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The map label for this gene is hemA [H]

Identifier: 161899030

GI number: 161899030

Start: 913262

End: 914491

Strand: Direct

Name: hemA [H]

Synonym: TM1040_0860

Alternate gene names: 161899030

Gene position: 913262-914491 (Clockwise)

Preceding gene: 99080699

Following gene: 99080702

Centisome position: 28.53

GC content: 59.59

Gene sequence:

>1230_bases
ATGACGGTGGACTATACCGCACAACTCGACGCAGCGATTGAACGCCTTCACGAAGAAGGCCGCTACCGGACGTTCATTGA
TATCGAGCGTCGCCGGGGGCAGTTTCCGCATGCGGTCTGGACCCGTCCCGATGGCAGCGAACAGGACATCACCGTCTGGT
GCGGCAACGACTATCTCGGCATGGGGCAGCACCCGGTTGTGCTGAAGGCGATGCGCGATGCAATTGATGCCACTGGTGCG
GGCTCTGGCGGGACGCGCAATATCTCCGGCACCACTGTCTATCACAAAGAACTCGAGAGCGAGCTTGCCGATCTGCACGG
CAAGGAAGCGGCGCTTTTGTTCACCTCCGCCTACATTGCCAACGATGCCACGCTGTCGACCCTGCCGAAACTGCTGCCGG
GTCTCATTATCTATTCCGACGCTTTGAACCACGCGTCCATGATCGAGGGTGTGCGCCGAAATGGCGGGGCCAAGCGAGTC
TTTCGCCATAATGATGTCGCCCACCTGCGCGAACTCCTCGAGGCTGACGATCCCGCCGCGCCCAAGCTCATCGCATTTGA
GAGCGTCTACTCGATGGATGGCGACTTTGGCCCGATTGCGGAAATCTGCGATCTCGCCGATGAATTCAACGCGCTGACCT
ATATCGACGAAGTCCACGCCGTCGGCATGTATGGCCCTCGCGGCGGTGGCGTCACAGAGCGTGACAACCTCGCCCATCGT
ATCGACATCATCAACGGCACGCTCGCCAAGGCCTATGGCGTCATGGGCGGCTATATCGCCGCCTCTGCCAAGATGTGCGA
TGCGATCCGGTCCTATGCGCCGGGCTTTATCTTCACCACCTCGCTTGCGCCTTCGATTGCGGCCGGGGCCGCGGCCTCCG
TGCGTCATCTCAAGACAGCGCAGGACCTGCGCGATAAGCATCAGGAGCAGGCGCGCTATCTCAAAACCCGCCTCAAGATG
ATGGGACTGCCCGTGATCGATCACGGCAGCCACATCGTTCCGGTGATCGTTGGCGATCCGGTTCATACCAAGAAACTGTC
GGATATGTTGCTCTCGGACTTTGGTATCTATGTGCAGCCGATCAACTTCCCGACCGTGCCGCGTGGTACAGAGCGCCTAC
GATTCACGCCATCGCCAGTGCATGGGCCCAGCGAAATGGACCATTTGATCCGCGCAATGGATAAGCTTTGGTCGCATTGT
GCGCTGAATCGCGCCGAATTGGCCGGATAA

Upstream 100 bases:

>100_bases
TTAGACACCGCGAGATAGATCGCGGGTGTGGATGCTCCACGGGGCAGGTCGGGATCAAGACGCAGCCAAGCCGGACTGGC
ATCGGCACAAAGCTATGGAG

Downstream 100 bases:

>100_bases
GCCCAAGCTAAGTGTTCATTAAACGGAATTGTGTTATTCTTTCATCAATGAAACCACGCTGACGAATCGGGAATCGGTTT
GTACGGTGCGGATGTCGCAA

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MTVDYTAQLDAAIERLHEEGRYRTFIDIERRRGQFPHAVWTRPDGSEQDITVWCGNDYLGMGQHPVVLKAMRDAIDATGA
GSGGTRNISGTTVYHKELESELADLHGKEAALLFTSAYIANDATLSTLPKLLPGLIIYSDALNHASMIEGVRRNGGAKRV
FRHNDVAHLRELLEADDPAAPKLIAFESVYSMDGDFGPIAEICDLADEFNALTYIDEVHAVGMYGPRGGGVTERDNLAHR
IDIINGTLAKAYGVMGGYIAASAKMCDAIRSYAPGFIFTTSLAPSIAAGAAASVRHLKTAQDLRDKHQEQARYLKTRLKM
MGLPVIDHGSHIVPVIVGDPVHTKKLSDMLLSDFGIYVQPINFPTVPRGTERLRFTPSPVHGPSEMDHLIRAMDKLWSHC
ALNRAELAG

Sequences:

>Translated_409_residues
MTVDYTAQLDAAIERLHEEGRYRTFIDIERRRGQFPHAVWTRPDGSEQDITVWCGNDYLGMGQHPVVLKAMRDAIDATGA
GSGGTRNISGTTVYHKELESELADLHGKEAALLFTSAYIANDATLSTLPKLLPGLIIYSDALNHASMIEGVRRNGGAKRV
FRHNDVAHLRELLEADDPAAPKLIAFESVYSMDGDFGPIAEICDLADEFNALTYIDEVHAVGMYGPRGGGVTERDNLAHR
IDIINGTLAKAYGVMGGYIAASAKMCDAIRSYAPGFIFTTSLAPSIAAGAAASVRHLKTAQDLRDKHQEQARYLKTRLKM
MGLPVIDHGSHIVPVIVGDPVHTKKLSDMLLSDFGIYVQPINFPTVPRGTERLRFTPSPVHGPSEMDHLIRAMDKLWSHC
ALNRAELAG
>Mature_408_residues
TVDYTAQLDAAIERLHEEGRYRTFIDIERRRGQFPHAVWTRPDGSEQDITVWCGNDYLGMGQHPVVLKAMRDAIDATGAG
SGGTRNISGTTVYHKELESELADLHGKEAALLFTSAYIANDATLSTLPKLLPGLIIYSDALNHASMIEGVRRNGGAKRVF
RHNDVAHLRELLEADDPAAPKLIAFESVYSMDGDFGPIAEICDLADEFNALTYIDEVHAVGMYGPRGGGVTERDNLAHRI
DIINGTLAKAYGVMGGYIAASAKMCDAIRSYAPGFIFTTSLAPSIAAGAAASVRHLKTAQDLRDKHQEQARYLKTRLKMM
GLPVIDHGSHIVPVIVGDPVHTKKLSDMLLSDFGIYVQPINFPTVPRGTERLRFTPSPVHGPSEMDHLIRAMDKLWSHCA
LNRAELAG

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=396, Percent_Identity=51.7676767676768, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI83977440, Length=396, Percent_Identity=51.7676767676768, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI83977444, Length=396, Percent_Identity=51.7676767676768, Blast_Score=424, Evalue=1e-119,
Organism=Homo sapiens, GI4502025, Length=404, Percent_Identity=50.2475247524753, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI40316939, Length=404, Percent_Identity=50.2475247524753, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI7657118, Length=386, Percent_Identity=33.160621761658, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI284448556, Length=345, Percent_Identity=33.9130434782609, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI119220554, Length=368, Percent_Identity=30.7065217391304, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI4758668, Length=359, Percent_Identity=29.2479108635098, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI5454084, Length=239, Percent_Identity=26.3598326359833, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1790046, Length=399, Percent_Identity=34.3358395989975, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1786993, Length=342, Percent_Identity=33.9181286549708, Blast_Score=169, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71994529, Length=392, Percent_Identity=32.9081632653061, Blast_Score=217, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI32566772, Length=376, Percent_Identity=29.7872340425532, Blast_Score=157, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI17560912, Length=362, Percent_Identity=28.7292817679558, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17560914, Length=362, Percent_Identity=28.7292817679558, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI71982617, Length=259, Percent_Identity=27.7992277992278, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71982625, Length=259, Percent_Identity=27.7992277992278, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320438, Length=423, Percent_Identity=47.2813238770686, Blast_Score=389, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6320267, Length=358, Percent_Identity=28.2122905027933, Blast_Score=139, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6323954, Length=291, Percent_Identity=24.3986254295533, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17137420, Length=400, Percent_Identity=50.5, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24662918, Length=351, Percent_Identity=35.042735042735, Blast_Score=231, Evalue=8e-61,
Organism=Drosophila melanogaster, GI17136286, Length=329, Percent_Identity=30.0911854103343, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24653280, Length=299, Percent_Identity=25.0836120401338, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24653276, Length=299, Percent_Identity=25.0836120401338, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24653278, Length=299, Percent_Identity=25.0836120401338, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 44740; Mature: 44609

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVDYTAQLDAAIERLHEEGRYRTFIDIERRRGQFPHAVWTRPDGSEQDITVWCGNDYLG
CCCCCHHHHHHHHHHHHHCCCEEEEEEEHHHCCCCCCEEECCCCCCCCCEEEEECCCCCC
MGQHPVVLKAMRDAIDATGAGSGGTRNISGTTVYHKELESELADLHGKEAALLFTSAYIA
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHHHC
NDATLSTLPKLLPGLIIYSDALNHASMIEGVRRNGGAKRVFRHNDVAHLRELLEADDPAA
CCCHHHHHHHHHHHHEEHHHHCCHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHCCCCCC
PKLIAFESVYSMDGDFGPIAEICDLADEFNALTYIDEVHAVGMYGPRGGGVTERDNLAHR
CCEEEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHE
IDIINGTLAKAYGVMGGYIAASAKMCDAIRSYAPGFIFTTSLAPSIAAGAAASVRHLKTA
EHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHH
QDLRDKHQEQARYLKTRLKMMGLPVIDHGSHIVPVIVGDPVHTKKLSDMLLSDFGIYVQP
HHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEE
INFPTVPRGTERLRFTPSPVHGPSEMDHLIRAMDKLWSHCALNRAELAG
CCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure 
TVDYTAQLDAAIERLHEEGRYRTFIDIERRRGQFPHAVWTRPDGSEQDITVWCGNDYLG
CCCCHHHHHHHHHHHHHCCCEEEEEEEHHHCCCCCCEEECCCCCCCCCEEEEECCCCCC
MGQHPVVLKAMRDAIDATGAGSGGTRNISGTTVYHKELESELADLHGKEAALLFTSAYIA
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHHHC
NDATLSTLPKLLPGLIIYSDALNHASMIEGVRRNGGAKRVFRHNDVAHLRELLEADDPAA
CCCHHHHHHHHHHHHEEHHHHCCHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHCCCCCC
PKLIAFESVYSMDGDFGPIAEICDLADEFNALTYIDEVHAVGMYGPRGGGVTERDNLAHR
CCEEEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHE
IDIINGTLAKAYGVMGGYIAASAKMCDAIRSYAPGFIFTTSLAPSIAAGAAASVRHLKTA
EHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHH
QDLRDKHQEQARYLKTRLKMMGLPVIDHGSHIVPVIVGDPVHTKKLSDMLLSDFGIYVQP
HHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEE
INFPTVPRGTERLRFTPSPVHGPSEMDHLIRAMDKLWSHCALNRAELAG
CCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7928952 [H]