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The map label for this gene is pyrC [H]

Identifier: 94994197

GI number: 94994197

Start: 774219

End: 775487

Strand: Direct

Name: pyrC [H]

Synonym: MGAS10750_Spy0801

Alternate gene names: 94994197

Gene position: 774219-775487 (Clockwise)

Preceding gene: 94994196

Following gene: 94994199

Centisome position: 39.97

GC content: 41.06

Gene sequence:

>1269_bases
ATGATACTCATCAAAAATGGACGCGTTATGGACCCGAAATCGCAGAGAGATCAAGTGGCAGATGTCTTGATTGATGGTAA
ACAGATTGTAAAGATAGCTTCAGCTATTGAATGCCAAGAAGCTCAAGTGATTGATGCTAGTGGTCTTATTGTTGCCCCGG
GTTTGGTCGATATTCATGTGCATTTTAGAGAACCCGGTCAAACGCACAAAGAAGATATTCACACGGGAGCCTTGGCAGCA
GCAGCAGGTGGTGTGACTACGGTTGTCATGATGGCTAATACCAATCCTGTCATTTCAGATGTCGAAACTTTACAGGAAGT
GCTAGCTAGCGCAGCTAAAGAAAAGATTCATATTTACACCAATGCCAGTGTCACCCAAGCCTTTAATGGAAAAGACGTGA
CTGATTTTAAAGCTTTGTTGGAAGCAGGAGCAGTAAGCTTTTCAGATGATGGTATTCCCTTAGAAAGTTCTAAAGTTTTA
AAAGAAGCCTTTGATTTGGCTAATGCCAACCAAACTTTCATTTCTTTGCATGAGGAAGATCCTCAGTTAAATGGGGTTCT
TGGTTTTAATGAAGGTATTGCTGAGGAGCATTTTCATTTTTGTGGGGCAACTGGTGTAGCAGAATATAGTATGATTGCAA
GAGATGTCATGATTGCTTATGACAGGCAAGCTCATGTTCATATCCAACATTTATCTAAAGCAGAATCGGTTCAAGTAGTG
GCTTTTGCTCAGCAGTTGGGTGCTAAGGTAACTGCTGAAGTGTCCCCACAACATTTTTCAACAACTGAAGATCTCTTATT
GACCGCAGGTACCAGCGCCAAGATGAATCCTCCCCTTCGTACACAAAGAGATCGCTTAGCTGTCATAGAAGGCTTGAAAT
CAGGTGTTATCACAGTCATTGCCACTGATCATGCTCCTCATCACAAGGATGAAAAAGCTGTTGATGATATGACTAAAGCC
CCATCTGGTATGACAGGACTTGAAACTTCTTTGTCATTAGGTTTGACGCATTTGGTTGAACCAGGTCATCTTACACTTAT
GTCACTATTAGAAAAAATGACGCTTAATCCAGCTTTGCTTTATGGTTTTGATGCGGGTTATTTGGCAGAAAATGGTCCAG
CAGATTTGGTTATTTTTGCAGACAAGCAAGAACGTCTGATCACTGAGAACTTTGTTTCTAAAGCTAGTAATTCCCCATTT
ATTGGTAACAAACTCAAAGGTGTCGTGAAATACACTATTGCAGACGGAGAGGTTGTTTACCCTAATTAA

Upstream 100 bases:

>100_bases
GACATTTTGATACCTTTAATAAGTGAAATGAGCGCAGTAGATTTTTCCTATTAAAGAACGTAAGGTCTTATGGTTAAAAC
AGATAAATAAAGGAGAAAAC

Downstream 100 bases:

>100_bases
CAAATGAGTTAAAACAAAAAAGCCTGACTTTCAGAGAAAGTCAGGCTTTTAGTAAATTTATTTTTTAGGCACTTGTTTGC
TTAAATTTAGCCCCCAAGGT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MILIKNGRVMDPKSQRDQVADVLIDGKQIVKIASAIECQEAQVIDASGLIVAPGLVDIHVHFREPGQTHKEDIHTGALAA
AAGGVTTVVMMANTNPVISDVETLQEVLASAAKEKIHIYTNASVTQAFNGKDVTDFKALLEAGAVSFSDDGIPLESSKVL
KEAFDLANANQTFISLHEEDPQLNGVLGFNEGIAEEHFHFCGATGVAEYSMIARDVMIAYDRQAHVHIQHLSKAESVQVV
AFAQQLGAKVTAEVSPQHFSTTEDLLLTAGTSAKMNPPLRTQRDRLAVIEGLKSGVITVIATDHAPHHKDEKAVDDMTKA
PSGMTGLETSLSLGLTHLVEPGHLTLMSLLEKMTLNPALLYGFDAGYLAENGPADLVIFADKQERLITENFVSKASNSPF
IGNKLKGVVKYTIADGEVVYPN

Sequences:

>Translated_422_residues
MILIKNGRVMDPKSQRDQVADVLIDGKQIVKIASAIECQEAQVIDASGLIVAPGLVDIHVHFREPGQTHKEDIHTGALAA
AAGGVTTVVMMANTNPVISDVETLQEVLASAAKEKIHIYTNASVTQAFNGKDVTDFKALLEAGAVSFSDDGIPLESSKVL
KEAFDLANANQTFISLHEEDPQLNGVLGFNEGIAEEHFHFCGATGVAEYSMIARDVMIAYDRQAHVHIQHLSKAESVQVV
AFAQQLGAKVTAEVSPQHFSTTEDLLLTAGTSAKMNPPLRTQRDRLAVIEGLKSGVITVIATDHAPHHKDEKAVDDMTKA
PSGMTGLETSLSLGLTHLVEPGHLTLMSLLEKMTLNPALLYGFDAGYLAENGPADLVIFADKQERLITENFVSKASNSPF
IGNKLKGVVKYTIADGEVVYPN
>Mature_422_residues
MILIKNGRVMDPKSQRDQVADVLIDGKQIVKIASAIECQEAQVIDASGLIVAPGLVDIHVHFREPGQTHKEDIHTGALAA
AAGGVTTVVMMANTNPVISDVETLQEVLASAAKEKIHIYTNASVTQAFNGKDVTDFKALLEAGAVSFSDDGIPLESSKVL
KEAFDLANANQTFISLHEEDPQLNGVLGFNEGIAEEHFHFCGATGVAEYSMIARDVMIAYDRQAHVHIQHLSKAESVQVV
AFAQQLGAKVTAEVSPQHFSTTEDLLLTAGTSAKMNPPLRTQRDRLAVIEGLKSGVITVIATDHAPHHKDEKAVDDMTKA
PSGMTGLETSLSLGLTHLVEPGHLTLMSLLEKMTLNPALLYGFDAGYLAENGPADLVIFADKQERLITENFVSKASNSPF
IGNKLKGVVKYTIADGEVVYPN

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=389, Percent_Identity=31.3624678663239, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI4503051, Length=453, Percent_Identity=22.9580573951435, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI62422571, Length=453, Percent_Identity=22.9580573951435, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786722, Length=437, Percent_Identity=29.2906178489703, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI87082175, Length=443, Percent_Identity=27.313769751693, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI193204318, Length=399, Percent_Identity=32.5814536340852, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI86575075, Length=449, Percent_Identity=24.4988864142539, Blast_Score=78, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6322218, Length=396, Percent_Identity=26.7676767676768, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24642586, Length=380, Percent_Identity=30.7894736842105, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI18859883, Length=409, Percent_Identity=26.8948655256724, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45277; Mature: 45277

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILIKNGRVMDPKSQRDQVADVLIDGKQIVKIASAIECQEAQVIDASGLIVAPGLVDIHV
CEEECCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEECCCCCEEECCEEEEEE
HFREPGQTHKEDIHTGALAAAAGGVTTVVMMANTNPVISDVETLQEVLASAAKEKIHIYT
EECCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCEEEEEE
NASVTQAFNGKDVTDFKALLEAGAVSFSDDGIPLESSKVLKEAFDLANANQTFISLHEED
CCCEEECCCCCCHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCC
PQLNGVLGFNEGIAEEHFHFCGATGVAEYSMIARDVMIAYDRQAHVHIQHLSKAESVQVV
CCCCEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHEECCCCEEEHHHHCCCCCCHHH
AFAQQLGAKVTAEVSPQHFSTTEDLLLTAGTSAKMNPPLRTQRDRLAVIEGLKSGVITVI
HHHHHHCCEEEEECCCCCCCCCHHEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEE
ATDHAPHHKDEKAVDDMTKAPSGMTGLETSLSLGLTHLVEPGHLTLMSLLEKMTLNPALL
EECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCHHHHCCCCCHHHHHHHHHHCCCCEEE
YGFDAGYLAENGPADLVIFADKQERLITENFVSKASNSPFIGNKLKGVVKYTIADGEVVY
EECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCEEEC
PN
CC
>Mature Secondary Structure
MILIKNGRVMDPKSQRDQVADVLIDGKQIVKIASAIECQEAQVIDASGLIVAPGLVDIHV
CEEECCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEECCCCCEEECCEEEEEE
HFREPGQTHKEDIHTGALAAAAGGVTTVVMMANTNPVISDVETLQEVLASAAKEKIHIYT
EECCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCEEEEEE
NASVTQAFNGKDVTDFKALLEAGAVSFSDDGIPLESSKVLKEAFDLANANQTFISLHEED
CCCEEECCCCCCHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCC
PQLNGVLGFNEGIAEEHFHFCGATGVAEYSMIARDVMIAYDRQAHVHIQHLSKAESVQVV
CCCCEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHEECCCCEEEHHHHCCCCCCHHH
AFAQQLGAKVTAEVSPQHFSTTEDLLLTAGTSAKMNPPLRTQRDRLAVIEGLKSGVITVI
HHHHHHCCEEEEECCCCCCCCCHHEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEE
ATDHAPHHKDEKAVDDMTKAPSGMTGLETSLSLGLTHLVEPGHLTLMSLLEKMTLNPALL
EECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCHHHHCCCCCHHHHHHHHHHCCCCEEE
YGFDAGYLAENGPADLVIFADKQERLITENFVSKASNSPFIGNKLKGVVKYTIADGEVVY
EECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCEEEC
PN
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]