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The map label for this gene is pyrC [H]

Identifier: 94984609

GI number: 94984609

Start: 521151

End: 522404

Strand: Reverse

Name: pyrC [H]

Synonym: Dgeo_0502

Alternate gene names: 94984609

Gene position: 522404-521151 (Counterclockwise)

Preceding gene: 94984610

Following gene: 94984605

Centisome position: 21.17

GC content: 68.1

Gene sequence:

>1254_bases
ATGACACAACTCACCATTACCAACATCAAGCGCCCCAGCAGGGACCGTCTCGAATCCGTCACCATCGAGCATGGCGTGAT
CAAAGGCTGGAACCTCGGCGAACTCGGGGACGTGCTGGACGGGCAGGGCGGTACCGTCGCCCCCGCCCTGATCGAACTGC
ACGCCCACCTGCGCGAGCCGGGGCAGACCGAAAAGGAAGACCTGGCCTCGGGTCTGGCCGCCGCCGCCGCAGGCGGATAC
GGCACCGTCGTCTCGATGCCAAACACGTCGCCGGTCGTGGATGACCCGGCCATCGTGCGTTCGCTGATCGAGAAGGCGGA
GGGGGTCGGCCTGGCCCGGCTCAAGCCCGCCGCTGCCCTCACCCGGGGGCAAAAGGGCGAACAGCTCGCAGAACTCGCCT
TCCTGAGGGACGCCGGCGCCGCCATGTTCACCGACGACGGACGCACAAACGAGAATGCGCGGGTGCTGCGGCTGGGCTTG
GAATACGCCCGCAGCCTGGGCATGGTCGTCAGCGTTCACGCGGAAGACGCTGCCCTGCGCGCCGACGGCGTGATGAACGA
GGGGCTGGTGTCGGAGGAACTGGGCCTGCCCGGCAATCCTGGGGCGGCGGAGGCAGCTCGGGTGGCGCGTGACCTGGAAC
TGGTGGCGCTTACGGGCGCGCGGCTGCACCTACAGCATCTCTCAACGGCCCGCGCCCTTGAGCTGGTGCGGGACGCCAAG
CGGCGCGGCCTCCCCGTCACCTGTGAAGTCTGCCCGCACCACCTCACCCTCACCGACGAGGCGCTGCGATCCTTCGATGC
GATCTATAAAGTCGCGCCGCCCCTACGGACGCAGGCGGACGCTGCCGCCCTCCTGGAAGGGCTGCTGGACGGCACCGTTG
ATTGCCTGGCTACCGATCACGCGCCCCACACCCGCGCGGAAAAGGAACGCGACCTGCTGCAAGCGCCCTTCGGCATCCCC
TCGCTCGAACTGGCCTTTCCGCTGATGTGGACGCGCTTCGGCGAACAACTCGGCCTCGAGAAACTGCTTGAACTGATGAC
GGCGGCCCCCGCCCGCGTGCTGGGCTGGCCCGAACCAACACTGAACGCGGGTGCACCCGCCGACCTGGTGGTGCTCGATC
TCACCACTGAGCGTGAGGTCAACCCCGCCACCTTCAGGAGTAAGGCGAAGTTTTCACCCTGGGCCGGCGAACAGCTGAGG
GGCTGGCCGCTGCTGACGGTGGTGGGCGGCAAGCTCGCGTTCCGGCGCGCGTAA

Upstream 100 bases:

>100_bases
CCAGTCAGCCATCAGCGGCAACGTTTGCGCCTCTGCAGGAAGCTGAAGGCTGCTGGCCGAGCCTACTCACAGGAAGCGTG
CTCAAAGGAATGGACTACCA

Downstream 100 bases:

>100_bases
GAGCATCCAGCACAAGCTGGGTTACAGATCCAGCGGGTCGGGCCTTTGCGAGGCCGCCTCGCCCTCGTCCTTGTCATTGC
GCTGGAGCGCCTCTTCTAGC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MTQLTITNIKRPSRDRLESVTIEHGVIKGWNLGELGDVLDGQGGTVAPALIELHAHLREPGQTEKEDLASGLAAAAAGGY
GTVVSMPNTSPVVDDPAIVRSLIEKAEGVGLARLKPAAALTRGQKGEQLAELAFLRDAGAAMFTDDGRTNENARVLRLGL
EYARSLGMVVSVHAEDAALRADGVMNEGLVSEELGLPGNPGAAEAARVARDLELVALTGARLHLQHLSTARALELVRDAK
RRGLPVTCEVCPHHLTLTDEALRSFDAIYKVAPPLRTQADAAALLEGLLDGTVDCLATDHAPHTRAEKERDLLQAPFGIP
SLELAFPLMWTRFGEQLGLEKLLELMTAAPARVLGWPEPTLNAGAPADLVVLDLTTEREVNPATFRSKAKFSPWAGEQLR
GWPLLTVVGGKLAFRRA

Sequences:

>Translated_417_residues
MTQLTITNIKRPSRDRLESVTIEHGVIKGWNLGELGDVLDGQGGTVAPALIELHAHLREPGQTEKEDLASGLAAAAAGGY
GTVVSMPNTSPVVDDPAIVRSLIEKAEGVGLARLKPAAALTRGQKGEQLAELAFLRDAGAAMFTDDGRTNENARVLRLGL
EYARSLGMVVSVHAEDAALRADGVMNEGLVSEELGLPGNPGAAEAARVARDLELVALTGARLHLQHLSTARALELVRDAK
RRGLPVTCEVCPHHLTLTDEALRSFDAIYKVAPPLRTQADAAALLEGLLDGTVDCLATDHAPHTRAEKERDLLQAPFGIP
SLELAFPLMWTRFGEQLGLEKLLELMTAAPARVLGWPEPTLNAGAPADLVVLDLTTEREVNPATFRSKAKFSPWAGEQLR
GWPLLTVVGGKLAFRRA
>Mature_416_residues
TQLTITNIKRPSRDRLESVTIEHGVIKGWNLGELGDVLDGQGGTVAPALIELHAHLREPGQTEKEDLASGLAAAAAGGYG
TVVSMPNTSPVVDDPAIVRSLIEKAEGVGLARLKPAAALTRGQKGEQLAELAFLRDAGAAMFTDDGRTNENARVLRLGLE
YARSLGMVVSVHAEDAALRADGVMNEGLVSEELGLPGNPGAAEAARVARDLELVALTGARLHLQHLSTARALELVRDAKR
RGLPVTCEVCPHHLTLTDEALRSFDAIYKVAPPLRTQADAAALLEGLLDGTVDCLATDHAPHTRAEKERDLLQAPFGIPS
LELAFPLMWTRFGEQLGLEKLLELMTAAPARVLGWPEPTLNAGAPADLVVLDLTTEREVNPATFRSKAKFSPWAGEQLRG
WPLLTVVGGKLAFRRA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=386, Percent_Identity=34.4559585492228, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI19923821, Length=431, Percent_Identity=25.2900232018561, Blast_Score=89, Evalue=8e-18,
Organism=Escherichia coli, GI1786722, Length=419, Percent_Identity=26.7303102625298, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI87082175, Length=424, Percent_Identity=26.1792452830189, Blast_Score=116, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI193204318, Length=378, Percent_Identity=30.952380952381, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI86575075, Length=416, Percent_Identity=23.7980769230769, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322218, Length=429, Percent_Identity=28.6713286713287, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24642586, Length=373, Percent_Identity=30.2949061662198, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI18859883, Length=397, Percent_Identity=26.9521410579345, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 44523; Mature: 44391

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLTITNIKRPSRDRLESVTIEHGVIKGWNLGELGDVLDGQGGTVAPALIELHAHLREP
CCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCC
GQTEKEDLASGLAAAAAGGYGTVVSMPNTSPVVDDPAIVRSLIEKAEGVGLARLKPAAAL
CCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHCCHHHHH
TRGQKGEQLAELAFLRDAGAAMFTDDGRTNENARVLRLGLEYARSLGMVVSVHAEDAALR
HCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCHHHH
ADGVMNEGLVSEELGLPGNPGAAEAARVARDLELVALTGARLHLQHLSTARALELVRDAK
HCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHH
RRGLPVTCEVCPHHLTLTDEALRSFDAIYKVAPPLRTQADAAALLEGLLDGTVDCLATDH
HCCCCEEEECCCCEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHCCCC
APHTRAEKERDLLQAPFGIPSLELAFPLMWTRFGEQLGLEKLLELMTAAPARVLGWPEPT
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHCCCCCCC
LNAGAPADLVVLDLTTEREVNPATFRSKAKFSPWAGEQLRGWPLLTVVGGKLAFRRA
CCCCCCCCEEEEEECCCCCCCHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure 
TQLTITNIKRPSRDRLESVTIEHGVIKGWNLGELGDVLDGQGGTVAPALIELHAHLREP
CEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCC
GQTEKEDLASGLAAAAAGGYGTVVSMPNTSPVVDDPAIVRSLIEKAEGVGLARLKPAAAL
CCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHCCHHHHH
TRGQKGEQLAELAFLRDAGAAMFTDDGRTNENARVLRLGLEYARSLGMVVSVHAEDAALR
HCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCHHHH
ADGVMNEGLVSEELGLPGNPGAAEAARVARDLELVALTGARLHLQHLSTARALELVRDAK
HCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHH
RRGLPVTCEVCPHHLTLTDEALRSFDAIYKVAPPLRTQADAAALLEGLLDGTVDCLATDH
HCCCCEEEECCCCEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHCCCC
APHTRAEKERDLLQAPFGIPSLELAFPLMWTRFGEQLGLEKLLELMTAAPARVLGWPEPT
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHCCCCCCC
LNAGAPADLVVLDLTTEREVNPATFRSKAKFSPWAGEQLRGWPLLTVVGGKLAFRRA
CCCCCCCCEEEEEECCCCCCCHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]