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The map label for this gene is parC [H]

Identifier: 94994200

GI number: 94994200

Start: 778355

End: 780820

Strand: Direct

Name: parC [H]

Synonym: MGAS10750_Spy0804

Alternate gene names: 94994200

Gene position: 778355-780820 (Clockwise)

Preceding gene: 94994199

Following gene: 94994201

Centisome position: 40.18

GC content: 40.31

Gene sequence:

>2466_bases
TTGAATATGTCAAACATTCAAAACATGTCCCTTGAGGATATTATGGGAGAACGCTTCGGCCGTTATTCCAAGTATATTAT
TCAGGAACGGGCGCTTCCAGATATTCGAGATGGATTGAAACCCGTTCAGCGTCGGATTCTTTATTCGATGAATAAGGATG
GCAATACTTTTGAAAAAGGTTACCGTAAATCAGCCAAATCAGTTGGTAATATTATGGGGAATTTCCACCCGCATGGGGAT
TCCTCTATTTATGATGCCATGGTTCGGATGAGTCAAGATTGGAAGAACCGTGAAATCCTTGTTGAAATGCACGGAAATAA
TGGTTCAATGGATGGCGATCCGCCTGCGGCTATGCGTTATACAGAAGCTCGCTTGTCTGAAATTGCAGGTTATCTTCTTC
AAGACATTGAGAAAAATACGGTCTCTTTTGCGTGGAACTTTGATGACACAGAAAAAGAACCCACCGTTTTACCAGCAGCT
TTTCCTAACTTACTTGTCAATGGGTCTTCTGGTATTTCCGCAGGCTATGCGACAGATATTCCACCGCACAATTTGTCAGA
AGTGATTGATGCTGTTGTGTATATGATTGATCATCCCAAAGCTAGTTTAGAGAAATTGATGGAATTTTTGCCTGGGCCAG
ATTTCCCAACAGGAGGTATTATCCAAGGAGCTGACGAAATCAAAAAAGCCTACGAAACAGGCAAGGGACGTGTCGTTGTT
CGCTCTAGGACAGAAATCGAGGAACTTAAAGGTGGTAAACAACAAATTATTGTCACTGAGATTCCTTATGAAGTTAACAA
AGCAGTCTTGGTCAAAAAGATTGACGATGTGCGTGTTAACAATAAAGTCCCAGGCATCGTAGAAGTACGCGATGAATCTG
ATCGCACAGGTCTTCGCATAGCTATTGAGTTGAAAAAAGAGGCTGATAGCCAAACCATTCTAAATTATTTGTTGAAATAC
ACAGATCTTCAAGTTAATTATAATTTTAATATGGTTGCTATTGATCACTTTACGCCACGCCAAGTAGGTCTTCAAAAAAT
CTTATCAAGCTATATCAGCCACCGCAAAGATATTATTATTGAGCGGTCTAAATTCGATAAAGCCAAAGCTGAAAAACGCC
TCCACATTGTTGAAGGATTGATTCGTGTCTTGTCCATCTTAGATGAGATTATTGCTTTGATTAGATCGTCTGACAATAAG
GCTGATGCTAAAGAAAATCTGAAAGTCAGCTATGATTTCTCTGAGGAACAAGCAGAAGCGATTGTAACCTTGCAGCTTTA
TCGTTTAACTAATACCGATATTGTTACTCTCCAAAATGAAGAAAATGATTTAAGAGACTTAATCACGACCCTGTCCGCTA
TTATCGGTGACGAAGCAACCATGTATAACGTCATGAAACGTGAATTAAGAGAAGTGAAAAAGAAATTCGCCAATCCTCGT
TTATCAGAGTTACAAGCAGAAAGTCAAATCATTGAGATTGACACTGCCAGCTTGATTGCAGAGGAAGAAACTTTTGTTAG
TGTGACACGGGGCGGATACCTCAAAAGAACCAGCCCACGATCCTTCAATGCGTCTAGTTTGGAAGAAGTTGGCAAGAGAG
ATGATGACGAACTCATCTTCGTTAAACAGGCCAAAACAACAGAACACCTTTTGTTGTTTACAACTTTAGGCAATGTCATT
TACCGGCCAATCCATGAATTGACCGATTTACGTTGGAAGGATATCGGTGAACATTTATCACAAACTATTTCAAACTTCGC
GACAGAAGAAGAGATTCTCTACGCTGATATTGTGACTTCCTTTGACCAGGGCTTGTATGTGGCTGTCACACAAAATGGTT
TTATCAAACGCTTTGATCGTAAAGAACTAAGTCCTTGGCGAACTTATAAATCTAAATCAACCAAATATGTGAAGCTAAAG
GATGACAAAGACCGCGTGGTTACCTTGTCACCAGTTATTATGGAAGACCTCCTATTAGTGACTAAAAATGGTTATGCTTT
GCGATTCTCCAGTCAGGAAGTGCCTATTCAAGGGTTGAAATCTGCTGGTGTTAAAGGCATTAACTTGAAAAATGATGACA
GCCTTGCCTCAGCCTTTGCTGTGACAAGTAACTCTTTCTTTGTCTTAACTCAGAGGGGTTCTCTCAAACGGATGGCTGTC
GATGATATTCCTCAGACAAGTCGTGCCAATCGTGGACTATTGGTCCTACGAGAGTTAAAAACCAAACCTCATAGAGTTTT
TCTGGCCGGAGGCGTTCAATCAGATACTTCAGCTGAGCAGTTTGATTTGTTCACTGATATACCTGAAGAAGAAACTAATC
AACAAATGCTTGAAGTCATTAGTAAGACTGGTCAAACCTACGAGATTGCTTTAGAAACGCTTTCGTTATCGGAAAGAACC
AGCAATGGCTCCTTTATTTCAGACACTATTTCGGATCAAGAAGTACTGGTAGCTAGAACACGTTAA

Upstream 100 bases:

>100_bases
AAATACGGTGTTTTAGTCATACAAGTTTCTCACAGATAATTACAAGTGCTAAAGACGATTGTTTTTTAGGTAATTAATAA
ATAATGAAAAAGAAAGCTAT

Downstream 100 bases:

>100_bases
AAAGAGTGAAAACTCTTTTTAATTTTATGGTAAATTTAGAATATTAATGCAAAAGAATAGAATAAACTTGAAAATTATTG
AAAAAAAGTTACAATAGAAA

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 821; Mature: 821

Protein sequence:

>821_residues
MNMSNIQNMSLEDIMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFEKGYRKSAKSVGNIMGNFHPHGD
SSIYDAMVRMSQDWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKNTVSFAWNFDDTEKEPTVLPAA
FPNLLVNGSSGISAGYATDIPPHNLSEVIDAVVYMIDHPKASLEKLMEFLPGPDFPTGGIIQGADEIKKAYETGKGRVVV
RSRTEIEELKGGKQQIIVTEIPYEVNKAVLVKKIDDVRVNNKVPGIVEVRDESDRTGLRIAIELKKEADSQTILNYLLKY
TDLQVNYNFNMVAIDHFTPRQVGLQKILSSYISHRKDIIIERSKFDKAKAEKRLHIVEGLIRVLSILDEIIALIRSSDNK
ADAKENLKVSYDFSEEQAEAIVTLQLYRLTNTDIVTLQNEENDLRDLITTLSAIIGDEATMYNVMKRELREVKKKFANPR
LSELQAESQIIEIDTASLIAEEETFVSVTRGGYLKRTSPRSFNASSLEEVGKRDDDELIFVKQAKTTEHLLLFTTLGNVI
YRPIHELTDLRWKDIGEHLSQTISNFATEEEILYADIVTSFDQGLYVAVTQNGFIKRFDRKELSPWRTYKSKSTKYVKLK
DDKDRVVTLSPVIMEDLLLVTKNGYALRFSSQEVPIQGLKSAGVKGINLKNDDSLASAFAVTSNSFFVLTQRGSLKRMAV
DDIPQTSRANRGLLVLRELKTKPHRVFLAGGVQSDTSAEQFDLFTDIPEEETNQQMLEVISKTGQTYEIALETLSLSERT
SNGSFISDTISDQEVLVARTR

Sequences:

>Translated_821_residues
MNMSNIQNMSLEDIMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFEKGYRKSAKSVGNIMGNFHPHGD
SSIYDAMVRMSQDWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKNTVSFAWNFDDTEKEPTVLPAA
FPNLLVNGSSGISAGYATDIPPHNLSEVIDAVVYMIDHPKASLEKLMEFLPGPDFPTGGIIQGADEIKKAYETGKGRVVV
RSRTEIEELKGGKQQIIVTEIPYEVNKAVLVKKIDDVRVNNKVPGIVEVRDESDRTGLRIAIELKKEADSQTILNYLLKY
TDLQVNYNFNMVAIDHFTPRQVGLQKILSSYISHRKDIIIERSKFDKAKAEKRLHIVEGLIRVLSILDEIIALIRSSDNK
ADAKENLKVSYDFSEEQAEAIVTLQLYRLTNTDIVTLQNEENDLRDLITTLSAIIGDEATMYNVMKRELREVKKKFANPR
LSELQAESQIIEIDTASLIAEEETFVSVTRGGYLKRTSPRSFNASSLEEVGKRDDDELIFVKQAKTTEHLLLFTTLGNVI
YRPIHELTDLRWKDIGEHLSQTISNFATEEEILYADIVTSFDQGLYVAVTQNGFIKRFDRKELSPWRTYKSKSTKYVKLK
DDKDRVVTLSPVIMEDLLLVTKNGYALRFSSQEVPIQGLKSAGVKGINLKNDDSLASAFAVTSNSFFVLTQRGSLKRMAV
DDIPQTSRANRGLLVLRELKTKPHRVFLAGGVQSDTSAEQFDLFTDIPEEETNQQMLEVISKTGQTYEIALETLSLSERT
SNGSFISDTISDQEVLVARTR
>Mature_821_residues
MNMSNIQNMSLEDIMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFEKGYRKSAKSVGNIMGNFHPHGD
SSIYDAMVRMSQDWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKNTVSFAWNFDDTEKEPTVLPAA
FPNLLVNGSSGISAGYATDIPPHNLSEVIDAVVYMIDHPKASLEKLMEFLPGPDFPTGGIIQGADEIKKAYETGKGRVVV
RSRTEIEELKGGKQQIIVTEIPYEVNKAVLVKKIDDVRVNNKVPGIVEVRDESDRTGLRIAIELKKEADSQTILNYLLKY
TDLQVNYNFNMVAIDHFTPRQVGLQKILSSYISHRKDIIIERSKFDKAKAEKRLHIVEGLIRVLSILDEIIALIRSSDNK
ADAKENLKVSYDFSEEQAEAIVTLQLYRLTNTDIVTLQNEENDLRDLITTLSAIIGDEATMYNVMKRELREVKKKFANPR
LSELQAESQIIEIDTASLIAEEETFVSVTRGGYLKRTSPRSFNASSLEEVGKRDDDELIFVKQAKTTEHLLLFTTLGNVI
YRPIHELTDLRWKDIGEHLSQTISNFATEEEILYADIVTSFDQGLYVAVTQNGFIKRFDRKELSPWRTYKSKSTKYVKLK
DDKDRVVTLSPVIMEDLLLVTKNGYALRFSSQEVPIQGLKSAGVKGINLKNDDSLASAFAVTSNSFFVLTQRGSLKRMAV
DDIPQTSRANRGLLVLRELKTKPHRVFLAGGVQSDTSAEQFDLFTDIPEEETNQQMLEVISKTGQTYEIALETLSLSERT
SNGSFISDTISDQEVLVARTR

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=318, Percent_Identity=25.1572327044025, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI19913406, Length=318, Percent_Identity=24.5283018867925, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1788562, Length=804, Percent_Identity=37.3134328358209, Blast_Score=507, Evalue=1e-144,
Organism=Escherichia coli, GI1789396, Length=728, Percent_Identity=32.2802197802198, Blast_Score=350, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI17535065, Length=181, Percent_Identity=29.2817679558011, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI212645657, Length=179, Percent_Identity=29.0502793296089, Blast_Score=73, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI212645845, Length=398, Percent_Identity=25.1256281407035, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=187, Percent_Identity=26.7379679144385, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17136538, Length=231, Percent_Identity=26.8398268398268, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005741 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 92713; Mature: 92713

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMSNIQNMSLEDIMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFEKG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
YRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQDWKNREILVEMHGNNGSMDGDPPAAMRY
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHH
TEARLSEIAGYLLQDIEKNTVSFAWNFDDTEKEPTVLPAAFPNLLVNGSSGISAGYATDI
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEECCCCCHHEEECCCCCCCCCCCCC
PPHNLSEVIDAVVYMIDHPKASLEKLMEFLPGPDFPTGGIIQGADEIKKAYETGKGRVVV
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEE
RSRTEIEELKGGKQQIIVTEIPYEVNKAVLVKKIDDVRVNNKVPGIVEVRDESDRTGLRI
ECCHHHHHHCCCCEEEEEEECCCCCCCEEEEEECCCEEECCCCCCEEEECCCCCCCCEEE
AIELKKEADSQTILNYLLKYTDLQVNYNFNMVAIDHFTPRQVGLQKILSSYISHRKDIII
EEEECCCCCHHHHHHHHHHHHEEEEEECEEEEEEECCCCHHHHHHHHHHHHHCCCHHEEE
ERSKFDKAKAEKRLHIVEGLIRVLSILDEIIALIRSSDNKADAKENLKVSYDFSEEQAEA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHE
IVTLQLYRLTNTDIVTLQNEENDLRDLITTLSAIIGDEATMYNVMKRELREVKKKFANPR
EEEEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCC
LSELQAESQIIEIDTASLIAEEETFVSVTRGGYLKRTSPRSFNASSLEEVGKRDDDELIF
HHHHHCCCEEEEEEHHHHHCCCCCEEEEECCCEEECCCCCCCCHHHHHHHCCCCCCCEEE
VKQAKTTEHLLLFTTLGNVIYRPIHELTDLRWKDIGEHLSQTISNFATEEEILYADIVTS
EEECCCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
FDQGLYVAVTQNGFIKRFDRKELSPWRTYKSKSTKYVKLKDDKDRVVTLSPVIMEDLLLV
CCCCEEEEEECCCHHHHCCHHCCCHHHHHHCCCCEEEEEECCCCCEEEECHHHHHHHHHE
TKNGYALRFSSQEVPIQGLKSAGVKGINLKNDDSLASAFAVTSNSFFVLTQRGSLKRMAV
ECCCEEEEECCCCCCHHHHHHCCCCCCCCCCCCHHHHHHEEECCCEEEEECCCCCCHHHH
DDIPQTSRANRGLLVLRELKTKPHRVFLAGGVQSDTSAEQFDLFTDIPEEETNQQMLEVI
HCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCHHHHHHHHHH
SKTGQTYEIALETLSLSERTSNGSFISDTISDQEVLVARTR
HHCCCEEEEEEEHHHHHCCCCCCCEEECCCCCCEEEEEECC
>Mature Secondary Structure
MNMSNIQNMSLEDIMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFEKG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
YRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQDWKNREILVEMHGNNGSMDGDPPAAMRY
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHH
TEARLSEIAGYLLQDIEKNTVSFAWNFDDTEKEPTVLPAAFPNLLVNGSSGISAGYATDI
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEECCCCCHHEEECCCCCCCCCCCCC
PPHNLSEVIDAVVYMIDHPKASLEKLMEFLPGPDFPTGGIIQGADEIKKAYETGKGRVVV
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEE
RSRTEIEELKGGKQQIIVTEIPYEVNKAVLVKKIDDVRVNNKVPGIVEVRDESDRTGLRI
ECCHHHHHHCCCCEEEEEEECCCCCCCEEEEEECCCEEECCCCCCEEEECCCCCCCCEEE
AIELKKEADSQTILNYLLKYTDLQVNYNFNMVAIDHFTPRQVGLQKILSSYISHRKDIII
EEEECCCCCHHHHHHHHHHHHEEEEEECEEEEEEECCCCHHHHHHHHHHHHHCCCHHEEE
ERSKFDKAKAEKRLHIVEGLIRVLSILDEIIALIRSSDNKADAKENLKVSYDFSEEQAEA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHE
IVTLQLYRLTNTDIVTLQNEENDLRDLITTLSAIIGDEATMYNVMKRELREVKKKFANPR
EEEEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCC
LSELQAESQIIEIDTASLIAEEETFVSVTRGGYLKRTSPRSFNASSLEEVGKRDDDELIF
HHHHHCCCEEEEEEHHHHHCCCCCEEEEECCCEEECCCCCCCCHHHHHHHCCCCCCCEEE
VKQAKTTEHLLLFTTLGNVIYRPIHELTDLRWKDIGEHLSQTISNFATEEEILYADIVTS
EEECCCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
FDQGLYVAVTQNGFIKRFDRKELSPWRTYKSKSTKYVKLKDDKDRVVTLSPVIMEDLLLV
CCCCEEEEEECCCHHHHCCHHCCCHHHHHHCCCCEEEEEECCCCCEEEECHHHHHHHHHE
TKNGYALRFSSQEVPIQGLKSAGVKGINLKNDDSLASAFAVTSNSFFVLTQRGSLKRMAV
ECCCEEEEECCCCCCHHHHHHCCCCCCCCCCCCHHHHHHEEECCCEEEEECCCCCCHHHH
DDIPQTSRANRGLLVLRELKTKPHRVFLAGGVQSDTSAEQFDLFTDIPEEETNQQMLEVI
HCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCHHHHHHHHHH
SKTGQTYEIALETLSLSERTSNGSFISDTISDQEVLVARTR
HHCCCEEEEEEEHHHHHCCCCCCCEEECCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]