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The map label for this gene is fhs2 [H]

Identifier: 94995262

GI number: 94995262

Start: 1825885

End: 1827558

Strand: Direct

Name: fhs2 [H]

Synonym: MGAS10750_Spy1866

Alternate gene names: 94995262

Gene position: 1825885-1827558 (Clockwise)

Preceding gene: 94995261

Following gene: 94995263

Centisome position: 94.26

GC content: 47.19

Gene sequence:

>1674_bases
ATGGTTTTATCAGATATTGAAATAGCCAACTCTGTCTCTATGGAACCTATCAGTAAGGTTGCCGATCAATTAGGGATCGA
CAAGGAAGCGCTCTGTCTCTATGGTAAGTACAAGGCAAAAATTAATGCCCGTCAACTGGTCGCCTTAAAAGACAAACCTG
ATGGCAAACTCATTCTTGTCACTGCTATCTCACCAACACCAGCTGGTGAAGGCAAAACCACCACTTCCGTTGGATTGGTA
GATGCTCTTTCTGCCATTGGAAAAAAAGCAGTTATTGCCCTTCGTGAACCTTCTCTTGGTCCTGTTTTTGGGGTTAAGGG
AGGAGCTGCTGGCGGTGGCCACGCGCAAGTTGTCCCAATGGAAGACATCAACCTTCACTTTACAGGGGACTTTCATGCCA
TCGGTGTCGCCAACAACTTATTAGCTGCCTTGATTGATAACCACATTCACCATGGCAATAGCCTAGGCATTGATTCCAGA
CGTATTACTTGGAAACGTGTGGTGGATATGAATGACCGCCAGCTTCGTCATATTGTTGACGGCTTGCAAGGCAAGGTCAA
CGGGGTCCCTCGTGAGGATGGTTACGACATTACCGTCGCCTCTGAAATCATGGCAATCCTGTGCCTATCCGAAAATATCT
CTGACCTCAAAGCCCGCCTTGAAAAAATCATCATCGGTTACAACTATCAAGGCGAACCTGTAACAGCTAAAGACTTGAAA
GCTGGTGGTGCCCTAGCCGATCTGCTCAAGGACGCGATTCATCCTAATCTCGTGCAAACCCTGGAACACACACCAGCCCT
CATTCACGGTGGCCCATTTGCTAATATCGCCCATGGCTGTAATAGTGTCCTCGCCACCAAACTAGCCTTGAAATATGGTG
ATTATGCCGTTACCGAAGCTGGATTTGGTGCTGACCTTGGAGCTGAAAAATTCATTGACATCAAATGCCGCATGTCAGGC
CTTCGTCCAGCAGCCGTTGTCCTAGTAGCCACTATTCGTGCCCTTAAAATGCACGGTGGCGTTCAAAAAACTGACTTGGC
TACTGAAAATGTTCAAGCCGTTGTGGATGGTTTGCCTAACCTTGACAAACATTTGGCTAATATCCAAGACGTCTATGGCC
TTCCAGTTGTCGTTGCAATCAATAAATTCCCGCTTGATACCGATGCTGAATTACAAGCTGTCTATGATGCCTGCAACAAA
CGTGGCGTTGACGTTGTGATTTCTGATGTTTGGGCAAATGGCGGAGCTGGTGGCCGTGAACTGGCTGAAAAAGTCGTGAC
ACTAGCCGAGCAAGACAATCAATTCCGCTTTGTTTATGAGGAAGACGATAGCATTGAAACCAAACTGACTAAAATCGTTA
CCAAAGTTTACGGTGGTAAAGGCATCACCTTGAGCCCAGCAGCCAAACGTGAACTGGCTGACTTAGAACGCCTAGGCTTT
GGCAACTACCCAATTTGCATGGCCAAAACCCAATATTCCTTCTCAGACGATGCCAAAACACTTGGCGCACCAACTGACTT
TACAGTGACTATTAGCAACCTCAAAGTGTCTGCAGGAGCAGGATTTATCGTTGCTCTGACGGGTGCTATCATGACCATGC
CTGGCCTTCCAAAAGTACCTGCCAGCGAAACCATTGATATTGACGAGGAGGGCAACATCACAGGACTATTCTAA

Upstream 100 bases:

>100_bases
ATCGCCAAAAAGGACAAGCCTTATTAGACAAGGGCTGTCACTTGGCAGATGACATCTACACGAAAATTCTCGATATTGTT
TAACAAGTAAAGGAGCAACT

Downstream 100 bases:

>100_bases
TTGGAAACAAGGAGAGAACAAATGACAAAGGTAACTATCAAAGCGCCCTCTGATTACCTCCAAACTGACTGGTCTGGCGG
TGAAACCAACCAATTGTTCC

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase 2; FHS 2; FTHFS 2 [H]

Number of amino acids: Translated: 557; Mature: 557

Protein sequence:

>557_residues
MVLSDIEIANSVSMEPISKVADQLGIDKEALCLYGKYKAKINARQLVALKDKPDGKLILVTAISPTPAGEGKTTTSVGLV
DALSAIGKKAVIALREPSLGPVFGVKGGAAGGGHAQVVPMEDINLHFTGDFHAIGVANNLLAALIDNHIHHGNSLGIDSR
RITWKRVVDMNDRQLRHIVDGLQGKVNGVPREDGYDITVASEIMAILCLSENISDLKARLEKIIIGYNYQGEPVTAKDLK
AGGALADLLKDAIHPNLVQTLEHTPALIHGGPFANIAHGCNSVLATKLALKYGDYAVTEAGFGADLGAEKFIDIKCRMSG
LRPAAVVLVATIRALKMHGGVQKTDLATENVQAVVDGLPNLDKHLANIQDVYGLPVVVAINKFPLDTDAELQAVYDACNK
RGVDVVISDVWANGGAGGRELAEKVVTLAEQDNQFRFVYEEDDSIETKLTKIVTKVYGGKGITLSPAAKRELADLERLGF
GNYPICMAKTQYSFSDDAKTLGAPTDFTVTISNLKVSAGAGFIVALTGAIMTMPGLPKVPASETIDIDEEGNITGLF

Sequences:

>Translated_557_residues
MVLSDIEIANSVSMEPISKVADQLGIDKEALCLYGKYKAKINARQLVALKDKPDGKLILVTAISPTPAGEGKTTTSVGLV
DALSAIGKKAVIALREPSLGPVFGVKGGAAGGGHAQVVPMEDINLHFTGDFHAIGVANNLLAALIDNHIHHGNSLGIDSR
RITWKRVVDMNDRQLRHIVDGLQGKVNGVPREDGYDITVASEIMAILCLSENISDLKARLEKIIIGYNYQGEPVTAKDLK
AGGALADLLKDAIHPNLVQTLEHTPALIHGGPFANIAHGCNSVLATKLALKYGDYAVTEAGFGADLGAEKFIDIKCRMSG
LRPAAVVLVATIRALKMHGGVQKTDLATENVQAVVDGLPNLDKHLANIQDVYGLPVVVAINKFPLDTDAELQAVYDACNK
RGVDVVISDVWANGGAGGRELAEKVVTLAEQDNQFRFVYEEDDSIETKLTKIVTKVYGGKGITLSPAAKRELADLERLGF
GNYPICMAKTQYSFSDDAKTLGAPTDFTVTISNLKVSAGAGFIVALTGAIMTMPGLPKVPASETIDIDEEGNITGLF
>Mature_557_residues
MVLSDIEIANSVSMEPISKVADQLGIDKEALCLYGKYKAKINARQLVALKDKPDGKLILVTAISPTPAGEGKTTTSVGLV
DALSAIGKKAVIALREPSLGPVFGVKGGAAGGGHAQVVPMEDINLHFTGDFHAIGVANNLLAALIDNHIHHGNSLGIDSR
RITWKRVVDMNDRQLRHIVDGLQGKVNGVPREDGYDITVASEIMAILCLSENISDLKARLEKIIIGYNYQGEPVTAKDLK
AGGALADLLKDAIHPNLVQTLEHTPALIHGGPFANIAHGCNSVLATKLALKYGDYAVTEAGFGADLGAEKFIDIKCRMSG
LRPAAVVLVATIRALKMHGGVQKTDLATENVQAVVDGLPNLDKHLANIQDVYGLPVVVAINKFPLDTDAELQAVYDACNK
RGVDVVISDVWANGGAGGRELAEKVVTLAEQDNQFRFVYEEDDSIETKLTKIVTKVYGGKGITLSPAAKRELADLERLGF
GNYPICMAKTQYSFSDDAKTLGAPTDFTVTISNLKVSAGAGFIVALTGAIMTMPGLPKVPASETIDIDEEGNITGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI36796743, Length=621, Percent_Identity=45.8937198067633, Blast_Score=466, Evalue=1e-131,
Organism=Homo sapiens, GI222136639, Length=621, Percent_Identity=43.9613526570048, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI310124614, Length=84, Percent_Identity=45.2380952380952, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17568737, Length=625, Percent_Identity=45.12, Blast_Score=457, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17568739, Length=625, Percent_Identity=45.12, Blast_Score=457, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=44.5686900958466, Blast_Score=469, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6319558, Length=633, Percent_Identity=42.8120063191153, Blast_Score=459, Evalue=1e-130,
Organism=Drosophila melanogaster, GI62472483, Length=621, Percent_Identity=45.5716586151369, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI45551871, Length=621, Percent_Identity=45.5716586151369, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24645718, Length=621, Percent_Identity=45.5716586151369, Blast_Score=490, Evalue=1e-138,
Organism=Drosophila melanogaster, GI17137370, Length=621, Percent_Identity=45.5716586151369, Blast_Score=490, Evalue=1e-138,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 59101; Mature: 59101

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLSDIEIANSVSMEPISKVADQLGIDKEALCLYGKYKAKINARQLVALKDKPDGKLILV
CEECCCCCCCCCCCCHHHHHHHHHCCCHHHEEEEECCEEEECCEEEEEEECCCCCCEEEE
TAISPTPAGEGKTTTSVGLVDALSAIGKKAVIALREPSLGPVFGVKGGAAGGGHAQVVPM
EEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCEEECCCCCCCCCCEEEEEE
EDINLHFTGDFHAIGVANNLLAALIDNHIHHGNSLGIDSRRITWKRVVDMNDRQLRHIVD
CCCEEEEECCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHH
GLQGKVNGVPREDGYDITVASEIMAILCLSENISDLKARLEKIIIGYNYQGEPVTAKDLK
HHCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHEEEEECCCCCCCCHHHHC
AGGALADLLKDAIHPNLVQTLEHTPALIHGGPFANIAHGCNSVLATKLALKYGDYAVTEA
CCCHHHHHHHHHHCHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEECC
GFGADLGAEKFIDIKCRMSGLRPAAVVLVATIRALKMHGGVQKTDLATENVQAVVDGLPN
CCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHCCCC
LDKHLANIQDVYGLPVVVAINKFPLDTDAELQAVYDACNKRGVDVVISDVWANGGAGGRE
HHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHH
LAEKVVTLAEQDNQFRFVYEEDDSIETKLTKIVTKVYGGKGITLSPAAKRELADLERLGF
HHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHCCC
GNYPICMAKTQYSFSDDAKTLGAPTDFTVTISNLKVSAGAGFIVALTGAIMTMPGLPKVP
CCCCEEEEECCCCCCCCHHHCCCCCCEEEEEEEEEEECCCCEEEEEHHHHHHCCCCCCCC
ASETIDIDEEGNITGLF
CCCEECCCCCCCEEECC
>Mature Secondary Structure
MVLSDIEIANSVSMEPISKVADQLGIDKEALCLYGKYKAKINARQLVALKDKPDGKLILV
CEECCCCCCCCCCCCHHHHHHHHHCCCHHHEEEEECCEEEECCEEEEEEECCCCCCEEEE
TAISPTPAGEGKTTTSVGLVDALSAIGKKAVIALREPSLGPVFGVKGGAAGGGHAQVVPM
EEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCEEECCCCCCCCCCEEEEEE
EDINLHFTGDFHAIGVANNLLAALIDNHIHHGNSLGIDSRRITWKRVVDMNDRQLRHIVD
CCCEEEEECCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHH
GLQGKVNGVPREDGYDITVASEIMAILCLSENISDLKARLEKIIIGYNYQGEPVTAKDLK
HHCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHEEEEECCCCCCCCHHHHC
AGGALADLLKDAIHPNLVQTLEHTPALIHGGPFANIAHGCNSVLATKLALKYGDYAVTEA
CCCHHHHHHHHHHCHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEECC
GFGADLGAEKFIDIKCRMSGLRPAAVVLVATIRALKMHGGVQKTDLATENVQAVVDGLPN
CCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHCCCC
LDKHLANIQDVYGLPVVVAINKFPLDTDAELQAVYDACNKRGVDVVISDVWANGGAGGRE
HHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHH
LAEKVVTLAEQDNQFRFVYEEDDSIETKLTKIVTKVYGGKGITLSPAAKRELADLERLGF
HHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHCCC
GNYPICMAKTQYSFSDDAKTLGAPTDFTVTISNLKVSAGAGFIVALTGAIMTMPGLPKVP
CCCCEEEEECCCCCCCCHHHCCCCCCEEEEEEEEEEECCCCEEEEEHHHHHHCCCCCCCC
ASETIDIDEEGNITGLF
CCCEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]