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The map label for this gene is xseA [H]

Identifier: 94984256

GI number: 94984256

Start: 138469

End: 139710

Strand: Reverse

Name: xseA [H]

Synonym: Dgeo_0148

Alternate gene names: 94984256

Gene position: 139710-138469 (Counterclockwise)

Preceding gene: 94984257

Following gene: 94984251

Centisome position: 5.66

GC content: 70.45

Gene sequence:

>1242_bases
GTGACGGGGCGGGGGCGCAAGCGGACGGAGGTGACGCGGACACCGGAACACTTCCTGGACCTCGCGGACGTGCTGGTCTA
CGTAGGTCAGGTGATCGCGCGGGGCGTGCCGGGAGCCGTCTGGGTGCGCGCCGAAGTCGCCAGCCTCACCGATCGGCGCC
ACCTCTACCTGGACCTGGTGCAGCTCGAAGACGGCGTGGAGGTGGCCAAGTGCCGCGCCACCGTCTGGGCACGGGAACGC
TTCGCGTTAGAGGGCAAGTTCCGGCGGGCAACGGGCGGGGGGAGCCTCACGGCGGGCCTCAAGGTACTGCTCTTTTGCAC
GGCGGAATTTCACCCGCAGTACGGCTTTTCGCTCAACGTGCTGGATGTAGCACCGGAATTCACGCTGGGGGACGCCGCAC
TTAAGCTCGACGCGCTGCGCGAGACGCTCACTCGCGAGGGGGTGTATGGCCTCAACCGCACCCTGCCCGCCCCAACCGAC
TTCGTGCGGGTGGCGGTGATCAGCCCAGCGGAGGCGGCGGGTCTGGGCGACTTCCGCCGCGAGACAGACGCGCTGGAGGC
GGCCGGGATCGTACGGTTTCTGTATCTGGAGGCAACCTTCCAAGGCCGCGAGGCGTCGGCGAGCCTCAGCGGCGCGGTGG
CTGCGGCCCGCGCGGCACATGAGGCCGAAACCCTCGGAGGTCCGCTCGACGCACTGGTGGTGATCCGCGGCGGCGGCGCC
GTGACGGACCTCGCCTGGCTGAACGACCTGGCGGTGGCCCGCGCACTCGCCACCTTTCCAGTCCCCGTGATCACCGGCCT
GGGCCACGCCCGCGACGACACCCTGCTCGACGAGATGGCCTGCATCCGCACCGACACCCCCAGCAAGGCGGCGGCCCTGA
TCGTGCGGACAGTGATGGCGGCCGCCGCGCAGGCCCAGGAGGACATCCGCACCATCCGCGCTCACGCTCGCAACACGTTG
GTGAATGCCGAGGCGGGGGCGCGCTGGCTGCTGGACCGCCTGCTGGGCAGCGCCCGCCGTCAGACCGACGCCGCACAGGC
CCAGACCGACGCCTTGATGCGGCAGACTCTAGGCCTTACGCCGGAACGCACGCTGGCACGCGGCTACGTCCTGGTGCGTG
ACGCGCAGGGCCAGCCGGTCACCCGGGCCGCGCAGGTGGACGGGGGGCAGATCCTGACACTGGAGTTCGCAGACGGACAG
GCGGAGGTGCGAGCCGAAAGGACAGATCCGCAGAGGGTCTGA

Upstream 100 bases:

>100_bases
TGGGGCGCGGCGCGGTGGGCCTGGCAGCGCTGTACGCCGGACTGAGTGTGGGGCTAGGCCTGCTGGCGGCAGTCGCAGGT
CGCCTGCTGGGGACGCGGCT

Downstream 100 bases:

>100_bases
TTCCCCTGGAGGCGACTGGGTCGCCCCTCTCGGCCTTCCAGCTCACGCGAGCACAGCCTAGTGGGCCGCTGCCACCGCCC
GCACCACCTCGTCCTGGATG

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MTGRGRKRTEVTRTPEHFLDLADVLVYVGQVIARGVPGAVWVRAEVASLTDRRHLYLDLVQLEDGVEVAKCRATVWARER
FALEGKFRRATGGGSLTAGLKVLLFCTAEFHPQYGFSLNVLDVAPEFTLGDAALKLDALRETLTREGVYGLNRTLPAPTD
FVRVAVISPAEAAGLGDFRRETDALEAAGIVRFLYLEATFQGREASASLSGAVAAARAAHEAETLGGPLDALVVIRGGGA
VTDLAWLNDLAVARALATFPVPVITGLGHARDDTLLDEMACIRTDTPSKAAALIVRTVMAAAAQAQEDIRTIRAHARNTL
VNAEAGARWLLDRLLGSARRQTDAAQAQTDALMRQTLGLTPERTLARGYVLVRDAQGQPVTRAAQVDGGQILTLEFADGQ
AEVRAERTDPQRV

Sequences:

>Translated_413_residues
MTGRGRKRTEVTRTPEHFLDLADVLVYVGQVIARGVPGAVWVRAEVASLTDRRHLYLDLVQLEDGVEVAKCRATVWARER
FALEGKFRRATGGGSLTAGLKVLLFCTAEFHPQYGFSLNVLDVAPEFTLGDAALKLDALRETLTREGVYGLNRTLPAPTD
FVRVAVISPAEAAGLGDFRRETDALEAAGIVRFLYLEATFQGREASASLSGAVAAARAAHEAETLGGPLDALVVIRGGGA
VTDLAWLNDLAVARALATFPVPVITGLGHARDDTLLDEMACIRTDTPSKAAALIVRTVMAAAAQAQEDIRTIRAHARNTL
VNAEAGARWLLDRLLGSARRQTDAAQAQTDALMRQTLGLTPERTLARGYVLVRDAQGQPVTRAAQVDGGQILTLEFADGQ
AEVRAERTDPQRV
>Mature_412_residues
TGRGRKRTEVTRTPEHFLDLADVLVYVGQVIARGVPGAVWVRAEVASLTDRRHLYLDLVQLEDGVEVAKCRATVWARERF
ALEGKFRRATGGGSLTAGLKVLLFCTAEFHPQYGFSLNVLDVAPEFTLGDAALKLDALRETLTREGVYGLNRTLPAPTDF
VRVAVISPAEAAGLGDFRRETDALEAAGIVRFLYLEATFQGREASASLSGAVAAARAAHEAETLGGPLDALVVIRGGGAV
TDLAWLNDLAVARALATFPVPVITGLGHARDDTLLDEMACIRTDTPSKAAALIVRTVMAAAAQAQEDIRTIRAHARNTLV
NAEAGARWLLDRLLGSARRQTDAAQAQTDALMRQTLGLTPERTLARGYVLVRDAQGQPVTRAAQVDGGQILTLEFADGQA
EVRAERTDPQRV

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides [H]

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family [H]

Homologues:

Organism=Escherichia coli, GI1788856, Length=277, Percent_Identity=27.4368231046931, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003753
- InterPro:   IPR020579 [H]

Pfam domain/function: PF02601 Exonuc_VII_L [H]

EC number: =3.1.11.6 [H]

Molecular weight: Translated: 44351; Mature: 44220

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGRGRKRTEVTRTPEHFLDLADVLVYVGQVIARGVPGAVWVRAEVASLTDRRHLYLDLV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHCCCCEEEEEEE
QLEDGVEVAKCRATVWARERFALEGKFRRATGGGSLTAGLKVLLFCTAEFHPQYGFSLNV
ECCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHEEEEEEHHCCCCCCCEEEE
LDVAPEFTLGDAALKLDALRETLTREGVYGLNRTLPAPTDFVRVAVISPAEAAGLGDFRR
EECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCHHHCCCCHHHH
ETDALEAAGIVRFLYLEATFQGREASASLSGAVAAARAAHEAETLGGPLDALVVIRGGGA
HHHHHHHHHHHHEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCC
VTDLAWLNDLAVARALATFPVPVITGLGHARDDTLLDEMACIRTDTPSKAAALIVRTVMA
HHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
AAAQAQEDIRTIRAHARNTLVNAEAGARWLLDRLLGSARRQTDAAQAQTDALMRQTLGLT
HHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PERTLARGYVLVRDAQGQPVTRAAQVDGGQILTLEFADGQAEVRAERTDPQRV
CCHHHHCCEEEEECCCCCCCCEEEECCCCEEEEEEECCCCCEEEECCCCCCCC
>Mature Secondary Structure 
TGRGRKRTEVTRTPEHFLDLADVLVYVGQVIARGVPGAVWVRAEVASLTDRRHLYLDLV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHCCCCEEEEEEE
QLEDGVEVAKCRATVWARERFALEGKFRRATGGGSLTAGLKVLLFCTAEFHPQYGFSLNV
ECCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHEEEEEEHHCCCCCCCEEEE
LDVAPEFTLGDAALKLDALRETLTREGVYGLNRTLPAPTDFVRVAVISPAEAAGLGDFRR
EECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCHHHCCCCHHHH
ETDALEAAGIVRFLYLEATFQGREASASLSGAVAAARAAHEAETLGGPLDALVVIRGGGA
HHHHHHHHHHHHEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCC
VTDLAWLNDLAVARALATFPVPVITGLGHARDDTLLDEMACIRTDTPSKAAALIVRTVMA
HHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
AAAQAQEDIRTIRAHARNTLVNAEAGARWLLDRLLGSARRQTDAAQAQTDALMRQTLGLT
HHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PERTLARGYVLVRDAQGQPVTRAAQVDGGQILTLEFADGQAEVRAERTDPQRV
CCHHHHCCEEEEECCCCCCCCEEEECCCCEEEEEEECCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]