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The map label for this gene is pdxA [H]

Identifier: 94311526

GI number: 94311526

Start: 2816488

End: 2817489

Strand: Direct

Name: pdxA [H]

Synonym: Rmet_2590

Alternate gene names: 94311526

Gene position: 2816488-2817489 (Clockwise)

Preceding gene: 94311525

Following gene: 94311527

Centisome position: 71.7

GC content: 66.67

Gene sequence:

>1002_bases
ATGAGCGACTACATTCCTGTCATCGGCATCACGATGGGTGATGCCACGGGCATCGGGCCCGAAGTCATCGTCAAGAGCCT
GGCCCACGAAACCGTCTACGCCCAATGCCGCCCGCTGGTTATCGGCGATGCGCGCCGTCTCGAGCAGGCAGGCAGGCTCG
TCAACTCGGCACTCAAGATCCGCGCGATCCAGTCGCCCGAGGAAGCACGCTTCGAGCCGGGCACGATCGATTGCATCGAC
CTGGGCCTGATCCCCGAAGACCTGCCGTTCGGCAAACTGTCTGCCGTGGCGGGCGACGCGGCGTTCCGCTACATCGAGCG
CGCGGTCAGACTGGCGCAGGAAGAAAAGATCGATGCGATCTGCACCGCGCCGCTGAACAAGGAAGCCCTGCACGCGGGCG
GCCACAAGTTTCCGGGCCACACCGAGATGCTGGCGCACCTGACCGGCACGCCCGAAGTCTCGATGATGCTCGTCGCGCCG
AAGCTGCGCGTGATTCACGTCACCACGCACATCGGCCTGCTTGATGCCATCCGCAAGATCGAACCCGGTCTGGTACAGCG
CACGATCGAGCGCGGCCAGGTGACGCTGCAGCGCGCGGGCATCGCTGCCCCGCGCATCGGCGTCTGCGGCATCAACCCGC
ACGCTGGCGAGAACGGCCTGTTCGGTCACGGCGAGGAAGAGCAGAAGATCATTCCGGCCGTGGAAGCGCTGCGCGCGCGC
GGCTGGGACGTGGAAGGCCCGCTGCCGGCCGATACACTGTTCTACCGCGCCGGCCGTGGCGATTTCGACCTCGTGGTGGC
CATGTATCACGATCAGGGCCATGGCCCGGTCAAGGTGCTTGGCCTGGAAGCCGGCGTGAACATCACCGTGGGCCTGCCAG
TCATCCGCACGTCGGTGGACCACGGCACCGCGTTCGACATCGCCGGCAAGGGCATCGCCGACGAACGCAGCCTGCTGGAA
GCATTGCGCCAGGGCGCGGAGCTGGCTACCCGCCGCGCGTGA

Upstream 100 bases:

>100_bases
CACCAAGGCCGGTGCATTCGGCACCGAAGCTGCGTTGTGGCTGGCGTGGCAAGCCATGCGCCAGAACTGAACCGCCCCAC
GAAACGGGATAAAGACAAAC

Downstream 100 bases:

>100_bases
GCAGGACGGCGGCCCTGCCGCCCTGCCACACAGCTTGAGCCAGCCACCGCTGCGGTAAGATCGGGGATCGTTTTCGATCC
CCTTTTCTCTTTTCCCATCC

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MSDYIPVIGITMGDATGIGPEVIVKSLAHETVYAQCRPLVIGDARRLEQAGRLVNSALKIRAIQSPEEARFEPGTIDCID
LGLIPEDLPFGKLSAVAGDAAFRYIERAVRLAQEEKIDAICTAPLNKEALHAGGHKFPGHTEMLAHLTGTPEVSMMLVAP
KLRVIHVTTHIGLLDAIRKIEPGLVQRTIERGQVTLQRAGIAAPRIGVCGINPHAGENGLFGHGEEEQKIIPAVEALRAR
GWDVEGPLPADTLFYRAGRGDFDLVVAMYHDQGHGPVKVLGLEAGVNITVGLPVIRTSVDHGTAFDIAGKGIADERSLLE
ALRQGAELATRRA

Sequences:

>Translated_333_residues
MSDYIPVIGITMGDATGIGPEVIVKSLAHETVYAQCRPLVIGDARRLEQAGRLVNSALKIRAIQSPEEARFEPGTIDCID
LGLIPEDLPFGKLSAVAGDAAFRYIERAVRLAQEEKIDAICTAPLNKEALHAGGHKFPGHTEMLAHLTGTPEVSMMLVAP
KLRVIHVTTHIGLLDAIRKIEPGLVQRTIERGQVTLQRAGIAAPRIGVCGINPHAGENGLFGHGEEEQKIIPAVEALRAR
GWDVEGPLPADTLFYRAGRGDFDLVVAMYHDQGHGPVKVLGLEAGVNITVGLPVIRTSVDHGTAFDIAGKGIADERSLLE
ALRQGAELATRRA
>Mature_332_residues
SDYIPVIGITMGDATGIGPEVIVKSLAHETVYAQCRPLVIGDARRLEQAGRLVNSALKIRAIQSPEEARFEPGTIDCIDL
GLIPEDLPFGKLSAVAGDAAFRYIERAVRLAQEEKIDAICTAPLNKEALHAGGHKFPGHTEMLAHLTGTPEVSMMLVAPK
LRVIHVTTHIGLLDAIRKIEPGLVQRTIERGQVTLQRAGIAAPRIGVCGINPHAGENGLFGHGEEEQKIIPAVEALRARG
WDVEGPLPADTLFYRAGRGDFDLVVAMYHDQGHGPVKVLGLEAGVNITVGLPVIRTSVDHGTAFDIAGKGIADERSLLEA
LRQGAELATRRA

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=317, Percent_Identity=39.1167192429022, Blast_Score=180, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 35650; Mature: 35518

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDYIPVIGITMGDATGIGPEVIVKSLAHETVYAQCRPLVIGDARRLEQAGRLVNSALKI
CCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHE
RAIQSPEEARFEPGTIDCIDLGLIPEDLPFGKLSAVAGDAAFRYIERAVRLAQEEKIDAI
EEECCCHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
CTAPLNKEALHAGGHKFPGHTEMLAHLTGTPEVSMMLVAPKLRVIHVTTHIGLLDAIRKI
ECCCCCHHHHHCCCCCCCCHHHHHHHHCCCCCEEEEEEECCEEEEEEEHHHHHHHHHHHC
EPGLVQRTIERGQVTLQRAGIAAPRIGVCGINPHAGENGLFGHGEEEQKIIPAVEALRAR
CCHHHHHHHHHCCEEEECCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
GWDVEGPLPADTLFYRAGRGDFDLVVAMYHDQGHGPVKVLGLEAGVNITVGLPVIRTSVD
CCCCCCCCCHHHHEEECCCCCEEEEEEEEECCCCCCEEEEEEECCCEEEECCCEEEECCC
HGTAFDIAGKGIADERSLLEALRQGAELATRRA
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDYIPVIGITMGDATGIGPEVIVKSLAHETVYAQCRPLVIGDARRLEQAGRLVNSALKI
CCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHE
RAIQSPEEARFEPGTIDCIDLGLIPEDLPFGKLSAVAGDAAFRYIERAVRLAQEEKIDAI
EEECCCHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
CTAPLNKEALHAGGHKFPGHTEMLAHLTGTPEVSMMLVAPKLRVIHVTTHIGLLDAIRKI
ECCCCCHHHHHCCCCCCCCHHHHHHHHCCCCCEEEEEEECCEEEEEEEHHHHHHHHHHHC
EPGLVQRTIERGQVTLQRAGIAAPRIGVCGINPHAGENGLFGHGEEEQKIIPAVEALRAR
CCHHHHHHHHHCCEEEECCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
GWDVEGPLPADTLFYRAGRGDFDLVVAMYHDQGHGPVKVLGLEAGVNITVGLPVIRTSVD
CCCCCCCCCHHHHEEECCCCCEEEEEEEEECCCCCCEEEEEEECCCEEEECCCEEEECCC
HGTAFDIAGKGIADERSLLEALRQGAELATRRA
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]