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The map label for this gene is lrp [H]

Identifier: 99081015

GI number: 99081015

Start: 1263806

End: 1264339

Strand: Reverse

Name: lrp [H]

Synonym: TM1040_1174

Alternate gene names: 99081015

Gene position: 1264339-1263806 (Counterclockwise)

Preceding gene: 99081017

Following gene: 99081014

Centisome position: 39.5

GC content: 56.18

Gene sequence:

>534_bases
ATGATTCTTCAGGGCGTTCGACTGGATGGATGTGTCACACAAATGAAGAAGCAAGGTCTCGACGCGACAGAAATTCGGAT
CCTGAGCGCCGTGCAGCAACACGGCCAACTGAGCAAGACCCGGCTTGCGGAGCTTGTGAACCTCTCGCCCACTCCCTGTT
GGGCGCGCCTGGTACGGCTCAAGGCCGCTGGCTATATTCGCGGCTATCATGCCGAATTGGCACTCGACCGGATCATTGAT
TTTACCCAAGTGGTCGTCACCATCTCGCTCACCCATCACCGCAAGACGGATTTTGACAGGTTTGAAACCTACATCCGCGG
ACTTGATGAAGTGATCGACTGTGTCGCCACCGGAGGTGGCATGGATTATGTCATGAAGGTCGCCACCCCCACGCTTGCCG
CCTTTCAGAGCCTCATGGATGAGATGCTCTCGGCCGAGCTCTCCATCGATCGCTACATGACCTACATCGCGACTCGTCAG
ATCAAGACGAGCCGCCCGAACCTCGCGAAACTGGTCGCCAAAAGCGAGAAATGA

Upstream 100 bases:

>100_bases
CGGGAAAATGAAAAATTGACGTGGCCATATGAGGAACGGTCGGAAACCCCGCTCAGGACAGCGGAAATTTCATTCATGAT
CGAGCCAGTAGCCCCTGTGG

Downstream 100 bases:

>100_bases
CCCGACAAGTCTGATCTGTCCAAAACGGGCGTCAAAATTGGTCTGAACGGTCTGAGAATTTGAAAACTCCGGACCAAATT
GCGCGCGTTTTTCGATCTAA

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MILQGVRLDGCVTQMKKQGLDATEIRILSAVQQHGQLSKTRLAELVNLSPTPCWARLVRLKAAGYIRGYHAELALDRIID
FTQVVVTISLTHHRKTDFDRFETYIRGLDEVIDCVATGGGMDYVMKVATPTLAAFQSLMDEMLSAELSIDRYMTYIATRQ
IKTSRPNLAKLVAKSEK

Sequences:

>Translated_177_residues
MILQGVRLDGCVTQMKKQGLDATEIRILSAVQQHGQLSKTRLAELVNLSPTPCWARLVRLKAAGYIRGYHAELALDRIID
FTQVVVTISLTHHRKTDFDRFETYIRGLDEVIDCVATGGGMDYVMKVATPTLAAFQSLMDEMLSAELSIDRYMTYIATRQ
IKTSRPNLAKLVAKSEK
>Mature_177_residues
MILQGVRLDGCVTQMKKQGLDATEIRILSAVQQHGQLSKTRLAELVNLSPTPCWARLVRLKAAGYIRGYHAELALDRIID
FTQVVVTISLTHHRKTDFDRFETYIRGLDEVIDCVATGGGMDYVMKVATPTLAAFQSLMDEMLSAELSIDRYMTYIATRQ
IKTSRPNLAKLVAKSEK

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=155, Percent_Identity=32.258064516129, Blast_Score=90, Evalue=9e-20,
Organism=Escherichia coli, GI87081742, Length=149, Percent_Identity=31.5436241610738, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 19847; Mature: 19847

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILQGVRLDGCVTQMKKQGLDATEIRILSAVQQHGQLSKTRLAELVNLSPTPCWARLVRL
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHH
KAAGYIRGYHAELALDRIIDFTQVVVTISLTHHRKTDFDRFETYIRGLDEVIDCVATGGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
MDYVMKVATPTLAAFQSLMDEMLSAELSIDRYMTYIATRQIKTSRPNLAKLVAKSEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
>Mature Secondary Structure
MILQGVRLDGCVTQMKKQGLDATEIRILSAVQQHGQLSKTRLAELVNLSPTPCWARLVRL
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHH
KAAGYIRGYHAELALDRIIDFTQVVVTISLTHHRKTDFDRFETYIRGLDEVIDCVATGGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
MDYVMKVATPTLAAFQSLMDEMLSAELSIDRYMTYIATRQIKTSRPNLAKLVAKSEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]