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The map label for this gene is gyaR [H]

Identifier: 94314715

GI number: 94314715

Start: 2553878

End: 2554885

Strand: Direct

Name: gyaR [H]

Synonym: Rmet_5796

Alternate gene names: 94314715

Gene position: 2553878-2554885 (Clockwise)

Preceding gene: 94314713

Following gene: 94314721

Centisome position: 98.98

GC content: 66.57

Gene sequence:

>1008_bases
ATGGCGCTTCGGCCGCTGAAGCCGACATCCAGAAGCAGTCTCTCCCTCGCCTTGCCGTTACGTCCTGAAGTCATGAAGCC
CGCTCTGCTCATCCTCAACCATCTCGAACCTGCCCACCTCGCCCTTATCGCCGAACACTACGACGTTCGCTATGCGCCGA
CTGCCGCCGAACGCGCTACCGAGGTCGCTACCAATGGCAAGACCTTCCGCGCGGTGCTCACCATCGGCAGCATTGGCTTG
ACCGCGAAAGAAATCGACGCCATGCCCGCGCTGGAGCTGGTCTGCGCGATGGGTGCCGGCTACGAGAACATTGACACCGC
CAAATGCCGCGAACGCGGCATTGCCGTCGGCAACGGCGCCGGCACCAATGACAGTTGCGTGGCAGACCATGCGATGGCGT
TGCTGCTGGCGTCGGTACGCCGCGTACCCGCGTACGATCGCGCCACGCGCGAAGGCATCTGGCGCAATGCGCTGCCGCTG
GCCCCGAATTTGTCGGGCAAGCGGATGGGCATCGTCGGGCTGGGCACGATCGGCCGGCGAATCGCGCAACGTGGTCTCGG
GTTCGATCTGGAAATCGGCTATCACAACCGCCGCCCGCGCACGGACGTGCCGCATCGCTACTTCGACAGCGTGATGTCCC
TGGCCGAATGGGCCGACTACCTGATCATCGCCACGCCGGGCGGCGCAGAGACGCGCCATATGGTCGACACGCCCGTGCTG
CGCGCGCTGGGCCCGGCGGGCTATCTGGTGAATATCGCGCGTGGCAGCGTGGTAGACACGGCGGCGCTGGCGGCCGCGCT
TCGGGCAGGCGAACTAGGCGGCGCGGGGCTCGATGTCTACGAAAGCGAGCCGGCACCGCCCGTCGAACTGTTCGATTGCC
CCAACGTCGTGCTGACGCCGCACGTGGCCGGCTGGTCGCCCGAAGCAATCTTCGCCTCGGTCAGCCAGTTCGTCGAGAAC
GCGCGGCGGCACTTTGCCGGCGAGCCGCTGGTGGCGCCGGTACTCTGA

Upstream 100 bases:

>100_bases
CGCCAAAGCGTACCCATTTCTGCGCACGCCAAATGCCCGAAGCGTACCCGTTTCTGCGAGCGTGGGCGAGGGCCGGCAGC
CATCGAGCATCAGGCATAAA

Downstream 100 bases:

>100_bases
TCAGCCGACAGATCAGGCGGTCACAGGAAACACCACCCGCACACACAGCCCCGGCGCCGCATCTTCCAGAAAGACGCGCG
CGCCGTGCGACTGTGCGATC

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MALRPLKPTSRSSLSLALPLRPEVMKPALLILNHLEPAHLALIAEHYDVRYAPTAAERATEVATNGKTFRAVLTIGSIGL
TAKEIDAMPALELVCAMGAGYENIDTAKCRERGIAVGNGAGTNDSCVADHAMALLLASVRRVPAYDRATREGIWRNALPL
APNLSGKRMGIVGLGTIGRRIAQRGLGFDLEIGYHNRRPRTDVPHRYFDSVMSLAEWADYLIIATPGGAETRHMVDTPVL
RALGPAGYLVNIARGSVVDTAALAAALRAGELGGAGLDVYESEPAPPVELFDCPNVVLTPHVAGWSPEAIFASVSQFVEN
ARRHFAGEPLVAPVL

Sequences:

>Translated_335_residues
MALRPLKPTSRSSLSLALPLRPEVMKPALLILNHLEPAHLALIAEHYDVRYAPTAAERATEVATNGKTFRAVLTIGSIGL
TAKEIDAMPALELVCAMGAGYENIDTAKCRERGIAVGNGAGTNDSCVADHAMALLLASVRRVPAYDRATREGIWRNALPL
APNLSGKRMGIVGLGTIGRRIAQRGLGFDLEIGYHNRRPRTDVPHRYFDSVMSLAEWADYLIIATPGGAETRHMVDTPVL
RALGPAGYLVNIARGSVVDTAALAAALRAGELGGAGLDVYESEPAPPVELFDCPNVVLTPHVAGWSPEAIFASVSQFVEN
ARRHFAGEPLVAPVL
>Mature_334_residues
ALRPLKPTSRSSLSLALPLRPEVMKPALLILNHLEPAHLALIAEHYDVRYAPTAAERATEVATNGKTFRAVLTIGSIGLT
AKEIDAMPALELVCAMGAGYENIDTAKCRERGIAVGNGAGTNDSCVADHAMALLLASVRRVPAYDRATREGIWRNALPLA
PNLSGKRMGIVGLGTIGRRIAQRGLGFDLEIGYHNRRPRTDVPHRYFDSVMSLAEWADYLIIATPGGAETRHMVDTPVLR
ALGPAGYLVNIARGSVVDTAALAAALRAGELGGAGLDVYESEPAPPVELFDCPNVVLTPHVAGWSPEAIFASVSQFVENA
RRHFAGEPLVAPVL

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI61743967, Length=268, Percent_Identity=28.7313432835821, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI4557497, Length=268, Percent_Identity=28.7313432835821, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI23308577, Length=233, Percent_Identity=29.6137339055794, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI145580578, Length=247, Percent_Identity=29.1497975708502, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI4557499, Length=247, Percent_Identity=29.1497975708502, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI145580575, Length=265, Percent_Identity=28.3018867924528, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI6912396, Length=220, Percent_Identity=30, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI87082289, Length=308, Percent_Identity=29.8701298701299, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1789279, Length=245, Percent_Identity=31.0204081632653, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1787645, Length=247, Percent_Identity=27.1255060728745, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1788660, Length=266, Percent_Identity=29.3233082706767, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI87081824, Length=184, Percent_Identity=30.4347826086957, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=310, Percent_Identity=26.1290322580645, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI25147481, Length=256, Percent_Identity=30.078125, Blast_Score=98, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6324055, Length=237, Percent_Identity=32.9113924050633, Blast_Score=115, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6320925, Length=310, Percent_Identity=25.1612903225806, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322116, Length=315, Percent_Identity=24.1269841269841, Blast_Score=102, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6324964, Length=249, Percent_Identity=28.5140562248996, Blast_Score=86, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6321253, Length=313, Percent_Identity=24.2811501597444, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28574286, Length=274, Percent_Identity=32.1167883211679, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI45551003, Length=268, Percent_Identity=31.3432835820896, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45552429, Length=268, Percent_Identity=31.3432835820896, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24585514, Length=268, Percent_Identity=31.3432835820896, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28574282, Length=268, Percent_Identity=31.3432835820896, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28574284, Length=268, Percent_Identity=31.3432835820896, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24646446, Length=244, Percent_Identity=30.7377049180328, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646448, Length=244, Percent_Identity=30.7377049180328, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646452, Length=244, Percent_Identity=30.7377049180328, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646450, Length=244, Percent_Identity=30.7377049180328, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI62472511, Length=244, Percent_Identity=30.7377049180328, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28571528, Length=259, Percent_Identity=32.4324324324324, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI19921140, Length=308, Percent_Identity=29.5454545454545, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24585516, Length=254, Percent_Identity=27.9527559055118, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35716; Mature: 35584

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALRPLKPTSRSSLSLALPLRPEVMKPALLILNHLEPAHLALIAEHYDVRYAPTAAERAT
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCHHHHEEEHHHCCCEECCCHHHHHH
EVATNGKTFRAVLTIGSIGLTAKEIDAMPALELVCAMGAGYENIDTAKCRERGIAVGNGA
HHHCCCCEEEEEEEECCCCCCHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHCCCEECCCC
GTNDSCVADHAMALLLASVRRVPAYDRATREGIWRNALPLAPNLSGKRMGIVGLGTIGRR
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHCCCCCCCCCCCCEEEEEECHHHHHH
IAQRGLGFDLEIGYHNRRPRTDVPHRYFDSVMSLAEWADYLIIATPGGAETRHMVDTPVL
HHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHH
RALGPAGYLVNIARGSVVDTAALAAALRAGELGGAGLDVYESEPAPPVELFDCPNVVLTP
HHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCEEECC
HVAGWSPEAIFASVSQFVENARRHFAGEPLVAPVL
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
ALRPLKPTSRSSLSLALPLRPEVMKPALLILNHLEPAHLALIAEHYDVRYAPTAAERAT
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCHHHHEEEHHHCCCEECCCHHHHHH
EVATNGKTFRAVLTIGSIGLTAKEIDAMPALELVCAMGAGYENIDTAKCRERGIAVGNGA
HHHCCCCEEEEEEEECCCCCCHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHCCCEECCCC
GTNDSCVADHAMALLLASVRRVPAYDRATREGIWRNALPLAPNLSGKRMGIVGLGTIGRR
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHCCCCCCCCCCCCEEEEEECHHHHHH
IAQRGLGFDLEIGYHNRRPRTDVPHRYFDSVMSLAEWADYLIIATPGGAETRHMVDTPVL
HHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHH
RALGPAGYLVNIARGSVVDTAALAAALRAGELGGAGLDVYESEPAPPVELFDCPNVVLTP
HHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCEEECC
HVAGWSPEAIFASVSQFVENARRHFAGEPLVAPVL
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA