Click here to switch to the map view.

The map label for this gene is edd1 [H]

Identifier: 94314721

GI number: 94314721

Start: 2560235

End: 2562337

Strand: Direct

Name: edd1 [H]

Synonym: Rmet_5802

Alternate gene names: 94314721

Gene position: 2560235-2562337 (Clockwise)

Preceding gene: 94314715

Following gene: 94314725

Centisome position: 99.23

GC content: 66.9

Gene sequence:

>2103_bases
TTGAGTCCGCCGCGCGGCGCATTGGTTCCGGCCATGGTACGTCACTCGCCGCCGCTTGGGCAGGGGGAAGTGGCCACGAG
CATGACCCGCGCCGCACATCGGACCCAAAGCGTACCCGTTTCTGCGTGGCCCGGGTCACCGTGGCGGAACATCCGTGAGC
CGCGTCAATCCCACATGCAGACGCCCCATGCAGACGGACATGTCGTCGATCGGGACGGCATTCCGATGATGCCCAGGAAT
TTCGACTACGCTGATAGCGCCCTACAGGAGACTTCCATGCCCCGCCACCCCGTACTGGATGCGGTCACGGCCCGCATCGT
GGCCCGCAGTGCCCCTACCCGCCAGGCCTACCTGCAACGCACCCGCGCCATGGCGGGCCAGAAGGTCGAACGCGCCAACC
TGTCGTGCACCAATCTCGCACACGGTGTGGCGGCGATGCCCGATGACGCGAAGATCCGGCTCAAGGCGCAGGAGCGGCCG
AATCTCGCGATCGTGTCGGCCTACAACGAGATGCTGTCCGCACACCAGCCGCTGAACGCCTTTCCGCAGTGGATCAAGGA
AGCCGCGCTGGAAGCCGGCGGTACCGCGCAGTTCGCCGGTGGCACGCCGGCCATGTGCGATGGGGTCACGCAGGGCCAGG
ACGGCATGGACCTGTCGCTGTTCTCGCGTGACGTGATCGCGATGGCCACCGCGGTCGCGCTATCGCACCAGATGTTCGAC
GGCGTGCTCTGCCTCGGCGTGTGCGACAAGATCGTGCCAGGCCTGGTGATGGGCGCGCTGTCGTTCGGACACCTGCCCGC
CGTGTTCGTGCCGGGTGGCCCGATGACGACCGGCATGGGCAACGAGGAAAAGGCGCACATCCGCCAGCTCTACGCGGAAG
GCAAGATCGGGCGCGAGGAACTGCTGGAAGCCGAGACACGGTCGTACCACGGCCCGGGCACCTGCACGTTCTACGGCACC
GCCAATTCGAACCAGATGCTCATGGAGATCATGGGCCTCCATCTGCCGGGCACGGCCTTCATCAATCCGAACACGCCGCT
CCGCGAGGCCCTGACCCGCGAATCCGCGCGCCAGGCGCTGCGGCTCGTCCACGGCGGCACGCGCTACATGCCGATTGCCG
AAGTCCTGGACGAACGCGCCTTTGTTAACGGTATCGTCGGGTTGCTGGCCACTGGTGGGTCCACCAACCACACGTTGCAC
CTGATCGCCATGGCCCGCGTGGCCGGCATTCTCCTGACCTGGGACGATTTCGACGAACTGTCCGCCGCCGTGCCCTTGCT
GGCGCGCGTGTACCCGAACGGCAAGGCCGACGTGAACCAGTTCCAGGCGGCCGGCGGGCTGCCGGTGGTGATACGTGGGC
TGCTGTCGCTGGGACTGCTGCATGACGACGTCAATACGATCGCCGGCACCGGTCTGGCCGATTACACGCGCGAGCCGGTG
CTGCGAGACGGCAAGCTGAGCTGGATCGACGGCCCGGTGAAGTCCCTGGACGACACCATCGTGCGCACCGCCGACAGCCC
GTTCGCCCCCGACGGCGGTATCAAGCTGCTCGATGGCAAGCTCGGCCGCTGCGTCATCAAGACATCGGCCGTCAAACCCG
AGCATCAGGTCGTGGAAGCACCCGCCATCGTGTTCCATCGCCAGGACGATCTGCTGGCTGCCTTCAAGCGTGGCGAGCTG
GAGCGTGATTTCGTGGCCGTGCTCCCGTGGCAAGGCCCGTCCGCGTGCGGGATGCCCGAGCTGCACAAGCTCACGCCGAC
GCTGACGTTGCTGCAGGATCGCGGCTTCCACGTGGCGCTGGTGACGGATGGCCGCATGTCGGGCGCATCGGGCAAAGTAC
CGGCTGCCATCCACGTCTGCCCCGAAGCGCATTCGGGCGGAGAGATCGGCAAGGTCCGCACGGGCGATATCGTGCGCGTG
GATGCCCCGGCAGGCGTGCTCACGGTCAGGGTCGACGAGGCGGAATGGGCGTCCCGGCCCATGGACACGCCCGATCTGAC
ACGCAATCGGCATGGCGTGGGCCGCGACCTCTTCGGCGGCTTTCGCGCGCACGTGAGCACAGCCGAAGCCGGCGCGTGTT
CGCTGTTCGCGGAAGAGCATTAA

Upstream 100 bases:

>100_bases
TGCGCCGCGCCAGGTCTCCGGTGCCGCCGAACAGCACCATGTCGAAATCGGGCAAGCTCACCCTGGGCTCCTTGCGGGGG
ATGGGGCGCCCCGGCAACTA

Downstream 100 bases:

>100_bases
TGGAATTGGGGGGACGGCCGCCGGGGCGGCGGCCGCGAAAGCGTACCCGTTTCTGCGTACGATTCTTGCGCGCGTTTTGT
ACGCGTTTTGCCCGCGTTTC

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 700; Mature: 699

Protein sequence:

>700_residues
MSPPRGALVPAMVRHSPPLGQGEVATSMTRAAHRTQSVPVSAWPGSPWRNIREPRQSHMQTPHADGHVVDRDGIPMMPRN
FDYADSALQETSMPRHPVLDAVTARIVARSAPTRQAYLQRTRAMAGQKVERANLSCTNLAHGVAAMPDDAKIRLKAQERP
NLAIVSAYNEMLSAHQPLNAFPQWIKEAALEAGGTAQFAGGTPAMCDGVTQGQDGMDLSLFSRDVIAMATAVALSHQMFD
GVLCLGVCDKIVPGLVMGALSFGHLPAVFVPGGPMTTGMGNEEKAHIRQLYAEGKIGREELLEAETRSYHGPGTCTFYGT
ANSNQMLMEIMGLHLPGTAFINPNTPLREALTRESARQALRLVHGGTRYMPIAEVLDERAFVNGIVGLLATGGSTNHTLH
LIAMARVAGILLTWDDFDELSAAVPLLARVYPNGKADVNQFQAAGGLPVVIRGLLSLGLLHDDVNTIAGTGLADYTREPV
LRDGKLSWIDGPVKSLDDTIVRTADSPFAPDGGIKLLDGKLGRCVIKTSAVKPEHQVVEAPAIVFHRQDDLLAAFKRGEL
ERDFVAVLPWQGPSACGMPELHKLTPTLTLLQDRGFHVALVTDGRMSGASGKVPAAIHVCPEAHSGGEIGKVRTGDIVRV
DAPAGVLTVRVDEAEWASRPMDTPDLTRNRHGVGRDLFGGFRAHVSTAEAGACSLFAEEH

Sequences:

>Translated_700_residues
MSPPRGALVPAMVRHSPPLGQGEVATSMTRAAHRTQSVPVSAWPGSPWRNIREPRQSHMQTPHADGHVVDRDGIPMMPRN
FDYADSALQETSMPRHPVLDAVTARIVARSAPTRQAYLQRTRAMAGQKVERANLSCTNLAHGVAAMPDDAKIRLKAQERP
NLAIVSAYNEMLSAHQPLNAFPQWIKEAALEAGGTAQFAGGTPAMCDGVTQGQDGMDLSLFSRDVIAMATAVALSHQMFD
GVLCLGVCDKIVPGLVMGALSFGHLPAVFVPGGPMTTGMGNEEKAHIRQLYAEGKIGREELLEAETRSYHGPGTCTFYGT
ANSNQMLMEIMGLHLPGTAFINPNTPLREALTRESARQALRLVHGGTRYMPIAEVLDERAFVNGIVGLLATGGSTNHTLH
LIAMARVAGILLTWDDFDELSAAVPLLARVYPNGKADVNQFQAAGGLPVVIRGLLSLGLLHDDVNTIAGTGLADYTREPV
LRDGKLSWIDGPVKSLDDTIVRTADSPFAPDGGIKLLDGKLGRCVIKTSAVKPEHQVVEAPAIVFHRQDDLLAAFKRGEL
ERDFVAVLPWQGPSACGMPELHKLTPTLTLLQDRGFHVALVTDGRMSGASGKVPAAIHVCPEAHSGGEIGKVRTGDIVRV
DAPAGVLTVRVDEAEWASRPMDTPDLTRNRHGVGRDLFGGFRAHVSTAEAGACSLFAEEH
>Mature_699_residues
SPPRGALVPAMVRHSPPLGQGEVATSMTRAAHRTQSVPVSAWPGSPWRNIREPRQSHMQTPHADGHVVDRDGIPMMPRNF
DYADSALQETSMPRHPVLDAVTARIVARSAPTRQAYLQRTRAMAGQKVERANLSCTNLAHGVAAMPDDAKIRLKAQERPN
LAIVSAYNEMLSAHQPLNAFPQWIKEAALEAGGTAQFAGGTPAMCDGVTQGQDGMDLSLFSRDVIAMATAVALSHQMFDG
VLCLGVCDKIVPGLVMGALSFGHLPAVFVPGGPMTTGMGNEEKAHIRQLYAEGKIGREELLEAETRSYHGPGTCTFYGTA
NSNQMLMEIMGLHLPGTAFINPNTPLREALTRESARQALRLVHGGTRYMPIAEVLDERAFVNGIVGLLATGGSTNHTLHL
IAMARVAGILLTWDDFDELSAAVPLLARVYPNGKADVNQFQAAGGLPVVIRGLLSLGLLHDDVNTIAGTGLADYTREPVL
RDGKLSWIDGPVKSLDDTIVRTADSPFAPDGGIKLLDGKLGRCVIKTSAVKPEHQVVEAPAIVFHRQDDLLAAFKRGELE
RDFVAVLPWQGPSACGMPELHKLTPTLTLLQDRGFHVALVTDGRMSGASGKVPAAIHVCPEAHSGGEIGKVRTGDIVRVD
APAGVLTVRVDEAEWASRPMDTPDLTRNRHGVGRDLFGGFRAHVSTAEAGACSLFAEEH

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=602, Percent_Identity=59.9667774086379, Blast_Score=737, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=543, Percent_Identity=29.6500920810313, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI2367371, Length=472, Percent_Identity=32.4152542372881, Blast_Score=171, Evalue=2e-43,
Organism=Escherichia coli, GI1786464, Length=501, Percent_Identity=30.3393213572854, Blast_Score=152, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6322476, Length=504, Percent_Identity=30.952380952381, Blast_Score=184, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 74962; Mature: 74830

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPPRGALVPAMVRHSPPLGQGEVATSMTRAAHRTQSVPVSAWPGSPWRNIREPRQSHMQ
CCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHCC
TPHADGHVVDRDGIPMMPRNFDYADSALQETSMPRHPVLDAVTARIVARSAPTRQAYLQR
CCCCCCEEECCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHH
TRAMAGQKVERANLSCTNLAHGVAAMPDDAKIRLKAQERPNLAIVSAYNEMLSAHQPLNA
HHHHHCCCHHHCCCCHHHHHCCCCCCCCCCEEEEEECCCCCEEEEHHHHHHHHHCCCHHH
FPQWIKEAALEAGGTAQFAGGTPAMCDGVTQGQDGMDLSLFSRDVIAMATAVALSHQMFD
HHHHHHHHHHCCCCCEEECCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GVLCLGVCDKIVPGLVMGALSFGHLPAVFVPGGPMTTGMGNEEKAHIRQLYAEGKIGREE
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCHHH
LLEAETRSYHGPGTCTFYGTANSNQMLMEIMGLHLPGTAFINPNTPLREALTRESARQAL
HHHHHHHCCCCCCEEEEEECCCCCHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHH
RLVHGGTRYMPIAEVLDERAFVNGIVGLLATGGSTNHTLHLIAMARVAGILLTWDDFDEL
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCEEEEECCHHHH
SAAVPLLARVYPNGKADVNQFQAAGGLPVVIRGLLSLGLLHDDVNTIAGTGLADYTREPV
HHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCC
LRDGKLSWIDGPVKSLDDTIVRTADSPFAPDGGIKLLDGKLGRCVIKTSAVKPEHQVVEA
CCCCCEEECCCCHHHHHHHHHCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCHHHHHCC
PAIVFHRQDDLLAAFKRGELERDFVAVLPWQGPSACGMPELHKLTPTLTLLQDRGFHVAL
CEEEEECCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHHHCCHHEEEECCCCEEEE
VTDGRMSGASGKVPAAIHVCPEAHSGGEIGKVRTGDIVRVDAPAGVLTVRVDEAEWASRP
EECCCCCCCCCCCCEEEEECCCCCCCCCCCCEECCCEEEEECCCCEEEEEECCHHHHCCC
MDTPDLTRNRHGVGRDLFGGFRAHVSTAEAGACSLFAEEH
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCC
>Mature Secondary Structure 
SPPRGALVPAMVRHSPPLGQGEVATSMTRAAHRTQSVPVSAWPGSPWRNIREPRQSHMQ
CCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHCC
TPHADGHVVDRDGIPMMPRNFDYADSALQETSMPRHPVLDAVTARIVARSAPTRQAYLQR
CCCCCCEEECCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHH
TRAMAGQKVERANLSCTNLAHGVAAMPDDAKIRLKAQERPNLAIVSAYNEMLSAHQPLNA
HHHHHCCCHHHCCCCHHHHHCCCCCCCCCCEEEEEECCCCCEEEEHHHHHHHHHCCCHHH
FPQWIKEAALEAGGTAQFAGGTPAMCDGVTQGQDGMDLSLFSRDVIAMATAVALSHQMFD
HHHHHHHHHHCCCCCEEECCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GVLCLGVCDKIVPGLVMGALSFGHLPAVFVPGGPMTTGMGNEEKAHIRQLYAEGKIGREE
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCHHH
LLEAETRSYHGPGTCTFYGTANSNQMLMEIMGLHLPGTAFINPNTPLREALTRESARQAL
HHHHHHHCCCCCCEEEEEECCCCCHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHH
RLVHGGTRYMPIAEVLDERAFVNGIVGLLATGGSTNHTLHLIAMARVAGILLTWDDFDEL
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCEEEEECCHHHH
SAAVPLLARVYPNGKADVNQFQAAGGLPVVIRGLLSLGLLHDDVNTIAGTGLADYTREPV
HHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCC
LRDGKLSWIDGPVKSLDDTIVRTADSPFAPDGGIKLLDGKLGRCVIKTSAVKPEHQVVEA
CCCCCEEECCCCHHHHHHHHHCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCHHHHHCC
PAIVFHRQDDLLAAFKRGELERDFVAVLPWQGPSACGMPELHKLTPTLTLLQDRGFHVAL
CEEEEECCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHHHCCHHEEEECCCCEEEE
VTDGRMSGASGKVPAAIHVCPEAHSGGEIGKVRTGDIVRVDAPAGVLTVRVDEAEWASRP
EECCCCCCCCCCCCEEEEECCCCCCCCCCCCEECCCEEEEECCCCEEEEEECCHHHHCCC
MDTPDLTRNRHGVGRDLFGGFRAHVSTAEAGACSLFAEEH
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045900; 10984043 [H]