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The map label for this gene is pqqL [C]

Identifier: 94986323

GI number: 94986323

Start: 2344401

End: 2345627

Strand: Reverse

Name: pqqL [C]

Synonym: Dgeo_2224

Alternate gene names: 94986323

Gene position: 2345627-2344401 (Counterclockwise)

Preceding gene: 94986324

Following gene: 94986322

Centisome position: 95.07

GC content: 69.36

Gene sequence:

>1227_bases
ATGACCGTCCGCTGCACCCTCCCGAATGGCCTGACTCTCCTCCTTGAACCCGATGCAGAGGCACAGACTGTGGCTGCCGG
CTATTTTGTGGCGACCGGGTCACGCGACGAGCGCCCGGAGGAGCTGGGGGCCTCACACTTCCTCGAACACCTGATGTTCA
AGGGGTCGGAGCGGCTGGACGCCGCCACCCTGAATGCGCGCCTCGACGAGCTGGGCGGAAACGCGAACGCCTTTACCAGC
GAGGAGGCCACGGTCTACCACGCCGCAACCCTGCCCGAGCAGGCGCCCGAGCTGCTGGAGACGTTGACTGAACTGCTGCG
GCCCGCCCTGCGGCCGGCAGACATCGAACCCGAGCGTGGTGTGATTCTCGAAGAGATCGCGATGTACGCCGAGCAGCCCG
CCGTGCGGGTGGTGGATGAGCTGCGCGCTACCTACTGGGGCGAGCATCCCCTGGGGCACGCGGTGCTGGGCACGCCGCAG
ACCGTGGGATCCCTCTCCCGCGAGGCGCTGGCGCGCAACCATCGCGAGCGCTACGGCGCAGACCGGGTGACCCTTGCGGT
GGTTGGGGCCTTTGATGCGGACCAGGTGCTGACCTGGGCCCAGGAGGAGCTGAAGAGCTGGCCCGCCGGAACCCCGCAGG
CCGCCAGCATCTCCCCCCGCCCCCCCGCCCCTGGCACTGTCCGCACCCTGCACGACGACCGCCTGATGCGGGTGCAGGTC
GCGCTGGCGCTGCCCGGCCTCCCCACCACCCATCCACTGCGCGAGGCCGCTGTGGTGCTGGCCGAACTGCTTGGCGGTGA
GAACGGCCTGCTGTACTGGGCGCTGCTCGACACCGGCTTGGCTGACAGCGCTGATCTGGCGCACCTGGACTATCGCGACG
CGGGCACCTTCGAGGGTGGCTTTTCCTGTGATCCCGAGCGCGCACAGACGGTGTTGGATACCTACCGCGCCGTGCTGCAA
AGGGCGCCCGACACCCTGACCGAGGCCGCCGTTCGCCGCGCTGCGCGCAAGCTGGCGGTGAGCAGCCTGTTGCGTGCGGA
GACGCCACAGGGCCGTTTGTTTGCGCTGGGGATGGAGTACGTGGCCCTGGGGCAGGCACTCTCCACCGCTGAGCTCGCAG
AACGCTTTGCTCGGGTGACGCCGGGGGACGTGCGAGCCGTGCTGGAGCTTTGCCCACTGACCACGCCGACGGTGGTGGCG
CTGGGGCCGATCAAGGCCATGCGCTGA

Upstream 100 bases:

>100_bases
TTGCGGCCCTCACCCTGGAGCGGGTGAACGCTTTCCTGGCTGAGTATGACCCTGTCGCACAGGCGACCATCGTGACGCTT
GGCCCGGCGGAGGTACAGGC

Downstream 100 bases:

>100_bases
TCCAATCCTGGGCTTGCCCCGATATGTGCCGGCCTTTGGGCCAGATCGACTCCGCCAACGTGCTGTGGGAAAAATGACTT
GAGAGAATGATGGGAGATGC

Product: peptidase M16-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MTVRCTLPNGLTLLLEPDAEAQTVAAGYFVATGSRDERPEELGASHFLEHLMFKGSERLDAATLNARLDELGGNANAFTS
EEATVYHAATLPEQAPELLETLTELLRPALRPADIEPERGVILEEIAMYAEQPAVRVVDELRATYWGEHPLGHAVLGTPQ
TVGSLSREALARNHRERYGADRVTLAVVGAFDADQVLTWAQEELKSWPAGTPQAASISPRPPAPGTVRTLHDDRLMRVQV
ALALPGLPTTHPLREAAVVLAELLGGENGLLYWALLDTGLADSADLAHLDYRDAGTFEGGFSCDPERAQTVLDTYRAVLQ
RAPDTLTEAAVRRAARKLAVSSLLRAETPQGRLFALGMEYVALGQALSTAELAERFARVTPGDVRAVLELCPLTTPTVVA
LGPIKAMR

Sequences:

>Translated_408_residues
MTVRCTLPNGLTLLLEPDAEAQTVAAGYFVATGSRDERPEELGASHFLEHLMFKGSERLDAATLNARLDELGGNANAFTS
EEATVYHAATLPEQAPELLETLTELLRPALRPADIEPERGVILEEIAMYAEQPAVRVVDELRATYWGEHPLGHAVLGTPQ
TVGSLSREALARNHRERYGADRVTLAVVGAFDADQVLTWAQEELKSWPAGTPQAASISPRPPAPGTVRTLHDDRLMRVQV
ALALPGLPTTHPLREAAVVLAELLGGENGLLYWALLDTGLADSADLAHLDYRDAGTFEGGFSCDPERAQTVLDTYRAVLQ
RAPDTLTEAAVRRAARKLAVSSLLRAETPQGRLFALGMEYVALGQALSTAELAERFARVTPGDVRAVLELCPLTTPTVVA
LGPIKAMR
>Mature_407_residues
TVRCTLPNGLTLLLEPDAEAQTVAAGYFVATGSRDERPEELGASHFLEHLMFKGSERLDAATLNARLDELGGNANAFTSE
EATVYHAATLPEQAPELLETLTELLRPALRPADIEPERGVILEEIAMYAEQPAVRVVDELRATYWGEHPLGHAVLGTPQT
VGSLSREALARNHRERYGADRVTLAVVGAFDADQVLTWAQEELKSWPAGTPQAASISPRPPAPGTVRTLHDDRLMRVQVA
LALPGLPTTHPLREAAVVLAELLGGENGLLYWALLDTGLADSADLAHLDYRDAGTFEGGFSCDPERAQTVLDTYRAVLQR
APDTLTEAAVRRAARKLAVSSLLRAETPQGRLFALGMEYVALGQALSTAELAERFARVTPGDVRAVLELCPLTTPTVVAL
GPIKAMR

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=419, Percent_Identity=26.9689737470167, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI46593007, Length=422, Percent_Identity=28.1990521327014, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1787770, Length=243, Percent_Identity=25.1028806584362, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71999683, Length=400, Percent_Identity=27.75, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17553678, Length=412, Percent_Identity=22.8155339805825, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323192, Length=402, Percent_Identity=28.8557213930348, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6321813, Length=416, Percent_Identity=23.0769230769231, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319426, Length=403, Percent_Identity=23.5732009925558, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323421, Length=209, Percent_Identity=26.7942583732057, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357875, Length=413, Percent_Identity=29.2978208232446, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24646943, Length=413, Percent_Identity=29.2978208232446, Blast_Score=149, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 44011; Mature: 43880

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVRCTLPNGLTLLLEPDAEAQTVAAGYFVATGSRDERPEELGASHFLEHLMFKGSERLD
CEEEEECCCCCEEEECCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHH
AATLNARLDELGGNANAFTSEEATVYHAATLPEQAPELLETLTELLRPALRPADIEPERG
HHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
VILEEIAMYAEQPAVRVVDELRATYWGEHPLGHAVLGTPQTVGSLSREALARNHRERYGA
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHCC
DRVTLAVVGAFDADQVLTWAQEELKSWPAGTPQAASISPRPPAPGTVRTLHDDRLMRVQV
CEEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEE
ALALPGLPTTHPLREAAVVLAELLGGENGLLYWALLDTGLADSADLAHLDYRDAGTFEGG
EEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
FSCDPERAQTVLDTYRAVLQRAPDTLTEAAVRRAARKLAVSSLLRAETPQGRLFALGMEY
CCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHH
VALGQALSTAELAERFARVTPGDVRAVLELCPLTTPTVVALGPIKAMR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCHHHCC
>Mature Secondary Structure 
TVRCTLPNGLTLLLEPDAEAQTVAAGYFVATGSRDERPEELGASHFLEHLMFKGSERLD
EEEEECCCCCEEEECCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHH
AATLNARLDELGGNANAFTSEEATVYHAATLPEQAPELLETLTELLRPALRPADIEPERG
HHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
VILEEIAMYAEQPAVRVVDELRATYWGEHPLGHAVLGTPQTVGSLSREALARNHRERYGA
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHCC
DRVTLAVVGAFDADQVLTWAQEELKSWPAGTPQAASISPRPPAPGTVRTLHDDRLMRVQV
CEEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEE
ALALPGLPTTHPLREAAVVLAELLGGENGLLYWALLDTGLADSADLAHLDYRDAGTFEGG
EEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
FSCDPERAQTVLDTYRAVLQRAPDTLTEAAVRRAARKLAVSSLLRAETPQGRLFALGMEY
CCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHH
VALGQALSTAELAERFARVTPGDVRAVLELCPLTTPTVVALGPIKAMR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]