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The map label for this gene is betC [H]

Identifier: 104779347

GI number: 104779347

Start: 35321

End: 36838

Strand: Reverse

Name: betC [H]

Synonym: PSEEN0034

Alternate gene names: 104779347

Gene position: 36838-35321 (Counterclockwise)

Preceding gene: 104779350

Following gene: 104779346

Centisome position: 0.63

GC content: 65.35

Gene sequence:

>1518_bases
ATGAAACAACCCAACATCCTGTTCATCATGGCCGACCAGATGGCCGCGCCGCTGCTGCCGATCTACACCCCATCGCCGAT
CAAGATGCCCAACCTGGCGCGCCTCGCCGAGCAGGCCGTGGTGTTCGACTCCGCCTACTGCAACAGCCCGCTGTGCGCGC
CCTCGCGCTTCACCCTGGTCAGCGGCCAGTTGCCCAGCCGCATCGGCGCCTACGACAACGCCGCCGACTTTCCTGCCGAC
ATTCCGACTTACGCCCACTACCTGCGCCGCCTCGGCTACCGCACCGCGCTCTCGGGCAAGATGCACTTCTGCGGCCCGGA
CCAGCTGCACGGCTACGAGGAGCGCCTGACCAGCGACATCTACCCGGCCGACTACGGCTGGGCGGTGAACTGGGACGCGC
CAGACCAACGCCCGAGCTGGTACCACAACATGTCCTCGGTGCTGCAGGCCGGGCCGTGCGTACGCACCAACCAGCTGGAT
TTCGATGAGGAAGTGGTGTTCAAGGCACGCCAGTATCTCTACGACCATGTGCGCGAAGACCATGGCCGGCCTTTCTGCCT
GACCGTGTCGATGACCCACCCCCACGACCCGTACACCATCCCCAAACGCTACTGGGATCTCTACGAGGCTGTGGATATCC
CGCTGCCCCGCGACGTGATCGCCCAAAGCCAGCAAGACCCGCATTCGCAACGCCTGCTCAAGGTCTACGACCTGTGGGAC
AAGCCGCTGCCCGTGGACAAGATCCGCGATGCCCGCCGCGCCTACTTCGGCGCCTGCAGCTACATCGACGACAATATCGG
CCTGCTTGTGCAGACGCTGGAAGACTGCGGCCTGGCCGACGACACCCTGATCGTCTTCTCCGGCGACCACGGCGACATGC
TTGGCGAGCGAGGGCTCTGGTACAAGATGCACTGGTTCGAGATGTCGGCGCGGGTGCCGCTGCTGATCCACGCGCCCAAG
CGCTTCGCACCCGCGCGGATCAGCGCCAGCGTATCCACCTGCGACCTGCTGCCGACCCTGGTCGAACTGGCCGGCGGCGC
TGTGGATAAAGACCTGCACCTGGACGGCCGCTCACTGCTCGGGCACCTGCAAGGGCAGGGCGGGCATGACGAGGTGATCG
GCGAATACATGGCCGAGGGTACCGTCGGCCCGCTGATGATGATCCGCCGCGGCGCCTACAAGTTCGTGTACAGCGAAGAC
GACCCCTGTTTACTCTACGACCTGAGCCGCGACCCGCACGAGCGGGAGAACCTCACCGGCAGCCCGGACCACCAGGTGCT
GCTGCAGGCATTTGTCGATGAAGCGAAGCAACGCTGGGATATCCCCAGCCTGCGCCAGCAGGTGCTGGCCAGCCAGCGCC
GCCGCCGCCTGGTGGCCGAGGCGCTGGCCATCGGCACGCTGAAAAGCTGGGACCACCAACCCTTGGTGGACGCCAGCCAA
CAGTACATGCGCAACCACATCGATCTCGACGACCTCGAGCGCAAGGCACGTTATCCACAGCCCGCACCCCTGGATTGA

Upstream 100 bases:

>100_bases
TAACCCCAGTCATTGCCCGGCATGGGCTTTACCCACGTTATCCACAGCACCATGCTGGATTGCAAGCGTTCACCATAATC
CTCGACGATGGAAGGGCACC

Downstream 100 bases:

>100_bases
GAAGAGAGGCCGCCATGCAGAAGTTCTCCACCGCCGTGCTCGCCCTGGCCCTGAGCCTGGGCACGGCCCACGCCGCCGAC
GGCAACGTGCAATGCAGCAC

Product: choline sulfatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MKQPNILFIMADQMAAPLLPIYTPSPIKMPNLARLAEQAVVFDSAYCNSPLCAPSRFTLVSGQLPSRIGAYDNAADFPAD
IPTYAHYLRRLGYRTALSGKMHFCGPDQLHGYEERLTSDIYPADYGWAVNWDAPDQRPSWYHNMSSVLQAGPCVRTNQLD
FDEEVVFKARQYLYDHVREDHGRPFCLTVSMTHPHDPYTIPKRYWDLYEAVDIPLPRDVIAQSQQDPHSQRLLKVYDLWD
KPLPVDKIRDARRAYFGACSYIDDNIGLLVQTLEDCGLADDTLIVFSGDHGDMLGERGLWYKMHWFEMSARVPLLIHAPK
RFAPARISASVSTCDLLPTLVELAGGAVDKDLHLDGRSLLGHLQGQGGHDEVIGEYMAEGTVGPLMMIRRGAYKFVYSED
DPCLLYDLSRDPHERENLTGSPDHQVLLQAFVDEAKQRWDIPSLRQQVLASQRRRRLVAEALAIGTLKSWDHQPLVDASQ
QYMRNHIDLDDLERKARYPQPAPLD

Sequences:

>Translated_505_residues
MKQPNILFIMADQMAAPLLPIYTPSPIKMPNLARLAEQAVVFDSAYCNSPLCAPSRFTLVSGQLPSRIGAYDNAADFPAD
IPTYAHYLRRLGYRTALSGKMHFCGPDQLHGYEERLTSDIYPADYGWAVNWDAPDQRPSWYHNMSSVLQAGPCVRTNQLD
FDEEVVFKARQYLYDHVREDHGRPFCLTVSMTHPHDPYTIPKRYWDLYEAVDIPLPRDVIAQSQQDPHSQRLLKVYDLWD
KPLPVDKIRDARRAYFGACSYIDDNIGLLVQTLEDCGLADDTLIVFSGDHGDMLGERGLWYKMHWFEMSARVPLLIHAPK
RFAPARISASVSTCDLLPTLVELAGGAVDKDLHLDGRSLLGHLQGQGGHDEVIGEYMAEGTVGPLMMIRRGAYKFVYSED
DPCLLYDLSRDPHERENLTGSPDHQVLLQAFVDEAKQRWDIPSLRQQVLASQRRRRLVAEALAIGTLKSWDHQPLVDASQ
QYMRNHIDLDDLERKARYPQPAPLD
>Mature_505_residues
MKQPNILFIMADQMAAPLLPIYTPSPIKMPNLARLAEQAVVFDSAYCNSPLCAPSRFTLVSGQLPSRIGAYDNAADFPAD
IPTYAHYLRRLGYRTALSGKMHFCGPDQLHGYEERLTSDIYPADYGWAVNWDAPDQRPSWYHNMSSVLQAGPCVRTNQLD
FDEEVVFKARQYLYDHVREDHGRPFCLTVSMTHPHDPYTIPKRYWDLYEAVDIPLPRDVIAQSQQDPHSQRLLKVYDLWD
KPLPVDKIRDARRAYFGACSYIDDNIGLLVQTLEDCGLADDTLIVFSGDHGDMLGERGLWYKMHWFEMSARVPLLIHAPK
RFAPARISASVSTCDLLPTLVELAGGAVDKDLHLDGRSLLGHLQGQGGHDEVIGEYMAEGTVGPLMMIRRGAYKFVYSED
DPCLLYDLSRDPHERENLTGSPDHQVLLQAFVDEAKQRWDIPSLRQQVLASQRRRRLVAEALAIGTLKSWDHQPLVDASQ
QYMRNHIDLDDLERKARYPQPAPLD

Specific function: Converts choline-O-sulfate into choline [H]

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4557659, Length=422, Percent_Identity=27.7251184834123, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI39930577, Length=446, Percent_Identity=24.4394618834081, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI5360208, Length=318, Percent_Identity=27.0440251572327, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI4504061, Length=398, Percent_Identity=24.6231155778894, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI262118210, Length=345, Percent_Identity=27.536231884058, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1790112, Length=431, Percent_Identity=27.8422273781903, Blast_Score=137, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24656835, Length=412, Percent_Identity=26.9417475728155, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR017785
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.6 [H]

Molecular weight: Translated: 57389; Mature: 57389

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQPNILFIMADQMAAPLLPIYTPSPIKMPNLARLAEQAVVFDSAYCNSPLCAPSRFTLV
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
SGQLPSRIGAYDNAADFPADIPTYAHYLRRLGYRTALSGKMHFCGPDQLHGYEERLTSDI
CCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCEECCCCHHHCCHHHHHHCCC
YPADYGWAVNWDAPDQRPSWYHNMSSVLQAGPCVRTNQLDFDEEVVFKARQYLYDHVRED
CCCCCCEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
HGRPFCLTVSMTHPHDPYTIPKRYWDLYEAVDIPLPRDVIAQSQQDPHSQRLLKVYDLWD
CCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHCC
KPLPVDKIRDARRAYFGACSYIDDNIGLLVQTLEDCGLADDTLIVFSGDHGDMLGERGLW
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCE
YKMHWFEMSARVPLLIHAPKRFAPARISASVSTCDLLPTLVELAGGAVDKDLHLDGRSLL
EEEEEEECCCCCCEEEECCCCCCCCHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
GHLQGQGGHDEVIGEYMAEGTVGPLMMIRRGAYKFVYSEDDPCLLYDLSRDPHERENLTG
HHHCCCCCHHHHHHHHHHCCCCHHHHHHHHCCEEEEECCCCCEEEEECCCCCCHHHCCCC
SPDHQVLLQAFVDEAKQRWDIPSLRQQVLASQRRRRLVAEALAIGTLKSWDHQPLVDASQ
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
QYMRNHIDLDDLERKARYPQPAPLD
HHHHHCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKQPNILFIMADQMAAPLLPIYTPSPIKMPNLARLAEQAVVFDSAYCNSPLCAPSRFTLV
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
SGQLPSRIGAYDNAADFPADIPTYAHYLRRLGYRTALSGKMHFCGPDQLHGYEERLTSDI
CCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCEECCCCHHHCCHHHHHHCCC
YPADYGWAVNWDAPDQRPSWYHNMSSVLQAGPCVRTNQLDFDEEVVFKARQYLYDHVRED
CCCCCCEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
HGRPFCLTVSMTHPHDPYTIPKRYWDLYEAVDIPLPRDVIAQSQQDPHSQRLLKVYDLWD
CCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHCC
KPLPVDKIRDARRAYFGACSYIDDNIGLLVQTLEDCGLADDTLIVFSGDHGDMLGERGLW
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCE
YKMHWFEMSARVPLLIHAPKRFAPARISASVSTCDLLPTLVELAGGAVDKDLHLDGRSLL
EEEEEEECCCCCCEEEECCCCCCCCHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
GHLQGQGGHDEVIGEYMAEGTVGPLMMIRRGAYKFVYSEDDPCLLYDLSRDPHERENLTG
HHHCCCCCHHHHHHHHHHCCCCHHHHHHHHCCEEEEECCCCCEEEEECCCCCCHHHCCCC
SPDHQVLLQAFVDEAKQRWDIPSLRQQVLASQRRRRLVAEALAIGTLKSWDHQPLVDASQ
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
QYMRNHIDLDDLERKARYPQPAPLD
HHHHHCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9141699; 11481430; 9736747 [H]