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The map label for this gene is iclR [H]

Identifier: 94313654

GI number: 94313654

Start: 1375839

End: 1376663

Strand: Direct

Name: iclR [H]

Synonym: Rmet_4732

Alternate gene names: 94313654

Gene position: 1375839-1376663 (Clockwise)

Preceding gene: 94313653

Following gene: 94313655

Centisome position: 53.33

GC content: 64.0

Gene sequence:

>825_bases
ATGGAAGATGTGATCGAAATGGCGGAGATCGCCGCCGCACCCAAGGAAAGCAAACGCAAGGAAGACCGCCATTTCGTGAC
CGCGCTGGCGCGTGGTCTGGATGTGCTGGCGTGCTTTCGTGCATTCGACAGCGAACTTGGCAATGCCGAACTCGCCAAGC
GCTGTGGCCTGCCGAAATCGACGATTTCGCGCCTGACCCACACGCTGACCGAACTTGGCTACCTCCAGGCCCTGACGGAC
CCCGTTCGTTACCGCCTGGGCAGTTCCGCACTGGCGCTGGCGCCCGCCGCGCAGCAGGGTGCAGAGGTCCTGGCGGTGGC
GCGGCCCTACATGCAGGAATTGGCGGATTTGTCGCAAGGCGTCGCCTCACTGATCGTGCGCGACCGCGGACGTATGCTGG
TATTCGAGAACTGCCAGTCCGAGACCTACCTGACTCTGCGCGTCGCCGTGGGAAGCCGCGTATCGGGGCTCAATACGGCA
GCAGGCCGTGCCTACCTGGTGGCATTGCCGCCAGCCGAGCAGCGTCAGGCGCTAACGGCATTCCGCACGGACGAGAAGGT
CGCCCCTGCCGAAGCAGAAGCCATCCTCGCGAACAGCCGTGACGAGCAACGCCGGCTTGGCTGCACCACGTCGTTTGGTG
AATGGCTGCCCGACATCAATTCGATCGCCCACGCGTTCCGGCCGGGTCCCTCATTGCCCCCGATGACGCTGAGCTGCAGC
GGTCCCAATGCGATCGTGCCGCCAGCCCATCTGCTGGAGAAAGTGCGTCCGCTGCTGCGTGACCATATCCGCAAGATCGA
AGCCGCGTTCGGTGTCACACGGTAA

Upstream 100 bases:

>100_bases
GCGTCCTTCCCCCTTTTCGCAAGACCACGCCTGCTCGCAGGCACCACCATCCAGGCGAAGCTGCACGTGCAACTTGCCAC
GGGCAAAGAGTGAGCACGCC

Downstream 100 bases:

>100_bases
CGGAGCGCAACACTGACGGGATGGGAAACGGTTGCGGGCACGCCGCACCGGAATGCCGTACGATGCGGGTTTCCCGCTAT
CAACCGGACCCGGTTCCATG

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MEDVIEMAEIAAAPKESKRKEDRHFVTALARGLDVLACFRAFDSELGNAELAKRCGLPKSTISRLTHTLTELGYLQALTD
PVRYRLGSSALALAPAAQQGAEVLAVARPYMQELADLSQGVASLIVRDRGRMLVFENCQSETYLTLRVAVGSRVSGLNTA
AGRAYLVALPPAEQRQALTAFRTDEKVAPAEAEAILANSRDEQRRLGCTTSFGEWLPDINSIAHAFRPGPSLPPMTLSCS
GPNAIVPPAHLLEKVRPLLRDHIRKIEAAFGVTR

Sequences:

>Translated_274_residues
MEDVIEMAEIAAAPKESKRKEDRHFVTALARGLDVLACFRAFDSELGNAELAKRCGLPKSTISRLTHTLTELGYLQALTD
PVRYRLGSSALALAPAAQQGAEVLAVARPYMQELADLSQGVASLIVRDRGRMLVFENCQSETYLTLRVAVGSRVSGLNTA
AGRAYLVALPPAEQRQALTAFRTDEKVAPAEAEAILANSRDEQRRLGCTTSFGEWLPDINSIAHAFRPGPSLPPMTLSCS
GPNAIVPPAHLLEKVRPLLRDHIRKIEAAFGVTR
>Mature_274_residues
MEDVIEMAEIAAAPKESKRKEDRHFVTALARGLDVLACFRAFDSELGNAELAKRCGLPKSTISRLTHTLTELGYLQALTD
PVRYRLGSSALALAPAAQQGAEVLAVARPYMQELADLSQGVASLIVRDRGRMLVFENCQSETYLTLRVAVGSRVSGLNTA
AGRAYLVALPPAEQRQALTAFRTDEKVAPAEAEAILANSRDEQRRLGCTTSFGEWLPDINSIAHAFRPGPSLPPMTLSCS
GPNAIVPPAHLLEKVRPLLRDHIRKIEAAFGVTR

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=196, Percent_Identity=23.9795918367347, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29740; Mature: 29740

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDVIEMAEIAAAPKESKRKEDRHFVTALARGLDVLACFRAFDSELGNAELAKRCGLPKS
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHH
TISRLTHTLTELGYLQALTDPVRYRLGSSALALAPAAQQGAEVLAVARPYMQELADLSQG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHHH
VASLIVRDRGRMLVFENCQSETYLTLRVAVGSRVSGLNTAAGRAYLVALPPAEQRQALTA
HHHHHHHCCCCEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHH
FRTDEKVAPAEAEAILANSRDEQRRLGCTTSFGEWLPDINSIAHAFRPGPSLPPMTLSCS
HHCCCCCCCHHHHHHHHCCCHHHHHHCCCCCHHHHCCCHHHHHHHHCCCCCCCCEEEECC
GPNAIVPPAHLLEKVRPLLRDHIRKIEAAFGVTR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEDVIEMAEIAAAPKESKRKEDRHFVTALARGLDVLACFRAFDSELGNAELAKRCGLPKS
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHH
TISRLTHTLTELGYLQALTDPVRYRLGSSALALAPAAQQGAEVLAVARPYMQELADLSQG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHHH
VASLIVRDRGRMLVFENCQSETYLTLRVAVGSRVSGLNTAAGRAYLVALPPAEQRQALTA
HHHHHHHCCCCEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHH
FRTDEKVAPAEAEAILANSRDEQRRLGCTTSFGEWLPDINSIAHAFRPGPSLPPMTLSCS
HHCCCCCCCHHHHHHHHCCCHHHHHHCCCCCHHHHCCCHHHHHHHHCCCCCCCCEEEECC
GPNAIVPPAHLLEKVRPLLRDHIRKIEAAFGVTR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]