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The map label for this gene is envZ [H]

Identifier: 94312407

GI number: 94312407

Start: 3756167

End: 3757480

Strand: Reverse

Name: envZ [H]

Synonym: Rmet_3476

Alternate gene names: 94312407

Gene position: 3757480-3756167 (Counterclockwise)

Preceding gene: 94312408

Following gene: 94312405

Centisome position: 95.66

GC content: 68.42

Gene sequence:

>1314_bases
ATGGCCGCGCAGATGCCGCCATCGGCGGACGATCCACCGATCGTGCGGCCCGAATTGCGTTCCAGCGCATCGGAGACGCC
CCGAAGGCGCTTCGATTCGATGTTCGTGCGGCTGTTCTTCGTGATGGCCGCGATCATGCTTGCTGTTCACGTGCTGGGCG
TGACCGTGATCGAGGGGTTCTTCCCGCGCCCGGGTTCGGAGCGCTACATGGAACGGATGCGCCGCGCCGCCTCGGAAGCC
GAGGCGGCCGGCCACTCATTGCCTGCACCACTGCCGGGCGCGTTAGCATCGCTCAGCCATCCGCACGGGCCGCCACCACC
GCCCAATGATGACGATGACGACGGCGACAACGACGGGCCCCCGCTGCATCCCGACGCATTCCGCATGCAGAAAGGCGGCG
TACTCATGCCGCCCGGACCACCTGGGCCACCTGGGCCACCGTCCGGTTTCCATATTCGAGGTCTCTGGCCGCCGCACTTG
GGCATGTTGTTCCAGCTCGTGGCCATCCTGATTGCATCGTGGGTTGGCGCGCGTCTGCTGGCGCGGCCCGTGCAGCAACT
GGCCAGTGGCGCGAACCGGCTGGCGCAGGACGTCCACGCGCCGCCGCTGGAGGAGGAGATGGGCCCAGCCGAAGCGCGTG
ACGCTACCCGGGCACTGAACCTGATGCAGCAGCGCATCCGCACCCAGCTGGCGCAGCAATCACGCTTCCTGGCGGCGGTG
TCGCACGATCTGCGCACGCCGCTGACGCGCATGAGCCTGCGCATCGAGCGCATCGAGGACAACAACGTGCGCTACCGTCT
GCGCCAGGATCTGGCCGAGATGAACGGACTGATCGACGCCACGCTGTACTACCTGCGCGAGCGAGACGATGCCGCCGGCC
CGCGCCAGCGCGTGGACGTGCTGGCACTGCTGCAGGCGATCGTCGACGATGCCCAGGAAATGGGCCAGGACGTGCGGCTT
TCCGGCACCGCCGTGCCGCTGCTGGCGTACCCGGCCGAACTGCGCCGCGCGGTAGTCAATCTGGTGGAGAACGCGCACCG
GTACGGCGGCGCCGCCCATATCGTGCTGACCGACAGCGCCGAGCGCGTGATCATCGACGTGTCCGATAACGGCCCGGGTA
TTCCGCCCGCGGAACTCCAGCGCGTGCTGGAGCCGTTCTATCGCGTGGAGTCGTCGCGCAGCCGTGCCACAGGCGGTGTG
GGAATGGGGTTGGCGATCGCCGCCGATATCGTGGCGCGACACGGCGGGGAACTCACGCTGAGCAACCGTACCGAGGGCGG
CCTGCGCGTGCGCATTGTGCTGCCGCGCGCCTGA

Upstream 100 bases:

>100_bases
CTGCGCCAGAAGCTGCGTGACGATCCGCGCGACTCGGCACTGATCCGCACCGTGCGTGGCGAAGGGTACGTCTTCACGGG
CACCGTGGAGCACTGACGGC

Downstream 100 bases:

>100_bases
CGGGGCATCGGCCCATCGGTGGCTCAGGCGCGTTGGGGCAAACCGCTCTTGTTGATCGGCGCCAATTGCACGTACTGCGA
ACCGCGTAGTCCGCGCGTGA

Product: Periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MAAQMPPSADDPPIVRPELRSSASETPRRRFDSMFVRLFFVMAAIMLAVHVLGVTVIEGFFPRPGSERYMERMRRAASEA
EAAGHSLPAPLPGALASLSHPHGPPPPPNDDDDDGDNDGPPLHPDAFRMQKGGVLMPPGPPGPPGPPSGFHIRGLWPPHL
GMLFQLVAILIASWVGARLLARPVQQLASGANRLAQDVHAPPLEEEMGPAEARDATRALNLMQQRIRTQLAQQSRFLAAV
SHDLRTPLTRMSLRIERIEDNNVRYRLRQDLAEMNGLIDATLYYLRERDDAAGPRQRVDVLALLQAIVDDAQEMGQDVRL
SGTAVPLLAYPAELRRAVVNLVENAHRYGGAAHIVLTDSAERVIIDVSDNGPGIPPAELQRVLEPFYRVESSRSRATGGV
GMGLAIAADIVARHGGELTLSNRTEGGLRVRIVLPRA

Sequences:

>Translated_437_residues
MAAQMPPSADDPPIVRPELRSSASETPRRRFDSMFVRLFFVMAAIMLAVHVLGVTVIEGFFPRPGSERYMERMRRAASEA
EAAGHSLPAPLPGALASLSHPHGPPPPPNDDDDDGDNDGPPLHPDAFRMQKGGVLMPPGPPGPPGPPSGFHIRGLWPPHL
GMLFQLVAILIASWVGARLLARPVQQLASGANRLAQDVHAPPLEEEMGPAEARDATRALNLMQQRIRTQLAQQSRFLAAV
SHDLRTPLTRMSLRIERIEDNNVRYRLRQDLAEMNGLIDATLYYLRERDDAAGPRQRVDVLALLQAIVDDAQEMGQDVRL
SGTAVPLLAYPAELRRAVVNLVENAHRYGGAAHIVLTDSAERVIIDVSDNGPGIPPAELQRVLEPFYRVESSRSRATGGV
GMGLAIAADIVARHGGELTLSNRTEGGLRVRIVLPRA
>Mature_436_residues
AAQMPPSADDPPIVRPELRSSASETPRRRFDSMFVRLFFVMAAIMLAVHVLGVTVIEGFFPRPGSERYMERMRRAASEAE
AAGHSLPAPLPGALASLSHPHGPPPPPNDDDDDGDNDGPPLHPDAFRMQKGGVLMPPGPPGPPGPPSGFHIRGLWPPHLG
MLFQLVAILIASWVGARLLARPVQQLASGANRLAQDVHAPPLEEEMGPAEARDATRALNLMQQRIRTQLAQQSRFLAAVS
HDLRTPLTRMSLRIERIEDNNVRYRLRQDLAEMNGLIDATLYYLRERDDAAGPRQRVDVLALLQAIVDDAQEMGQDVRLS
GTAVPLLAYPAELRRAVVNLVENAHRYGGAAHIVLTDSAERVIIDVSDNGPGIPPAELQRVLEPFYRVESSRSRATGGVG
MGLAIAADIVARHGGELTLSNRTEGGLRVRIVLPRA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=280, Percent_Identity=32.8571428571429, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1790346, Length=265, Percent_Identity=29.0566037735849, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87082128, Length=301, Percent_Identity=29.9003322259136, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1788393, Length=280, Percent_Identity=30, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1786783, Length=331, Percent_Identity=25.9818731117825, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1786600, Length=239, Percent_Identity=32.2175732217573, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1787894, Length=227, Percent_Identity=30.8370044052863, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1786912, Length=242, Percent_Identity=31.8181818181818, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87081816, Length=282, Percent_Identity=28.3687943262411, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790551, Length=299, Percent_Identity=25.4180602006689, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789403, Length=247, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790861, Length=250, Percent_Identity=27.6, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1789149, Length=229, Percent_Identity=26.6375545851528, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787374, Length=345, Percent_Identity=24.3478260869565, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47547; Mature: 47416

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAQMPPSADDPPIVRPELRSSASETPRRRFDSMFVRLFFVMAAIMLAVHVLGVTVIEGF
CCCCCCCCCCCCCCCCHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FPRPGSERYMERMRRAASEAEAAGHSLPAPLPGALASLSHPHGPPPPPNDDDDDGDNDGP
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCC
PLHPDAFRMQKGGVLMPPGPPGPPGPPSGFHIRGLWPPHLGMLFQLVAILIASWVGARLL
CCCCHHHHHCCCCEECCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
ARPVQQLASGANRLAQDVHAPPLEEEMGPAEARDATRALNLMQQRIRTQLAQQSRFLAAV
HHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHDLRTPLTRMSLRIERIEDNNVRYRLRQDLAEMNGLIDATLYYLRERDDAAGPRQRVDV
HHHHHCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LALLQAIVDDAQEMGQDVRLSGTAVPLLAYPAELRRAVVNLVENAHRYGGAAHIVLTDSA
HHHHHHHHHHHHHCCCCEEECCCCCHHHHCHHHHHHHHHHHHHHHHHHCCEEEEEEECCC
ERVIIDVSDNGPGIPPAELQRVLEPFYRVESSRSRATGGVGMGLAIAADIVARHGGELTL
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEE
SNRTEGGLRVRIVLPRA
CCCCCCCEEEEEEECCC
>Mature Secondary Structure 
AAQMPPSADDPPIVRPELRSSASETPRRRFDSMFVRLFFVMAAIMLAVHVLGVTVIEGF
CCCCCCCCCCCCCCCHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FPRPGSERYMERMRRAASEAEAAGHSLPAPLPGALASLSHPHGPPPPPNDDDDDGDNDGP
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCC
PLHPDAFRMQKGGVLMPPGPPGPPGPPSGFHIRGLWPPHLGMLFQLVAILIASWVGARLL
CCCCHHHHHCCCCEECCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
ARPVQQLASGANRLAQDVHAPPLEEEMGPAEARDATRALNLMQQRIRTQLAQQSRFLAAV
HHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHDLRTPLTRMSLRIERIEDNNVRYRLRQDLAEMNGLIDATLYYLRERDDAAGPRQRVDV
HHHHHCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LALLQAIVDDAQEMGQDVRLSGTAVPLLAYPAELRRAVVNLVENAHRYGGAAHIVLTDSA
HHHHHHHHHHHHHCCCCEEECCCCCHHHHCHHHHHHHHHHHHHHHHHHCCEEEEEEECCC
ERVIIDVSDNGPGIPPAELQRVLEPFYRVESSRSRATGGVGMGLAIAADIVARHGGELTL
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEE
SNRTEGGLRVRIVLPRA
CCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]