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The map label for this gene is pdhR [H]

Identifier: 94314819

GI number: 94314819

Start: 100320

End: 101018

Strand: Direct

Name: pdhR [H]

Synonym: Rmet_5900

Alternate gene names: 94314819

Gene position: 100320-101018 (Clockwise)

Preceding gene: 94314814

Following gene: 94314821

Centisome position: 3.89

GC content: 67.38

Gene sequence:

>699_bases
ATGGGGGCAGGCAACGCACGCAACCGCGTGGAAGACATCATGCGCAGGATGGAGACCGCGCTGCTGGACGGCACCTGGCC
CGTCGGCACGCGGCTGCCTGCGGAGCGTGTTCTGGCGGAGCAGTTTGGGGTGGCGCGCAACACGATCCGCGAGGCGATCC
AGCGCCTGGCGGCGCGCAACCTGCTGCAAAGCCGACGCGGCGCGGGCGTATACGTCACCGATCAGTTGCGCACGGGCATC
GCCTCGCCCTGGGGCCAGCTCGTGGCCGATCACCCGGCGCTGCGCGATGACATTCTGGAGTTCCGCCGGGTGCTGGAAGG
CGCCACCGCCTACTTCGCGGCGTTGCGTGCCGATGCAGCGGATCTGAAGCGTATACGCGCGCTGCTCAAGGAACTGGAGC
GCTCGCGCATGACCGATGACAAGCGCGCCGAGGCCGATGCGGATGCGAAGCTGCACGACGCCATCGCGCAGGCTTCGCAC
AACACGATGTTCCTGCATCTGCATACCAGCGTGATTGGCATGTTGCGCGAGCACATCACGATCAACGGCACCGGGCTGCG
CGAGGCCGACGATGAGTCGTCGGACCTGCTGCTGCGGCAGCACCGCACGCTTTGCGAGGCGATTCTGGCGCGCCGGCCGG
AAGAAGCCCGCACGGCGATGCAGACGCACATCGACTTCGTGCGGAGCAAGGTCGACTAG

Upstream 100 bases:

>100_bases
AGGCGCTGCGACATTTTTGGGCGCATAATTCCCGCTCTCGCGCCGGAGCACAAATTGGTTGGACCAGTTGCCGGAACGAC
CGGATTTCAAGGGATGAGGG

Downstream 100 bases:

>100_bases
TCTTCCCGCATATTGGTCGTACCAATTTCTGCGTACGACAAAGCAATGAAATCAAGCACTTGGCTGAGCGCCTACACAAG
CCCGGCCGTGCTCAGTTCGC

Product: GntR-family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MGAGNARNRVEDIMRRMETALLDGTWPVGTRLPAERVLAEQFGVARNTIREAIQRLAARNLLQSRRGAGVYVTDQLRTGI
ASPWGQLVADHPALRDDILEFRRVLEGATAYFAALRADAADLKRIRALLKELERSRMTDDKRAEADADAKLHDAIAQASH
NTMFLHLHTSVIGMLREHITINGTGLREADDESSDLLLRQHRTLCEAILARRPEEARTAMQTHIDFVRSKVD

Sequences:

>Translated_232_residues
MGAGNARNRVEDIMRRMETALLDGTWPVGTRLPAERVLAEQFGVARNTIREAIQRLAARNLLQSRRGAGVYVTDQLRTGI
ASPWGQLVADHPALRDDILEFRRVLEGATAYFAALRADAADLKRIRALLKELERSRMTDDKRAEADADAKLHDAIAQASH
NTMFLHLHTSVIGMLREHITINGTGLREADDESSDLLLRQHRTLCEAILARRPEEARTAMQTHIDFVRSKVD
>Mature_231_residues
GAGNARNRVEDIMRRMETALLDGTWPVGTRLPAERVLAEQFGVARNTIREAIQRLAARNLLQSRRGAGVYVTDQLRTGIA
SPWGQLVADHPALRDDILEFRRVLEGATAYFAALRADAADLKRIRALLKELERSRMTDDKRAEADADAKLHDAIAQASHN
TMFLHLHTSVIGMLREHITINGTGLREADDESSDLLLRQHRTLCEAILARRPEEARTAMQTHIDFVRSKVD

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=216, Percent_Identity=39.8148148148148, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1790032, Length=207, Percent_Identity=34.2995169082126, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1790780, Length=209, Percent_Identity=30.622009569378, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1789353, Length=227, Percent_Identity=29.0748898678414, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI48994955, Length=211, Percent_Identity=27.9620853080569, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87082208, Length=224, Percent_Identity=25, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1789621, Length=203, Percent_Identity=27.5862068965517, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 26035; Mature: 25904

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAGNARNRVEDIMRRMETALLDGTWPVGTRLPAERVLAEQFGVARNTIREAIQRLAARN
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLQSRRGAGVYVTDQLRTGIASPWGQLVADHPALRDDILEFRRVLEGATAYFAALRADAA
HHHHHCCCCEEEEHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHH
DLKRIRALLKELERSRMTDDKRAEADADAKLHDAIAQASHNTMFLHLHTSVIGMLREHIT
HHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHC
INGTGLREADDESSDLLLRQHRTLCEAILARRPEEARTAMQTHIDFVRSKVD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GAGNARNRVEDIMRRMETALLDGTWPVGTRLPAERVLAEQFGVARNTIREAIQRLAARN
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLQSRRGAGVYVTDQLRTGIASPWGQLVADHPALRDDILEFRRVLEGATAYFAALRADAA
HHHHHCCCCEEEEHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHH
DLKRIRALLKELERSRMTDDKRAEADADAKLHDAIAQASHNTMFLHLHTSVIGMLREHIT
HHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHC
INGTGLREADDESSDLLLRQHRTLCEAILARRPEEARTAMQTHIDFVRSKVD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]