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The map label for this gene is thiD [H]

Identifier: 94986019

GI number: 94986019

Start: 2022809

End: 2023573

Strand: Reverse

Name: thiD [H]

Synonym: Dgeo_1919

Alternate gene names: 94986019

Gene position: 2023573-2022809 (Counterclockwise)

Preceding gene: 94986020

Following gene: 94986018

Centisome position: 82.02

GC content: 71.11

Gene sequence:

>765_bases
ATGACCGTTCCCGTTGCTCTCACCATCGCTGGCTCCGACTCCGGGGGCGGGGCGGGGATCCAGGCGGACCTCAAGACCTT
TGAGGCGCATGGCGTCTTCGGCACGTCCGTCCTGACGGTGATCACCGCGCAGAATACGCGGGGCGTGCGGGCAGCACAGG
TTCTCCCGCCTGAACTGGTGACGGCCCAGCTCGAGGCTGTTCTGGAGGATTTTCCGGTGGCCGCCGTCAAGACTGGGGCG
CTGGGCGATGCGGCGGTGGTGCGGGCTGTGGCCGACGTCCTGCGCGGGCGGGACTTGCCCCTGGTGGTGGATCCGGTCCT
GCTCGCCAAAAGCGGCGATCCCCTGCTGGCGCCGGAGGCGGTGGACGCGCTGCTGGAGGAGCTGCTGCCCCTTGCAACGT
TGGTCACGCCCAATCTGCCGGAGGCCAGGGTGCTGTTCGGCTCGCCAGACTCCTCTGCCTGGCCACTGCTGCTCAAGGGG
GGACACGCGGAGGGCGAGACCGTCACCGACGAGCTGCGGACCCCGGAAACTCACCTGCGGCTGTGTGCGCCGCGCCAGCA
CACACGCCACACCCACGGCACCGGCTGCACCCTCTCCGCGGCCATTACCGCCCACCTCGCGCGGGGACTGGCGCTGGTGG
ACGCCGTCCGGGAAGCCCATGCCTACGTTCAGGCCGCCCTGCGCGCCGCGCCCGGCCTGGGCACGGGCCACGGCCCACTG
GGGCACGCGCTGGGACGATTGGCTTGGGACAGTGCAGCGCGCTAG

Upstream 100 bases:

>100_bases
CGGGTGTGTTCGTCGCGACGGGGCACGGGCGGCACGGCGCGTTGCTCGCTCCGGTCACGGCGGCACGCATCGTGGGCCTG
TTGGAACAGGGTGTGAGCGC

Downstream 100 bases:

>100_bases
GCCCCGGCCTTTGTGACCGTGGCGGTATGGACTTTTCGGTCCTTCTTGTACACTGAACCTAACGCTCGTTAGGCCGCTGG
ATTCAGGAGGGACCCTATGA

Product: phosphomethylpyrimidine kinase type-2

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MTVPVALTIAGSDSGGGAGIQADLKTFEAHGVFGTSVLTVITAQNTRGVRAAQVLPPELVTAQLEAVLEDFPVAAVKTGA
LGDAAVVRAVADVLRGRDLPLVVDPVLLAKSGDPLLAPEAVDALLEELLPLATLVTPNLPEARVLFGSPDSSAWPLLLKG
GHAEGETVTDELRTPETHLRLCAPRQHTRHTHGTGCTLSAAITAHLARGLALVDAVREAHAYVQAALRAAPGLGTGHGPL
GHALGRLAWDSAAR

Sequences:

>Translated_254_residues
MTVPVALTIAGSDSGGGAGIQADLKTFEAHGVFGTSVLTVITAQNTRGVRAAQVLPPELVTAQLEAVLEDFPVAAVKTGA
LGDAAVVRAVADVLRGRDLPLVVDPVLLAKSGDPLLAPEAVDALLEELLPLATLVTPNLPEARVLFGSPDSSAWPLLLKG
GHAEGETVTDELRTPETHLRLCAPRQHTRHTHGTGCTLSAAITAHLARGLALVDAVREAHAYVQAALRAAPGLGTGHGPL
GHALGRLAWDSAAR
>Mature_253_residues
TVPVALTIAGSDSGGGAGIQADLKTFEAHGVFGTSVLTVITAQNTRGVRAAQVLPPELVTAQLEAVLEDFPVAAVKTGAL
GDAAVVRAVADVLRGRDLPLVVDPVLLAKSGDPLLAPEAVDALLEELLPLATLVTPNLPEARVLFGSPDSSAWPLLLKGG
HAEGETVTDELRTPETHLRLCAPRQHTRHTHGTGCTLSAAITAHLARGLALVDAVREAHAYVQAALRAAPGLGTGHGPLG
HALGRLAWDSAAR

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=256, Percent_Identity=45.703125, Blast_Score=198, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6325378, Length=252, Percent_Identity=32.9365079365079, Blast_Score=125, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6324997, Length=271, Percent_Identity=33.9483394833948, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324517, Length=274, Percent_Identity=31.021897810219, Blast_Score=108, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 26079; Mature: 25948

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVPVALTIAGSDSGGGAGIQADLKTFEAHGVFGTSVLTVITAQNTRGVRAAQVLPPELV
CCCEEEEEEECCCCCCCCCEEHHHHHHHHCCCHHCEEEEEEEECCCCCCCHHHCCCHHHH
TAQLEAVLEDFPVAAVKTGALGDAAVVRAVADVLRGRDLPLVVDPVLLAKSGDPLLAPEA
HHHHHHHHHHCCHHEEECCCCCHHHHHHHHHHHHCCCCCCEEECCEEEECCCCCCCCHHH
VDALLEELLPLATLVTPNLPEARVLFGSPDSSAWPLLLKGGHAEGETVTDELRTPETHLR
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCCCCCCHHHHHCCCHHHHE
LCAPRQHTRHTHGTGCTLSAAITAHLARGLALVDAVREAHAYVQAALRAAPGLGTGHGPL
ECCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
GHALGRLAWDSAAR
HHHHHHHHHHCCCC
>Mature Secondary Structure 
TVPVALTIAGSDSGGGAGIQADLKTFEAHGVFGTSVLTVITAQNTRGVRAAQVLPPELV
CCEEEEEEECCCCCCCCCEEHHHHHHHHCCCHHCEEEEEEEECCCCCCCHHHCCCHHHH
TAQLEAVLEDFPVAAVKTGALGDAAVVRAVADVLRGRDLPLVVDPVLLAKSGDPLLAPEA
HHHHHHHHHHCCHHEEECCCCCHHHHHHHHHHHHCCCCCCEEECCEEEECCCCCCCCHHH
VDALLEELLPLATLVTPNLPEARVLFGSPDSSAWPLLLKGGHAEGETVTDELRTPETHLR
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCCCCCCHHHHHCCCHHHHE
LCAPRQHTRHTHGTGCTLSAAITAHLARGLALVDAVREAHAYVQAALRAAPGLGTGHGPL
ECCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
GHALGRLAWDSAAR
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481431; 8246891 [H]