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The map label for this gene is fruA [H]

Identifier: 94994149

GI number: 94994149

Start: 730262

End: 732208

Strand: Direct

Name: fruA [H]

Synonym: MGAS10750_Spy0753

Alternate gene names: 94994149

Gene position: 730262-732208 (Clockwise)

Preceding gene: 94994148

Following gene: 94994150

Centisome position: 37.7

GC content: 41.45

Gene sequence:

>1947_bases
ATGAAAATTCAAGATTTATTGAGAAAAGATATTATGATTCTCGATTTACAGGCTATTTCTAAAGAAGTTGCCATTGACGA
GATGATTACTAAATTAGTTGAAAAAGATATTGTACATGATTTTGATGTCTTTAAAAAGAGTATCATGACACGTGAAGAAC
AAACATCAACAGGGCTTGGTGATGGGATTGCCATGCCTCATTCTAAAAATATTGTAGTAGATAAACCAGCGGTCTTGTTT
GCGAAATCAAATAAAGGCGTGGATTATAAGGCTTTAGATGGTCAACCAACGGATCTCTTCTTTATGATTGCTGCGCCTCA
AGGAGCAAATGATACTCACTTGGCTGCGCTAGCAGAATTATCACAATACCTTTTGAAAGACGGCTTTGCTGATAAACTTC
GTGCTGCAGCGACACCAGAAGCAGTCATTGCTGTTTTTGATGAAGCGTCAACAGCTAAAGAAGAAGTGGTTGCTCCAACA
AGTGGTCAAGACTTTATCGTTGCTGTTACAGCTTGTCTGACAGGAATTGCTCACACTTATATGGCAGAAGAGGCTTTGAA
AAAACAAGCTGCAGAAATGGGAGTAGCTATTAAAGTTGAAACAAACGGTGCTTCTGGTGTGGCTAATCGTTTAACCGCTG
AAGATATTCAGAGAGCTAAAGGAGTTATTGTTGCAGCTGATAAAACGGTTGAAATGGACCGTTTTGATGGTAAACAATTC
ATTGCTCGCCCTGTTGCAGATGGTATCAAGAAAAGTCAGGAATTGATTTCTTTGATTTTAAACAATGAAGGAAACACTTA
TCATGCTAAAAATGGAAAATCTGAAACAGCAGTATCAACTGAGAAAACAAGTTTAGGCGGTGCTTTCTATAAACACTTGA
TGGGCGGTGTCTCACAAATGTTGCCATTTGTTATTGGTGGCGGGATTATGATTGCTCTAGCATTTTTATTGGATAACATG
CTTGGTGTGCCAAATGATCAGCTTGGAAGTCTTGGATCCTATCATGAAATAGCAGCTATTTTTATGAACATTGGTGGAGC
AGTCTTTTCCTTCATGTTACCAGTACTAGCAGGTTATATCGCTTATTCTATTGCTGAAAAACCGGGCTTAGTAGCTGGTT
TTGTGGCAGGTGCCATTGCCTCAAATGGTCTTGCTTTTGGTAAGGTACCATTTGCAGCAGGAGGAGAAGTGAGCTTGGGC
TTAACAGGCGTGCCATCAGGTTTCCTTGGGGCGCTTGTGGGTGGTTTCCTTGCCGGTGGTGTTATTCTTGCCCTTCGTAA
ATTGTTGGCAGCCCTACCACGTTCTCTAGAAGGGGTTAAATCTATCCTCCTTTACCCATTACTTGGCGTCCTTGTCACTG
GTTTCTTGATGCTTTTTGTCAATATTCCAATGGCAGCTATTAACACAGCTCTTAATGATTTCTTACAAGGTCTTTCAGGA
AGCTCTGCTGTCCTTATGGGACTTCTTGTTGGTGGAATGATGGCTGTTGACATGGGTGGTCCTGTTAATAAGGCAGCTTA
TGTTTTTGGTACAGGAACTTTAGCAGCTACTGTGGCAAATGGTGGTTCGGTCGTTATGGCCGCTGTTATGGCAGGTGGTA
TGGTACCTCCTCTTGCTGTTTTTGTAGCCACTCTCTTGTTTAAAGATAAATTTACCAAAGAAGAACGTGAATCAGGCTTG
ACAAATATTGTTATGGGACTTTCATTCATCACCGAAGGAGCAATTCCGTTTGGTGCGGCTGACCCAGCACGTGCGATTCC
TAGCTTTATCGCAGGTTCTGCCTTGACAGGAGCTCTTGTTGGTTTGGCTGGTATTAAATTAATGGCGCCACATGGTGGTA
TCTTCGTAATTGCTTTAACAAGCAATCCAATCTTATATCTTGTCTTTGTTGTGATTGGTGCCCTTGTATCAGGTATCTTA
TTTGGCGCTCTTCGCAAAAAAGCCTAA

Upstream 100 bases:

>100_bases
AATGGGGCGTGGCTTGTGGTACAGCGACGGCTTTCTCTGATGACTTGGCGACAATTGCATTTATTAAGGAAACATATCAT
AAAGTTGAGGTAGAAAAACG

Downstream 100 bases:

>100_bases
AAGGTAAAGAACTTTTTTCTTACTAAAACTAGAATCTGTCAAGGTTCTAGTTTTTTGCTATACTAGAGTTAAAGGATAAG
AAATGAGGACCTCTGAAGGT

Product: PTS system, fructose-specific IIABC component

Products: NA

Alternate protein names: EIIABC-Fru; Fructose-specific phosphotransferase enzyme IIA component; EII-Fru; PTS system fructose-specific EIIA component; Fructose-specific phosphotransferase enzyme IIB component; EIII-Fru; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 648; Mature: 648

Protein sequence:

>648_residues
MKIQDLLRKDIMILDLQAISKEVAIDEMITKLVEKDIVHDFDVFKKSIMTREEQTSTGLGDGIAMPHSKNIVVDKPAVLF
AKSNKGVDYKALDGQPTDLFFMIAAPQGANDTHLAALAELSQYLLKDGFADKLRAAATPEAVIAVFDEASTAKEEVVAPT
SGQDFIVAVTACLTGIAHTYMAEEALKKQAAEMGVAIKVETNGASGVANRLTAEDIQRAKGVIVAADKTVEMDRFDGKQF
IARPVADGIKKSQELISLILNNEGNTYHAKNGKSETAVSTEKTSLGGAFYKHLMGGVSQMLPFVIGGGIMIALAFLLDNM
LGVPNDQLGSLGSYHEIAAIFMNIGGAVFSFMLPVLAGYIAYSIAEKPGLVAGFVAGAIASNGLAFGKVPFAAGGEVSLG
LTGVPSGFLGALVGGFLAGGVILALRKLLAALPRSLEGVKSILLYPLLGVLVTGFLMLFVNIPMAAINTALNDFLQGLSG
SSAVLMGLLVGGMMAVDMGGPVNKAAYVFGTGTLAATVANGGSVVMAAVMAGGMVPPLAVFVATLLFKDKFTKEERESGL
TNIVMGLSFITEGAIPFGAADPARAIPSFIAGSALTGALVGLAGIKLMAPHGGIFVIALTSNPILYLVFVVIGALVSGIL
FGALRKKA

Sequences:

>Translated_648_residues
MKIQDLLRKDIMILDLQAISKEVAIDEMITKLVEKDIVHDFDVFKKSIMTREEQTSTGLGDGIAMPHSKNIVVDKPAVLF
AKSNKGVDYKALDGQPTDLFFMIAAPQGANDTHLAALAELSQYLLKDGFADKLRAAATPEAVIAVFDEASTAKEEVVAPT
SGQDFIVAVTACLTGIAHTYMAEEALKKQAAEMGVAIKVETNGASGVANRLTAEDIQRAKGVIVAADKTVEMDRFDGKQF
IARPVADGIKKSQELISLILNNEGNTYHAKNGKSETAVSTEKTSLGGAFYKHLMGGVSQMLPFVIGGGIMIALAFLLDNM
LGVPNDQLGSLGSYHEIAAIFMNIGGAVFSFMLPVLAGYIAYSIAEKPGLVAGFVAGAIASNGLAFGKVPFAAGGEVSLG
LTGVPSGFLGALVGGFLAGGVILALRKLLAALPRSLEGVKSILLYPLLGVLVTGFLMLFVNIPMAAINTALNDFLQGLSG
SSAVLMGLLVGGMMAVDMGGPVNKAAYVFGTGTLAATVANGGSVVMAAVMAGGMVPPLAVFVATLLFKDKFTKEERESGL
TNIVMGLSFITEGAIPFGAADPARAIPSFIAGSALTGALVGLAGIKLMAPHGGIFVIALTSNPILYLVFVVIGALVSGIL
FGALRKKA
>Mature_648_residues
MKIQDLLRKDIMILDLQAISKEVAIDEMITKLVEKDIVHDFDVFKKSIMTREEQTSTGLGDGIAMPHSKNIVVDKPAVLF
AKSNKGVDYKALDGQPTDLFFMIAAPQGANDTHLAALAELSQYLLKDGFADKLRAAATPEAVIAVFDEASTAKEEVVAPT
SGQDFIVAVTACLTGIAHTYMAEEALKKQAAEMGVAIKVETNGASGVANRLTAEDIQRAKGVIVAADKTVEMDRFDGKQF
IARPVADGIKKSQELISLILNNEGNTYHAKNGKSETAVSTEKTSLGGAFYKHLMGGVSQMLPFVIGGGIMIALAFLLDNM
LGVPNDQLGSLGSYHEIAAIFMNIGGAVFSFMLPVLAGYIAYSIAEKPGLVAGFVAGAIASNGLAFGKVPFAAGGEVSLG
LTGVPSGFLGALVGGFLAGGVILALRKLLAALPRSLEGVKSILLYPLLGVLVTGFLMLFVNIPMAAINTALNDFLQGLSG
SSAVLMGLLVGGMMAVDMGGPVNKAAYVFGTGTLAATVANGGSVVMAAVMAGGMVPPLAVFVATLLFKDKFTKEERESGL
TNIVMGLSFITEGAIPFGAADPARAIPSFIAGSALTGALVGLAGIKLMAPHGGIFVIALTSNPILYLVFVVIGALVSGIL
FGALRKKA

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=492, Percent_Identity=43.2926829268293, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI1786951, Length=626, Percent_Identity=35.1437699680511, Blast_Score=317, Evalue=2e-87,
Organism=Escherichia coli, GI87082348, Length=478, Percent_Identity=35.9832635983264, Blast_Score=216, Evalue=4e-57,
Organism=Escherichia coli, GI1790386, Length=338, Percent_Identity=36.9822485207101, Blast_Score=182, Evalue=6e-47,
Organism=Escherichia coli, GI1788729, Length=390, Percent_Identity=27.4358974358974, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1790387, Length=95, Percent_Identity=44.2105263157895, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI2367327, Length=135, Percent_Identity=25.9259259259259, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI1789597, Length=156, Percent_Identity=28.8461538461538, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788730, Length=95, Percent_Identity=40, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1790390, Length=96, Percent_Identity=35.4166666666667, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004715
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 67178; Mature: 67178

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIQDLLRKDIMILDLQAISKEVAIDEMITKLVEKDIVHDFDVFKKSIMTREEQTSTGLG
CCHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCC
DGIAMPHSKNIVVDKPAVLFAKSNKGVDYKALDGQPTDLFFMIAAPQGANDTHLAALAEL
CCCCCCCCCCEEEECCEEEEEECCCCCCEEECCCCCCCEEEEEECCCCCCHHHHHHHHHH
SQYLLKDGFADKLRAAATPEAVIAVFDEASTAKEEVVAPTSGQDFIVAVTACLTGIAHTY
HHHHHHCCCHHHHHHCCCCHHHEEEECCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHH
MAEEALKKQAAEMGVAIKVETNGASGVANRLTAEDIQRAKGVIVAADKTVEMDRFDGKQF
HHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEECCEEEHHHCCCHHH
IARPVADGIKKSQELISLILNNEGNTYHAKNGKSETAVSTEKTSLGGAFYKHLMGGVSQM
HHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LPFVIGGGIMIALAFLLDNMLGVPNDQLGSLGSYHEIAAIFMNIGGAVFSFMLPVLAGYI
HHHHHCCHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYSIAEKPGLVAGFVAGAIASNGLAFGKVPFAAGGEVSLGLTGVPSGFLGALVGGFLAGG
HHHHHCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHH
VILALRKLLAALPRSLEGVKSILLYPLLGVLVTGFLMLFVNIPMAAINTALNDFLQGLSG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
SSAVLMGLLVGGMMAVDMGGPVNKAAYVFGTGTLAATVANGGSVVMAAVMAGGMVPPLAV
CHHHHHHHHHHHHHEEECCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHHCCCCHHHHH
FVATLLFKDKFTKEERESGLTNIVMGLSFITEGAIPFGAADPARAIPSFIAGSALTGALV
HHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GLAGIKLMAPHGGIFVIALTSNPILYLVFVVIGALVSGILFGALRKKA
HHHCCEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIQDLLRKDIMILDLQAISKEVAIDEMITKLVEKDIVHDFDVFKKSIMTREEQTSTGLG
CCHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCC
DGIAMPHSKNIVVDKPAVLFAKSNKGVDYKALDGQPTDLFFMIAAPQGANDTHLAALAEL
CCCCCCCCCCEEEECCEEEEEECCCCCCEEECCCCCCCEEEEEECCCCCCHHHHHHHHHH
SQYLLKDGFADKLRAAATPEAVIAVFDEASTAKEEVVAPTSGQDFIVAVTACLTGIAHTY
HHHHHHCCCHHHHHHCCCCHHHEEEECCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHH
MAEEALKKQAAEMGVAIKVETNGASGVANRLTAEDIQRAKGVIVAADKTVEMDRFDGKQF
HHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEECCEEEHHHCCCHHH
IARPVADGIKKSQELISLILNNEGNTYHAKNGKSETAVSTEKTSLGGAFYKHLMGGVSQM
HHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LPFVIGGGIMIALAFLLDNMLGVPNDQLGSLGSYHEIAAIFMNIGGAVFSFMLPVLAGYI
HHHHHCCHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYSIAEKPGLVAGFVAGAIASNGLAFGKVPFAAGGEVSLGLTGVPSGFLGALVGGFLAGG
HHHHHCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHH
VILALRKLLAALPRSLEGVKSILLYPLLGVLVTGFLMLFVNIPMAAINTALNDFLQGLSG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
SSAVLMGLLVGGMMAVDMGGPVNKAAYVFGTGTLAATVANGGSVVMAAVMAGGMVPPLAV
CHHHHHHHHHHHHHEEECCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHHCCCCHHHHH
FVATLLFKDKFTKEERESGLTNIVMGLSFITEGAIPFGAADPARAIPSFIAGSALTGALV
HHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GLAGIKLMAPHGGIFVIALTSNPILYLVFVVIGALVSGILFGALRKKA
HHHCCEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]