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The map label for this gene is gcvT [H]

Identifier: 99081014

GI number: 99081014

Start: 1262504

End: 1263646

Strand: Reverse

Name: gcvT [H]

Synonym: TM1040_1173

Alternate gene names: 99081014

Gene position: 1263646-1262504 (Counterclockwise)

Preceding gene: 99081015

Following gene: 99081013

Centisome position: 39.48

GC content: 59.49

Gene sequence:

>1143_bases
ATGACGCAAGCAGACGATTTCGGCTTTGGCACCCAGATCCGCAAATCCCCGTATTTCGACGCCACCGTGCGTTGGGGAGC
AAAGGGTTTTTCCGTTTACAATCATATGTATATCCCGCGCGACTTTGGCGATCCGGAGCAGAACTTCTGGAACCTCGTCA
ACGATGCAATCCTATGCGATGTCGCGGTCGAGCGCCAGGTGGAGATCACCGGACCGGATGCGGCAAAATTCGTTCAGATG
CTCACTCCGCGCGACCTGTCGACCATGGCCGTGGGTCAGTGCAAATACATCCTGATCACCAATGCCGAAGGCGGCATCTT
GAACGACCCGATCCTGCTGCGGCTGGCTGAAAACCACTTCTGGATTTCGCTTGCTGACAGCGACATCCTGCTCTGGGCGC
AGGGCGTGGCGGTGCACTCTGGCCTGGATGTGCAGATTTGCGAACCGGACGTCTCTCCGCTGCAGCTGCAGGGGCCGAAA
TCTGGGCTGGTGATGCAGGAGCTCTTTGGCGAGAGCATCATGGACCTCAAATACTACTGGCTGCGCGAACTCGACCTCGA
TGGTATCCCGTTGATTGTCTCGCGCACCGGCTGGTCGAGCGAGCTTGGCTATGAGCTCTATCTGCGCGACGGAAGCCAGG
GCGACGCACTCTGGGAACGGATCATGGCGGCGGGGATGCAGCATGGTTTGAAGCCGGGCCACACCTCCTCCATTCGCCGG
ATCGAAGGGGGCATGCTCTCTTATCATGCGGATGCCGATATTCACACCAACCCCTTCGAGCTGGGCTTTGACCGGCTTGT
AAACCTCGACATGGAAGCCGACTTCATCGGCAAGGCGGCGCTCAAGCGCATCCAAAAGGAAGGTCCCGCACGCCTGCAGG
TTGGTCTGGTAATCGACGCCGCACCGCTGCGGGGGCCCAACACCACGTTCTGGCCGATCACCAAGAATGGCGAAACCATC
GGCAAGGTCACATCCGCCGTCTATTCCCCGCGCCTTGAAAAGAACATCGCCCTGGCGATGGTGGACGCCGAACACGCGGT
GATCGGCAGCGACGTTGAGGTGACAATGACCTCGGGTGCAACCTCTGCCAGCGTTGTGGAGCGTCCCTTCTTTGATCCGC
GCAAGCAGATTGCCGCCGCCTGA

Upstream 100 bases:

>100_bases
TTGAAAACTCCGGACCAAATTGCGCGCGTTTTTCGATCTAAATCGTCGTCGAACACAGGCTTGTCTCGGCCGATCTGGCC
GACCGTTGGGAGGACGACAC

Downstream 100 bases:

>100_bases
GCGTTGGAGAGGAGACCAAAACATGTCCCATCTCGCGATCGAATTGCACTGGCAACGTACTGAAAACGAACTGCAAACCG
GTAAGTTCTCGAACGAGCAC

Product: glycine cleavage T protein (aminomethyl transferase)

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MTQADDFGFGTQIRKSPYFDATVRWGAKGFSVYNHMYIPRDFGDPEQNFWNLVNDAILCDVAVERQVEITGPDAAKFVQM
LTPRDLSTMAVGQCKYILITNAEGGILNDPILLRLAENHFWISLADSDILLWAQGVAVHSGLDVQICEPDVSPLQLQGPK
SGLVMQELFGESIMDLKYYWLRELDLDGIPLIVSRTGWSSELGYELYLRDGSQGDALWERIMAAGMQHGLKPGHTSSIRR
IEGGMLSYHADADIHTNPFELGFDRLVNLDMEADFIGKAALKRIQKEGPARLQVGLVIDAAPLRGPNTTFWPITKNGETI
GKVTSAVYSPRLEKNIALAMVDAEHAVIGSDVEVTMTSGATSASVVERPFFDPRKQIAAA

Sequences:

>Translated_380_residues
MTQADDFGFGTQIRKSPYFDATVRWGAKGFSVYNHMYIPRDFGDPEQNFWNLVNDAILCDVAVERQVEITGPDAAKFVQM
LTPRDLSTMAVGQCKYILITNAEGGILNDPILLRLAENHFWISLADSDILLWAQGVAVHSGLDVQICEPDVSPLQLQGPK
SGLVMQELFGESIMDLKYYWLRELDLDGIPLIVSRTGWSSELGYELYLRDGSQGDALWERIMAAGMQHGLKPGHTSSIRR
IEGGMLSYHADADIHTNPFELGFDRLVNLDMEADFIGKAALKRIQKEGPARLQVGLVIDAAPLRGPNTTFWPITKNGETI
GKVTSAVYSPRLEKNIALAMVDAEHAVIGSDVEVTMTSGATSASVVERPFFDPRKQIAAA
>Mature_379_residues
TQADDFGFGTQIRKSPYFDATVRWGAKGFSVYNHMYIPRDFGDPEQNFWNLVNDAILCDVAVERQVEITGPDAAKFVQML
TPRDLSTMAVGQCKYILITNAEGGILNDPILLRLAENHFWISLADSDILLWAQGVAVHSGLDVQICEPDVSPLQLQGPKS
GLVMQELFGESIMDLKYYWLRELDLDGIPLIVSRTGWSSELGYELYLRDGSQGDALWERIMAAGMQHGLKPGHTSSIRRI
EGGMLSYHADADIHTNPFELGFDRLVNLDMEADFIGKAALKRIQKEGPARLQVGLVIDAAPLRGPNTTFWPITKNGETIG
KVTSAVYSPRLEKNIALAMVDAEHAVIGSDVEVTMTSGATSASVVERPFFDPRKQIAAA

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI24797151, Length=249, Percent_Identity=32.1285140562249, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI44662838, Length=376, Percent_Identity=26.063829787234, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI257796258, Length=365, Percent_Identity=26.3013698630137, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI257796256, Length=331, Percent_Identity=27.190332326284, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI194306651, Length=388, Percent_Identity=26.8041237113402, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI197927446, Length=309, Percent_Identity=25.8899676375405, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI21361378, Length=309, Percent_Identity=25.8899676375405, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1789272, Length=339, Percent_Identity=25.0737463126844, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17560118, Length=333, Percent_Identity=29.1291291291291, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI32563613, Length=303, Percent_Identity=27.0627062706271, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994052, Length=331, Percent_Identity=25.9818731117825, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71994045, Length=331, Percent_Identity=25.9818731117825, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320222, Length=388, Percent_Identity=25, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI20129441, Length=326, Percent_Identity=28.2208588957055, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28571104, Length=291, Percent_Identity=26.1168384879725, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 41931; Mature: 41800

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQADDFGFGTQIRKSPYFDATVRWGAKGFSVYNHMYIPRDFGDPEQNFWNLVNDAILCD
CCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHEEEE
VAVERQVEITGPDAAKFVQMLTPRDLSTMAVGQCKYILITNAEGGILNDPILLRLAENHF
EEEEEEEEECCCCHHHHHHHHCCCCCCCEEECCEEEEEEECCCCCCCCCCEEEEEECCEE
WISLADSDILLWAQGVAVHSGLDVQICEPDVSPLQLQGPKSGLVMQELFGESIMDLKYYW
EEEEECCCEEEEECCEEEECCCEEEEECCCCCCEEECCCCCCHHHHHHHCCHHHHHHHHH
LRELDLDGIPLIVSRTGWSSELGYELYLRDGSQGDALWERIMAAGMQHGLKPGHTSSIRR
HHHCCCCCCEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHH
IEGGMLSYHADADIHTNPFELGFDRLVNLDMEADFIGKAALKRIQKEGPARLQVGLVIDA
HCCCEEEEECCCCCCCCCHHHCHHHHEECCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEE
APLRGPNTTFWPITKNGETIGKVTSAVYSPRLEKNIALAMVDAEHAVIGSDVEVTMTSGA
CCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCEEEEEEECCCEEECCCEEEEEECCC
TSASVVERPFFDPRKQIAAA
CCHHHHHCCCCCCHHHHCCC
>Mature Secondary Structure 
TQADDFGFGTQIRKSPYFDATVRWGAKGFSVYNHMYIPRDFGDPEQNFWNLVNDAILCD
CCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHEEEE
VAVERQVEITGPDAAKFVQMLTPRDLSTMAVGQCKYILITNAEGGILNDPILLRLAENHF
EEEEEEEEECCCCHHHHHHHHCCCCCCCEEECCEEEEEEECCCCCCCCCCEEEEEECCEE
WISLADSDILLWAQGVAVHSGLDVQICEPDVSPLQLQGPKSGLVMQELFGESIMDLKYYW
EEEEECCCEEEEECCEEEECCCEEEEECCCCCCEEECCCCCCHHHHHHHCCHHHHHHHHH
LRELDLDGIPLIVSRTGWSSELGYELYLRDGSQGDALWERIMAAGMQHGLKPGHTSSIRR
HHHCCCCCCEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHH
IEGGMLSYHADADIHTNPFELGFDRLVNLDMEADFIGKAALKRIQKEGPARLQVGLVIDA
HCCCEEEEECCCCCCCCCHHHCHHHHEECCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEE
APLRGPNTTFWPITKNGETIGKVTSAVYSPRLEKNIALAMVDAEHAVIGSDVEVTMTSGA
CCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCEEEEEEECCCEEECCCEEEEEECCC
TSASVVERPFFDPRKQIAAA
CCHHHHHCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA