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The map label for this gene is gcvT [H]

Identifier: 99081095

GI number: 99081095

Start: 1349387

End: 1351786

Strand: Direct

Name: gcvT [H]

Synonym: TM1040_1254

Alternate gene names: 99081095

Gene position: 1349387-1351786 (Clockwise)

Preceding gene: 99081090

Following gene: 99081097

Centisome position: 42.16

GC content: 59.17

Gene sequence:

>2400_bases
ATGCCCAAAGACCTTCCCGCACACGCCTCCGTAGTCGTCATCGGCGGCGGCATCATGGGGTGTTCGACACTCTATCACCT
CGCAAAGATGGGAGCGCACGACGCGATCCTGCTCGAACGCAACCAGCTGACCTCTGGCACCACCTGGCACTCTGCGGCTC
AGGTGCGGGCGCTGCGCCATTCGCGCAACCTCACCCGAATGATCCAATACTCGGTGGAGCTCTACAGCCAGCTCGAGCGT
GAAACCGGGCAGAGTGTTGGCTGGATTCAAAAAGGCTCCCTGTCGCTGGCCACCAATCCTGACCGGCTGGTTCATATCCA
GCGGCAGGAGGCGCTTGCACATGCCTATGGTATTGAAGCGACATCGATTTCACCGCAGGAGGCCAAAGAACGCTGGCCGC
TGATGAACGCGGATGATGTGCTTGGCGCAGTGTGGTCGCCCGATGATGGCCGGGTCTCGCCTTCGGACGTCTGTGCCGCA
TTGGTCAAGGGCGCAAAATCCCTGGGTGCGCGTCTCTTTGAACAAACTGGTGTGACGGGAATTCTGACGGAGAATGGCCG
CGTCAAAGGAGTCGAAACGAGCCGCGGTGTCGTCATGTGCGATGCGATTGCCCTATGTGCGGGGCTGTGGTCGCGTGAGA
TCGGTGCCATGGCCGGGGCCGAGGTCCCTGCCCTTGCCTGCGAGCATTTCTACCTGCTGACCAAGCCGATTGACGGAATC
CAGGGCAACACGCCGACCCTCTCGGATCACGACAACCATCTGTATATTCGAGACGATTCCGGCGGGCTGCTGGTGGGTTG
TTTTGAACCCATGGGCAAAGCAATCGCGCCCGGGCGTCTTGATGAAAGCTTTGAATTTGGCCTGCTCCCCGAGGATTGGG
ACCATTTTGAGCCGATGATGCTGAACGCGCTGCACCGTTTGCCCGCATTGGAAACGGCAGAGGTCAAAATGCTGCTTAAC
GGCCCCGAGAGTTTCACGCCCGATGGCACGTTTATGCTCGGTGAAACCGCCGAGACGCGTGGGTTGTTCTTGGGGTGTGG
GATGAATTCGGTGGGGATCGCGTCGGGAGGTGGCGCGGGCATGAACCTTGCGCATGCAATCCTGCATGGCGCGCCAGCCT
ATGATCTCTCTGAAGCGGACGCAAAGCGCTTTGCGCCGGTCTTCAATTCATTGGATCACCTGATGGCGCGCGCGCCCGAG
ATCCTCGGCACCCATTACGAAATTGCATACCCGGACCGACAATTGTCTACTGCGCGCAATCTGCGCCCCCTGCCCGTTCA
CGCGGCGCATGTCTCGTCCGCTGCGCATTTTGGTCAGGTCTACGGGTGGGAACGCCCGCTTTATTTCGGAAGGACCGCGG
AACCAAGGCTGAGGTTCGAACGGCCGGACTGGTTCTCCAATGTCGCCAATGAGGTCAAGGCCGCACACACCCGTGCTGCC
GTGTTTGATGCCTCTTCCTTTGGCAAAATTGACGTGACAGGACCGGATTCTGAGGCGTTTCTTTTGCATGTTTGTTCGGG
TCACATGGCGCGCGCGCCCGGATCCGTCATCTATACCGCCATGCTGAACGAACATGGGCGGTTTGAATCTGACATCACGG
TGCACCGACTTGCGACAGATCATTACCGTTTGTTTGTCGGCACAGCGGCCATCAAGCGAGACATGGCCTGGCTTCTGCGG
CACAGCCGCGAGTTCGACGTAAAGATATGTGATACAACAGAAGATTTCGCCACCTTTGGTTTGATGGGGCCAGAGGCTAT
GCGCATTGCGCGCGATCTTGGCGCCGCAGAGCTGGCCTCACTTGGCTATTTCAAACATGGCGAAGCGATGATCGCGGGGC
ATCCTGTGCGCGCGGCCCGGCTCTCTTATGTTGGCGAGGCTGGTTGGGAAATCACCTGCAAGACTACATCCGCGCAAGAG
GTCTACACCGCGCTCCTTGATGCAGGTGCGACCCCGGCCGGGCTCTATGCGCAGACCTCCATGCGCATCGAGAAAGGGTT
CTGCGCGATGGGGCATGAATTGGACAGCGATGTAAGCCCGCTTGAGGTCGGCCTTGGTTTCGCCCTACGCAAGAGTGGTG
GCTTTATCGGTGCTCAAGCGCTTGAAGAGATGAAGAAAAAAAGCCTCAACCATCAAATCGTTTCGCTCCTGTTCGAGGAG
GTGGATGTGGTGCCGCTGGGGCATGAGCCGGTCAGTGCGCGCGGTGACATCATCGGGCATACGACCTCCTGTGCCTTTGG
CTACCGCATCGGGCGCCCGGTCGCTTTGGCTTTTTGCAAAGCGGGATTGGAAACCGGCCATGAGGTAGAGGTCAATATTG
CAGGGCGTCGGGCGACAGCGCGGGTTCAGATTGGGCCGGTGTTCGATCCTGAAGGCCTCCGGATGCGCGACATTGGCTAA

Upstream 100 bases:

>100_bases
TTTGCTCACATTGACGGGTTTCGTGATTTCATCAAGGCTTTTTTGCACGCCCGGTTCGCCGGGACACTGATCCTGATTCC
GCCCAAAATGGAATGACACC

Downstream 100 bases:

>100_bases
AACAGGGCGCGACACAGCGGTTCTAGGGGTAATTTTGCAAAAACGCACCCCAAACCCCACCAGATTGGGGGTGCTTGGAT
GAGATACCGCAAAGCGCATT

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 799; Mature: 798

Protein sequence:

>799_residues
MPKDLPAHASVVVIGGGIMGCSTLYHLAKMGAHDAILLERNQLTSGTTWHSAAQVRALRHSRNLTRMIQYSVELYSQLER
ETGQSVGWIQKGSLSLATNPDRLVHIQRQEALAHAYGIEATSISPQEAKERWPLMNADDVLGAVWSPDDGRVSPSDVCAA
LVKGAKSLGARLFEQTGVTGILTENGRVKGVETSRGVVMCDAIALCAGLWSREIGAMAGAEVPALACEHFYLLTKPIDGI
QGNTPTLSDHDNHLYIRDDSGGLLVGCFEPMGKAIAPGRLDESFEFGLLPEDWDHFEPMMLNALHRLPALETAEVKMLLN
GPESFTPDGTFMLGETAETRGLFLGCGMNSVGIASGGGAGMNLAHAILHGAPAYDLSEADAKRFAPVFNSLDHLMARAPE
ILGTHYEIAYPDRQLSTARNLRPLPVHAAHVSSAAHFGQVYGWERPLYFGRTAEPRLRFERPDWFSNVANEVKAAHTRAA
VFDASSFGKIDVTGPDSEAFLLHVCSGHMARAPGSVIYTAMLNEHGRFESDITVHRLATDHYRLFVGTAAIKRDMAWLLR
HSREFDVKICDTTEDFATFGLMGPEAMRIARDLGAAELASLGYFKHGEAMIAGHPVRAARLSYVGEAGWEITCKTTSAQE
VYTALLDAGATPAGLYAQTSMRIEKGFCAMGHELDSDVSPLEVGLGFALRKSGGFIGAQALEEMKKKSLNHQIVSLLFEE
VDVVPLGHEPVSARGDIIGHTTSCAFGYRIGRPVALAFCKAGLETGHEVEVNIAGRRATARVQIGPVFDPEGLRMRDIG

Sequences:

>Translated_799_residues
MPKDLPAHASVVVIGGGIMGCSTLYHLAKMGAHDAILLERNQLTSGTTWHSAAQVRALRHSRNLTRMIQYSVELYSQLER
ETGQSVGWIQKGSLSLATNPDRLVHIQRQEALAHAYGIEATSISPQEAKERWPLMNADDVLGAVWSPDDGRVSPSDVCAA
LVKGAKSLGARLFEQTGVTGILTENGRVKGVETSRGVVMCDAIALCAGLWSREIGAMAGAEVPALACEHFYLLTKPIDGI
QGNTPTLSDHDNHLYIRDDSGGLLVGCFEPMGKAIAPGRLDESFEFGLLPEDWDHFEPMMLNALHRLPALETAEVKMLLN
GPESFTPDGTFMLGETAETRGLFLGCGMNSVGIASGGGAGMNLAHAILHGAPAYDLSEADAKRFAPVFNSLDHLMARAPE
ILGTHYEIAYPDRQLSTARNLRPLPVHAAHVSSAAHFGQVYGWERPLYFGRTAEPRLRFERPDWFSNVANEVKAAHTRAA
VFDASSFGKIDVTGPDSEAFLLHVCSGHMARAPGSVIYTAMLNEHGRFESDITVHRLATDHYRLFVGTAAIKRDMAWLLR
HSREFDVKICDTTEDFATFGLMGPEAMRIARDLGAAELASLGYFKHGEAMIAGHPVRAARLSYVGEAGWEITCKTTSAQE
VYTALLDAGATPAGLYAQTSMRIEKGFCAMGHELDSDVSPLEVGLGFALRKSGGFIGAQALEEMKKKSLNHQIVSLLFEE
VDVVPLGHEPVSARGDIIGHTTSCAFGYRIGRPVALAFCKAGLETGHEVEVNIAGRRATARVQIGPVFDPEGLRMRDIG
>Mature_798_residues
PKDLPAHASVVVIGGGIMGCSTLYHLAKMGAHDAILLERNQLTSGTTWHSAAQVRALRHSRNLTRMIQYSVELYSQLERE
TGQSVGWIQKGSLSLATNPDRLVHIQRQEALAHAYGIEATSISPQEAKERWPLMNADDVLGAVWSPDDGRVSPSDVCAAL
VKGAKSLGARLFEQTGVTGILTENGRVKGVETSRGVVMCDAIALCAGLWSREIGAMAGAEVPALACEHFYLLTKPIDGIQ
GNTPTLSDHDNHLYIRDDSGGLLVGCFEPMGKAIAPGRLDESFEFGLLPEDWDHFEPMMLNALHRLPALETAEVKMLLNG
PESFTPDGTFMLGETAETRGLFLGCGMNSVGIASGGGAGMNLAHAILHGAPAYDLSEADAKRFAPVFNSLDHLMARAPEI
LGTHYEIAYPDRQLSTARNLRPLPVHAAHVSSAAHFGQVYGWERPLYFGRTAEPRLRFERPDWFSNVANEVKAAHTRAAV
FDASSFGKIDVTGPDSEAFLLHVCSGHMARAPGSVIYTAMLNEHGRFESDITVHRLATDHYRLFVGTAAIKRDMAWLLRH
SREFDVKICDTTEDFATFGLMGPEAMRIARDLGAAELASLGYFKHGEAMIAGHPVRAARLSYVGEAGWEITCKTTSAQEV
YTALLDAGATPAGLYAQTSMRIEKGFCAMGHELDSDVSPLEVGLGFALRKSGGFIGAQALEEMKKKSLNHQIVSLLFEEV
DVVPLGHEPVSARGDIIGHTTSCAFGYRIGRPVALAFCKAGLETGHEVEVNIAGRRATARVQIGPVFDPEGLRMRDIG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI197927446, Length=870, Percent_Identity=35.9770114942529, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI21361378, Length=870, Percent_Identity=35.9770114942529, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI194306651, Length=823, Percent_Identity=34.9939246658566, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI24797151, Length=815, Percent_Identity=32.1472392638037, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI257796258, Length=360, Percent_Identity=24.7222222222222, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI44662838, Length=360, Percent_Identity=24.7222222222222, Blast_Score=82, Evalue=3e-15,
Organism=Homo sapiens, GI257796256, Length=284, Percent_Identity=25, Blast_Score=73, Evalue=9e-13,
Organism=Escherichia coli, GI1789272, Length=381, Percent_Identity=28.0839895013123, Blast_Score=130, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI32563613, Length=821, Percent_Identity=29.8416565164434, Blast_Score=340, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI71994045, Length=828, Percent_Identity=25.8454106280193, Blast_Score=251, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI71994052, Length=835, Percent_Identity=25.6287425149701, Blast_Score=249, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI17560118, Length=348, Percent_Identity=25.8620689655172, Blast_Score=101, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320222, Length=285, Percent_Identity=27.719298245614, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28571104, Length=826, Percent_Identity=31.8401937046005, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI20130091, Length=856, Percent_Identity=30.1401869158879, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI20129441, Length=354, Percent_Identity=26.8361581920904, Blast_Score=101, Evalue=2e-21,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 86427; Mature: 86296

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKDLPAHASVVVIGGGIMGCSTLYHLAKMGAHDAILLERNQLTSGTTWHSAAQVRALRH
CCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHH
SRNLTRMIQYSVELYSQLERETGQSVGWIQKGSLSLATNPDRLVHIQRQEALAHAYGIEA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCEEEECCCCCEEEEHHHHHHHHHHCCCC
TSISPQEAKERWPLMNADDVLGAVWSPDDGRVSPSDVCAALVKGAKSLGARLFEQTGVTG
CCCCHHHHHHHCCCCCHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
ILTENGRVKGVETSRGVVMCDAIALCAGLWSREIGAMAGAEVPALACEHFYLLTKPIDGI
EEECCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCEEEEECCCCCC
QGNTPTLSDHDNHLYIRDDSGGLLVGCFEPMGKAIAPGRLDESFEFGLLPEDWDHFEPMM
CCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
LNALHRLPALETAEVKMLLNGPESFTPDGTFMLGETAETRGLFLGCGMNSVGIASGGGAG
HHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCEEEECCCCCCCCCCCCCCC
MNLAHAILHGAPAYDLSEADAKRFAPVFNSLDHLMARAPEILGTHYEIAYPDRQLSTARN
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHCCCEEEECCCHHHHHHHC
LRPLPVHAAHVSSAAHFGQVYGWERPLYFGRTAEPRLRFERPDWFSNVANEVKAAHTRAA
CCCCCEEHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEECCCHHHHHHHHHHHHHHHHHE
VFDASSFGKIDVTGPDSEAFLLHVCSGHMARAPGSVIYTAMLNEHGRFESDITVHRLATD
EEECCCCCEEEECCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEECC
HYRLFVGTAAIKRDMAWLLRHSREFDVKICDTTEDFATFGLMGPEAMRIARDLGAAELAS
CEEEEEEHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHCCCCHHHHHHHHHCCHHHHHH
LGYFKHGEAMIAGHPVRAARLSYVGEAGWEITCKTTSAQEVYTALLDAGATPAGLYAQTS
CCCEECCCEEEECCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCEEHHH
MRIEKGFCAMGHELDSDVSPLEVGLGFALRKSGGFIGAQALEEMKKKSLNHQIVSLLFEE
HHHHCCHHHCCCCCCCCCCCHHHCCCEEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHH
VDVVPLGHEPVSARGDIIGHTTSCAFGYRIGRPVALAFCKAGLETGHEVEVNIAGRRATA
CCEEECCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCEEE
RVQIGPVFDPEGLRMRDIG
EEEECCCCCCCCCEECCCC
>Mature Secondary Structure 
PKDLPAHASVVVIGGGIMGCSTLYHLAKMGAHDAILLERNQLTSGTTWHSAAQVRALRH
CCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHH
SRNLTRMIQYSVELYSQLERETGQSVGWIQKGSLSLATNPDRLVHIQRQEALAHAYGIEA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCEEEECCCCCEEEEHHHHHHHHHHCCCC
TSISPQEAKERWPLMNADDVLGAVWSPDDGRVSPSDVCAALVKGAKSLGARLFEQTGVTG
CCCCHHHHHHHCCCCCHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
ILTENGRVKGVETSRGVVMCDAIALCAGLWSREIGAMAGAEVPALACEHFYLLTKPIDGI
EEECCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCEEEEECCCCCC
QGNTPTLSDHDNHLYIRDDSGGLLVGCFEPMGKAIAPGRLDESFEFGLLPEDWDHFEPMM
CCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
LNALHRLPALETAEVKMLLNGPESFTPDGTFMLGETAETRGLFLGCGMNSVGIASGGGAG
HHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCEEEECCCCCCCCCCCCCCC
MNLAHAILHGAPAYDLSEADAKRFAPVFNSLDHLMARAPEILGTHYEIAYPDRQLSTARN
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHCCCEEEECCCHHHHHHHC
LRPLPVHAAHVSSAAHFGQVYGWERPLYFGRTAEPRLRFERPDWFSNVANEVKAAHTRAA
CCCCCEEHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEECCCHHHHHHHHHHHHHHHHHE
VFDASSFGKIDVTGPDSEAFLLHVCSGHMARAPGSVIYTAMLNEHGRFESDITVHRLATD
EEECCCCCEEEECCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEECC
HYRLFVGTAAIKRDMAWLLRHSREFDVKICDTTEDFATFGLMGPEAMRIARDLGAAELAS
CEEEEEEHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHCCCCHHHHHHHHHCCHHHHHH
LGYFKHGEAMIAGHPVRAARLSYVGEAGWEITCKTTSAQEVYTALLDAGATPAGLYAQTS
CCCEECCCEEEECCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCEEHHH
MRIEKGFCAMGHELDSDVSPLEVGLGFALRKSGGFIGAQALEEMKKKSLNHQIVSLLFEE
HHHHCCHHHCCCCCCCCCCCHHHCCCEEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHH
VDVVPLGHEPVSARGDIIGHTTSCAFGYRIGRPVALAFCKAGLETGHEVEVNIAGRRATA
CCEEECCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCEEE
RVQIGPVFDPEGLRMRDIG
EEEECCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA