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The map label for this gene is lpd [H]

Identifier: 94986420

GI number: 94986420

Start: 2441754

End: 2443157

Strand: Reverse

Name: lpd [H]

Synonym: Dgeo_2323

Alternate gene names: 94986420

Gene position: 2443157-2441754 (Counterclockwise)

Preceding gene: 94986421

Following gene: 94986419

Centisome position: 99.03

GC content: 65.6

Gene sequence:

>1404_bases
ATGACGAAACAGATGGACTTTGACCTGCTCGTGATCGGGGCTGGGCCGGGGGGCTATCACGCCGCGATTCGCGGAGCGCA
GCTGGGCCTCAAGGTTGCCTGCGCGGAGCGCGAAGCGTTGGGCGGCGTGTGCCTGAATGTGGGCTGCATTCCGACCAAGG
CGCTGCTGCACGCGGGCGAGATGATGGCCGCTGCCCACGAGGCCGCCGACTTCGGCCTGTCCTTTGGCGAGCAGCGGCTG
AACGTTGCCAAGCTCAACGCCTGGAAGGACGGCATCGTCAAGAGGCTGACCGGCGGCGTGGGCAGCCTCTTTAAGGCCAA
TAAGGTGACGCACCTTCAGGGCCAAGCGAGCTTCGTGGACCCCCATACCGTCAAGGTGGGCGACAAGACCTATACCGCGG
CCAACATCATCATTGCCACCGGCTCGGAACCCGCCCGGCTGCCGGGGTTGGATGTGGACCAACAGAGCATCGTGGACTCC
ACCGGCGCGCTTGTTGTTCCCGATCCTATCCCCGCGCGGATGCTGTGTGTGGGGGGCGGCGTGATCGGCTTCGAGTTCGC
GCACGTGTACAACAACCTGGGGAGCAAGGTGAAGGTGATCGAGTTCCTGCCTAGCATCATCCCCGGGGCTGACGCCGATG
CGGTGAAGGAATTCAGCCGGGCGATGAAGAAGCAAGGCATCGAGATCGAGACTGAAACCAAGGCCAATAAGGCCGAGAAG
AAGGCCGACGGCATCCACGTCGAGCTGGAGAGCGTGAAGACCGGCGAAAAGCGGGTCGAGGTCTTCGACCGGGTGCTCGT
CGCGGTGGGTCGCCGCCCCCGTACCGACGGCCTCAACGTGCAGGCAGCGGGTGTGACCATCACCGAGCGCGGCTTTATCC
CCGCAGACCGCGAGCAGCGCACCAACGTGCCCCATATCTACGCAATCGGTGATGTGGCCGGAAACCCGATGCTGGCGCAC
AAGGCGATGAAGGAAGGGCTGGTCGCCGCCGAGGTGATCGCTGGGAAGCCCGCCGCGCAGGACGCCGTTGCCATCCCCGG
CGTCGTCTACACCAGCCCCGAACTCGCCTGGGTGGGCCTGACCGAGCAGGAGGCCAAGGACAAGGGCTACGAGGTCAAGA
CCGGCACCTTCCCCTTCAGCGCCTCGGGCCGCGCGATGACCCTCCAGCAGACCGACGGCTTCGTGAAGATGGTGGTGGAA
AAGGACACGGACCTGGTGCTGGGCGTGCACATCGTCGGACCGCACGCTTCGGACATGCTGGGCGAGGCGAGCCTGGCGCT
GGAGATGGCCGCCACCGCCACCGACATCGCCCTGACCATCCACGCCCACCCCACCCTGGGCGAGAGCGTGCTGGAAGCCG
CCGAGGCGGTGCACAAGCAGGCGATCCACATCATGAACCGCTGA

Upstream 100 bases:

>100_bases
GAGGCGTGAACAACTCACCAGCACGAGTGGTCAATGCACCTGATCCAACTCCCGAAAAGCGTGATTGGTGCGGCCTGAGG
GGGCGCGTTAGACTGCCCGC

Downstream 100 bases:

>100_bases
GCTTTCTGCAAGGCTTTCTGCAAGCTGCCGCTGGCGGGGATCTGGGAGGGTTCCCGCCGCGCCCTGTTGGCCCTGCTATA
CTCCTGCCGCTGCGCGCTCG

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MTKQMDFDLLVIGAGPGGYHAAIRGAQLGLKVACAEREALGGVCLNVGCIPTKALLHAGEMMAAAHEAADFGLSFGEQRL
NVAKLNAWKDGIVKRLTGGVGSLFKANKVTHLQGQASFVDPHTVKVGDKTYTAANIIIATGSEPARLPGLDVDQQSIVDS
TGALVVPDPIPARMLCVGGGVIGFEFAHVYNNLGSKVKVIEFLPSIIPGADADAVKEFSRAMKKQGIEIETETKANKAEK
KADGIHVELESVKTGEKRVEVFDRVLVAVGRRPRTDGLNVQAAGVTITERGFIPADREQRTNVPHIYAIGDVAGNPMLAH
KAMKEGLVAAEVIAGKPAAQDAVAIPGVVYTSPELAWVGLTEQEAKDKGYEVKTGTFPFSASGRAMTLQQTDGFVKMVVE
KDTDLVLGVHIVGPHASDMLGEASLALEMAATATDIALTIHAHPTLGESVLEAAEAVHKQAIHIMNR

Sequences:

>Translated_467_residues
MTKQMDFDLLVIGAGPGGYHAAIRGAQLGLKVACAEREALGGVCLNVGCIPTKALLHAGEMMAAAHEAADFGLSFGEQRL
NVAKLNAWKDGIVKRLTGGVGSLFKANKVTHLQGQASFVDPHTVKVGDKTYTAANIIIATGSEPARLPGLDVDQQSIVDS
TGALVVPDPIPARMLCVGGGVIGFEFAHVYNNLGSKVKVIEFLPSIIPGADADAVKEFSRAMKKQGIEIETETKANKAEK
KADGIHVELESVKTGEKRVEVFDRVLVAVGRRPRTDGLNVQAAGVTITERGFIPADREQRTNVPHIYAIGDVAGNPMLAH
KAMKEGLVAAEVIAGKPAAQDAVAIPGVVYTSPELAWVGLTEQEAKDKGYEVKTGTFPFSASGRAMTLQQTDGFVKMVVE
KDTDLVLGVHIVGPHASDMLGEASLALEMAATATDIALTIHAHPTLGESVLEAAEAVHKQAIHIMNR
>Mature_466_residues
TKQMDFDLLVIGAGPGGYHAAIRGAQLGLKVACAEREALGGVCLNVGCIPTKALLHAGEMMAAAHEAADFGLSFGEQRLN
VAKLNAWKDGIVKRLTGGVGSLFKANKVTHLQGQASFVDPHTVKVGDKTYTAANIIIATGSEPARLPGLDVDQQSIVDST
GALVVPDPIPARMLCVGGGVIGFEFAHVYNNLGSKVKVIEFLPSIIPGADADAVKEFSRAMKKQGIEIETETKANKAEKK
ADGIHVELESVKTGEKRVEVFDRVLVAVGRRPRTDGLNVQAAGVTITERGFIPADREQRTNVPHIYAIGDVAGNPMLAHK
AMKEGLVAAEVIAGKPAAQDAVAIPGVVYTSPELAWVGLTEQEAKDKGYEVKTGTFPFSASGRAMTLQQTDGFVKMVVEK
DTDLVLGVHIVGPHASDMLGEASLALEMAATATDIALTIHAHPTLGESVLEAAEAVHKQAIHIMNR

Specific function: Has chromate reductase activity [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=459, Percent_Identity=45.7516339869281, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI50301238, Length=456, Percent_Identity=31.359649122807, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI22035672, Length=477, Percent_Identity=31.0272536687631, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI291045266, Length=430, Percent_Identity=28.1395348837209, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI148277065, Length=480, Percent_Identity=28.5416666666667, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI33519430, Length=480, Percent_Identity=28.5416666666667, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI33519428, Length=480, Percent_Identity=28.5416666666667, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI33519426, Length=480, Percent_Identity=28.5416666666667, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI148277071, Length=480, Percent_Identity=28.5416666666667, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI291045268, Length=422, Percent_Identity=26.5402843601896, Blast_Score=132, Evalue=5e-31,
Organism=Escherichia coli, GI1786307, Length=460, Percent_Identity=46.7391304347826, Blast_Score=400, Evalue=1e-112,
Organism=Escherichia coli, GI1789915, Length=436, Percent_Identity=32.3394495412844, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI87082354, Length=464, Percent_Identity=29.9568965517241, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI87081717, Length=455, Percent_Identity=27.9120879120879, Blast_Score=169, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI32565766, Length=465, Percent_Identity=45.5913978494624, Blast_Score=389, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71983419, Length=457, Percent_Identity=29.7592997811816, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71983429, Length=457, Percent_Identity=29.7592997811816, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17557007, Length=485, Percent_Identity=29.0721649484536, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71982272, Length=480, Percent_Identity=27.0833333333333, Blast_Score=142, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6321091, Length=479, Percent_Identity=43.6325678496869, Blast_Score=368, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6325240, Length=475, Percent_Identity=32, Blast_Score=220, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6325166, Length=473, Percent_Identity=29.1754756871036, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI21358499, Length=455, Percent_Identity=45.7142857142857, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24640553, Length=482, Percent_Identity=31.7427385892116, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24640549, Length=480, Percent_Identity=31.875, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24640551, Length=478, Percent_Identity=31.7991631799163, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI17737741, Length=485, Percent_Identity=28.8659793814433, Blast_Score=151, Evalue=9e-37,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49232; Mature: 49101

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKQMDFDLLVIGAGPGGYHAAIRGAQLGLKVACAEREALGGVCLNVGCIPTKALLHAGE
CCCCCCCCEEEEECCCCCHHHHEECCCCCEEEEECCHHCCCCEEEEECCCCHHHHHHHHH
MMAAAHEAADFGLSFGEQRLNVAKLNAWKDGIVKRLTGGVGSLFKANKVTHLQGQASFVD
HHHHHHHHHHHCCCCCHHHCCEEEECHHHHHHHHHHHCCHHHHHHCCCEEEECCCCEECC
PHTVKVGDKTYTAANIIIATGSEPARLPGLDVDQQSIVDSTGALVVPDPIPARMLCVGGG
CEEEEECCCEEEEEEEEEECCCCCCCCCCCCCCHHHHHCCCCCEEECCCCCCEEEEECCC
VIGFEFAHVYNNLGSKVKVIEFLPSIIPGADADAVKEFSRAMKKQGIEIETETKANKAEK
CHHHHHHHHHHHCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHH
KADGIHVELESVKTGEKRVEVFDRVLVAVGRRPRTDGLNVQAAGVTITERGFIPADREQR
HCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECEEEEECCCCCCCCHHC
TNVPHIYAIGDVAGNPMLAHKAMKEGLVAAEVIAGKPAAQDAVAIPGVVYTSPELAWVGL
CCCCEEEEECCCCCCCHHHHHHHHCCCCEEHHHCCCCCCCCCEECCEEEEECCCEEEEEC
TEQEAKDKGYEVKTGTFPFSASGRAMTLQQTDGFVKMVVEKDTDLVLGVHIVGPHASDML
CHHHHHCCCEEEECCCCCCCCCCCEEEEEECCCEEEEEEECCCCEEEEEEEECCCHHHHH
GEASLALEMAATATDIALTIHAHPTLGESVLEAAEAVHKQAIHIMNR
CHHHHHEEHHCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKQMDFDLLVIGAGPGGYHAAIRGAQLGLKVACAEREALGGVCLNVGCIPTKALLHAGE
CCCCCCCEEEEECCCCCHHHHEECCCCCEEEEECCHHCCCCEEEEECCCCHHHHHHHHH
MMAAAHEAADFGLSFGEQRLNVAKLNAWKDGIVKRLTGGVGSLFKANKVTHLQGQASFVD
HHHHHHHHHHHCCCCCHHHCCEEEECHHHHHHHHHHHCCHHHHHHCCCEEEECCCCEECC
PHTVKVGDKTYTAANIIIATGSEPARLPGLDVDQQSIVDSTGALVVPDPIPARMLCVGGG
CEEEEECCCEEEEEEEEEECCCCCCCCCCCCCCHHHHHCCCCCEEECCCCCCEEEEECCC
VIGFEFAHVYNNLGSKVKVIEFLPSIIPGADADAVKEFSRAMKKQGIEIETETKANKAEK
CHHHHHHHHHHHCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHH
KADGIHVELESVKTGEKRVEVFDRVLVAVGRRPRTDGLNVQAAGVTITERGFIPADREQR
HCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECEEEEECCCCCCCCHHC
TNVPHIYAIGDVAGNPMLAHKAMKEGLVAAEVIAGKPAAQDAVAIPGVVYTSPELAWVGL
CCCCEEEEECCCCCCCHHHHHHHHCCCCEEHHHCCCCCCCCCEECCEEEEECCCEEEEEC
TEQEAKDKGYEVKTGTFPFSASGRAMTLQQTDGFVKMVVEKDTDLVLGVHIVGPHASDML
CHHHHHCCCEEEECCCCCCCCCCCEEEEEECCCEEEEEEECCCCEEEEEEEECCCHHHHH
GEASLALEMAATATDIALTIHAHPTLGESVLEAAEAVHKQAIHIMNR
CHHHHHEEHHCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA