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The map label for this gene is srtR [H]

Identifier: 94994349

GI number: 94994349

Start: 905477

End: 906163

Strand: Direct

Name: srtR [H]

Synonym: MGAS10750_Spy0953

Alternate gene names: 94994349

Gene position: 905477-906163 (Clockwise)

Preceding gene: 94994348

Following gene: 94994350

Centisome position: 46.74

GC content: 31.3

Gene sequence:

>687_bases
ATGTATAAGATTTTAGCCATAGATGATGATAAAGAAATTCTGAAGCTTATGAAGACTGCTTTGGAGATTGAAAATTATCA
TGTTATAACCTGTCAAGAGATAGAATTACCAATAGTTTTTGATGATTTTAAAGGATATGATTTGATCTTATTGGATATCA
TGATGCCTAATATAAGTGGAACTGAGTTTTGTTATAAAATTCGGGAAGAAGTTCATTCTCCAATTATTTTTGTTAGCGCT
TTAGATGGCGATAATGAAATTGTCCAAGCTTTAAATATAGGGGGAGACGATTTTATTGTGAAACCATTTAGCTTAAAACA
ATTCGTAGCTAAAGTTAACTCTCATTTGAAGAGAGAAGAGAGAGCAAAGATAAAGAATGAGGCTGAGGAGAGAGTGAAGC
GCAGTTTTCCACCTATAGAAATCTATCTAGAGGAACGTATGTTATATATTGATAAACAGCCGTTATTCCTGACTTATAGA
GAGTACGAAATTTTAGAATTACTGTCACGTCATCTGTATAAAGTTTTCACAAAAGAAGAGATATATGAACAAGTATATAG
CGATGAAGCTTCAGCATTGTTTCATTCTATTTCAGAATATATCTATCAGATTAGAATGAAATTTTCAAGTTTTGGAATTA
ATCCAATAAAAACTATTCGCGGGATTGGTTATAAATGGGATGTTTAA

Upstream 100 bases:

>100_bases
AGTTGATGTTTCGTAAATAACTATATTAAAGAAATGATTCCTGCCGCTTACATTAAGAATAGTTTATTTGTAAGTATTTC
ATTATTTAAAAGGGGTAATA

Downstream 100 bases:

>100_bases
AAAATATTCAATAAAAAATCGTGTTTGGCGCGCCGTCGTTGAAATTGTCTTTGGAGTTTGTATCACTGTTTTAATGATTG
CGATAATATCGCTTTCTTTT

Product: lantibiotic biosynthesis two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MYKILAIDDDKEILKLMKTALEIENYHVITCQEIELPIVFDDFKGYDLILLDIMMPNISGTEFCYKIREEVHSPIIFVSA
LDGDNEIVQALNIGGDDFIVKPFSLKQFVAKVNSHLKREERAKIKNEAEERVKRSFPPIEIYLEERMLYIDKQPLFLTYR
EYEILELLSRHLYKVFTKEEIYEQVYSDEASALFHSISEYIYQIRMKFSSFGINPIKTIRGIGYKWDV

Sequences:

>Translated_228_residues
MYKILAIDDDKEILKLMKTALEIENYHVITCQEIELPIVFDDFKGYDLILLDIMMPNISGTEFCYKIREEVHSPIIFVSA
LDGDNEIVQALNIGGDDFIVKPFSLKQFVAKVNSHLKREERAKIKNEAEERVKRSFPPIEIYLEERMLYIDKQPLFLTYR
EYEILELLSRHLYKVFTKEEIYEQVYSDEASALFHSISEYIYQIRMKFSSFGINPIKTIRGIGYKWDV
>Mature_228_residues
MYKILAIDDDKEILKLMKTALEIENYHVITCQEIELPIVFDDFKGYDLILLDIMMPNISGTEFCYKIREEVHSPIIFVSA
LDGDNEIVQALNIGGDDFIVKPFSLKQFVAKVNSHLKREERAKIKNEAEERVKRSFPPIEIYLEERMLYIDKQPLFLTYR
EYEILELLSRHLYKVFTKEEIYEQVYSDEASALFHSISEYIYQIRMKFSSFGINPIKTIRGIGYKWDV

Specific function: Member of the two-component regulatory system nisK/nisR involved in the regulation of the biosynthesis of lantibiotic nisin. NisR may function as a regulatory protein [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=26.5486725663717, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=26.3157894736842, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=30.3030303030303, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=29.5652173913043, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=26.1061946902655, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=25.5605381165919, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI1786784, Length=185, Percent_Identity=28.6486486486486, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1786599, Length=230, Percent_Identity=23.4782608695652, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1787375, Length=180, Percent_Identity=28.3333333333333, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1790860, Length=187, Percent_Identity=27.807486631016, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=23.6607142857143, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=24.7863247863248, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=22.8070175438596, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26945; Mature: 26945

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKILAIDDDKEILKLMKTALEIENYHVITCQEIELPIVFDDFKGYDLILLDIMMPNISG
CEEEEEECCCHHHHHHHHHHHHHCCEEEEEEEEEEEEEEEECCCCCEEEEEEEECCCCCC
TEFCYKIREEVHSPIIFVSALDGDNEIVQALNIGGDDFIVKPFSLKQFVAKVNSHLKREE
HHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHH
RAKIKNEAEERVKRSFPPIEIYLEERMLYIDKQPLFLTYREYEILELLSRHLYKVFTKEE
HHHHHHHHHHHHHHCCCCEEEEEECEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
IYEQVYSDEASALFHSISEYIYQIRMKFSSFGINPIKTIRGIGYKWDV
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCEECCC
>Mature Secondary Structure
MYKILAIDDDKEILKLMKTALEIENYHVITCQEIELPIVFDDFKGYDLILLDIMMPNISG
CEEEEEECCCHHHHHHHHHHHHHCCEEEEEEEEEEEEEEEECCCCCEEEEEEEECCCCCC
TEFCYKIREEVHSPIIFVSALDGDNEIVQALNIGGDDFIVKPFSLKQFVAKVNSHLKREE
HHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHH
RAKIKNEAEERVKRSFPPIEIYLEERMLYIDKQPLFLTYREYEILELLSRHLYKVFTKEE
HHHHHHHHHHHHHHCCCCEEEEEECEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
IYEQVYSDEASALFHSISEYIYQIRMKFSSFGINPIKTIRGIGYKWDV
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8478324; 8161176 [H]