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The map label for this gene is htrA [H]

Identifier: 94984659

GI number: 94984659

Start: 586701

End: 587972

Strand: Reverse

Name: htrA [H]

Synonym: Dgeo_0552

Alternate gene names: 94984659

Gene position: 587972-586701 (Counterclockwise)

Preceding gene: 94984660

Following gene: 94984658

Centisome position: 23.83

GC content: 66.04

Gene sequence:

>1272_bases
ATGAGACGACCGATGCTCGCAGCCATCCTGGTGCTGGTGGGTCTGGGCCTGGGAGCTACCCTGCTCCGGGATCAGGTGCC
CATCTCAGACGCGCAGAAGAGCCCCGCTGCCACCACAGCCCCCACAGCGGGCACCGAGGCCGGGGCGCGCCTCCAAAATG
AGCAGAACACGATCGACATCGTGAGCCGCTATGAGCCGGGGCTGGTGTACATCAGCACCGAGCAGCAGGTGGTGCAACAG
GATCCGCTGGGGTGGATGTTGGGCGGCCAGGATGAGACTCAGGTGGTGCAGGGGGTGGGGAGCGGCTTTTTCGTGAACGA
GCAGGGCGACATCCTCACCAATTACCACGTGGTCGCGGGTGAGAACGGGCAGGGTCCCGCCAGCAGCATTCGCGTGCGGG
TGATGAACCGTGAGCAGAGTGTGCCTGCCCGCGTCATCGGCCTTGCGCCGCAGTATGACCTCGCGCTGATCCGCGCCGAG
GGACTGGACAAGAGCCTGATCCGGCCCATCCCGCTGGGTGACAGCGACACACTGAAGGCTGGACAAAAAGCCATCGCGAT
GGGCGCGCCCTTCGGGCTGGACTTCAGTGTCACGGAAGGCATCGTGAGCAGCACCGCCCGGCAGATTCCAATCGGCTTCT
CGGCCACCGGCGAGGGCATCACTCAAAAGGCGATCCAGACGGATGCCGCCATCAATCCCGGCAACAGCGGCGGCCCGCTG
CTGGACTCGAGCGGGCGCGTGATCGGCATCAACACCCAAATTCTCTCACCCGCTGGCGCAGCAACCGGGGTCGGGCAGAA
CGCGGGCGTTGGCTTTGCTATTCCGATCAATGCCGCCAAGAATCTGCTGCCCCGGCTCCAGCAGGCCAAGGGCGGCATTG
TGACGGCACCCCGGCTCGGCATCACGGTGGGGTTGGTGGTCCAGGGACCGGGGCAGCTCCTGCCGGTGGGCCTCAGCGCC
CTCAGCAGCCAGGGCAAGCGGGAACTGGGCCTGCCCGAAACGGGACTGGTCGTGGGTCAGGTGGAACCCAACACGCCCGC
GGCCAAGTCTGGCCTGCGCGGCGGCACCCGCACGCAGACCTTCCGGGGTGGGCAGATCGTGGTGGGCGGCGACGTGATTA
CCGCAGCAGATGGAAAACCGGTGGACGGCATCGAGGATCTCCAGGCCGTGCTGATTGACAAGCAGCCGGGGGATAGCGTC
ACGCTGCGCGTTGTGCGGGGTAAGCAGACGCGGGACGTGAAGGTCACCCTGGACAACAGCTCCTTCGAGTAA

Upstream 100 bases:

>100_bases
GCGGCAGGAAGGCTAGAGGGGCCGACTGCAGGAACGAATTTGTGAGATACCCGTCCTCTCCCCTGGCGCAGCACCCGCTC
CAGGCAGGGATAATGCCTGC

Downstream 100 bases:

>100_bases
GCCGTGGACAGCACGGCACAGGACCCCACCGGGCAGGCGTGGCAACGTCTTTTGGTCGCCGATCGCCGCTGGCTGACTGA
CCTGGCACAGCGGGCGGGAC

Product: peptidase S1 and S6, chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MRRPMLAAILVLVGLGLGATLLRDQVPISDAQKSPAATTAPTAGTEAGARLQNEQNTIDIVSRYEPGLVYISTEQQVVQQ
DPLGWMLGGQDETQVVQGVGSGFFVNEQGDILTNYHVVAGENGQGPASSIRVRVMNREQSVPARVIGLAPQYDLALIRAE
GLDKSLIRPIPLGDSDTLKAGQKAIAMGAPFGLDFSVTEGIVSSTARQIPIGFSATGEGITQKAIQTDAAINPGNSGGPL
LDSSGRVIGINTQILSPAGAATGVGQNAGVGFAIPINAAKNLLPRLQQAKGGIVTAPRLGITVGLVVQGPGQLLPVGLSA
LSSQGKRELGLPETGLVVGQVEPNTPAAKSGLRGGTRTQTFRGGQIVVGGDVITAADGKPVDGIEDLQAVLIDKQPGDSV
TLRVVRGKQTRDVKVTLDNSSFE

Sequences:

>Translated_423_residues
MRRPMLAAILVLVGLGLGATLLRDQVPISDAQKSPAATTAPTAGTEAGARLQNEQNTIDIVSRYEPGLVYISTEQQVVQQ
DPLGWMLGGQDETQVVQGVGSGFFVNEQGDILTNYHVVAGENGQGPASSIRVRVMNREQSVPARVIGLAPQYDLALIRAE
GLDKSLIRPIPLGDSDTLKAGQKAIAMGAPFGLDFSVTEGIVSSTARQIPIGFSATGEGITQKAIQTDAAINPGNSGGPL
LDSSGRVIGINTQILSPAGAATGVGQNAGVGFAIPINAAKNLLPRLQQAKGGIVTAPRLGITVGLVVQGPGQLLPVGLSA
LSSQGKRELGLPETGLVVGQVEPNTPAAKSGLRGGTRTQTFRGGQIVVGGDVITAADGKPVDGIEDLQAVLIDKQPGDSV
TLRVVRGKQTRDVKVTLDNSSFE
>Mature_423_residues
MRRPMLAAILVLVGLGLGATLLRDQVPISDAQKSPAATTAPTAGTEAGARLQNEQNTIDIVSRYEPGLVYISTEQQVVQQ
DPLGWMLGGQDETQVVQGVGSGFFVNEQGDILTNYHVVAGENGQGPASSIRVRVMNREQSVPARVIGLAPQYDLALIRAE
GLDKSLIRPIPLGDSDTLKAGQKAIAMGAPFGLDFSVTEGIVSSTARQIPIGFSATGEGITQKAIQTDAAINPGNSGGPL
LDSSGRVIGINTQILSPAGAATGVGQNAGVGFAIPINAAKNLLPRLQQAKGGIVTAPRLGITVGLVVQGPGQLLPVGLSA
LSSQGKRELGLPETGLVVGQVEPNTPAAKSGLRGGTRTQTFRGGQIVVGGDVITAADGKPVDGIEDLQAVLIDKQPGDSV
TLRVVRGKQTRDVKVTLDNSSFE

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=341, Percent_Identity=31.6715542521994, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI22129776, Length=352, Percent_Identity=28.6931818181818, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI7019477, Length=366, Percent_Identity=30.8743169398907, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI24308541, Length=373, Percent_Identity=29.7587131367292, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI1789629, Length=327, Percent_Identity=33.9449541284404, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1786356, Length=324, Percent_Identity=34.5679012345679, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1789630, Length=324, Percent_Identity=29.6296296296296, Blast_Score=90, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24646839, Length=329, Percent_Identity=30.6990881458967, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 43569; Mature: 43569

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRPMLAAILVLVGLGLGATLLRDQVPISDAQKSPAATTAPTAGTEAGARLQNEQNTIDI
CCCHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCEEE
VSRYEPGLVYISTEQQVVQQDPLGWMLGGQDETQVVQGVGSGFFVNEQGDILTNYHVVAG
EECCCCCEEEEECCHHHHHHCCCCEEECCCCHHHHHHHCCCCEEECCCCCEEEEEEEEEC
ENGQGPASSIRVRVMNREQSVPARVIGLAPQYDLALIRAEGLDKSLIRPIPLGDSDTLKA
CCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCEEEEEECCCCHHHCCCCCCCCCHHHHH
GQKAIAMGAPFGLDFSVTEGIVSSTARQIPIGFSATGEGITQKAIQTDAAINPGNSGGPL
CCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCE
LDSSGRVIGINTQILSPAGAATGVGQNAGVGFAIPINAAKNLLPRLQQAKGGIVTAPRLG
ECCCCCEEEEEEEEECCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCCCEEECCCCC
ITVGLVVQGPGQLLPVGLSALSSQGKRELGLPETGLVVGQVEPNTPAAKSGLRGGTRTQT
EEEEEEEECCCCEEHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCHHHHCCCCCCCCEE
FRGGQIVVGGDVITAADGKPVDGIEDLQAVLIDKQPGDSVTLRVVRGKQTRDVKVTLDNS
ECCCEEEECCCEEEECCCCCCCCHHHHHEEEECCCCCCCEEEEEEECCCCCEEEEEECCC
SFE
CCC
>Mature Secondary Structure
MRRPMLAAILVLVGLGLGATLLRDQVPISDAQKSPAATTAPTAGTEAGARLQNEQNTIDI
CCCHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCEEE
VSRYEPGLVYISTEQQVVQQDPLGWMLGGQDETQVVQGVGSGFFVNEQGDILTNYHVVAG
EECCCCCEEEEECCHHHHHHCCCCEEECCCCHHHHHHHCCCCEEECCCCCEEEEEEEEEC
ENGQGPASSIRVRVMNREQSVPARVIGLAPQYDLALIRAEGLDKSLIRPIPLGDSDTLKA
CCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCEEEEEECCCCHHHCCCCCCCCCHHHHH
GQKAIAMGAPFGLDFSVTEGIVSSTARQIPIGFSATGEGITQKAIQTDAAINPGNSGGPL
CCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCE
LDSSGRVIGINTQILSPAGAATGVGQNAGVGFAIPINAAKNLLPRLQQAKGGIVTAPRLG
ECCCCCEEEEEEEEECCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCCCEEECCCCC
ITVGLVVQGPGQLLPVGLSALSSQGKRELGLPETGLVVGQVEPNTPAAKSGLRGGTRTQT
EEEEEEEECCCCEEHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCHHHHCCCCCCCCEE
FRGGQIVVGGDVITAADGKPVDGIEDLQAVLIDKQPGDSVTLRVVRGKQTRDVKVTLDNS
ECCCEEEECCCEEEECCCCCCCCHHHHHEEEECCCCCCCEEEEEEECCCCCEEEEEECCC
SFE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]