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The map label for this gene is fchA [H]

Identifier: 94995261

GI number: 94995261

Start: 1825241

End: 1825867

Strand: Direct

Name: fchA [H]

Synonym: MGAS10750_Spy1865

Alternate gene names: 94995261

Gene position: 1825241-1825867 (Clockwise)

Preceding gene: 94995260

Following gene: 94995262

Centisome position: 94.22

GC content: 43.86

Gene sequence:

>627_bases
ATGGGTTTAGTTGATTTAAGCTTAACAGATTTCGCTAAAGTCCTTGGCTCAGATGCCCCTGATCCAGGTGGTGGTTCTGC
TGCTGCTCTCTCTGGCGCTAATGGCATTTCCTTGACTAAGATGGTCTGTGAATTGACCCTCGGTAAGAAAAAATACGCTG
ACTACCAAGATATTATTACAGAGGTCCATGCTAAAAGCACCGCTCTACAAGCTAGCTTGCTTGCAGCCATTGACAAAGAT
ACCGAAGCCTTCAACCTGGTTTCTGCCGTTTTTGATATGCCAAAAGAGACTGACGAAGACAAGGCTGCTAGACGAACTGC
CATGCAAAAGGCCTTGAAAACAGCTGCACAATCACCTTTTGAGATGATGACCCTCATGGTCGAAGCACTTGAGATCACTG
CAACAGCTGTCGGTAAGTCTAATACAAATGCTGCTAGCGACTTAGGAGTTGCTGCTTTAAACTTAAAAGCAGGTTTACAA
GGCGCTTGGTTGAATGTTTTGATTAATCTGTCTGGCATCAAAGATGAAGACTTTGTTACCGACTATCGCCAAAAAGGACA
AGCCTTATTAGACAAGGGCTGTCACTTGGCAGATGACATCTACACGAAAATTCTCGATATTGTTTAA

Upstream 100 bases:

>100_bases
AAGGCCTTAATCGATGTGGCTGAATACTACTTACAAGTTGAGGACTTTGACTACCATAAACAGGTTCTTGAAAACCATTT
GCTAGGTTAGGAGGTTCTCT

Downstream 100 bases:

>100_bases
CAAGTAAAGGAGCAACTATGGTTTTATCAGATATTGAAATAGCCAACTCTGTCTCTATGGAACCTATCAGTAAGGTTGCC
GATCAATTAGGGATCGACAA

Product: formiminotetrahydrofolate cyclodeaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MGLVDLSLTDFAKVLGSDAPDPGGGSAAALSGANGISLTKMVCELTLGKKKYADYQDIITEVHAKSTALQASLLAAIDKD
TEAFNLVSAVFDMPKETDEDKAARRTAMQKALKTAAQSPFEMMTLMVEALEITATAVGKSNTNAASDLGVAALNLKAGLQ
GAWLNVLINLSGIKDEDFVTDYRQKGQALLDKGCHLADDIYTKILDIV

Sequences:

>Translated_208_residues
MGLVDLSLTDFAKVLGSDAPDPGGGSAAALSGANGISLTKMVCELTLGKKKYADYQDIITEVHAKSTALQASLLAAIDKD
TEAFNLVSAVFDMPKETDEDKAARRTAMQKALKTAAQSPFEMMTLMVEALEITATAVGKSNTNAASDLGVAALNLKAGLQ
GAWLNVLINLSGIKDEDFVTDYRQKGQALLDKGCHLADDIYTKILDIV
>Mature_207_residues
GLVDLSLTDFAKVLGSDAPDPGGGSAAALSGANGISLTKMVCELTLGKKKYADYQDIITEVHAKSTALQASLLAAIDKDT
EAFNLVSAVFDMPKETDEDKAARRTAMQKALKTAAQSPFEMMTLMVEALEITATAVGKSNTNAASDLGVAALNLKAGLQG
AWLNVLINLSGIKDEDFVTDYRQKGQALLDKGCHLADDIYTKILDIV

Specific function: Required for both C1 and C2 metabolism [H]

COG id: COG3404

COG function: function code E; Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cyclodeaminase/cyclohydrolase family [H]

Homologues:

Organism=Homo sapiens, GI46255035, Length=155, Percent_Identity=31.6129032258064, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI11140815, Length=155, Percent_Identity=31.6129032258064, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007044 [H]

Pfam domain/function: PF04961 FTCD_C [H]

EC number: =3.5.4.9 [H]

Molecular weight: Translated: 21956; Mature: 21825

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLVDLSLTDFAKVLGSDAPDPGGGSAAALSGANGISLTKMVCELTLGKKKYADYQDIIT
CCEECCHHHHHHHHHCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHCHHHCCCHHHHHH
EVHAKSTALQASLLAAIDKDTEAFNLVSAVFDMPKETDEDKAARRTAMQKALKTAAQSPF
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHH
EMMTLMVEALEITATAVGKSNTNAASDLGVAALNLKAGLQGAWLNVLINLSGIKDEDFVT
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHEEECCCCCCHHHHH
DYRQKGQALLDKGCHLADDIYTKILDIV
HHHHHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
GLVDLSLTDFAKVLGSDAPDPGGGSAAALSGANGISLTKMVCELTLGKKKYADYQDIIT
CEECCHHHHHHHHHCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHCHHHCCCHHHHHH
EVHAKSTALQASLLAAIDKDTEAFNLVSAVFDMPKETDEDKAARRTAMQKALKTAAQSPF
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHH
EMMTLMVEALEITATAVGKSNTNAASDLGVAALNLKAGLQGAWLNVLINLSGIKDEDFVT
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHEEECCCCCCHHHHH
DYRQKGQALLDKGCHLADDIYTKILDIV
HHHHHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7961516; 10215859 [H]