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The map label for this gene is csd [H]

Identifier: 99081090

GI number: 99081090

Start: 1342754

End: 1343974

Strand: Direct

Name: csd [H]

Synonym: TM1040_1249

Alternate gene names: 99081090

Gene position: 1342754-1343974 (Clockwise)

Preceding gene: 99081089

Following gene: 99081095

Centisome position: 41.95

GC content: 54.05

Gene sequence:

>1221_bases
ATGTATGATGTCGAAAAAATCCGCTCTGACTTTCCGATCCTGTCACGCGAAGTGAACGGAAAGCCGCTGGTCTATCTCGA
TAACGGGGCCTCTGCGCAGAAACCTCAGGTTGTGATCGATGCCGTGACCAAGGCATACGCGGAAGAATATTCAAATGTTC
ACCGTGGCTTGCATTATCTTTCTAATCTCGCGACTGAGAAATACGAAAGCGTACGCGGCATCATCGCAAAGTTTTTGAAC
GCGGGTCACGAAGATCACATCGTGCTGAATTCCGGAACCACAGAGGGTATCAACCTCGTGGCGTATTCCTGGGCCATGCC
GCGGATGGAAGCCGGCGATGAGATCATCCTCTCCGTCATGGAGCACCATGCGAACATCGTGCCCTGGCATTTCCTGCGCG
AACGCCAAGGTGTCGTCATCAAATGGATCGACACGGACGCGGACGGAAGCCTGGACCCGCAAAAGGTTCTGGACGCCATT
ACACCAAAAACCAAGCTGATCGCAGTCACCCAGTGTTCCAATGTCTTGGGAACCGTTGTTGATGTAAAATCCATCACAAA
AGGCGCGCATGACAAAGGCGTGCCAGTGCTTGTCGACGGCTCTCAGGGCGCGGTTCACATGCCCGTGGATGTGCAGGATC
TCGACTGTGATTTCTATGCCGTCACCGGGCACAAGCTTTATGGTCCGTCTGGGTCCGGCGCGATCTATATCAAGCCGGAG
CGTATGGCCGAGATGCGTCCGTTTATTGGCGGCGGCGATATGATCAAAGAAGTGTCCAAGGATCAGGTGATCTACAACGA
TCCGCCGATGAAGTTCGAGGCTGGTACGCCAGGGATCGTGCAGACGATCGGTTTCGGCGTCGCGCTCGAATATATGATGG
AGATCGGAATGGCAGAAATTGCCGCCCATGAGGCCGATCTGCGAGACTATGCATCGGAGCGTTTCAAGGGGTTGAACTGG
TTGAATATTCAGGGCCATGCTCCTGGAAAAGCAGCGATATTCAGTCTGACCCTTGAGGGCGCGGCACATGCGCATGACAT
TTCAACCATTCTCGACAAGAAAGGTGTCGCGGTGCGTGCCGGGCATCATTGTGCGGGGCCTTTGATGGATCATCTTGGCG
TCTCTGCAACTTGCCGCGCGAGCTTTGGCATGTACAACACGCGTCCAGAGGTAGATACGTTGATTGAGGCGCTAGAACTC
GCACATGAGCTTTTTGGCTAG

Upstream 100 bases:

>100_bases
GGCAAATCTGCAGGCGTGATCCTGTTGGCCGGGCTTGGTGCGATGATCGCTGTTTTGATCCTGATGGGCCTTTTTGCGCC
CACAATTCTGGAGACGTCCA

Downstream 100 bases:

>100_bases
GACTGGTGGGGCTCCAATCGGAGTGTATGCTCTATAGTAGCATATTTTACATAATACTGATTATGGGATTTGTATTCGCC
CTCATATCCAGCGTCGATCA

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MYDVEKIRSDFPILSREVNGKPLVYLDNGASAQKPQVVIDAVTKAYAEEYSNVHRGLHYLSNLATEKYESVRGIIAKFLN
AGHEDHIVLNSGTTEGINLVAYSWAMPRMEAGDEIILSVMEHHANIVPWHFLRERQGVVIKWIDTDADGSLDPQKVLDAI
TPKTKLIAVTQCSNVLGTVVDVKSITKGAHDKGVPVLVDGSQGAVHMPVDVQDLDCDFYAVTGHKLYGPSGSGAIYIKPE
RMAEMRPFIGGGDMIKEVSKDQVIYNDPPMKFEAGTPGIVQTIGFGVALEYMMEIGMAEIAAHEADLRDYASERFKGLNW
LNIQGHAPGKAAIFSLTLEGAAHAHDISTILDKKGVAVRAGHHCAGPLMDHLGVSATCRASFGMYNTRPEVDTLIEALEL
AHELFG

Sequences:

>Translated_406_residues
MYDVEKIRSDFPILSREVNGKPLVYLDNGASAQKPQVVIDAVTKAYAEEYSNVHRGLHYLSNLATEKYESVRGIIAKFLN
AGHEDHIVLNSGTTEGINLVAYSWAMPRMEAGDEIILSVMEHHANIVPWHFLRERQGVVIKWIDTDADGSLDPQKVLDAI
TPKTKLIAVTQCSNVLGTVVDVKSITKGAHDKGVPVLVDGSQGAVHMPVDVQDLDCDFYAVTGHKLYGPSGSGAIYIKPE
RMAEMRPFIGGGDMIKEVSKDQVIYNDPPMKFEAGTPGIVQTIGFGVALEYMMEIGMAEIAAHEADLRDYASERFKGLNW
LNIQGHAPGKAAIFSLTLEGAAHAHDISTILDKKGVAVRAGHHCAGPLMDHLGVSATCRASFGMYNTRPEVDTLIEALEL
AHELFG
>Mature_406_residues
MYDVEKIRSDFPILSREVNGKPLVYLDNGASAQKPQVVIDAVTKAYAEEYSNVHRGLHYLSNLATEKYESVRGIIAKFLN
AGHEDHIVLNSGTTEGINLVAYSWAMPRMEAGDEIILSVMEHHANIVPWHFLRERQGVVIKWIDTDADGSLDPQKVLDAI
TPKTKLIAVTQCSNVLGTVVDVKSITKGAHDKGVPVLVDGSQGAVHMPVDVQDLDCDFYAVTGHKLYGPSGSGAIYIKPE
RMAEMRPFIGGGDMIKEVSKDQVIYNDPPMKFEAGTPGIVQTIGFGVALEYMMEIGMAEIAAHEADLRDYASERFKGLNW
LNIQGHAPGKAAIFSLTLEGAAHAHDISTILDKKGVAVRAGHHCAGPLMDHLGVSATCRASFGMYNTRPEVDTLIEALEL
AHELFG

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI156713448, Length=427, Percent_Identity=26.9320843091335, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI32307132, Length=403, Percent_Identity=23.3250620347395, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI1787970, Length=407, Percent_Identity=48.1572481572482, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1789175, Length=408, Percent_Identity=40.4411764705882, Blast_Score=303, Evalue=1e-83,
Organism=Escherichia coli, GI48994898, Length=357, Percent_Identity=26.0504201680672, Blast_Score=99, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI25143064, Length=229, Percent_Identity=27.5109170305677, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI193211090, Length=376, Percent_Identity=24.468085106383, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17533177, Length=335, Percent_Identity=24.7761194029851, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319831, Length=398, Percent_Identity=23.1155778894472, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI20129463, Length=242, Percent_Identity=27.2727272727273, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44230; Mature: 44230

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDVEKIRSDFPILSREVNGKPLVYLDNGASAQKPQVVIDAVTKAYAEEYSNVHRGLHYL
CCCHHHHHCCCCEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SNLATEKYESVRGIIAKFLNAGHEDHIVLNSGTTEGINLVAYSWAMPRMEAGDEIILSVM
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHH
EHHANIVPWHFLRERQGVVIKWIDTDADGSLDPQKVLDAITPKTKLIAVTQCSNVLGTVV
HHCCCCCCHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCEEEEEEHHHHHHHHHH
DVKSITKGAHDKGVPVLVDGSQGAVHMPVDVQDLDCDFYAVTGHKLYGPSGSGAIYIKPE
HHHHHHCCCCCCCCEEEEECCCCCEECCCCCEECCCCEEEEECCEEECCCCCCEEEECHH
RMAEMRPFIGGGDMIKEVSKDQVIYNDPPMKFEAGTPGIVQTIGFGVALEYMMEIGMAEI
HHHHHCCCCCCHHHHHHHCCCCEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHCHHHH
AAHEADLRDYASERFKGLNWLNIQGHAPGKAAIFSLTLEGAAHAHDISTILDKKGVAVRA
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCEEEC
GHHCAGPLMDHLGVSATCRASFGMYNTRPEVDTLIEALELAHELFG
CCCCCHHHHHHCCCCEEEHHHCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYDVEKIRSDFPILSREVNGKPLVYLDNGASAQKPQVVIDAVTKAYAEEYSNVHRGLHYL
CCCHHHHHCCCCEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SNLATEKYESVRGIIAKFLNAGHEDHIVLNSGTTEGINLVAYSWAMPRMEAGDEIILSVM
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHH
EHHANIVPWHFLRERQGVVIKWIDTDADGSLDPQKVLDAITPKTKLIAVTQCSNVLGTVV
HHCCCCCCHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCEEEEEEHHHHHHHHHH
DVKSITKGAHDKGVPVLVDGSQGAVHMPVDVQDLDCDFYAVTGHKLYGPSGSGAIYIKPE
HHHHHHCCCCCCCCEEEEECCCCCEECCCCCEECCCCEEEEECCEEECCCCCCEEEECHH
RMAEMRPFIGGGDMIKEVSKDQVIYNDPPMKFEAGTPGIVQTIGFGVALEYMMEIGMAEI
HHHHHCCCCCCHHHHHHHCCCCEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHCHHHH
AAHEADLRDYASERFKGLNWLNIQGHAPGKAAIFSLTLEGAAHAHDISTILDKKGVAVRA
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCEEEC
GHHCAGPLMDHLGVSATCRASFGMYNTRPEVDTLIEALELAHELFG
CCCCCHHHHHHCCCCEEEHHHCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]