHHCCCCCCEEEEEEECCCCCCC
ADVIARRLDDMEGASGGVVCGSGMAAVSAVLLGLLQTGDHVIGGDQLYGRSLRLMKEDLP
HHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCC
RLGIATTLANPGDVAAIRAAIRPETKLILVEAVSNPTLAVADIDGLAALCREHGILLAVD
CCCEEEECCCCCCHHHHHHHHCCCCEEEEEEECCCCEEEEECCHHHHHHHHHCCEEEEEC
NTFTTPRAFKPFEHGADIVIHSVTKLLAGHSDVMLGYVVAKDPALNDRMRVFSVTTGMTP
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCC
SPFDCWLAERGLLSFDLRFDRAEATAARLADHIATLPGIKRVIYPTRKDHPDHARAEALL
CCHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCHHHHHHHH
KGRGCNMVSFELDGGREAANAFTRAAEGLSFAPTLGDVGTTLSHPASSSHRALTAENRAE
HCCCCCEEEEEECCCHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCEEECCCHHH
LGLHEGFFRVSVGLEDPEALCAIFENAITSAMS
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNSRPSVMRPHGLPDSASHPVVTPLSPSVVYASETPDALDDQYEGRVHGYTYSREGHPN
CCCCCCCCCCCCCCCCCCCCCEECCCCCCEEEECCCCCHHCCCCCCEEEEEEECCCCCCC
ADVIARRLDDMEGASGGVVCGSGMAAVSAVLLGLLQTGDHVIGGDQLYGRSLRLMKEDLP
HHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCC
RLGIATTLANPGDVAAIRAAIRPETKLILVEAVSNPTLAVADIDGLAALCREHGILLAVD
CCCEEEECCCCCCHHHHHHHHCCCCEEEEEEECCCCEEEEECCHHHHHHHHHCCEEEEEC
NTFTTPRAFKPFEHGADIVIHSVTKLLAGHSDVMLGYVVAKDPALNDRMRVFSVTTGMTP
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCC
SPFDCWLAERGLLSFDLRFDRAEATAARLADHIATLPGIKRVIYPTRKDHPDHARAEALL
CCHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCHHHHHHHH
KGRGCNMVSFELDGGREAANAFTRAAEGLSFAPTLGDVGTTLSHPASSSHRALTAENRAE
HCCCCCEEEEEECCCHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCEEECCCHHH
LGLHEGFFRVSVGLEDPEALCAIFENAITSAMS
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]