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The map label for this gene is parE [H]

Identifier: 94994199

GI number: 94994199

Start: 776318

End: 778270

Strand: Direct

Name: parE [H]

Synonym: MGAS10750_Spy0803

Alternate gene names: 94994199

Gene position: 776318-778270 (Clockwise)

Preceding gene: 94994197

Following gene: 94994200

Centisome position: 40.08

GC content: 41.53

Gene sequence:

>1953_bases
GTGTTGACTAAGAAAGAAATTACAATTAATAATTATAATGACGATGCTATCCAAGTCCTAGAAGGGTTAGATGCTGTTCG
CAAGCGTCCAGGGATGTATATCGGTTCAACAGATGCTACGGGATTGCACCACCTGATTTGGGAAATTGTTGATAATGCTG
TCGATGAGGCCTTGTCTGGTTTTGGAGATGATATTAAGGTTGTTATCAATAAAGATGGCTCGGTCAGTGTGGCAGATAGC
GGACGTGGAATGCCAACAGGTCAGCATGCCATGGGGATTCCCACCGTTCAAGTTATTTTTACGATTCTTCATGCAGGTGG
TAAATTTGGTCAGGGTGGCTACAAAACGTCAGGTGGTTTGCACGGTGTTGGCTCCTCTGTTGTCAATGCTTTGTCTGCCT
GGTTAGAAGTCGAAATCACAAGAGACGGGGCAGTGTATCGTCAGCGCTTTGAAAATGGGGGGAAACCTGTTACAACCCTT
AAAAAAGTTGGCACAGCTCCTAAGTCTAAATCAGGAACGGTTGTAACCTTTATGCCTGATGATAAGATTTTTTCAACTAT
TGACTTTAAGTTCAATACCATTTCAGAACGATTGAAAGAATCTGCTTTTCTTTTGAAAAATGTCAAGATGAGCTTGACAG
ATCTTCGTGGAGATGACCCGATTATTGAAGAGTTTCATTATGAAAATGGGGTTCAAGATTTCGTCGAATACCTCAATGAA
GATAAGGAAACCTTGACACCTGTTATTTACATGGAAGGTCAAGACCAAGACTTTCAAGTCGAGGTTGCTTTGCAGTATAA
CGATGGTTTTTCCGACAATATCTTATCCTTTGTAAACAATGTGCGCACCAAAGATGGTGGAAGCCATGAAACGGGACTAA
AGTCAGCTATTACCAAAGCGATGAATGACTATGCTCGTAAAACCAATCTCTTAAAAGAAAAGGATAAAAATCTAGAGGGC
TCAGATTATCGAGAAGGACTCTCAGCAGTATTATCTATCTTAGTTCCTGAGCAGCACTTGCAATTTGAAGGACAGACCAA
AGACAAATTGGGAAGTCCCTTAGCGAGACCTATTGTAGAGAGCATTGTTTCTGAAAAATTAACCTTCTTTTTACTCGAAA
ATGGAGAAGTAGCTTCTCATCTAGTTCGCAAAGCCATTAAAGCTAGAGATGCTCGCGAAGCTGCTCGAAAAGCGCGTGAT
GACTCACGTAATGGTAAGAAAAACAAAAAAGACAAAGGCTTGTTGTCGGGAAAATTAACCCCAGCTCAGTCCAAAAATGC
CAAGAAAAATGAATTGTATCTGGTCGAAGGAGATTCTGCGGGAGGTTCAGCCAAACAAGGACGAGACCGCAAATTTCAGG
CTATTTTACCATTACGTGGCAAAGTTTTAAATACCGAAAAAGCTAAAATGGCTGATATCTTGAAAAATGAAGAAATTAAC
ACTATGGTTTATACCATTGGAGCTGGAGTGGGAGCTGACTTTAACCTCGAGGATATCAACTATGATAAGATTATTATCAT
GACCGATGCTGATACCGATGGGGCTCATATTCAGACTCTTTTGCTGACTTTCTTTTACCGTTACATGCGACCATTGGTAG
AAGCCGGTCATGTTTACATTGCCCTTCCACCTCTTTACAAAATGTCAAAAGGCAAAGGCAAAACTGAAAAAATTGCTTAT
GCTTGGACTGATGGTGAATTAGAAGATCTGCGCAGAGAATTTGGCAAGGGGGCTATTCTTCAACGCTATAAAGGACTGGG
TGAAATGAATGCTAACCAATTATGGGAAACCACTATGGACCCTGAAACCAGGACCCTTATTCGTGTTACTATTGACGACT
TGGCAAGAGCAGAGCGACGTGTTTCTGTGTTGATGGGTGACAAAGCAGCCCCACGCCGTCAGTGGATCGAGGATAACGTC
AAGTTTACCTTAGAAGAAAATACGGTGTTTTAG

Upstream 100 bases:

>100_bases
GAACTAGATCTGGAAAAGAATTCGGAAAAAATTAGCAAATTATTTTGCAAAATTGGTAAAAAACTTGTAAGATAAAAAAG
ATGAAACTGTCTGGAGGTCG

Downstream 100 bases:

>100_bases
TCATACAAGTTTCTCACAGATAATTACAAGTGCTAAAGACGATTGTTTTTTAGGTAATTAATAAATAATGAAAAAGAAAG
CTATTTGAATATGTCAAACA

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 650; Mature: 650

Protein sequence:

>650_residues
MLTKKEITINNYNDDAIQVLEGLDAVRKRPGMYIGSTDATGLHHLIWEIVDNAVDEALSGFGDDIKVVINKDGSVSVADS
GRGMPTGQHAMGIPTVQVIFTILHAGGKFGQGGYKTSGGLHGVGSSVVNALSAWLEVEITRDGAVYRQRFENGGKPVTTL
KKVGTAPKSKSGTVVTFMPDDKIFSTIDFKFNTISERLKESAFLLKNVKMSLTDLRGDDPIIEEFHYENGVQDFVEYLNE
DKETLTPVIYMEGQDQDFQVEVALQYNDGFSDNILSFVNNVRTKDGGSHETGLKSAITKAMNDYARKTNLLKEKDKNLEG
SDYREGLSAVLSILVPEQHLQFEGQTKDKLGSPLARPIVESIVSEKLTFFLLENGEVASHLVRKAIKARDAREAARKARD
DSRNGKKNKKDKGLLSGKLTPAQSKNAKKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVLNTEKAKMADILKNEEIN
TMVYTIGAGVGADFNLEDINYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGKGKTEKIAY
AWTDGELEDLRREFGKGAILQRYKGLGEMNANQLWETTMDPETRTLIRVTIDDLARAERRVSVLMGDKAAPRRQWIEDNV
KFTLEENTVF

Sequences:

>Translated_650_residues
MLTKKEITINNYNDDAIQVLEGLDAVRKRPGMYIGSTDATGLHHLIWEIVDNAVDEALSGFGDDIKVVINKDGSVSVADS
GRGMPTGQHAMGIPTVQVIFTILHAGGKFGQGGYKTSGGLHGVGSSVVNALSAWLEVEITRDGAVYRQRFENGGKPVTTL
KKVGTAPKSKSGTVVTFMPDDKIFSTIDFKFNTISERLKESAFLLKNVKMSLTDLRGDDPIIEEFHYENGVQDFVEYLNE
DKETLTPVIYMEGQDQDFQVEVALQYNDGFSDNILSFVNNVRTKDGGSHETGLKSAITKAMNDYARKTNLLKEKDKNLEG
SDYREGLSAVLSILVPEQHLQFEGQTKDKLGSPLARPIVESIVSEKLTFFLLENGEVASHLVRKAIKARDAREAARKARD
DSRNGKKNKKDKGLLSGKLTPAQSKNAKKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVLNTEKAKMADILKNEEIN
TMVYTIGAGVGADFNLEDINYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGKGKTEKIAY
AWTDGELEDLRREFGKGAILQRYKGLGEMNANQLWETTMDPETRTLIRVTIDDLARAERRVSVLMGDKAAPRRQWIEDNV
KFTLEENTVF
>Mature_650_residues
MLTKKEITINNYNDDAIQVLEGLDAVRKRPGMYIGSTDATGLHHLIWEIVDNAVDEALSGFGDDIKVVINKDGSVSVADS
GRGMPTGQHAMGIPTVQVIFTILHAGGKFGQGGYKTSGGLHGVGSSVVNALSAWLEVEITRDGAVYRQRFENGGKPVTTL
KKVGTAPKSKSGTVVTFMPDDKIFSTIDFKFNTISERLKESAFLLKNVKMSLTDLRGDDPIIEEFHYENGVQDFVEYLNE
DKETLTPVIYMEGQDQDFQVEVALQYNDGFSDNILSFVNNVRTKDGGSHETGLKSAITKAMNDYARKTNLLKEKDKNLEG
SDYREGLSAVLSILVPEQHLQFEGQTKDKLGSPLARPIVESIVSEKLTFFLLENGEVASHLVRKAIKARDAREAARKARD
DSRNGKKNKKDKGLLSGKLTPAQSKNAKKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVLNTEKAKMADILKNEEIN
TMVYTIGAGVGADFNLEDINYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGKGKTEKIAY
AWTDGELEDLRREFGKGAILQRYKGLGEMNANQLWETTMDPETRTLIRVTIDDLARAERRVSVLMGDKAAPRRQWIEDNV
KFTLEENTVF

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=636, Percent_Identity=25, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI19913406, Length=614, Percent_Identity=24.7557003257329, Blast_Score=111, Evalue=2e-24,
Organism=Escherichia coli, GI48994957, Length=548, Percent_Identity=50.9124087591241, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI1789408, Length=637, Percent_Identity=40.3453689167975, Blast_Score=422, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17535065, Length=638, Percent_Identity=26.0188087774295, Blast_Score=130, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI212645845, Length=592, Percent_Identity=25.6756756756757, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI212645657, Length=183, Percent_Identity=28.4153005464481, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=641, Percent_Identity=25.585023400936, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17136538, Length=677, Percent_Identity=26.2924667651403, Blast_Score=126, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005740
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: 5.99.1.-

Molecular weight: Translated: 72169; Mature: 72169

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTKKEITINNYNDDAIQVLEGLDAVRKRPGMYIGSTDATGLHHLIWEIVDNAVDEALSG
CCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHC
FGDDIKVVINKDGSVSVADSGRGMPTGQHAMGIPTVQVIFTILHAGGKFGQGGYKTSGGL
CCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
HGVGSSVVNALSAWLEVEITRDGAVYRQRFENGGKPVTTLKKVGTAPKSKSGTVVTFMPD
CCCHHHHHHHHHHHEEEEECCCCHHHHHHHHCCCCCHHHHHHHCCCCCCCCCEEEEECCC
DKIFSTIDFKFNTISERLKESAFLLKNVKMSLTDLRGDDPIIEEFHYENGVQDFVEYLNE
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHCC
DKETLTPVIYMEGQDQDFQVEVALQYNDGFSDNILSFVNNVRTKDGGSHETGLKSAITKA
CHHHCCCEEEECCCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
MNDYARKTNLLKEKDKNLEGSDYREGLSAVLSILVPEQHLQFEGQTKDKLGSPLARPIVE
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCHHHHCCHHHHHHHH
SIVSEKLTFFLLENGEVASHLVRKAIKARDAREAARKARDDSRNGKKNKKDKGLLSGKLT
HHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
PAQSKNAKKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVLNTEKAKMADILKNEEIN
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCEEECCHHHHHHHHHCCCCCC
TMVYTIGAGVGADFNLEDINYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYI
EEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEE
ALPPLYKMSKGKGKTEKIAYAWTDGELEDLRREFGKGAILQRYKGLGEMNANQLWETTMD
EECCCHHHCCCCCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHCCCCCCCHHHHHCCCCC
PETRTLIRVTIDDLARAERRVSVLMGDKAAPRRQWIEDNVKFTLEENTVF
CCCEEEEEEEHHHHHHHHHHHHHEECCCCCCHHHHHCCCCEEEEECCCCC
>Mature Secondary Structure
MLTKKEITINNYNDDAIQVLEGLDAVRKRPGMYIGSTDATGLHHLIWEIVDNAVDEALSG
CCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHC
FGDDIKVVINKDGSVSVADSGRGMPTGQHAMGIPTVQVIFTILHAGGKFGQGGYKTSGGL
CCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
HGVGSSVVNALSAWLEVEITRDGAVYRQRFENGGKPVTTLKKVGTAPKSKSGTVVTFMPD
CCCHHHHHHHHHHHEEEEECCCCHHHHHHHHCCCCCHHHHHHHCCCCCCCCCEEEEECCC
DKIFSTIDFKFNTISERLKESAFLLKNVKMSLTDLRGDDPIIEEFHYENGVQDFVEYLNE
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHCC
DKETLTPVIYMEGQDQDFQVEVALQYNDGFSDNILSFVNNVRTKDGGSHETGLKSAITKA
CHHHCCCEEEECCCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
MNDYARKTNLLKEKDKNLEGSDYREGLSAVLSILVPEQHLQFEGQTKDKLGSPLARPIVE
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCHHHHCCHHHHHHHH
SIVSEKLTFFLLENGEVASHLVRKAIKARDAREAARKARDDSRNGKKNKKDKGLLSGKLT
HHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
PAQSKNAKKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVLNTEKAKMADILKNEEIN
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCEEECCHHHHHHHHHCCCCCC
TMVYTIGAGVGADFNLEDINYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYI
EEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEE
ALPPLYKMSKGKGKTEKIAYAWTDGELEDLRREFGKGAILQRYKGLGEMNANQLWETTMD
EECCCHHHCCCCCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHCCCCCCCHHHHHCCCCC
PETRTLIRVTIDDLARAERRVSVLMGDKAAPRRQWIEDNVKFTLEENTVF
CCCEEEEEEEHHHHHHHHHHHHHEECCCCCCHHHHHCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8763932; 11463916; 8891124 [H]