| Definition | Streptococcus pyogenes MGAS10750 chromosome, complete genome. |
|---|---|
| Accession | NC_008024 |
| Length | 1,937,111 |
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The map label for this gene is srtK [H]
Identifier: 94994350
GI number: 94994350
Start: 906141
End: 907502
Strand: Direct
Name: srtK [H]
Synonym: MGAS10750_Spy0954
Alternate gene names: 94994350
Gene position: 906141-907502 (Clockwise)
Preceding gene: 94994349
Following gene: 94994351
Centisome position: 46.78
GC content: 29.07
Gene sequence:
>1362_bases TTGGTTATAAATGGGATGTTTAAAAAATATTCAATAAAAAATCGTGTTTGGCGCGCCGTCGTTGAAATTGTCTTTGGAGT TTGTATCACTGTTTTAATGATTGCGATAATATCGCTTTCTTTTTCAAAGTTAAATATAGTGACATCTCATAATGTGGGAG AAGAATTTTATATTAAAGATAAACAGTCAATCAAACAGTTGAACAATTATATGAAGACATTGGGATTAGATTATGTTGTT TTTGATAGAAAAACAGATAAAGCTATGGAAGGAAAATATTTATCTAAAGAATTTTCTTTATTTAACGAAGTTGCAGAAGA AAAAAATAATCTGACTTTTAATTCTGTACATTATGATTTATATACTAATATCAATTATAATATTGTCATAAGATATAATG AGATACCGGAGTTTTCTAACCATTACCTTAGAAATGTTTCATATAACATGTTGACATTTTATATTCTGGGAATAGGAACG AGTATCAGCATTGTAGTTGCTTTAACACGGTTTGTAAAAGAAATTTCTTTGAATTTCAAGGAAATCAAGAAGTTAGCAAA TAAAATGGGGATAGAAGTCCTTTCTGAAAATGAAAATTATTCTAAAATAATCGAGTTTGATGATATACTTAGAACTTTAC ATATTAAAGGTGATAATTTGAAAAGTTTGATTGAGCGAGAAATATTGGAAAAGCAAGATCTATCCTTTCAAATTGCAGCA CTTTCGCATGATATAAAAACACCTTTAACGGTTTTGAAAGGAAATCTTGAGTTATTAGAATTGACTACTTTAAATAAAAA TCAGGAAGGTTATATTGTATCTATGAACAATAGTATTTCTGTTTTTGAAGGCTATTTCAATTCTTTAATATCTTATACAC GCATGCTTTCAGAGGATAGATCAGTGAAACTAATTTTAGTTGAGGAGCTATTAAGTGAGTTACATTTTGAAGTCGATGAC TTATTGAATATCAATAATATTGAATTTTCTATTTGTAATAGACTTATTATCACTTCTTTTTATGGAGATGAGGAAAATCT GATAAGAGCTCTTTCTAACCTTTTAGTTAATGCAATAAGATTTATGCCCGTATTAGATAAAAAAATCGAAGTTATACTGT CTGAGTCAGGAGAGCAAATTCATTTTGAAATATGGAATAATGGTGAGCGTTTCAGTGATAGTACACTGAAAAAGGGAGAT AAATTATTTTACACGGAAGATTATAGCAGAGGTAACAAACATTATGGAATCGGTTTGGCATTTGTTAAAGGCGTTGCTAT CAAACACGGTGGGAATCTTCAATTGAATAATCCAGTTAGAGGAGGTGCTAGCGCCATAATCTCGATAAAAAAGAAAATTT AA
Upstream 100 bases:
>100_bases GAAGCTTCAGCATTGTTTCATTCTATTTCAGAATATATCTATCAGATTAGAATGAAATTTTCAAGTTTTGGAATTAATCC AATAAAAACTATTCGCGGGA
Downstream 100 bases:
>100_bases TAGATTTGATTGAAACTGGAGTATTTCAGGCAAAAAATCGTAAATTTTGGTGATTTTTGGCTAAAATACTTTTTTTCTGA ACAAATTCTGAACTTGGGGT
Product: lantibiotic biosynthesis sensor protein
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 453; Mature: 453
Protein sequence:
>453_residues MVINGMFKKYSIKNRVWRAVVEIVFGVCITVLMIAIISLSFSKLNIVTSHNVGEEFYIKDKQSIKQLNNYMKTLGLDYVV FDRKTDKAMEGKYLSKEFSLFNEVAEEKNNLTFNSVHYDLYTNINYNIVIRYNEIPEFSNHYLRNVSYNMLTFYILGIGT SISIVVALTRFVKEISLNFKEIKKLANKMGIEVLSENENYSKIIEFDDILRTLHIKGDNLKSLIEREILEKQDLSFQIAA LSHDIKTPLTVLKGNLELLELTTLNKNQEGYIVSMNNSISVFEGYFNSLISYTRMLSEDRSVKLILVEELLSELHFEVDD LLNINNIEFSICNRLIITSFYGDEENLIRALSNLLVNAIRFMPVLDKKIEVILSESGEQIHFEIWNNGERFSDSTLKKGD KLFYTEDYSRGNKHYGIGLAFVKGVAIKHGGNLQLNNPVRGGASAIISIKKKI
Sequences:
>Translated_453_residues MVINGMFKKYSIKNRVWRAVVEIVFGVCITVLMIAIISLSFSKLNIVTSHNVGEEFYIKDKQSIKQLNNYMKTLGLDYVV FDRKTDKAMEGKYLSKEFSLFNEVAEEKNNLTFNSVHYDLYTNINYNIVIRYNEIPEFSNHYLRNVSYNMLTFYILGIGT SISIVVALTRFVKEISLNFKEIKKLANKMGIEVLSENENYSKIIEFDDILRTLHIKGDNLKSLIEREILEKQDLSFQIAA LSHDIKTPLTVLKGNLELLELTTLNKNQEGYIVSMNNSISVFEGYFNSLISYTRMLSEDRSVKLILVEELLSELHFEVDD LLNINNIEFSICNRLIITSFYGDEENLIRALSNLLVNAIRFMPVLDKKIEVILSESGEQIHFEIWNNGERFSDSTLKKGD KLFYTEDYSRGNKHYGIGLAFVKGVAIKHGGNLQLNNPVRGGASAIISIKKKI >Mature_453_residues MVINGMFKKYSIKNRVWRAVVEIVFGVCITVLMIAIISLSFSKLNIVTSHNVGEEFYIKDKQSIKQLNNYMKTLGLDYVV FDRKTDKAMEGKYLSKEFSLFNEVAEEKNNLTFNSVHYDLYTNINYNIVIRYNEIPEFSNHYLRNVSYNMLTFYILGIGT SISIVVALTRFVKEISLNFKEIKKLANKMGIEVLSENENYSKIIEFDDILRTLHIKGDNLKSLIEREILEKQDLSFQIAA LSHDIKTPLTVLKGNLELLELTTLNKNQEGYIVSMNNSISVFEGYFNSLISYTRMLSEDRSVKLILVEELLSELHFEVDD LLNINNIEFSICNRLIITSFYGDEENLIRALSNLLVNAIRFMPVLDKKIEVILSESGEQIHFEIWNNGERFSDSTLKKGD KLFYTEDYSRGNKHYGIGLAFVKGVAIKHGGNLQLNNPVRGGASAIISIKKKI
Specific function: Member of the two-component regulatory system nisK/nisR involved in the regulation of the biosynthesis of lantibiotic nisin. NisK may function as a membrane-associated protein kinase that phosphorylates nisR in response to environmental signals [H]
COG id: COG0642
COG function: function code T; Signal transduction histidine kinase
Gene ontology:
Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 histidine kinase domain [H]
Homologues:
Organism=Escherichia coli, GI1786912, Length=227, Percent_Identity=27.7533039647577, Blast_Score=65, Evalue=8e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003594 - InterPro: IPR008358 - InterPro: IPR003661 - InterPro: IPR005467 - InterPro: IPR009082 [H]
Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]
EC number: =2.7.13.3 [H]
Molecular weight: Translated: 52015; Mature: 52015
Theoretical pI: Translated: 7.03; Mature: 7.03
Prosite motif: PS50109 HIS_KIN
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 2.6 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 2.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MVINGMFKKYSIKNRVWRAVVEIVFGVCITVLMIAIISLSFSKLNIVTSHNVGEEFYIKD CEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEECCCCCEEEECC KQSIKQLNNYMKTLGLDYVVFDRKTDKAMEGKYLSKEFSLFNEVAEEKNNLTFNSVHYDL HHHHHHHHHHHHHHCCCEEEEECCCCCHHCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEE YTNINYNIVIRYNEIPEFSNHYLRNVSYNMLTFYILGIGTSISIVVALTRFVKEISLNFK EECCCEEEEEEECCCCCHHHHHHHCCCHHHHHHEEHHCCCHHHHHHHHHHHHHHHCCCHH EIKKLANKMGIEVLSENENYSKIIEFDDILRTLHIKGDNLKSLIEREILEKQDLSFQIAA HHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEE LSHDIKTPLTVLKGNLELLELTTLNKNQEGYIVSMNNSISVFEGYFNSLISYTRMLSEDR HHCCCCCCHHHHCCCCEEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCC SVKLILVEELLSELHFEVDDLLNINNIEFSICNRLIITSFYGDEENLIRALSNLLVNAIR CEEEEEHHHHHHHHCCCHHHHCCCCCCHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHH FMPVLDKKIEVILSESGEQIHFEIWNNGERFSDSTLKKGDKLFYTEDYSRGNKHYGIGLA HHHHHHHHHHHHEECCCCEEEEEEECCCCCCCCHHHCCCCEEEEECCCCCCCCCEEEHHH FVKGVAIKHGGNLQLNNPVRGGASAIISIKKKI HHHCEEEECCCCEEECCCCCCCCCEEEEEECCC >Mature Secondary Structure MVINGMFKKYSIKNRVWRAVVEIVFGVCITVLMIAIISLSFSKLNIVTSHNVGEEFYIKD CEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEECCCCCEEEECC KQSIKQLNNYMKTLGLDYVVFDRKTDKAMEGKYLSKEFSLFNEVAEEKNNLTFNSVHYDL HHHHHHHHHHHHHHCCCEEEEECCCCCHHCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEE YTNINYNIVIRYNEIPEFSNHYLRNVSYNMLTFYILGIGTSISIVVALTRFVKEISLNFK EECCCEEEEEEECCCCCHHHHHHHCCCHHHHHHEEHHCCCHHHHHHHHHHHHHHHCCCHH EIKKLANKMGIEVLSENENYSKIIEFDDILRTLHIKGDNLKSLIEREILEKQDLSFQIAA HHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEE LSHDIKTPLTVLKGNLELLELTTLNKNQEGYIVSMNNSISVFEGYFNSLISYTRMLSEDR HHCCCCCCHHHHCCCCEEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCC SVKLILVEELLSELHFEVDDLLNINNIEFSICNRLIITSFYGDEENLIRALSNLLVNAIR CEEEEEHHHHHHHHCCCHHHHCCCCCCHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHH FMPVLDKKIEVILSESGEQIHFEIWNNGERFSDSTLKKGDKLFYTEDYSRGNKHYGIGLA HHHHHHHHHHHHEECCCCEEEEEEECCCCCCCCHHHCCCCEEEEECCCCCCCCCEEEHHH FVKGVAIKHGGNLQLNNPVRGGASAIISIKKKI HHHCEEEECCCCEEECCCCCCCCCEEEEEECCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 8161176 [H]